JP2020500885A5 - - Google Patents

Download PDF

Info

Publication number
JP2020500885A5
JP2020500885A5 JP2019529975A JP2019529975A JP2020500885A5 JP 2020500885 A5 JP2020500885 A5 JP 2020500885A5 JP 2019529975 A JP2019529975 A JP 2019529975A JP 2019529975 A JP2019529975 A JP 2019529975A JP 2020500885 A5 JP2020500885 A5 JP 2020500885A5
Authority
JP
Japan
Prior art keywords
antigen
seldeg
seq
target
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019529975A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020500885A (ja
JP7295799B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/064186 external-priority patent/WO2018102668A1/en
Publication of JP2020500885A publication Critical patent/JP2020500885A/ja
Publication of JP2020500885A5 publication Critical patent/JP2020500885A5/ja
Priority to JP2023095266A priority Critical patent/JP7832913B2/ja
Application granted granted Critical
Publication of JP7295799B2 publication Critical patent/JP7295799B2/ja
Priority to JP2025094049A priority patent/JP2025131743A/ja
Priority to JP2026035146A priority patent/JP2026097946A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019529975A 2016-12-02 2017-12-01 抗原特異的抗体を選択的に枯渇させるための融合タンパク質 Active JP7295799B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2023095266A JP7832913B2 (ja) 2016-12-02 2023-06-09 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2025094049A JP2025131743A (ja) 2016-12-02 2025-06-05 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2026035146A JP2026097946A (ja) 2016-12-02 2026-03-05 抗原特異的抗体を選択的に枯渇させるための融合タンパク質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662429367P 2016-12-02 2016-12-02
US62/429,367 2016-12-02
PCT/US2017/064186 WO2018102668A1 (en) 2016-12-02 2017-12-01 Fusion proteins for selectively depleting antigen-specific antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023095266A Division JP7832913B2 (ja) 2016-12-02 2023-06-09 抗原特異的抗体を選択的に枯渇させるための融合タンパク質

Publications (3)

Publication Number Publication Date
JP2020500885A JP2020500885A (ja) 2020-01-16
JP2020500885A5 true JP2020500885A5 (enExample) 2021-01-21
JP7295799B2 JP7295799B2 (ja) 2023-06-21

Family

ID=62242041

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019529975A Active JP7295799B2 (ja) 2016-12-02 2017-12-01 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2023095266A Active JP7832913B2 (ja) 2016-12-02 2023-06-09 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2025094049A Pending JP2025131743A (ja) 2016-12-02 2025-06-05 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2026035146A Pending JP2026097946A (ja) 2016-12-02 2026-03-05 抗原特異的抗体を選択的に枯渇させるための融合タンパク質

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2023095266A Active JP7832913B2 (ja) 2016-12-02 2023-06-09 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2025094049A Pending JP2025131743A (ja) 2016-12-02 2025-06-05 抗原特異的抗体を選択的に枯渇させるための融合タンパク質
JP2026035146A Pending JP2026097946A (ja) 2016-12-02 2026-03-05 抗原特異的抗体を選択的に枯渇させるための融合タンパク質

Country Status (7)

Country Link
US (2) US11459396B2 (enExample)
EP (1) EP3548073A4 (enExample)
JP (4) JP7295799B2 (enExample)
CN (1) CN110799210A (enExample)
AU (2) AU2017366674B2 (enExample)
CA (1) CA3045797A1 (enExample)
WO (1) WO2018102668A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020518240A (ja) * 2017-01-17 2020-06-25 ザ テキサス エー アンド エム ユニバーシティー システム 標的細胞のエンドリソソーム区画へのカーゴ分子の送達の向上のためのエンドリソソーム標的化コンジュゲート
AU2018318440A1 (en) 2017-08-15 2020-02-13 Kindred Biosciences, Inc. IgG Fc variants for veterinary use
EP3715374A1 (en) 2019-03-23 2020-09-30 Ablevia biotech GmbH Compound for the sequestration of undesirable antibodies in a patient
EP3715375A1 (en) 2019-03-23 2020-09-30 Ablevia biotech GmbH Compound for the prevention or treatment of pre-eclampsia
EP3715376A1 (en) 2019-03-23 2020-09-30 Ablevia biotech GmbH Compound for the prevention or treatment of myasthenia gravis
US11986536B2 (en) 2019-03-23 2024-05-21 Ablevia Biotech Gmbh Compound for the sequestration of undesirable antibodies in a patient
TWI922495B (zh) 2020-09-23 2026-04-21 奧地利商艾柏力維亞生技有限公司 用以於一患者中螯合非預期的抗peg抗體的化合物
WO2022063879A1 (en) 2020-09-23 2022-03-31 Ablevia Biotech Gmbh Compound for the sequestration of undesirable antibodies in a patient
KR20230074775A (ko) 2020-09-23 2023-05-31 아블레비아 바이오테크 게엠베하 바이러스 벡터의 효능 증가를 위한 화합물
WO2022063887A1 (en) 2020-09-23 2022-03-31 Ablevia Biotech Gmbh Compound for increasing the efficacy of factor viii replacement therapy
EP4217402A1 (en) 2020-09-23 2023-08-02 Ablevia biotech GmbH Compound for the prevention or treatment of autoantibody-mediated conditions
CN116710143A (zh) 2020-09-24 2023-09-05 艾柏力维亚生技有限公司 用于预防或治疗重症肌无力的化合物
WO2023180502A1 (en) 2022-03-24 2023-09-28 Ablevia Biotech Gmbh Compound for increasing efficacy of oncolytic viruses
CN119013290A (zh) 2022-04-13 2024-11-22 Ose免疫疗法公司 用于选择性清除抗体的新型分子
AU2023367846A1 (en) * 2022-10-26 2025-05-01 Amgen Inc. Multispecific molecules for clearance of immunoglobulins in the treatment of autoantibody-induced diseases
CN120624489B (zh) * 2025-08-18 2025-12-02 天津医科大学总医院 一种嵌合aqp4抗体受体、caar-t细胞及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332168B2 (en) 2000-08-22 2008-02-19 Micromet Ag Composition for the elimination of autoreactive B-cells
AU2002236499A1 (en) 2000-11-30 2002-06-11 Uab Research Foundation Receptor-mediated uptake of peptides that bind the human transferrin receptor
US20060235208A1 (en) 2002-09-27 2006-10-19 Xencor, Inc. Fc variants with optimized properties
EP1697520A2 (en) 2003-12-22 2006-09-06 Xencor, Inc. Fc polypeptides with novel fc ligand binding sites
WO2006130834A2 (en) 2005-05-31 2006-12-07 Board Of Regents, The University Of Texas System IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
PT3190128T (pt) * 2008-09-17 2019-02-07 Xencor Inc Composições e métodos para tratar distúrbios mediados pela ige
EP3415528B1 (en) 2011-04-13 2021-05-26 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
WO2012150319A1 (en) * 2011-05-05 2012-11-08 Novozymes Biopharma Dk A/S Albumin variants
CN106103476B (zh) * 2013-12-24 2020-11-27 阿尔金克斯有限公司 FcRn拮抗剂及使用方法
US20160060358A1 (en) 2014-08-28 2016-03-03 California Institute Of Technology Induction of antigen-specific tolerance
US20170334962A1 (en) * 2016-05-19 2017-11-23 Texas A&M University System FcRn-TARGETED ANTIGEN FUSION PROTEINS

Similar Documents

Publication Publication Date Title
US12404339B2 (en) Method of depleting target antigen-specific antibody from a patient by administering a fusion protein (Seldeg) for selectively depleting antigen-specific antibodies
JP7832906B2 (ja) 標的細胞のエンドリソソーム区画へのカーゴ分子の送達の向上のためのエンドリソソーム標的化コンジュゲート
JP2023109939A (ja) 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン
US10420820B2 (en) Targeting of pharmaceutical agents to pathologic areas using bifunctional fusion polypeptides
JP2020526503A5 (enExample)
CN103965363B (zh) 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途
SI2802606T1 (en) Improves the transfer of healing molecules through the hematoencephalic barrier
CN116987189A (zh) 单链可变片段cd3结合蛋白质
JP2015509097A5 (enExample)
JP2024507540A5 (enExample)
JP2024514556A5 (enExample)
CA2820630A1 (en) Dimeric molecular complexes with free cysteine residues and conjugates thereof
US10202432B2 (en) Dual targeting drug carrier and application thereof
JP2024542096A (ja) 新規タンパク質
WO2023246911A1 (zh) 基于t细胞受体的双特异性多肽分子及其用途
WO2017147820A1 (zh) 双重标靶药物载体
US20240392035A1 (en) Engineered anti-her2 bispecific proteins
JP2025530261A (ja) マルタボディを使用する化学療法耐性腫瘍の処置
WO2026054854A2 (en) Light chain amyloid fibril antibodies, amyloid fibril and phagocyte targeting bi-specific phagocyte engagers, car-phagocytes, and uses thereof
JP2026513850A (ja) Pdgfrアルファを発現するがんを治療する方法
WO2023169524A1 (zh) 白细胞介素2突变体以及含有其的复合物
CN118488971A (zh) 优化的Multabody构建体、组合物和方法