JP2016505251A5 - - Google Patents
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- JP2016505251A5 JP2016505251A5 JP2015545938A JP2015545938A JP2016505251A5 JP 2016505251 A5 JP2016505251 A5 JP 2016505251A5 JP 2015545938 A JP2015545938 A JP 2015545938A JP 2015545938 A JP2015545938 A JP 2015545938A JP 2016505251 A5 JP2016505251 A5 JP 2016505251A5
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- 238000000034 method Methods 0.000 claims description 46
- 108020001507 fusion proteins Proteins 0.000 claims description 44
- 102000037865 fusion proteins Human genes 0.000 claims description 44
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- 108050006654 Lipocalin Proteins 0.000 claims description 30
- 238000003776 cleavage reaction Methods 0.000 claims description 29
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735516P | 2012-12-10 | 2012-12-10 | |
| US61/735,516 | 2012-12-10 | ||
| US201361794685P | 2013-03-15 | 2013-03-15 | |
| US61/794,685 | 2013-03-15 | ||
| PCT/US2013/074215 WO2014093403A1 (en) | 2012-12-10 | 2013-12-10 | Lipocalin fusion partners |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505251A JP2016505251A (ja) | 2016-02-25 |
| JP2016505251A5 true JP2016505251A5 (enExample) | 2017-02-02 |
Family
ID=49883268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545938A Pending JP2016505251A (ja) | 2012-12-10 | 2013-12-10 | リポカリン融合パートナー |
| JP2015545941A Ceased JP2016505826A (ja) | 2012-12-10 | 2013-12-10 | スクリーニングの方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545941A Ceased JP2016505826A (ja) | 2012-12-10 | 2013-12-10 | スクリーニングの方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10156559B2 (enExample) |
| EP (2) | EP2928913A1 (enExample) |
| JP (2) | JP2016505251A (enExample) |
| CN (2) | CN105189540A (enExample) |
| AU (2) | AU2013359429A1 (enExample) |
| BR (2) | BR112015013525A2 (enExample) |
| CA (2) | CA2913127A1 (enExample) |
| IL (2) | IL239261A0 (enExample) |
| RU (2) | RU2015126650A (enExample) |
| SG (2) | SG11201504600UA (enExample) |
| WO (2) | WO2014093406A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2601182T3 (es) | 2010-05-11 | 2017-02-14 | Fred Hutchinson Cancer Research Center | Variantes de clorotoxina, conjugados y métodos para su utilización |
| US9289507B2 (en) | 2012-05-17 | 2016-03-22 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
| CN105189540A (zh) | 2012-12-10 | 2015-12-23 | 弗莱德哈钦森癌症研究中心 | 含脂质运载蛋白融合伴侣 |
| US11013814B2 (en) * | 2017-03-16 | 2021-05-25 | Blaze Bioscience, Inc. | Cartilage-homing peptide conjugates and methods of use thereof |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| KR101576904B1 (ko) | 2014-07-31 | 2015-12-14 | (주)케어젠 | 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도 |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| MX390894B (es) * | 2015-05-18 | 2025-03-21 | Pieris Pharmaceuticals Gmbh | Polipéptido de fusión anti-cáncer. |
| EP3313427A4 (en) * | 2015-06-26 | 2018-12-26 | Fred Hutchinson Cancer Research Center | Therapeutic peptides and methods of use thereof |
| BR112017027985A2 (pt) * | 2015-06-26 | 2018-08-28 | Hutchinson Fred Cancer Res | peptídeos terapêuticos e métodos de uso dos mesmos |
| JP6966424B2 (ja) * | 2015-09-09 | 2021-11-17 | フレッド ハッチンソン キャンサー リサーチ センター | 軟骨ホーミングペプチド |
| DK3362470T3 (da) * | 2015-10-13 | 2021-12-13 | Hope City | Kimære antigenreceptorer indeholdende et chlorotoxindomæne |
| WO2017083545A1 (en) * | 2015-11-10 | 2017-05-18 | Fred Hutchinson Cancer Research Center | Nkg2d decoys |
| CN105348392B (zh) * | 2015-11-18 | 2019-08-02 | 北京华金瑞清生物医药技术有限公司 | 一种Nav1.7抑制剂及其改造方法 |
| EP3442555A4 (en) * | 2016-04-15 | 2020-04-01 | Blaze Bioscience, Inc. | METHOD FOR TREATING BREAST CANCER |
| CA3021011A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| US20190292243A1 (en) * | 2016-08-22 | 2019-09-26 | Fred Hutchinson Cancer Research Center | Peptides and methods of use thereof |
| ES3015117T3 (en) | 2016-08-29 | 2025-04-29 | Fred Hutchinson Cancer Center | Chelating platform for delivery of radionuclides |
| CN106699866A (zh) * | 2016-12-13 | 2017-05-24 | 山西农业大学 | 一种鸡细胞外脂肪酸结合蛋白、原核表达及其纯化方法 |
| US11548923B2 (en) | 2017-01-18 | 2023-01-10 | Fred Hutchinson Cancer Center | Peptide compositions and methods of use thereof for disrupting TEAD interactions |
| EP3638290A4 (en) | 2017-06-15 | 2021-04-07 | Blaze Bioscience, Inc. | KIDNEY HOMING PEPTIDE CONJUGATES AND METHOD OF USING THEREOF |
| CN107739410B (zh) * | 2017-10-18 | 2021-07-30 | 南京鼓楼医院 | CD3单链抗体-iRGD融合蛋白、制备及其作为抗肿瘤药物的应用 |
| AU2018388583A1 (en) | 2017-12-19 | 2020-06-11 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| CA3093588A1 (en) * | 2018-03-16 | 2019-09-19 | Blaze Bioscience, Inc. | Truncated cartilage-homing peptides and peptide complexes and methods of use thereof |
| EP4076500A4 (en) * | 2019-12-19 | 2023-12-27 | Blaze Bioscience, Inc. | METHOD FOR TREATING VASCULAR LESIONS AND MALFORMATIONS |
| CN115329965B (zh) * | 2022-08-16 | 2025-08-01 | 北京有竹居网络技术有限公司 | 数据处理方法和电子设备 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444744A (en) | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| DE3407582A1 (de) | 1984-03-01 | 1985-09-05 | Dornier System Gmbh, 7990 Friedrichshafen | Schaltungsanordnung fuer einen regelkreis |
| FI882340L (fi) | 1986-09-19 | 1988-05-18 | Scripps Clinic Res | Paratropisk molekyl riktad mot human-gangliocid gd2. |
| US5591829A (en) | 1987-05-29 | 1997-01-07 | Matsushita; Shuzo | Antibodies modified with toxic substance |
| US5051364A (en) | 1989-02-16 | 1991-09-24 | The Salk Institute For Biological Studies | Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies |
| DE3909799A1 (de) | 1989-03-24 | 1990-09-27 | Behringwerke Ag | Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung |
| WO1991003489A1 (en) | 1989-09-08 | 1991-03-21 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| US5223253A (en) | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| GB2250993B (en) | 1990-11-21 | 1995-02-15 | Inst Nat Sante Rech Med | Stromelysin-3 and its application in the diagnosis and treatment of malignant breast cancer |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| ATE275197T1 (de) | 1991-09-20 | 2004-09-15 | Amgen Inc | Glial neurotrophe faktor |
| US5314992A (en) | 1991-11-25 | 1994-05-24 | Trustees Of Dartmouth College | Lipocortin-1 receptor protein and its uses |
| WO1993023075A1 (en) | 1992-05-14 | 1993-11-25 | Oncologix, Inc. | Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors |
| CZ286550B6 (cs) | 1993-01-14 | 2000-05-17 | Cancer Research Campaign Technology Ltd. | Kombinovaný farmaceutický prostředek pro léčbu lidských nádorových buněk, použití inhibitoru ATasy a temozolomidu pro jeho přípravu a souprava |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5688773A (en) | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
| US5985822A (en) | 1994-12-09 | 1999-11-16 | The Scripps Research Institute | Inhibition of glial cell proliferation with N-CAM homophilic peptides |
| US5756340A (en) | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
| JP3809502B2 (ja) | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
| JPH0971599A (ja) | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス（ｃａｖ）感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
| US5905027A (en) | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
| US6667156B2 (en) | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
| WO1997043301A2 (en) * | 1996-05-10 | 1997-11-20 | Novartis Ag | Identification of members of combinatorial libraries by mass spectrometry |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6555652B1 (en) | 1997-12-05 | 2003-04-29 | Kyogo Itoh | Tumor antigen peptide derivatives |
| GB9809776D0 (en) * | 1998-05-07 | 1998-07-08 | Nycomed Imaging As | Method |
| US6403625B1 (en) | 1998-08-12 | 2002-06-11 | Daiichi Pure Chemicals Co., Ltd. | Fluorescent labeling reagents |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| ATE253126T1 (de) | 1998-08-25 | 2003-11-15 | Univ Washington | Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen |
| US6214986B1 (en) | 1998-10-07 | 2001-04-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of bcl-x expression |
| US6629040B1 (en) * | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| BR0014252A (pt) | 1999-09-14 | 2002-11-19 | Biomedical Apherese Systeme Gm | Nanopartìculas magnéticas tendo atividade bioquìmica, método para sua produção e seus usos |
| AUPQ339899A0 (en) * | 1999-10-13 | 1999-11-04 | University Of Queensland, The | Novel molecules |
| AU4305101A (en) | 1999-11-22 | 2001-06-04 | Research Foundation Of The State University Of New York, The | Magnetic nanoparticles for selective therapy |
| DE10020376A1 (de) | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
| AU2002220265A1 (en) | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| US20020077921A1 (en) | 2000-12-15 | 2002-06-20 | Paul-David Morrison | Method and apparatus for an interactive catalog |
| WO2002069896A2 (en) | 2001-03-01 | 2002-09-12 | Northwest Hospital | Connexin enhances chemotherapy-induced apoptosis in human cancer cells inhibiting tumor cell proliferation |
| WO2003008583A2 (en) | 2001-03-02 | 2003-01-30 | Sagres Discovery | Novel compositions and methods for cancer |
| GB0115581D0 (en) * | 2001-06-26 | 2001-08-15 | Glaxo Group Ltd | Method of mass spectometry |
| WO2003000203A2 (en) | 2001-06-26 | 2003-01-03 | Uab Research Foundation | Chlorotoxin inhibition of cell invasion, cancer metastasis, angiogenesis and tissue remodeling |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
| EP1480665A2 (en) | 2002-02-04 | 2004-12-01 | Auburn University | Peptides for recognition and targeting of glial cell tumors |
| US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
| US20060088899A1 (en) | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
| EP2431385A3 (en) | 2002-05-31 | 2012-07-04 | Morphotek, Inc. | Combination therapy with chlorotoxin |
| US7563600B2 (en) * | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
| US7560160B2 (en) | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| US20050059038A1 (en) * | 2003-03-21 | 2005-03-17 | Adams Steven P. | Method of screening for target ligands |
| CN1791671A (zh) * | 2003-03-21 | 2006-06-21 | 先灵公司 | 靶配体的筛选方法 |
| KR20060031809A (ko) | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| DE10328251A1 (de) | 2003-06-24 | 2005-01-13 | Toximed Gmbh | Pharmazeutischer Wirkstoff |
| WO2005053611A2 (en) | 2003-11-26 | 2005-06-16 | Transmolecular, Inc. | Treatment of phosphatidylinositol phospholipid disorders |
| DE602004020570D1 (de) * | 2003-12-18 | 2009-05-28 | Biomethodes | Verfahren zur ortspezifischen Massenmutagenese |
| AU2005232616A1 (en) | 2004-04-06 | 2005-10-27 | Transmolecular, Inc. | Diagnosis and treatment of myeloid and lymphoid cell cancers |
| US20080153746A1 (en) | 2004-04-06 | 2008-06-26 | Transmolecular, Inc. | Diagnosis and Treatment of Myeloid and Lymphoid Cell Cancers |
| US7776824B2 (en) | 2004-05-06 | 2010-08-17 | The Trustees Of Columbia University | NGAL for reduction and amelioration of ischemic and nephrotoxic injuries |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| WO2006036928A2 (en) * | 2004-09-27 | 2006-04-06 | Wayne State University | Inhibitors of matrix metalloproteinases to treat neurological disorders |
| GB0422901D0 (en) | 2004-10-14 | 2004-11-17 | Ares Trading Sa | Lipocalin protein |
| KR100681763B1 (ko) | 2005-02-28 | 2007-02-15 | 재단법인 목암생명공학연구소 | 인간 리포칼린 2를 유효성분으로 포함하는 암 전이 억제용약학적 조성물, 이를 이용한 암 전이 억제 방법 |
| GB0504767D0 (en) * | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
| US20070037232A1 (en) | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| WO2006110585A2 (en) | 2005-04-07 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | Cancer-related genes (prlr) |
| WO2006110582A1 (en) | 2005-04-08 | 2006-10-19 | Xcyte Therapies, Inc. | Compositions and methods for the treatment of burns and sepsis |
| US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| WO2006115633A2 (en) | 2005-04-22 | 2006-11-02 | University Of Washington | Cyanine-chlorotoxin conjugate and method for intra-operative fluorescent visualization of cancer |
| MX2008002149A (es) | 2005-08-18 | 2008-04-22 | Ambrx Inc | Composiciones de arnt y sus usos. |
| CA2647907A1 (en) | 2006-03-31 | 2007-10-18 | Transmolecular, Inc. | Use of tm-601 for the diagnosis and treatment of tumors |
| US8106013B2 (en) | 2006-05-19 | 2012-01-31 | Georgia Tech Research Corporation | ABC transporter ligand GATX1 |
| CN101003788A (zh) | 2006-09-21 | 2007-07-25 | 武汉大学 | 一种蝎抗肿瘤转移肽及其制备方法和应用 |
| CN100564517C (zh) | 2006-09-21 | 2009-12-02 | 武汉大学 | 一种蝎抗神经胶质瘤肽及其制备方法和应用 |
| EP2081602A2 (en) | 2006-10-25 | 2009-07-29 | Amgen Inc. | Toxin peptide therapeutic agents |
| KR101631323B1 (ko) | 2007-06-21 | 2016-06-17 | 엑스엘-프로테인 게엠베하 | 증가된 생체내 및/또는 시험관내 안정성을 갖는 생물학적 활성 단백질 |
| US20090004105A1 (en) | 2007-06-27 | 2009-01-01 | Zhen Cheng | Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin |
| US20110091380A1 (en) | 2007-08-07 | 2011-04-21 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| WO2009029760A1 (en) | 2007-08-31 | 2009-03-05 | Iosemantics, Llc | Quality assurance tools for use with source code and a semantic model |
| WO2009049184A2 (en) | 2007-10-12 | 2009-04-16 | Transmolecular, Inc. | Systemic administration of chlorotoxin agents for the diagnosis and treatment of tumors |
| US20090123946A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| US20090123970A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| US20090124022A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Antibodies that bind to mammalian ngal and uses thereof |
| WO2009052390A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| US20090269777A1 (en) | 2007-10-19 | 2009-10-29 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| US20090176274A1 (en) | 2007-10-19 | 2009-07-09 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| EP2215481B2 (en) | 2007-11-15 | 2017-01-18 | Bioporto Diagnostics A/S | Diagnostic use of individual molecular forms of a biomarker |
| ES2535958T3 (es) | 2008-01-18 | 2015-05-19 | Visen Medical, Inc. | Agentes de imaginología fluorescentes |
| WO2009108762A2 (en) | 2008-02-26 | 2009-09-03 | The Penn State Research Foundation | Methods and compositions for treatment of retinoid-responsive conditions |
| US8093060B2 (en) | 2008-02-28 | 2012-01-10 | Canon Kabushiki Kaisha | Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same |
| WO2009114776A2 (en) | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
| US8470607B2 (en) | 2008-03-20 | 2013-06-25 | Morphotek, Inc. | Inhibition of angiogenesis |
| GB0807831D0 (en) | 2008-04-29 | 2008-06-04 | Cambridge Entpr Ltd | Agents for imaging cell death |
| CN101270158B (zh) | 2008-04-30 | 2010-12-22 | 武汉大学 | 一种靶向抗神经胶质瘤蛋白及制备方法和用途 |
| WO2009140599A1 (en) | 2008-05-15 | 2009-11-19 | Transmolecular, Inc. | Treatment of metastatic tumors |
| JP2009300110A (ja) | 2008-06-10 | 2009-12-24 | Olympus Corp | 移植細胞の光学的検出方法又はイメージング方法 |
| EP2313430B1 (en) * | 2008-06-24 | 2018-05-02 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
| US20100098637A1 (en) | 2008-09-23 | 2010-04-22 | The Regents Of The University Of Michigan | Dye-loaded nanoparticle |
| CN101381405B (zh) | 2008-09-24 | 2011-07-27 | 武汉摩尔生物科技有限公司 | 基因工程肿瘤靶向kct-w1多肽及制备方法和用途 |
| JP2010085108A (ja) | 2008-09-29 | 2010-04-15 | Nano Factory:Kk | 生体光イメージング用プローブ |
| US20100105150A1 (en) | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
| US20100331650A1 (en) * | 2009-06-25 | 2010-12-30 | Roche Diagnostics Operations, Inc. | Episodic blood glucose monitoring system with an interactive graphical user interface and methods thereof |
| CN102791827B (zh) | 2009-11-09 | 2016-11-16 | 华盛顿大学商业化中心 | 官能化发色聚合物点及其生物共轭体 |
| CN101921769B (zh) | 2010-01-11 | 2012-07-25 | 山西大学 | 一种重组腺病毒及其制备方法和应用 |
| WO2011094671A2 (en) | 2010-01-29 | 2011-08-04 | The Uab Research Foundation | N-terminally conjugated polypeptides for targeted therapy and diagnosis |
| CN106995493B (zh) | 2010-02-04 | 2021-09-24 | 卫材公司 | 氯毒素多肽和结合物及其应用 |
| CN101824084A (zh) | 2010-04-08 | 2010-09-08 | 山西大学 | 靶向性抗胶质瘤蛋白质及其应用 |
| ES2601182T3 (es) | 2010-05-11 | 2017-02-14 | Fred Hutchinson Cancer Research Center | Variantes de clorotoxina, conjugados y métodos para su utilización |
| AU2011290751B2 (en) * | 2010-08-16 | 2015-08-13 | Pieris Ag | Binding proteins for Hepcidin |
| DK2638173T3 (da) * | 2010-11-08 | 2019-09-30 | Univ Leland Stanford Junior | Fusionsproteiner omfattende et manipuleret knottin-peptid og anvendelser deraf |
| CN115201484A (zh) | 2010-12-28 | 2022-10-18 | 探索诊断投资公司 | 通过质谱法定量胰岛素 |
| WO2013036810A1 (en) * | 2011-09-07 | 2013-03-14 | X-Chem, Inc. | Methods for tagging dna-encoded libraries |
| CN105189540A (zh) | 2012-12-10 | 2015-12-23 | 弗莱德哈钦森癌症研究中心 | 含脂质运载蛋白融合伴侣 |
-
2013
- 2013-12-10 CN CN201380072523.0A patent/CN105189540A/zh active Pending
- 2013-12-10 WO PCT/US2013/074218 patent/WO2014093406A1/en not_active Ceased
- 2013-12-10 US US14/651,175 patent/US10156559B2/en active Active
- 2013-12-10 US US14/102,396 patent/US20140179560A1/en not_active Abandoned
- 2013-12-10 JP JP2015545938A patent/JP2016505251A/ja active Pending
- 2013-12-10 RU RU2015126650A patent/RU2015126650A/ru not_active Application Discontinuation
- 2013-12-10 SG SG11201504600UA patent/SG11201504600UA/en unknown
- 2013-12-10 AU AU2013359429A patent/AU2013359429A1/en not_active Abandoned
- 2013-12-10 EP EP13814341.7A patent/EP2928913A1/en not_active Withdrawn
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- 2013-12-10 US US14/651,172 patent/US20150316536A1/en not_active Abandoned
- 2013-12-10 CA CA2913029A patent/CA2913029A1/en not_active Abandoned
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