CA2975346A1 - Anti-surrogate light chain antibodies - Google Patents

Anti-surrogate light chain antibodies Download PDF

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Publication number
CA2975346A1
CA2975346A1 CA2975346A CA2975346A CA2975346A1 CA 2975346 A1 CA2975346 A1 CA 2975346A1 CA 2975346 A CA2975346 A CA 2975346A CA 2975346 A CA2975346 A CA 2975346A CA 2975346 A1 CA2975346 A1 CA 2975346A1
Authority
CA
Canada
Prior art keywords
antibody
sequence
seq
human
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2975346A
Other languages
English (en)
French (fr)
Inventor
Lawrence Horowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Children's Health Care D/b/a Children's Minnesota
Original Assignee
I2 Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I2 Pharmaceuticals Inc filed Critical I2 Pharmaceuticals Inc
Priority to CA3185253A priority Critical patent/CA3185253A1/en
Publication of CA2975346A1 publication Critical patent/CA2975346A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57426Specifically defined cancers leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2975346A 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies Pending CA2975346A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3185253A CA3185253A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562111018P 2015-02-02 2015-02-02
US62/111,018 2015-02-02
PCT/US2016/015166 WO2016126488A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3185253A Division CA3185253A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Publications (1)

Publication Number Publication Date
CA2975346A1 true CA2975346A1 (en) 2016-08-11

Family

ID=56564528

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2975346A Pending CA2975346A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies
CA3185253A Pending CA3185253A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3185253A Pending CA3185253A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Country Status (10)

Country Link
US (1) US10858448B2 (enExample)
EP (2) EP3253793A4 (enExample)
JP (1) JP2018507254A (enExample)
KR (1) KR102590740B1 (enExample)
CN (1) CN107849123A (enExample)
AU (1) AU2016215676B2 (enExample)
CA (2) CA2975346A1 (enExample)
HK (1) HK1247941A1 (enExample)
IL (1) IL253579A0 (enExample)
WO (1) WO2016126488A1 (enExample)

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* Cited by examiner, † Cited by third party
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WO2016126488A1 (en) 2015-02-02 2016-08-11 Sea Lane Biotechnologies, Llc Anti-surrogate light chain antibodies
WO2016127043A1 (en) 2015-02-05 2016-08-11 Stc.Unm Anti-pre-bcr antagonists and methods
AU2017366739B2 (en) 2016-12-02 2023-11-23 Angeles Therapeutics, Inc. Synthetic immune receptors and methods of use thereof
US11407828B2 (en) * 2019-02-01 2022-08-09 Novarock Biotherapeutics, Ltd. Anti-CLauDiN 18 antibodies and methods of use thereof
CA3138550A1 (en) * 2019-04-30 2020-11-05 Target Discovery Merger Sub II, LLC Cancer associated antibody compositions and methods of use
CN112300282A (zh) * 2020-11-03 2021-02-02 南京北恒生物科技有限公司 靶向cd7的人源化抗体及其用途
IL305188A (en) * 2021-02-16 2023-10-01 Childrens Health Care D/B/A Childrens Minnesota Methods for treating B-ALL by administering a pre-BCR complex antagonist
JP2025534161A (ja) * 2022-10-04 2025-10-14 ミンク セラピューティクス, インコーポレイテッド 線維芽細胞活性化タンパク質(fap)carインバリアントナチュラルキラーt細胞及びその使用
WO2025212740A1 (en) * 2024-04-03 2025-10-09 Mink Therapeutics, Inc. Composition and methods for treating colorectal cancer liver metastasis (crc liver mets)

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Also Published As

Publication number Publication date
US10858448B2 (en) 2020-12-08
KR20170120120A (ko) 2017-10-30
CA3185253A1 (en) 2016-08-11
EP3253793A1 (en) 2017-12-13
WO2016126488A1 (en) 2016-08-11
AU2016215676A1 (en) 2017-08-10
AU2016215676B2 (en) 2021-12-02
KR102590740B1 (ko) 2023-10-18
CN107849123A (zh) 2018-03-27
EP4177267A1 (en) 2023-05-10
US20180265594A1 (en) 2018-09-20
EP3253793A4 (en) 2018-11-14
JP2018507254A (ja) 2018-03-15
HK1247941A1 (zh) 2018-10-05
IL253579A0 (en) 2017-09-28

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