JP2018537117A5 - - Google Patents
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- Publication number
- JP2018537117A5 JP2018537117A5 JP2018536696A JP2018536696A JP2018537117A5 JP 2018537117 A5 JP2018537117 A5 JP 2018537117A5 JP 2018536696 A JP2018536696 A JP 2018536696A JP 2018536696 A JP2018536696 A JP 2018536696A JP 2018537117 A5 JP2018537117 A5 JP 2018537117A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibody according
- domain
- constant region
- bovine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283690 Bos taurus Species 0.000 claims 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022156598A JP2022185053A (ja) | 2015-10-05 | 2022-09-29 | 腸内消化に対する改善された安定性を有する抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562237270P | 2015-10-05 | 2015-10-05 | |
| US62/237,270 | 2015-10-05 | ||
| PCT/US2016/054304 WO2017062253A2 (en) | 2015-10-05 | 2016-09-29 | Antibodies with improved stability to intestinal digestion |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022156598A Division JP2022185053A (ja) | 2015-10-05 | 2022-09-29 | 腸内消化に対する改善された安定性を有する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537117A JP2018537117A (ja) | 2018-12-20 |
| JP2018537117A5 true JP2018537117A5 (enExample) | 2019-11-07 |
| JP7235287B2 JP7235287B2 (ja) | 2023-03-08 |
Family
ID=58488349
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536696A Active JP7235287B2 (ja) | 2015-10-05 | 2016-09-29 | 腸内消化に対する改善された安定性を有する抗体 |
| JP2022156598A Pending JP2022185053A (ja) | 2015-10-05 | 2022-09-29 | 腸内消化に対する改善された安定性を有する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022156598A Pending JP2022185053A (ja) | 2015-10-05 | 2022-09-29 | 腸内消化に対する改善された安定性を有する抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11891440B2 (enExample) |
| EP (1) | EP3359190A4 (enExample) |
| JP (2) | JP7235287B2 (enExample) |
| AU (2) | AU2016335912B2 (enExample) |
| BR (1) | BR112018006953A2 (enExample) |
| CA (1) | CA3039177A1 (enExample) |
| IL (1) | IL258496A (enExample) |
| WO (1) | WO2017062253A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019001896A (es) * | 2016-08-15 | 2019-08-29 | Univ Hokkaido Nat Univ Corp | Anticuerpo anti-pd-l1. |
| WO2020123798A1 (en) * | 2018-12-12 | 2020-06-18 | President And Fellows Of Harvard College | Bovine versions of fcmbl for the detection and treatment of bovine microbial infections |
| EP4247851A1 (en) * | 2020-11-20 | 2023-09-27 | Zoetis Services LLC | Bovine antibody variants |
| EP4695308A1 (en) * | 2023-09-14 | 2026-02-18 | Invitrogen BioServices India Private Limited | Engineered antibodies and uses thereof |
| CN120209146A (zh) * | 2025-03-31 | 2025-06-27 | 上海百英生物科技股份有限公司 | 一种包含非天然氨基酸修饰的Claudin 6抗体及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| US8647626B2 (en) * | 2007-10-02 | 2014-02-11 | Avaxia Biologics, Incorporated | Compositions comprising TNF-specific antibodies for oral delivery |
| EP2244735A4 (en) * | 2007-10-02 | 2011-02-23 | Avaxia Biologics Inc | ANTIBODY THERAPY FOR USE IN THE DIGESTIVE TUBE |
| BR112012010252A2 (pt) * | 2009-10-29 | 2016-12-06 | Janssen Biotech Inc | variantes de glicosilação de anticorpo |
| AR084210A1 (es) | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| BR112013016495A2 (pt) * | 2010-12-27 | 2018-05-22 | Japan Health Sciences Foundation | anticorpo monoclonal que reconhece a proteína l2 do papilomavírus humano (hpv) e método para medir o título de anticorpo que neutraliza o hpv usando a mesma |
| WO2013019889A2 (en) * | 2011-08-01 | 2013-02-07 | Avaxia Biologics, Inc. | Bovine polyclonal antibody specific for human tnf |
| RU2744911C2 (ru) * | 2016-08-15 | 2021-03-17 | Нэшнл Юниверсити Корпорейшн Хоккайдо Юниверсити | Антитело против pd-l1 |
-
2016
- 2016-09-29 WO PCT/US2016/054304 patent/WO2017062253A2/en not_active Ceased
- 2016-09-29 EP EP16854106.8A patent/EP3359190A4/en not_active Withdrawn
- 2016-09-29 CA CA3039177A patent/CA3039177A1/en active Pending
- 2016-09-29 AU AU2016335912A patent/AU2016335912B2/en active Active
- 2016-09-29 BR BR112018006953A patent/BR112018006953A2/pt not_active Application Discontinuation
- 2016-09-29 JP JP2018536696A patent/JP7235287B2/ja active Active
- 2016-09-29 US US15/765,958 patent/US11891440B2/en active Active
-
2018
- 2018-04-04 IL IL258496A patent/IL258496A/en unknown
-
2022
- 2022-09-29 JP JP2022156598A patent/JP2022185053A/ja active Pending
-
2023
- 2023-06-29 US US18/344,311 patent/US20240067715A1/en not_active Abandoned
- 2023-08-16 AU AU2023216791A patent/AU2023216791A1/en active Pending
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