JP2015509097A5 - - Google Patents
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- Publication number
- JP2015509097A5 JP2015509097A5 JP2014552303A JP2014552303A JP2015509097A5 JP 2015509097 A5 JP2015509097 A5 JP 2015509097A5 JP 2014552303 A JP2014552303 A JP 2014552303A JP 2014552303 A JP2014552303 A JP 2014552303A JP 2015509097 A5 JP2015509097 A5 JP 2015509097A5
- Authority
- JP
- Japan
- Prior art keywords
- binding molecule
- binding
- molecule
- tmem30a
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100026772 Cell cycle control protein 50A Human genes 0.000 claims description 24
- 101000910814 Homo sapiens Cell cycle control protein 50A Proteins 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 18
- 208000012902 Nervous system disease Diseases 0.000 claims description 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 208000016192 Demyelinating disease Diseases 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261585039P | 2012-01-10 | 2012-01-10 | |
| US61/585,039 | 2012-01-10 | ||
| PCT/US2013/021041 WO2013106577A2 (en) | 2012-01-10 | 2013-01-10 | Enhancement of transport of therapeutic molecules across the blood brain barrier |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509097A JP2015509097A (ja) | 2015-03-26 |
| JP2015509097A5 true JP2015509097A5 (enExample) | 2016-02-12 |
| JP6247226B2 JP6247226B2 (ja) | 2017-12-13 |
Family
ID=47633561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552303A Expired - Fee Related JP6247226B2 (ja) | 2012-01-10 | 2013-01-10 | 血液脳関門を越える治療分子の輸送の向上 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9676849B2 (enExample) |
| EP (1) | EP2802606B1 (enExample) |
| JP (1) | JP6247226B2 (enExample) |
| KR (1) | KR102104686B1 (enExample) |
| CN (1) | CN104159922B (enExample) |
| AU (1) | AU2013207927B2 (enExample) |
| BR (1) | BR112014016887A2 (enExample) |
| CA (1) | CA2860579A1 (enExample) |
| CY (1) | CY1120419T1 (enExample) |
| DK (1) | DK2802606T3 (enExample) |
| EA (1) | EA201491346A1 (enExample) |
| ES (1) | ES2677111T3 (enExample) |
| HR (1) | HRP20180937T1 (enExample) |
| HU (1) | HUE039033T2 (enExample) |
| IL (1) | IL233246B (enExample) |
| LT (1) | LT2802606T (enExample) |
| MX (1) | MX350378B (enExample) |
| NZ (1) | NZ626620A (enExample) |
| PL (1) | PL2802606T3 (enExample) |
| PT (1) | PT2802606T (enExample) |
| SI (1) | SI2802606T1 (enExample) |
| TR (1) | TR201809743T4 (enExample) |
| WO (1) | WO2013106577A2 (enExample) |
| ZA (1) | ZA201404873B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6148729B2 (ja) | 2012-07-04 | 2017-06-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 共有結合している抗原−抗体結合体 |
| BR112016014945A2 (pt) | 2014-01-03 | 2018-01-23 | F. Hoffmann-La Roche Ag | conjugado, formulação farmacêutica e uso |
| BR112016012666A2 (pt) | 2014-01-03 | 2017-09-26 | Hoffmann La Roche | conjugado, anticorpos, formulação farmacêutica e usos de conjugado |
| ES2895752T3 (es) * | 2014-01-03 | 2022-02-22 | Hoffmann La Roche | Anticuerpos biespecíficos anti-hapteno/anti-receptor de la barrera hematoencefálica, complejos de los mismos y su uso como lanzaderas a través de la barrera hematoencefálica |
| CN106459194B (zh) * | 2014-03-06 | 2019-10-18 | 加拿大国家研究委员会 | 胰岛素样生长因子1受体特异性抗体及其用途 |
| JP6541236B2 (ja) * | 2014-03-06 | 2019-07-10 | ナショナル リサーチ カウンシル オブ カナダ | インスリン様成長因子１受容体特異的抗体及びそれらの使用 |
| KR102355310B1 (ko) * | 2014-03-06 | 2022-01-24 | 내셔날 리서치 카운실 오브 캐나다 | 인슐린-유사 성장 인자 1 수용체-특이적 항체 및 그의 용도 |
| JP6391318B2 (ja) * | 2014-06-27 | 2018-09-19 | 学校法人順天堂 | アルツハイマー病予防治療薬のスクリーニング法 |
| EP3233922B1 (en) * | 2014-12-19 | 2022-05-11 | MedImmune Limited | Blood brain barrier transport molecules and uses thereof |
| SG11201705986QA (en) | 2015-01-29 | 2017-08-30 | Technophage Investigação E Desenvolvimento Em Biotecnologia Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
| FR3038517B1 (fr) * | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| US10738115B2 (en) * | 2016-07-06 | 2020-08-11 | National Research Council Of Canada | Humanized antibodies transmigrating the blood-brain barrier and uses thereof |
| EP3484518B1 (en) | 2016-07-07 | 2024-08-14 | The Board of Trustees of the Leland Stanford Junior University | Antibody adjuvant conjugates |
| EP3551666A4 (en) | 2016-12-12 | 2020-07-29 | National Research Council of Canada | VARIANTS OF ANTIBODIES CROSSING THE HEMATOENCEPHALIC BARRIER AND THEIR USES |
| KR20240095466A (ko) * | 2017-01-30 | 2024-06-25 | 내션얼 리서치 카운슬 오브 캐나다 | 혈액-뇌 장벽을 관통이동하는 화합물 및 이의 용도 |
| WO2019036725A2 (en) | 2017-08-18 | 2019-02-21 | Adrx, Inc. | PEPTIDE INHIBITORS OF TAU AGGREGATION |
| KR20200104333A (ko) * | 2017-12-28 | 2020-09-03 | 난징 레전드 바이오테크 씨오., 엘티디. | Tigit에 대한 단일-도메인 항체 및 이의 변이체 |
| US10688191B2 (en) | 2018-01-19 | 2020-06-23 | Hr Biomed, Llc | Delivery of a chemotherapy agent across the blood-brain barrier |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| WO2019246003A1 (en) * | 2018-06-18 | 2019-12-26 | Anwita Biosciences, Inc. | Anti-mesothelin constructs and uses thereof |
| EP3586860A1 (en) * | 2018-06-22 | 2020-01-01 | Universität Ulm | Complement inhibitors and uses thereof |
| US20210161993A1 (en) * | 2018-09-12 | 2021-06-03 | Pvp Labs Pte. Ltd. | Method for accelerated healing of burn wounds |
| KR20210100086A (ko) | 2018-10-04 | 2021-08-13 | 유니버시티 오브 로체스터 | 혈장 오스몰농도 조작에 의한 글림프 전달의 개선 |
| EP3873934A2 (en) | 2018-10-29 | 2021-09-08 | Biogen MA Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| CN113284553B (zh) * | 2021-05-28 | 2023-01-10 | 南昌大学 | 一种用于治疗药物成瘾的药物靶点结合能力测试方法 |
| CN117377487B (zh) | 2021-12-02 | 2024-11-22 | 领诺(上海)医药科技有限公司 | 转铁蛋白结合抗体及其应用 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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| CA2623841C (en) * | 2005-09-27 | 2019-03-12 | National Research Council Of Canada | Methods of identifying agents capable of tmem30a mediated transmigration across the blood brain barrier (bbb) |
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-
2013
- 2013-01-10 HR HRP20180937TT patent/HRP20180937T1/hr unknown
- 2013-01-10 NZ NZ626620A patent/NZ626620A/en not_active IP Right Cessation
- 2013-01-10 US US14/370,828 patent/US9676849B2/en active Active
- 2013-01-10 KR KR1020147018724A patent/KR102104686B1/ko not_active Expired - Fee Related
- 2013-01-10 EP EP13702529.2A patent/EP2802606B1/en active Active
- 2013-01-10 BR BR112014016887A patent/BR112014016887A2/pt not_active Application Discontinuation
- 2013-01-10 LT LTEP13702529.2T patent/LT2802606T/lt unknown
- 2013-01-10 MX MX2014008365A patent/MX350378B/es active IP Right Grant
- 2013-01-10 EA EA201491346A patent/EA201491346A1/ru unknown
- 2013-01-10 CN CN201380004989.7A patent/CN104159922B/zh not_active Expired - Fee Related
- 2013-01-10 CA CA2860579A patent/CA2860579A1/en active Pending
- 2013-01-10 WO PCT/US2013/021041 patent/WO2013106577A2/en not_active Ceased
- 2013-01-10 SI SI201331060T patent/SI2802606T1/en unknown
- 2013-01-10 AU AU2013207927A patent/AU2013207927B2/en not_active Ceased
- 2013-01-10 DK DK13702529.2T patent/DK2802606T3/en active
- 2013-01-10 JP JP2014552303A patent/JP6247226B2/ja not_active Expired - Fee Related
- 2013-01-10 TR TR2018/09743T patent/TR201809743T4/tr unknown
- 2013-01-10 PL PL13702529T patent/PL2802606T3/pl unknown
- 2013-01-10 HU HUE13702529A patent/HUE039033T2/hu unknown
- 2013-01-10 PT PT137025292T patent/PT2802606T/pt unknown
- 2013-01-10 ES ES13702529.2T patent/ES2677111T3/es active Active
-
2014
- 2014-06-19 IL IL233246A patent/IL233246B/en active IP Right Grant
- 2014-07-01 ZA ZA2014/04873A patent/ZA201404873B/en unknown
-
2018
- 2018-07-11 CY CY20181100721T patent/CY1120419T1/el unknown
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