JP2018502060A5 - - Google Patents
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- JP2018502060A5 JP2018502060A5 JP2017526534A JP2017526534A JP2018502060A5 JP 2018502060 A5 JP2018502060 A5 JP 2018502060A5 JP 2017526534 A JP2017526534 A JP 2017526534A JP 2017526534 A JP2017526534 A JP 2017526534A JP 2018502060 A5 JP2018502060 A5 JP 2018502060A5
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- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 27
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 239000012634 fragment Substances 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 4
- 241000282567 Macaca fascicularis Species 0.000 claims description 4
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 4
- 206010057249 Phagocytosis Diseases 0.000 claims description 3
- 101150036449 SIRPA gene Proteins 0.000 claims description 3
- 230000035931 haemagglutination Effects 0.000 claims description 3
- 102000044459 human CD47 Human genes 0.000 claims description 3
- 210000002540 macrophage Anatomy 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 230000008782 phagocytosis Effects 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 7
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 6
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 description 6
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 description 6
- 239000004172 quinoline yellow Substances 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081134P | 2014-11-18 | 2014-11-18 | |
| US62/081,134 | 2014-11-18 | ||
| PCT/US2015/061014 WO2016081423A1 (en) | 2014-11-18 | 2015-11-17 | Cd47 antibodies, methods, and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502060A JP2018502060A (ja) | 2018-01-25 |
| JP2018502060A5 true JP2018502060A5 (enExample) | 2020-01-30 |
| JP6857603B2 JP6857603B2 (ja) | 2021-04-14 |
Family
ID=54705894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526534A Expired - Fee Related JP6857603B2 (ja) | 2014-11-18 | 2015-11-17 | 抗ｃｄ１４７抗体、方法及び使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10864268B2 (enExample) |
| EP (1) | EP3221358B1 (enExample) |
| JP (1) | JP6857603B2 (enExample) |
| KR (1) | KR20170081699A (enExample) |
| CN (1) | CN107406503B (enExample) |
| AU (1) | AU2015350190B2 (enExample) |
| BR (1) | BR112017010303A2 (enExample) |
| CA (1) | CA2967379A1 (enExample) |
| EA (1) | EA201791093A1 (enExample) |
| IL (1) | IL252198A0 (enExample) |
| MX (1) | MX2017006485A (enExample) |
| PH (1) | PH12017500915A1 (enExample) |
| SG (1) | SG11201704058TA (enExample) |
| WO (1) | WO2016081423A1 (enExample) |
| ZA (1) | ZA201704117B (enExample) |
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| CN1308447C (zh) * | 2000-10-20 | 2007-04-04 | 中外制药株式会社 | 低分子化的激动剂抗体 |
| CA2545166A1 (en) * | 2003-11-11 | 2005-05-19 | Chugai Seiyaku Kabushiki Kaisha | Humanized anti-cd47 antibody |
| JP5027804B2 (ja) * | 2005-05-26 | 2012-09-19 | シアトル ジェネティクス，インコーポレーテッド | ヒト化抗ｃｄ４０抗体およびその使用方法 |
| CN101970730A (zh) | 2007-12-19 | 2011-02-09 | 森托科尔奥索生物科技公司 | 通过融合到pⅨ或pⅦ来设计和生成人从头pⅨ噬菌体展示文库,载体、抗体及方法 |
| KR101791430B1 (ko) | 2009-11-30 | 2017-10-30 | 얀센 바이오테크 인코포레이티드 | 이펙터 기능이 제거된 항체 Ｆｃ 돌연변이체 |
| PL3789038T3 (pl) * | 2010-05-14 | 2023-01-23 | The Board Of Trustees Of The Leland Stanford Junior University | Humanizowane i chimeryczne przeciwciała monoklonalne wobec cd47 |
| DK2804617T3 (da) * | 2012-01-17 | 2020-08-10 | Univ Leland Stanford Junior | Højaffine sirp-alpha-reagenser |
| SMT201900453T1 (it) | 2012-02-06 | 2019-11-13 | Inhibrx Inc | Anticorpi anti cd47 e relativi metodi d'uso |
| SG11201504469XA (en) * | 2012-12-12 | 2015-07-30 | Vasculox Inc | Therapeutic cd47 antibodies |
| US9873747B2 (en) * | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| EP2953643B1 (en) * | 2013-02-06 | 2023-02-22 | Inhibrx, Inc. | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
-
2015
- 2015-11-17 CA CA2967379A patent/CA2967379A1/en not_active Abandoned
- 2015-11-17 US US15/527,551 patent/US10864268B2/en not_active Expired - Fee Related
- 2015-11-17 MX MX2017006485A patent/MX2017006485A/es unknown
- 2015-11-17 CN CN201580073804.7A patent/CN107406503B/zh not_active Expired - Fee Related
- 2015-11-17 WO PCT/US2015/061014 patent/WO2016081423A1/en not_active Ceased
- 2015-11-17 EA EA201791093A patent/EA201791093A1/ru unknown
- 2015-11-17 BR BR112017010303A patent/BR112017010303A2/pt not_active Application Discontinuation
- 2015-11-17 EP EP15801630.3A patent/EP3221358B1/en active Active
- 2015-11-17 AU AU2015350190A patent/AU2015350190B2/en not_active Ceased
- 2015-11-17 KR KR1020177016228A patent/KR20170081699A/ko not_active Withdrawn
- 2015-11-17 SG SG11201704058TA patent/SG11201704058TA/en unknown
- 2015-11-17 JP JP2017526534A patent/JP6857603B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-10 IL IL252198A patent/IL252198A0/en unknown
- 2017-05-17 PH PH12017500915A patent/PH12017500915A1/en unknown
- 2017-06-15 ZA ZA2017/04117A patent/ZA201704117B/en unknown
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