|
US1166947A
(en)
|
1914-10-05 |
1916-01-04 |
Paramount Hosiery Form Drying Company |
Hosiery-finishing apparatus.
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4631190A
(en)
|
1981-06-26 |
1986-12-23 |
Shen Wei C |
Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
AU561343B2
(en)
|
1981-10-19 |
1987-05-07 |
Genentech Inc. |
Human immune interferon by recombinant dna
|
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US4889919A
(en)
|
1986-08-13 |
1989-12-26 |
Zymogenetics, Inc. |
Biologically active PDGF derived A-chain homodimers
|
|
US5157021A
(en)
|
1985-03-15 |
1992-10-20 |
Novo Nordisk A/S |
Insulin derivatives and pharmaceutical preparations containing these derivatives
|
|
US4745055A
(en)
|
1985-05-07 |
1988-05-17 |
California Biotechnology Inc. |
Fused protein for enzyme immunoassay system
|
|
IL78444A
(en)
|
1986-04-08 |
1992-05-25 |
Yeda Res & Dev |
Human gamma interferon-specific receptor protein,antibody against said protein,and compositions containing said protein and antibody
|
|
DE3751908T2
(de)
|
1986-07-07 |
1997-02-06 |
Centocor Inc |
Chimärisches Murine-Mensch-Immunoglobulin, spezifisch für tumorassoziertes 17-1A Antigen
|
|
NO873164L
(no)
|
1986-07-30 |
1988-02-01 |
Teijin Ltd |
Muse-humane kimaere antistoffer.
|
|
IL84285A
(en)
|
1986-10-27 |
1993-03-15 |
Int Genetic Engineering |
Chimeric antibody with specificity to human tumor antigen
|
|
GB8626412D0
(en)
|
1986-11-05 |
1986-12-03 |
Clark M R |
Antibodies
|
|
CA1339445C
(en)
|
1986-11-12 |
1997-09-09 |
The General Hospital Corporation |
Recombinant hybrid immunoglobulin molecules and method of use
|
|
EP0832981A1
(en)
|
1987-02-17 |
1998-04-01 |
Pharming B.V. |
DNA sequences to target proteins to the mammary gland for efficient secretion
|
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
|
FI903489A0
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
EP0474744B1
(en)
|
1989-05-22 |
1994-08-03 |
Zymogenetics, Inc. |
Pdgf -alpha- receptor
|
|
US5061786A
(en)
|
1989-05-25 |
1991-10-29 |
Genentech, Inc. |
Biologically active polypeptides based on transforming growth factor-β
|
|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
JPH0396383A
(ja)
|
1989-09-08 |
1991-04-22 |
Riso Kagaku Corp |
画像形成装置
|
|
DE10399023I2
(de)
|
1989-09-12 |
2006-11-23 |
Ahp Mfg B V |
TFN-bindende Proteine
|
|
US5633076A
(en)
|
1989-12-01 |
1997-05-27 |
Pharming Bv |
Method of producing a transgenic bovine or transgenic bovine embryo
|
|
US5648273A
(en)
|
1989-12-27 |
1997-07-15 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Hepatic growth factor receptor is the MET proto-oncogene
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
CA2040099A1
(en)
|
1990-05-01 |
1991-11-02 |
Mariano Barbacid |
Tyrosine kinase negative trkb
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5453491A
(en)
|
1990-09-11 |
1995-09-26 |
Kiyoshi Takatsu |
Murine interleukin-5 receptor
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
JPH04334377A
(ja)
|
1990-12-31 |
1992-11-20 |
Akzo Nv |
酸−不安定性リンカー分子
|
|
EP0580751A1
(en)
|
1991-04-19 |
1994-02-02 |
Schering Corporation |
Subunit of the human interleukin-3 receptor
|
|
US5227158A
(en)
|
1991-06-10 |
1993-07-13 |
Genentech, Inc. |
Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
|
|
US5348856A
(en)
|
1991-07-08 |
1994-09-20 |
E. R. Squibb & Sons, Inc. |
DNA encoding TRKC protein
|
|
US5756096A
(en)
|
1991-07-25 |
1998-05-26 |
Idec Pharmaceuticals Corporation |
Recombinant antibodies for human therapy
|
|
MX9204374A
(es)
|
1991-07-25 |
1993-03-01 |
Idec Pharma Corp |
Anticuerpo recombinante y metodo para su produccion.
|
|
JP3571337B2
(ja)
|
1992-02-11 |
2004-09-29 |
セル ジェネシス，インコーポレーテッド |
遺伝子標的現象による同型遺伝子接合
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
|
US5556623A
(en)
|
1993-03-30 |
1996-09-17 |
Eli Lilly And Company |
Antibody-drug conjugates
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US6740734B1
(en)
|
1994-01-14 |
2004-05-25 |
Biovitrum Ab |
Bacterial receptor structures
|
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US5686292A
(en)
|
1995-06-02 |
1997-11-11 |
Genentech, Inc. |
Hepatocyte growth factor receptor antagonist antibodies and uses thereof
|
|
US5811524A
(en)
|
1995-06-07 |
1998-09-22 |
Idec Pharmaceuticals Corporation |
Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
|
|
ATE242809T1
(de)
|
1995-09-08 |
2003-06-15 |
Genentech Inc |
Vegf-verwandtes protein
|
|
GB9524973D0
(en)
|
1995-12-06 |
1996-02-07 |
Lynxvale Ltd |
Viral vectors
|
|
JP2000515735A
(ja)
|
1996-07-03 |
2000-11-28 |
ジェネンテック インコーポレーテッド |
肝細胞成長因子レセプターアゴニスト
|
|
US6159462A
(en)
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
|
EP0941120A4
(en)
|
1996-11-05 |
2004-08-18 |
Bristol Myers Squibb Co |
BRANCHED PEPTIDLINKERS
|
|
DE69833755T2
(de)
|
1997-05-21 |
2006-12-28 |
Biovation Ltd. |
Verfahren zur herstellung von nicht-immunogenen proteinen
|
|
WO1998056915A2
(en)
|
1997-06-12 |
1998-12-17 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
PT1141014E
(pt)
|
1999-01-06 |
2005-04-29 |
Genentech Inc |
Variante mutante do factor de crescimento semelhante a insulina (igf-i)
|
|
DE60042550D1
(de)
|
1999-01-06 |
2009-08-27 |
Genentech Inc |
Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i)
|
|
SE9901379D0
(sv)
|
1999-04-19 |
1999-04-19 |
Pharmacia & Upjohn Ab |
Receptor structures
|
|
US6602977B1
(en)
|
1999-04-19 |
2003-08-05 |
Biovitrum Ab |
Receptor structures
|
|
US7943129B2
(en)
*
|
2000-05-26 |
2011-05-17 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
|
AU2001270609A1
(en)
|
2000-06-30 |
2002-01-14 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Heterodimeric fusion proteins
|
|
CA2421447C
(en)
|
2000-09-08 |
2012-05-08 |
Universitat Zurich |
Collections of repeat proteins comprising repeat modules
|
|
WO2002088171A2
(en)
|
2001-04-26 |
2002-11-07 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
NZ545776A
(en)
|
2003-08-22 |
2009-05-31 |
Biogen Idec Inc |
Improved antibodies having altered effector function and methods for making the same
|
|
AU2003264100A1
(en)
|
2003-08-25 |
2005-03-10 |
Pieris Proteolab Ag |
Muteins of a bilin-binding protein with affinity for a given target
|
|
CA2545603A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
|
|
JP2008500064A
(ja)
|
2004-05-21 |
2008-01-10 |
ザ ユーエービー リサーチ ファウンデーション |
可変性リンパ球受容体、その関連ポリペプチドおよび核酸、ならびにその使用
|
|
US20060234299A1
(en)
|
2004-11-16 |
2006-10-19 |
Avidia Research Institute |
Protein scaffolds and uses thereof
|
|
JP5269597B2
(ja)
|
2005-09-27 |
2013-08-21 |
ナショナル リサーチ カウンシル オブ カナダ |
血液―脳隔壁エピトープとその利用
|
|
WO2007095338A2
(en)
*
|
2006-02-15 |
2007-08-23 |
Imclone Systems Incorporated |
Functional antibodies
|
|
KR20100021601A
(ko)
|
2007-05-14 |
2010-02-25 |
바이오겐 아이덱 엠에이 인코포레이티드 |
단일-쇄 Ｆｃ(ＳｃＦｃ) 부분, 이를 포함하는 결합 폴리펩타이드, 및 이에 관련된 방법
|
|
AP2012006359A0
(en)
*
|
2010-03-03 |
2012-08-31 |
Boehringer Ingelheim Int |
Biparatopic abeta binding polypeptides
|
|
CA2796215C
(en)
*
|
2010-04-14 |
2021-05-18 |
National Research Council Of Canada |
Compositions and methods for brain delivery of analgesic peptides
|