JP2018507254A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018507254A5 JP2018507254A5 JP2017558627A JP2017558627A JP2018507254A5 JP 2018507254 A5 JP2018507254 A5 JP 2018507254A5 JP 2017558627 A JP2017558627 A JP 2017558627A JP 2017558627 A JP2017558627 A JP 2017558627A JP 2018507254 A5 JP2018507254 A5 JP 2018507254A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- light chain
- slc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010018324 Surrogate Immunoglobulin Light Chains Proteins 0.000 claims 20
- 102000002663 Surrogate Immunoglobulin Light Chains Human genes 0.000 claims 20
- 238000000034 method Methods 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 101000854886 Homo sapiens Immunoglobulin iota chain Proteins 0.000 claims 2
- 102100020744 Immunoglobulin iota chain Human genes 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000002067 Protein Subunits Human genes 0.000 claims 1
- 108010001267 Protein Subunits Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562111018P | 2015-02-02 | 2015-02-02 | |
| US62/111,018 | 2015-02-02 | ||
| PCT/US2016/015166 WO2016126488A1 (en) | 2015-02-02 | 2016-01-27 | Anti-surrogate light chain antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018507254A JP2018507254A (ja) | 2018-03-15 |
| JP2018507254A5 true JP2018507254A5 (enExample) | 2019-02-28 |
Family
ID=56564528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558627A Pending JP2018507254A (ja) | 2015-02-02 | 2016-01-27 | 抗代替軽鎖抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10858448B2 (enExample) |
| EP (2) | EP3253793A4 (enExample) |
| JP (1) | JP2018507254A (enExample) |
| KR (1) | KR102590740B1 (enExample) |
| CN (1) | CN107849123A (enExample) |
| AU (1) | AU2016215676B2 (enExample) |
| CA (2) | CA3185253A1 (enExample) |
| HK (1) | HK1247941A1 (enExample) |
| IL (1) | IL253579A0 (enExample) |
| WO (1) | WO2016126488A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018507254A (ja) | 2015-02-02 | 2018-03-15 | アイツー ファーマシューティカルズ， インコーポレーテッド | 抗代替軽鎖抗体 |
| HK1250146A1 (zh) | 2015-02-05 | 2018-11-30 | Stc.Unm | 抗前-bcr拮抗剂和方法 |
| CA3044682A1 (en) | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| US11407828B2 (en) * | 2019-02-01 | 2022-08-09 | Novarock Biotherapeutics, Ltd. | Anti-CLauDiN 18 antibodies and methods of use thereof |
| CN114127114B (zh) * | 2019-04-30 | 2025-02-25 | Absci公司 | 癌相关抗体组合物和使用方法 |
| CN112300282A (zh) * | 2020-11-03 | 2021-02-02 | 南京北恒生物科技有限公司 | 靶向cd7的人源化抗体及其用途 |
| WO2022177918A1 (en) | 2021-02-16 | 2022-08-25 | Children's Health Care D/B/A Children's Minnesota | Methods for treating b-all by administering a pre-bcr complex antagonist |
| CN120344653A (zh) * | 2022-10-04 | 2025-07-18 | 明克治疗公司 | 成纤维细胞活化蛋白(fap)car-恒定型自然杀伤t细胞及其用途 |
| WO2025212740A1 (en) * | 2024-04-03 | 2025-10-09 | Mink Therapeutics, Inc. | Composition and methods for treating colorectal cancer liver metastasis (crc liver mets) |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US62950A (en) | 1867-03-19 | Improvement in apparatus foe the manufacture of vinegar | ||
| US2010A (en) | 1841-03-18 | Machine foe | ||
| JPS60222842A (ja) | 1984-04-19 | 1985-11-07 | Fuji Photo Film Co Ltd | ハロゲン化銀写真乳剤およびその製造方法 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| EP0269127B1 (en) | 1986-11-27 | 1994-02-23 | F. Hoffmann-La Roche Ag | Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor |
| US5182205A (en) | 1986-11-27 | 1993-01-26 | Hoffmann-La Roche Inc. | Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| DE69233750D1 (de) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Bibliotheken heterodimerer Rezeptoren mittels Phagemiden |
| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US7067284B1 (en) | 1992-01-27 | 2006-06-27 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5233409A (en) | 1992-02-25 | 1993-08-03 | Schwab Karl W | Color analysis of organic constituents in sedimentary rocks for thermal maturity |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| US6326155B1 (en) | 1995-03-20 | 2001-12-04 | Dyax Corp. | Engineering affinity ligands for macromolecules |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| US7264963B1 (en) | 1995-08-18 | 2007-09-04 | Morphosys Ag | Protein(poly)peptide libraries |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| GB9712818D0 (en) | 1996-07-08 | 1997-08-20 | Cambridge Antibody Tech | Labelling and selection of specific binding molecules |
| WO1999006541A1 (fr) * | 1997-07-29 | 1999-02-11 | Sumitomo Electric Industries, Ltd. | Anticorps du recepteur des cellules pre-b non humaines |
| JPH11133028A (ja) * | 1997-10-29 | 1999-05-21 | Sumitomo Electric Ind Ltd | 抗ヒトプレｂ細胞レセプター抗体 |
| US20030215453A1 (en) * | 2002-05-14 | 2003-11-20 | Dedera Douglas A. | Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein |
| GB2377997A (en) * | 2001-07-24 | 2003-01-29 | Bookham Technology Plc | Connection of a non-perpendicular optical fibre to an optical device |
| JP4602614B2 (ja) | 2001-09-26 | 2010-12-22 | アイシン精機株式会社 | 自動車用ドア |
| JP4712724B2 (ja) * | 2003-12-23 | 2011-06-29 | クルセル ホランド ベー ヴェー | ＣＤ１ａに対するヒト結合分子 |
| US8131480B2 (en) | 2006-10-02 | 2012-03-06 | Sea Lane Biotechnologies Llc | Construction of diverse synthetic peptide and polypeptide libraries |
| EP2132312B1 (en) | 2007-03-27 | 2016-01-27 | Sea Lane Biotechnologies,llc. | Constructs and libraries comprising antibody surrogate light chain sequences |
| WO2010006286A2 (en) | 2008-07-11 | 2010-01-14 | Sea Lane Biotechnologies, Llc | Constructs and libraries comprising antibody surrogate kappa light chain sequences |
| TWI560271B (en) * | 2009-06-26 | 2016-12-01 | Sealane Biotechnologies Llc | Expression of surrogate light chains |
| IL269565B2 (en) * | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| JP2018507254A (ja) | 2015-02-02 | 2018-03-15 | アイツー ファーマシューティカルズ， インコーポレーテッド | 抗代替軽鎖抗体 |
| HK1250146A1 (zh) * | 2015-02-05 | 2018-11-30 | Stc.Unm | 抗前-bcr拮抗剂和方法 |
-
2016
- 2016-01-27 JP JP2017558627A patent/JP2018507254A/ja active Pending
- 2016-01-27 CA CA3185253A patent/CA3185253A1/en active Pending
- 2016-01-27 CA CA2975346A patent/CA2975346A1/en active Pending
- 2016-01-27 US US15/548,274 patent/US10858448B2/en active Active
- 2016-01-27 AU AU2016215676A patent/AU2016215676B2/en active Active
- 2016-01-27 CN CN201680019431.XA patent/CN107849123A/zh active Pending
- 2016-01-27 EP EP16747000.4A patent/EP3253793A4/en not_active Withdrawn
- 2016-01-27 WO PCT/US2016/015166 patent/WO2016126488A1/en not_active Ceased
- 2016-01-27 HK HK18107353.6A patent/HK1247941A1/zh unknown
- 2016-01-27 EP EP22202435.8A patent/EP4177267A1/en active Pending
- 2016-01-27 KR KR1020177024616A patent/KR102590740B1/ko active Active
-
2017
- 2017-07-19 IL IL253579A patent/IL253579A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018507254A5 (enExample) | ||
| WO2016207304A3 (en) | Monoclonal anti-il-1racp antibodies | |
| JP2017176174A5 (enExample) | ||
| JP2013506428A5 (enExample) | ||
| JP2016505634A5 (enExample) | ||
| CY1120414T1 (el) | Αντισωματα που συνδεονται me οχ40 και οι χρησεις τους | |
| JP2012143232A5 (enExample) | ||
| NZ716369A (en) | Anti-ox40 antibodies and methods of using the same | |
| FI3332006T3 (fi) | Uusia anti-PD-L1-vasta-aineita | |
| JP2020516603A5 (enExample) | ||
| EA201190132A1 (ru) | Гуманизированные антитела, связывающиеся с cd19, и их применение | |
| NZ587198A (en) | Monoclonal antibodies against the rgm a protein and uses thereof | |
| FI3683235T3 (fi) | Anti-IL-33-vasta-aineita ja niiden käyttöjä | |
| JP2017518366A5 (enExample) | ||
| CO6231038A2 (es) | Proteinas de union, incluyendo anticuerpos derivados de anticuerpo y fragmentos de anticuerpo que se unen especificamente a cd154 y sus usos | |
| NZ588713A (en) | Antibodies to receptor of advanced glycation end products (rage) and uses thereof | |
| JP2010513228A5 (enExample) | ||
| ES2572231T3 (es) | Anticuerpos monoclonales anti-IL-21 humana | |
| JP2021500916A5 (enExample) | ||
| JP2015527365A5 (enExample) | ||
| WO2006061723A3 (en) | Human monoclonal antibodies to influenza m2 protein and methods of making and using same | |
| JP2010509937A5 (enExample) | ||
| EA201790816A1 (ru) | Антитела, которые связываются с ccr6, и варианты применения указанных антител | |
| JOP20210286A1 (ar) | جسم مضاد أحادي النسيلة يرتبط نوعياً مع gitr | |
| JP2018504903A5 (enExample) |