JP2016519932A5 - - Google Patents
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- JP2016519932A5 JP2016519932A5 JP2016513127A JP2016513127A JP2016519932A5 JP 2016519932 A5 JP2016519932 A5 JP 2016519932A5 JP 2016513127 A JP2016513127 A JP 2016513127A JP 2016513127 A JP2016513127 A JP 2016513127A JP 2016519932 A5 JP2016519932 A5 JP 2016519932A5
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- 210000004027 cells Anatomy 0.000 claims 34
- 102000004965 antibodies Human genes 0.000 claims 8
- 108090001123 antibodies Proteins 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 4
- 210000003743 Erythrocytes Anatomy 0.000 claims 3
- 210000000987 Immune System Anatomy 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 231100000765 Toxin Toxicity 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 125000004429 atoms Chemical group 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000023 polynucleotide Polymers 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 210000003324 RBC Anatomy 0.000 claims 1
- 102000005632 Single-Chain Antibodies Human genes 0.000 claims 1
- 108010070144 Single-Chain Antibodies Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 230000000269 nucleophilic Effects 0.000 claims 1
- -1 radioisotope Proteins 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Claims (15)
- ヒト細胞に薬剤を結合させる方法において、ソルターゼの存在下で、ヒト細胞を、ソルターゼ認識配列及び薬剤を含むソルターゼ基質と、前記ソルターゼが前記ソルターゼ基質を前記ヒト細胞により発現された内在性の非操作ポリペプチドと結合させるのに好適な条件下で接触させるステップを含むことを特徴とする方法。
- 請求項1に記載の方法において、前記ソルターゼ基質を、前記細胞により発現された内在性の非操作ポリペプチドの細胞外部分に結合させることを特徴とする方法。
- 請求項1又は2に記載の方法において、前記ヒト細胞が、免疫系細胞、赤血球又はその前駆細胞であることを特徴とする方法。
- 請求項1乃至3の何れか1項に記載の方法において、前記ヒト細胞が非不死化細胞であることを特徴とする方法。
- 請求項1乃至4の何れか1項に記載の方法において、前記薬剤が、アミノ酸、ペプチド、タンパク質、ポリヌクレオチド、炭水化物、タグ、金属原子、キレート剤、造影剤、触媒、ポリマー、認識エレメント、小分子、脂質、標識、エピトープ、抗原、治療薬、架橋剤、毒素、放射性同位体、抗体、抗体ドメイン、クリックケミストリーハンドル、ウイルス、細胞、又は粒子を含むことを特徴とする方法。
- 請求項1乃至5の何れか1項に記載の方法に従って調製されることを特徴とする単離ヒト細胞又は単離ヒト細胞の集団。
- (i)ソルターゼ媒介反応において求核基の役割を果たすことができる配列を含む内在性の非操作ポリペプチドを含むヒト細胞;(ii)ソルターゼ認識モチーフを含むソルターゼ基質;及び(iii)ソルターゼを含むことを特徴とする組成物。
- 請求項7に記載の組成物において、前記ヒト細胞が、免疫系細胞、赤血球又はその前駆細胞であることを特徴とする組成物。
- 請求項7又は8に記載の組成物において、前記ヒト細胞が非不死化細胞であることを特徴とする組成物。
- 請求項7乃至9の何れか1項に記載の組成物において、前記薬剤が、アミノ酸、ペプチド、タンパク質、ポリヌクレオチド、炭水化物、タグ、金属原子、キレート剤、造影剤、触媒、ポリマー、認識エレメント、小分子、脂質、標識、エピトープ、抗原、治療薬、架橋剤、毒素、放射性同位体、抗体、抗体ドメイン、クリックケミストリーハンドル、ウイルス、細胞、又は粒子を含むことを特徴とする組成物。
- 結合部分又は治療薬がソルターゼ認識配列を介して連結されたヒト細胞において、前記結合部分又は治療薬が、前記細胞により発現される内在性の非遺伝子操作タンパク質に連結されることを特徴とするヒト細胞。
- 請求項11に記載のヒト細胞において、前記細胞が、ソルターゼ認識配列を介して連結された結合部分を有し、前記部分が抗体を含み、任意選択で、前記抗体は、モノクローナル抗体、一本鎖抗体、単一ドメイン抗体であり、さらに任意選択で、前記単一ドメイン抗体は、VHHであることを特徴とするヒト細胞。
- 請求項11に記載のヒト細胞において、前記細胞が、ソルターゼ認識配列を介して連結された治療薬を有し、前記治療薬が酵素を含むことを特徴とするヒト細胞。
- 請求項11乃至13の何れか1項に記載のヒト細胞において、ヒト細胞が免疫系細胞であるか、又はヒト細胞が赤血球又はその前駆細胞であることを特徴とするヒト細胞。
- 請求項11乃至14の何れか1項に記載のヒト細胞であって、疾患の治療が必要な被験者を治療する方法に用いるためのヒト細胞。
Priority Applications (1)
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JP2019079111A JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
Applications Claiming Priority (5)
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US201361822092P | 2013-05-10 | 2013-05-10 | |
US61/822,092 | 2013-05-10 | ||
US201461943094P | 2014-02-21 | 2014-02-21 | |
US61/943,094 | 2014-02-21 | ||
PCT/US2014/037545 WO2014183066A2 (en) | 2013-05-10 | 2014-05-09 | Protein modification of living cells using sortase |
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JP2019079111A Division JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
Publications (3)
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JP2016519932A JP2016519932A (ja) | 2016-07-11 |
JP2016519932A5 true JP2016519932A5 (ja) | 2017-06-22 |
JP6603209B2 JP6603209B2 (ja) | 2019-11-06 |
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JP2016513127A Active JP6603209B2 (ja) | 2013-05-10 | 2014-05-09 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
JP2019079111A Active JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
JP2021043795A Active JP7306731B2 (ja) | 2013-05-10 | 2021-03-17 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
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JP2019079111A Active JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
JP2021043795A Active JP7306731B2 (ja) | 2013-05-10 | 2021-03-17 | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
Country Status (5)
Country | Link |
---|---|
US (3) | US10260038B2 (ja) |
EP (2) | EP4119662A1 (ja) |
JP (3) | JP6603209B2 (ja) |
AU (3) | AU2014262469B2 (ja) |
WO (1) | WO2014183066A2 (ja) |
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- 2014-05-09 EP EP22173120.1A patent/EP4119662A1/en not_active Withdrawn
- 2014-05-09 EP EP14795120.6A patent/EP2994530A4/en not_active Withdrawn
- 2014-05-09 AU AU2014262469A patent/AU2014262469B2/en not_active Expired - Fee Related
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2019
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- 2019-04-11 US US16/381,654 patent/US11492590B2/en active Active
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