CA2775422A1 - Dll4- and vegf- binding bispecific antibodies for anti-angiogenesis therapy - Google Patents

Dll4- and vegf- binding bispecific antibodies for anti-angiogenesis therapy Download PDF

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Publication number
CA2775422A1
CA2775422A1 CA2775422A CA2775422A CA2775422A1 CA 2775422 A1 CA2775422 A1 CA 2775422A1 CA 2775422 A CA2775422 A CA 2775422A CA 2775422 A CA2775422 A CA 2775422A CA 2775422 A1 CA2775422 A1 CA 2775422A1
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CA
Canada
Prior art keywords
vhh
binding
seq
vhhs
vegf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2775422A
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English (en)
French (fr)
Inventor
Eric Borges
Andreas Gschwind
Joachim Boucneau
Evelyn De Tavernier
Joost Kolkman
Pascal Merchiers
Diane Van Hoorick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43431796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2775422(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CA2775422A1 publication Critical patent/CA2775422A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CA2775422A 2009-10-02 2010-10-01 Dll4- and vegf- binding bispecific antibodies for anti-angiogenesis therapy Abandoned CA2775422A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09172137 2009-10-02
EP09172137.3 2009-10-02
EP10175316 2010-09-03
EP10175316.8 2010-09-03
PCT/EP2010/064695 WO2011039370A1 (en) 2009-10-02 2010-10-01 Bispecific binding molecules for anti-angiogenesis therapy

Publications (1)

Publication Number Publication Date
CA2775422A1 true CA2775422A1 (en) 2011-04-07

Family

ID=43431796

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2775422A Abandoned CA2775422A1 (en) 2009-10-02 2010-10-01 Dll4- and vegf- binding bispecific antibodies for anti-angiogenesis therapy

Country Status (24)

Country Link
US (2) US20110172398A1 (enExample)
EP (1) EP2483314A1 (enExample)
JP (2) JP5833009B2 (enExample)
KR (1) KR20120101375A (enExample)
CN (2) CN105037542A (enExample)
AP (1) AP2012006188A0 (enExample)
AR (1) AR078515A1 (enExample)
AU (1) AU2010302589A1 (enExample)
BR (1) BR112012007239A2 (enExample)
CA (1) CA2775422A1 (enExample)
CL (1) CL2012000826A1 (enExample)
EA (1) EA201200548A1 (enExample)
EC (1) ECSP12011835A (enExample)
IL (1) IL218542A0 (enExample)
IN (1) IN2012DN02752A (enExample)
MA (1) MA33607B1 (enExample)
MX (1) MX2012003897A (enExample)
NZ (2) NZ626302A (enExample)
PE (1) PE20121024A1 (enExample)
PH (1) PH12012500525A1 (enExample)
TN (1) TN2012000145A1 (enExample)
TW (1) TW201124533A (enExample)
UY (1) UY32920A (enExample)
WO (1) WO2011039370A1 (enExample)

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JP2013506411A (ja) 2013-02-28
EA201200548A1 (ru) 2012-12-28
IN2012DN02752A (enExample) 2015-09-18
TW201124533A (en) 2011-07-16
KR20120101375A (ko) 2012-09-13
JP5833009B2 (ja) 2015-12-16
CN105037542A (zh) 2015-11-11
AP2012006188A0 (en) 2012-04-30
AR078515A1 (es) 2011-11-16
NZ626302A (en) 2015-09-25
US20110172398A1 (en) 2011-07-14
PE20121024A1 (es) 2012-08-10
AU2010302589A1 (en) 2012-04-19
CN102639566A (zh) 2012-08-15
NZ598956A (en) 2014-07-25
TN2012000145A1 (en) 2013-09-19
MA33607B1 (fr) 2012-09-01
EP2483314A1 (en) 2012-08-08
IL218542A0 (en) 2012-05-31
UY32920A (es) 2011-04-29
WO2011039370A1 (en) 2011-04-07
JP2016026207A (ja) 2016-02-12
PH12012500525A1 (en) 2012-11-26
BR112012007239A2 (pt) 2019-09-24
MX2012003897A (es) 2012-05-08
CN102639566B (zh) 2015-07-22
US20140120095A1 (en) 2014-05-01

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