JP2017529059A5 - - Google Patents
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- JP2017529059A5 JP2017529059A5 JP2016576027A JP2016576027A JP2017529059A5 JP 2017529059 A5 JP2017529059 A5 JP 2017529059A5 JP 2016576027 A JP2016576027 A JP 2016576027A JP 2016576027 A JP2016576027 A JP 2016576027A JP 2017529059 A5 JP2017529059 A5 JP 2017529059A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- modified
- dimer
- modified gdf15
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 68
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 68
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 68
- 239000000539 dimer Substances 0.000 claims description 26
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims description 21
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims description 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 19
- 150000001413 amino acids Chemical class 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 108010071390 Serum Albumin Proteins 0.000 claims description 9
- 102000007562 Serum Albumin Human genes 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 208000018914 glucose metabolism disease Diseases 0.000 claims description 7
- 102220005382 rs33914470 Human genes 0.000 claims description 6
- 102220143003 rs753997345 Human genes 0.000 claims description 6
- 102220025225 rs199476363 Human genes 0.000 claims description 5
- 102220123860 rs61760902 Human genes 0.000 claims description 5
- 238000006467 substitution reaction Methods 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 102220353134 c.68G>A Human genes 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 102200078418 rs1805085 Human genes 0.000 claims description 3
- 102220503690 GTP-binding protein REM 1_T94N_mutation Human genes 0.000 claims description 2
- 230000037396 body weight Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000000710 homodimer Substances 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 102200150805 rs1057519492 Human genes 0.000 claims description 2
- 102220230165 rs1064793071 Human genes 0.000 claims description 2
- 239000013603 viral vector Substances 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 102200090880 rs28933100 Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 description 17
- 102000037865 fusion proteins Human genes 0.000 description 17
- 229940024606 amino acid Drugs 0.000 description 15
- 108010076504 Protein Sorting Signals Proteins 0.000 description 7
- 102220058798 rs786202903 Human genes 0.000 description 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 3
- 230000004988 N-glycosylation Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229960000310 isoleucine Drugs 0.000 description 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 3
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 108091006905 Human Serum Albumin Proteins 0.000 description 2
- 102000008100 Human Serum Albumin Human genes 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 102200075235 rs118204106 Human genes 0.000 description 1
- 102220248744 rs145985140 Human genes 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031063P | 2014-07-30 | 2014-07-30 | |
| US62/031,063 | 2014-07-30 | ||
| US201562195908P | 2015-07-23 | 2015-07-23 | |
| US62/195,908 | 2015-07-23 | ||
| PCT/US2015/042510 WO2016018931A1 (en) | 2014-07-30 | 2015-07-28 | Compositions and methods of use for treating metabolic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529059A JP2017529059A (ja) | 2017-10-05 |
| JP2017529059A5 true JP2017529059A5 (enExample) | 2018-09-06 |
| JP6704358B2 JP6704358B2 (ja) | 2020-06-03 |
Family
ID=55179329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016576027A Active JP6704358B2 (ja) | 2014-07-30 | 2015-07-28 | 代謝障害を治療するための組成物および使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US9834586B2 (enExample) |
| EP (1) | EP3174894B1 (enExample) |
| JP (1) | JP6704358B2 (enExample) |
| KR (1) | KR20170065026A (enExample) |
| CN (1) | CN106573966B (enExample) |
| AP (1) | AP2016009663A0 (enExample) |
| AU (1) | AU2015296640B2 (enExample) |
| CA (1) | CA2953827A1 (enExample) |
| CL (1) | CL2017000201A1 (enExample) |
| CO (1) | CO2017000614A2 (enExample) |
| CR (1) | CR20170027A (enExample) |
| DO (1) | DOP2017000025A (enExample) |
| EA (1) | EA035581B1 (enExample) |
| EC (1) | ECSP17005276A (enExample) |
| ES (1) | ES2883158T3 (enExample) |
| IL (1) | IL249793B (enExample) |
| MD (1) | MD20170020A2 (enExample) |
| MX (1) | MX370115B (enExample) |
| MY (1) | MY192917A (enExample) |
| PE (1) | PE20170771A1 (enExample) |
| PH (1) | PH12017500153A1 (enExample) |
| SG (2) | SG11201700378PA (enExample) |
| SV (1) | SV2017005367A (enExample) |
| TN (1) | TN2016000578A1 (enExample) |
| TW (1) | TWI710570B (enExample) |
| UA (1) | UA123432C2 (enExample) |
| WO (1) | WO2016018931A1 (enExample) |
| ZA (1) | ZA201700311B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015506373A (ja) | 2012-01-26 | 2015-03-02 | アムジエン・インコーポレーテツド | 成長分化因子１５（ｇｄｆ−１５）ポリペプチド |
| WO2013148117A1 (en) | 2012-03-27 | 2013-10-03 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| BR112015018104A2 (pt) | 2013-01-30 | 2017-11-21 | Ngm Biopharmaceuticals Inc | polipeptídeos de gdf15 modificados, seu uso, composições compreendendo os mesmos e recipiente estéril compreendendo as referidas composições |
| US10981951B2 (en) | 2014-01-31 | 2021-04-20 | Mayo Foundation For Medical Education And Research | Therapeutics for the treatment of glaucoma |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| WO2016018931A1 (en) | 2014-07-30 | 2016-02-04 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| UA121973C2 (uk) * | 2014-10-31 | 2020-08-25 | Нджм Біофармасьютікалз, Інк. | Комплекс, що має активність фактора диференціації росту 15 (gdf15), та способи лікування ним ожиріння та гіперглікемії у суб'єкта |
| IL261666B2 (en) | 2016-03-31 | 2024-09-01 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| US10336812B2 (en) | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| CN109414471A (zh) | 2016-05-24 | 2019-03-01 | 诺和诺德股份有限公司 | Mic-1化合物及其用途 |
| CA3078452A1 (en) * | 2016-10-07 | 2018-04-12 | Beth Israel Deaconess Medical Center, Inc. | Compositions comprising relaxin and methods of use thereof |
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| EP3681529A1 (en) | 2017-09-10 | 2020-07-22 | Novo Nordisk A/S | Mic-1 and glp-1 for use in the treatment of obesity |
| JP2021511785A (ja) | 2018-01-19 | 2021-05-13 | ペプジーン インコーポレーテッドＰｅｐｇｅｎｅ Ｉｎｃ． | 組換えポリペプチド生産用ｎ末端融合パートナーおよびこれを用いた組換えポリペプチドの生産方法 |
| TWI724392B (zh) | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
| JOP20200258A1 (ar) | 2018-04-09 | 2020-10-11 | Amgen Inc | البروتينات الاندماجية لعامل تمايز النمو 15 |
| CN112543869A (zh) | 2018-08-10 | 2021-03-23 | 诺华股份有限公司 | Gfral细胞外结构域和使用方法 |
| US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| ES3011982T3 (en) | 2018-10-22 | 2025-04-08 | Janssen Sciences Ireland Unlimited Co | Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereof |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| WO2021067655A1 (en) | 2019-10-04 | 2021-04-08 | Amgen Inc. | Use of gdf15 for treating cardiometabolic syndrome and other conditions |
| WO2021107603A2 (en) * | 2019-11-26 | 2021-06-03 | Yuhan Corporation | Long-acting gdf15 fusion protein and pharmaceutical composition comprising same |
| CA3159979A1 (en) * | 2019-12-11 | 2021-06-17 | Yeonchul Kim | Fusion polypeptide comprising gdf15 and polypeptide region capable of o-glycosylation |
| EP4072543A4 (en) * | 2019-12-12 | 2024-02-07 | Qlaris Bio, Inc. | CONTROLLED RELEASE CROMAKALIM PRODRUGS |
| CN113597434B (zh) | 2019-12-31 | 2022-07-01 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| WO2023154953A1 (en) | 2022-02-14 | 2023-08-17 | Ngm Biopharmaceuticals, Inc. | Gdf15 polypeptides for treating and preventing autoimmune diseases |
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