JP2013506411A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013506411A5 JP2013506411A5 JP2012531451A JP2012531451A JP2013506411A5 JP 2013506411 A5 JP2013506411 A5 JP 2013506411A5 JP 2012531451 A JP2012531451 A JP 2012531451A JP 2012531451 A JP2012531451 A JP 2012531451A JP 2013506411 A5 JP2013506411 A5 JP 2013506411A5
- Authority
- JP
- Japan
- Prior art keywords
- vhh
- binding
- seq
- dll4
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700041286 delta Proteins 0.000 claims 8
- 101150109170 dll4 gene Proteins 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 7
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 102000058223 human VEGFA Human genes 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172137 | 2009-10-02 | ||
| EP09172137.3 | 2009-10-02 | ||
| EP10175316.8 | 2010-09-03 | ||
| EP10175316 | 2010-09-03 | ||
| PCT/EP2010/064695 WO2011039370A1 (en) | 2009-10-02 | 2010-10-01 | Bispecific binding molecules for anti-angiogenesis therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015211551A Division JP2016026207A (ja) | 2009-10-02 | 2015-10-28 | 抗脈管形成療法のための二重特異性結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506411A JP2013506411A (ja) | 2013-02-28 |
| JP2013506411A5 true JP2013506411A5 (enExample) | 2013-11-14 |
| JP5833009B2 JP5833009B2 (ja) | 2015-12-16 |
Family
ID=43431796
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531451A Expired - Fee Related JP5833009B2 (ja) | 2009-10-02 | 2010-10-01 | 抗脈管形成療法のための二重特異性結合分子 |
| JP2015211551A Pending JP2016026207A (ja) | 2009-10-02 | 2015-10-28 | 抗脈管形成療法のための二重特異性結合分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015211551A Pending JP2016026207A (ja) | 2009-10-02 | 2015-10-28 | 抗脈管形成療法のための二重特異性結合分子 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20110172398A1 (enExample) |
| EP (1) | EP2483314A1 (enExample) |
| JP (2) | JP5833009B2 (enExample) |
| KR (1) | KR20120101375A (enExample) |
| CN (2) | CN102639566B (enExample) |
| AP (1) | AP2012006188A0 (enExample) |
| AR (1) | AR078515A1 (enExample) |
| AU (1) | AU2010302589A1 (enExample) |
| BR (1) | BR112012007239A2 (enExample) |
| CA (1) | CA2775422A1 (enExample) |
| CL (1) | CL2012000826A1 (enExample) |
| EA (1) | EA201200548A1 (enExample) |
| EC (1) | ECSP12011835A (enExample) |
| IL (1) | IL218542A0 (enExample) |
| IN (1) | IN2012DN02752A (enExample) |
| MA (1) | MA33607B1 (enExample) |
| MX (1) | MX2012003897A (enExample) |
| NZ (2) | NZ626302A (enExample) |
| PE (1) | PE20121024A1 (enExample) |
| PH (1) | PH12012500525A1 (enExample) |
| TN (1) | TN2012000145A1 (enExample) |
| TW (1) | TW201124533A (enExample) |
| UY (1) | UY32920A (enExample) |
| WO (1) | WO2011039370A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2664738C (en) | 2006-09-29 | 2017-03-07 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| JP5646457B2 (ja) | 2008-04-29 | 2014-12-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
| AR072000A1 (es) | 2008-06-03 | 2010-07-28 | Abbott Lab | Proteinas de union multivalentes con capacidad de unir dos o mas antigenos y usos de la misma |
| JP2011523853A (ja) | 2008-06-03 | 2011-08-25 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリン及びその使用 |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
| MX336152B (es) | 2009-08-29 | 2016-01-08 | Abbvie Inc | Proteinas terapeutico de union a dll4. |
| UY32920A (es) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
| US8883145B2 (en) | 2009-10-16 | 2014-11-11 | Oncomed Pharmaceuticals, Inc. | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent |
| BR112012009450A2 (pt) | 2009-10-30 | 2017-05-23 | Novozymes Biopharma Dk As | variantes de albumina |
| EP3072904A1 (en) | 2010-03-02 | 2016-09-28 | Abbvie Inc. | Therapeutic dll4 binding proteins |
| PH12012502193A1 (en) | 2010-05-06 | 2021-08-09 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
| EA201291180A1 (ru) | 2010-05-06 | 2013-05-30 | Новартис Аг | Композиции и способы применения терапевтических антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) |
| BR112013001433A2 (pt) | 2010-07-19 | 2016-05-31 | Hoffmann La Roche | método de identificação de pacientes com maior probabilidade de responder a terapia anticâncer |
| CN103109189A (zh) | 2010-07-19 | 2013-05-15 | 霍夫曼-拉罗奇有限公司 | 鉴定响应抗癌疗法的可能性升高的患者的方法 |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| SG187938A1 (en) | 2010-08-26 | 2013-04-30 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
| US20120225081A1 (en) * | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| US20130323265A1 (en) * | 2010-11-15 | 2013-12-05 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer with dll4 antagonists |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| US20130078247A1 (en) | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| JP6170496B2 (ja) | 2011-09-23 | 2017-07-26 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｖｅｇｆ／ｄｌｌ４結合剤およびその使用 |
| AU2015268749B2 (en) * | 2011-09-23 | 2017-05-25 | Oncomed Pharmaceuticals, Inc. | VEGF/DLL4 binding agents and uses thereof |
| SG11201401717VA (en) | 2011-11-04 | 2014-05-29 | Novartis Ag | Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| CN104159920A (zh) | 2011-12-30 | 2014-11-19 | 艾伯维公司 | 针对il-13和/或il-17的双重可变结构域免疫球蛋白 |
| ES2664328T3 (es) | 2012-03-16 | 2018-04-19 | Albumedix A/S | Variantes de albúmina |
| EP2872534B1 (en) | 2012-07-13 | 2018-08-08 | Roche Glycart AG | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| JP2015532272A (ja) * | 2012-09-28 | 2015-11-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二重アンジオポエチン−２／Ｄｌｌ４結合剤および抗ＶＥＧＦ−Ｒ剤を含む薬学的組み合わせ |
| WO2014049100A1 (en) * | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents |
| US20150368329A1 (en) * | 2012-10-15 | 2015-12-24 | Oncomed Pharmaceuticals, Inc. | Methods of Treating Ocular Diseases |
| JP6371294B2 (ja) * | 2012-10-31 | 2018-08-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｄｌｌ４アンタゴニストによる処置の方法およびモニタリング |
| MY171664A (en) | 2012-11-01 | 2019-10-22 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulins and uses thereof |
| AU2013337644A1 (en) * | 2012-11-01 | 2015-05-07 | Abbvie Inc. | Stable Dual Variable Domain Immunoglobulin protein formulations |
| CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質 |
| TR201910592T4 (tr) * | 2013-07-09 | 2019-08-21 | Ablbio | Spesifik olarak dll4 ve vegf ye bağlanan yeni çift-hedefli protein ve bunun kullanımı. |
| WO2015123359A1 (en) * | 2014-02-11 | 2015-08-20 | Albany Medical College | Multi-functional mucosal vaccine platform |
| EP3125937A4 (en) * | 2014-04-04 | 2017-11-01 | Oncomed Pharmaceuticals, Inc. | Treatment of gastric cancer |
| US20170267784A1 (en) | 2014-10-23 | 2017-09-21 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
| WO2016070051A2 (en) | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| WO2016192613A1 (zh) * | 2015-06-01 | 2016-12-08 | 中山大学 | 具有融合至常规Fab片段的单域抗原结合片段的二价抗体 |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| CA2989966C (en) | 2015-08-20 | 2024-04-30 | Albumedix A/S | Albumin variants and conjugates |
| EP3353204B1 (en) | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
| TWI746473B (zh) * | 2015-11-02 | 2021-11-21 | 美商辛分子醫藥有限公司 | 針對細胞內抗原之單域抗體 |
| RU2018123709A (ru) * | 2015-12-04 | 2020-01-09 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Новые антитела для лечения онкологических заболеваний |
| JP6879511B2 (ja) * | 2016-01-29 | 2021-06-02 | 国立大学法人京都大学 | 血小板産生促進剤及びそれを用いた血小板の製造方法 |
| IL309890A (en) | 2017-01-30 | 2024-03-01 | Alexion Pharma Inc | Monovalent anti-properdin antibodies and antibody fragments |
| CN112004826B (zh) * | 2018-02-05 | 2024-06-14 | 自由大学基金会 | 反向激动性抗us28抗体 |
| CN111995686B (zh) * | 2019-05-27 | 2022-06-14 | 兰州大学 | 一种具有抗血管生成活性的药物及其制备方法 |
| TWI844709B (zh) * | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CN110452297B (zh) * | 2019-09-03 | 2020-04-14 | 上海洛启生物医药技术有限公司 | 抗vegf单域抗体及其应用 |
| TW202221027A (zh) * | 2020-09-17 | 2022-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｖｅｇｆ和ａｎｇ－２的雙特異性抗原結合分子 |
| CN112535738B (zh) * | 2020-12-04 | 2022-09-09 | 中国科学技术大学 | 奥沙利铂偶联物及其制备方法和应用 |
| CN116897164A (zh) * | 2021-02-10 | 2023-10-17 | 上海济煜医药科技有限公司 | 抗vegf抗体及其用途 |
| CN115724968B (zh) * | 2021-08-27 | 2023-08-08 | 三优生物医药(上海)有限公司 | Vegf结合分子及其用途 |
| EP4436996A4 (en) * | 2021-11-24 | 2025-10-08 | Linno Pharmaceuticals Inc | VEGF-BINDING PROTEIN AND ITS USE |
| CN116063469B (zh) * | 2022-08-29 | 2023-09-22 | 中山大学 | 一种寨卡病毒中和性纳米抗体及其制备方法与应用 |
| WO2024055995A1 (zh) * | 2022-09-14 | 2024-03-21 | 寻济生物科技（北京）有限公司 | 一种抗vegfa融合蛋白及其制备方法和应用 |
| EP4582447A4 (en) * | 2022-09-14 | 2026-01-21 | Quaerite Biopharm Res Beijing Co Ltd | ANTI-VEGFA ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THESE AND ITS USE |
| EP4620979A1 (en) | 2022-11-14 | 2025-09-24 | Cognano, Inc. | Antibody and method for producing antibody |
| CN117686722B (zh) * | 2023-12-20 | 2024-08-09 | 内蒙古元牛繁育科技有限公司 | 一种s100a4纳米抗体及其应用 |
| CN117860786B (zh) * | 2024-03-12 | 2024-06-04 | 北京贝来药业有限公司 | 基因修饰间充质干细胞在多种疾病中的制药用途和诊断用途 |
| CN120025456B (zh) * | 2024-03-13 | 2025-11-07 | 寻济生物科技（北京）有限公司 | 一种抗vegfa融合构建体及其制备方法和应用 |
| WO2025212751A1 (en) * | 2024-04-02 | 2025-10-09 | Therini Bio, Inc. | Multi-specific antigen-binding proteins which bind human fibrin yc or fibrinogen yc domain and vascular endothelial growth factor and methods of use |
| WO2026055310A1 (en) * | 2024-09-06 | 2026-03-12 | Merck Sharp & Dohme Llc | Multivalent fzd4, wnt co-receptor, and vegf binding molecules and uses thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| CA2433877C (en) | 2001-01-17 | 2014-11-18 | Aptevo Research And Development Llc | Binding domain-immunoglobulin fusion proteins |
| CA2447851C (en) | 2001-06-28 | 2012-08-28 | Domantis Limited | Dual-specific ligand and its use |
| AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| WO2004041862A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| DE60329627D1 (de) | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
| RU2357974C2 (ru) * | 2003-01-10 | 2009-06-10 | Аблинкс Н.В. | Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| WO2005040219A1 (en) * | 2003-10-28 | 2005-05-06 | Novo Nordisk A/S | Laminin-5 gamma2-binding peptides, related compositions, and use thereof |
| ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
| US20050284249A1 (en) | 2004-06-29 | 2005-12-29 | Arnone David F | Worm type gear mover assembly |
| AU2005293752A1 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease |
| US8048418B2 (en) * | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
| RU2464276C2 (ru) | 2005-05-18 | 2012-10-20 | Аблинкс Н.В. | Улучшенные нанотела против фактора некроза опухоли-альфа |
| DK2444424T3 (en) * | 2005-05-20 | 2018-12-03 | Ablynx Nv | IMPROVED NANOL BODIES (TM) FOR TREATING AGGREGATED MEDICINAL DISORDERS |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JP5489465B2 (ja) | 2005-12-16 | 2014-05-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｄｌｌ４アンタゴニストによって腫瘍増殖を阻害する治療方法 |
| KR20090016762A (ko) | 2006-06-06 | 2009-02-17 | 제넨테크, 인크. | 혈관 발달을 조정하기 위한 조성물 및 방법 |
| CN101490084A (zh) * | 2006-06-06 | 2009-07-22 | 健泰科生物技术公司 | 抗dll4抗体及其使用方法 |
| CA2654000A1 (en) | 2006-06-06 | 2008-05-22 | Genentech, Inc. | Anti-dll4 antibodies and methods using same |
| RS52685B (sr) * | 2006-08-07 | 2013-08-30 | Regeneron Pharmaceuticals, Inc. | Korišćenje antagonista dii4 u ishemijskom oštećenju ili vaskularnoj insuficijenciji |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| WO2008070513A1 (en) * | 2006-12-01 | 2008-06-12 | Alcon Research, Ltd. | Modulation of polysialylated neural adhesion molecules (psa-ncam) as a regulator of ocular disease |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| CA2678218A1 (en) * | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| GB0709333D0 (en) * | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
| WO2009095489A2 (en) | 2008-02-01 | 2009-08-06 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| CN101965362A (zh) | 2008-03-05 | 2011-02-02 | 埃博灵克斯股份有限公司 | 新型抗原结合二聚体-复合物及其制备方法和应用 |
| WO2009124931A2 (en) * | 2008-04-07 | 2009-10-15 | Ablynx Nv | Amino acid sequences directed against the notch pathways and uses thereof |
| JP5646457B2 (ja) * | 2008-04-29 | 2014-12-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
| US8268314B2 (en) * | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| CN102459346B (zh) * | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
| UY32920A (es) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
-
2010
- 2010-09-30 UY UY0001032920A patent/UY32920A/es not_active Application Discontinuation
- 2010-09-30 US US12/894,989 patent/US20110172398A1/en not_active Abandoned
- 2010-10-01 CN CN201080054891.9A patent/CN102639566B/zh not_active Expired - Fee Related
- 2010-10-01 MX MX2012003897A patent/MX2012003897A/es not_active Application Discontinuation
- 2010-10-01 PE PE2012000422A patent/PE20121024A1/es not_active Application Discontinuation
- 2010-10-01 NZ NZ626302A patent/NZ626302A/en not_active IP Right Cessation
- 2010-10-01 JP JP2012531451A patent/JP5833009B2/ja not_active Expired - Fee Related
- 2010-10-01 WO PCT/EP2010/064695 patent/WO2011039370A1/en not_active Ceased
- 2010-10-01 PH PH1/2012/500525A patent/PH12012500525A1/en unknown
- 2010-10-01 AP AP2012006188A patent/AP2012006188A0/xx unknown
- 2010-10-01 KR KR1020127011329A patent/KR20120101375A/ko not_active Ceased
- 2010-10-01 BR BR112012007239A patent/BR112012007239A2/pt not_active IP Right Cessation
- 2010-10-01 EP EP10768428A patent/EP2483314A1/en not_active Withdrawn
- 2010-10-01 CA CA2775422A patent/CA2775422A1/en not_active Abandoned
- 2010-10-01 NZ NZ598956A patent/NZ598956A/en not_active IP Right Cessation
- 2010-10-01 CN CN201510363066.1A patent/CN105037542A/zh active Pending
- 2010-10-01 TW TW099133632A patent/TW201124533A/zh unknown
- 2010-10-01 AR ARP100103596A patent/AR078515A1/es unknown
- 2010-10-01 IN IN2752DEN2012 patent/IN2012DN02752A/en unknown
- 2010-10-01 AU AU2010302589A patent/AU2010302589A1/en not_active Abandoned
- 2010-10-01 EA EA201200548A patent/EA201200548A1/ru unknown
-
2012
- 2012-03-08 IL IL218542A patent/IL218542A0/en unknown
- 2012-03-26 MA MA34720A patent/MA33607B1/fr unknown
- 2012-03-29 TN TNP2012000145A patent/TN2012000145A1/en unknown
- 2012-04-02 CL CL2012000826A patent/CL2012000826A1/es unknown
- 2012-04-26 EC ECSP12011835 patent/ECSP12011835A/es unknown
-
2013
- 2013-03-22 US US13/848,826 patent/US20140120095A1/en not_active Abandoned
-
2015
- 2015-10-28 JP JP2015211551A patent/JP2016026207A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013506411A5 (enExample) | ||
| WO2012094653A4 (en) | Compositions and methods for macromolecular drug delivery | |
| JP2014513941A5 (enExample) | ||
| HRP20161656T4 (hr) | Sredstva za vezanje na cd33 | |
| JP2012196206A5 (enExample) | ||
| JP2016538830A5 (enExample) | ||
| JP2016513669A5 (enExample) | ||
| JP2010534486A5 (enExample) | ||
| JP2020500885A5 (enExample) | ||
| CN110049997A (zh) | 改进的血清白蛋白结合免疫球蛋白单可变结构域 | |
| JP2013527761A5 (enExample) | ||
| JP2014508510A5 (enExample) | ||
| JP2017529059A5 (enExample) | ||
| JP2013516456A5 (enExample) | ||
| JP2016527286A5 (enExample) | ||
| HRP20180937T1 (hr) | Poboljšavanje transporta terapijskih molekula kroz krvno-moždanu barijeru | |
| JP2019506841A5 (enExample) | ||
| JP2017529067A (ja) | Ｃｄ３結合ドメイン | |
| HRP20190472T1 (hr) | Klaudin-6 specifični imunoreceptori i t-stanični epitopi | |
| JP2018538356A5 (enExample) | ||
| JP2014502955A5 (enExample) | ||
| JP2009518024A5 (enExample) | ||
| JP2011502177A5 (enExample) | ||
| JP2015522576A5 (enExample) | ||
| JP2010539921A5 (enExample) |