JP7235287B2 - 腸内消化に対する改善された安定性を有する抗体 - Google Patents

腸内消化に対する改善された安定性を有する抗体 Download PDF

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JP7235287B2
JP7235287B2 JP2018536696A JP2018536696A JP7235287B2 JP 7235287 B2 JP7235287 B2 JP 7235287B2 JP 2018536696 A JP2018536696 A JP 2018536696A JP 2018536696 A JP2018536696 A JP 2018536696A JP 7235287 B2 JP7235287 B2 JP 7235287B2
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antibody
bovine
antibodies
igg1
cells
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JP2018537117A5 (enExample
JP2018537117A (ja
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バートン，ランダル，エドワード
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サークル３３ エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2018536696A 2015-10-05 2016-09-29 腸内消化に対する改善された安定性を有する抗体 Active JP7235287B2 (ja)

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JP2022156598A JP2022185053A (ja) 2015-10-05 2022-09-29 腸内消化に対する改善された安定性を有する抗体

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US201562237270P 2015-10-05 2015-10-05
US62/237,270 2015-10-05
PCT/US2016/054304 WO2017062253A2 (en) 2015-10-05 2016-09-29 Antibodies with improved stability to intestinal digestion

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JP2018537117A JP2018537117A (ja) 2018-12-20
JP2018537117A5 JP2018537117A5 (enExample) 2019-11-07
JP7235287B2 true JP7235287B2 (ja) 2023-03-08

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JP2022156598A Pending JP2022185053A (ja) 2015-10-05 2022-09-29 腸内消化に対する改善された安定性を有する抗体

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US (2) US11891440B2 (enExample)
EP (1) EP3359190A4 (enExample)
JP (2) JP7235287B2 (enExample)
AU (2) AU2016335912B2 (enExample)
BR (1) BR112018006953A2 (enExample)
CA (1) CA3039177A1 (enExample)
IL (1) IL258496A (enExample)
WO (1) WO2017062253A2 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
MX2019001896A (es) * 2016-08-15 2019-08-29 Univ Hokkaido Nat Univ Corp Anticuerpo anti-pd-l1.
WO2020123798A1 (en) * 2018-12-12 2020-06-18 President And Fellows Of Harvard College Bovine versions of fcmbl for the detection and treatment of bovine microbial infections
KR20230110297A (ko) * 2020-11-20 2023-07-21 조에티스 서비시즈 엘엘씨 소 항체 변이체
EP4695308A1 (en) * 2023-09-14 2026-02-18 Invitrogen BioServices India Private Limited Engineered antibodies and uses thereof
CN120209146B (zh) * 2025-03-31 2026-07-28 上海百英生物科技股份有限公司 一种包含非天然氨基酸修饰的Claudin 6抗体及其制备方法和应用

Citations (2)

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JP2008508862A (ja) 2004-06-28 2008-03-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Ｆｃ−インターフェロン−β融合タンパク質
JP2014503202A (ja) 2010-12-08 2014-02-13 アッヴィ・インコーポレイテッド ＴＮＦ−α結合性タンパク質

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US6194551B1 (en) * 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US8647626B2 (en) * 2007-10-02 2014-02-11 Avaxia Biologics, Incorporated Compositions comprising TNF-specific antibodies for oral delivery
WO2009046168A1 (en) * 2007-10-02 2009-04-09 Avaxia Biologics, Inc. Antibody therapy for use in the digestive tract
EP2494061B1 (en) * 2009-10-29 2017-01-25 Janssen Biotech, Inc. Antibody glycosylation variants
MX2013007527A (es) * 2010-12-27 2014-02-27 Japan Health Science Found Anticuerpo monoclonal que reconoce la proteina l2 de virus de papiloma humano y metodo para medir el titulo del anticuerpo neutralizante de vph utilizando el mismo.
WO2013019889A2 (en) * 2011-08-01 2013-02-07 Avaxia Biologics, Inc. Bovine polyclonal antibody specific for human tnf
AU2017313495B2 (en) * 2016-08-15 2023-09-07 Fuso Pharmaceutical Industries, Ltd. Anti-PD-1 antibody

Patent Citations (2)

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JP2008508862A (ja) 2004-06-28 2008-03-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Ｆｃ−インターフェロン−β融合タンパク質
JP2014503202A (ja) 2010-12-08 2014-02-13 アッヴィ・インコーポレイテッド ＴＮＦ−α結合性タンパク質

Non-Patent Citations (3)

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Bhol, K. C. et al.，AVX-470: a novel oral anti-TNF antibody with therapeutic potential in inflammatory bowel disease，Inflamm. Bowel Dis.，2013年，Vol. 19(11)，pp. 2273-2281
Knight, K. L. et al.，Genetic engineering of bovine Ig. Construction and characterization of hapten-binding bovine/murine chimeric IgE, IgA, IgG1, IgG2, and IgG3 molecules，J. Immunol.，1988年，Vol. 140(10)，pp. 3654-3659
山本静雄 ほか，初乳抗体の腸管内での作用に関する研究，麻布大学雑誌，2008年，Vol. 17,18，pp. 202-210

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IL258496A (en) 2018-05-31
WO2017062253A3 (en) 2017-05-11
CA3039177A1 (en) 2017-04-13
AU2023216791A1 (en) 2023-09-07
EP3359190A2 (en) 2018-08-15
US11891440B2 (en) 2024-02-06
EP3359190A4 (en) 2020-05-06
BR112018006953A2 (pt) 2018-10-23
JP2018537117A (ja) 2018-12-20
US20220073602A1 (en) 2022-03-10
AU2016335912A1 (en) 2018-05-24
JP2022185053A (ja) 2022-12-13
US20240067715A1 (en) 2024-02-29
AU2016335912B2 (en) 2023-08-31
WO2017062253A2 (en) 2017-04-13

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