AU2016215676B2 - Anti-surrogate light chain antibodies - Google Patents

Anti-surrogate light chain antibodies Download PDF

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Publication number
AU2016215676B2
AU2016215676B2 AU2016215676A AU2016215676A AU2016215676B2 AU 2016215676 B2 AU2016215676 B2 AU 2016215676B2 AU 2016215676 A AU2016215676 A AU 2016215676A AU 2016215676 A AU2016215676 A AU 2016215676A AU 2016215676 B2 AU2016215676 B2 AU 2016215676B2
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AU
Australia
Prior art keywords
sequence
antibody
human
light chain
seq
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Active
Application number
AU2016215676A
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English (en)
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AU2016215676A1 (en
Inventor
Lawrence Horowitz
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Children's Health Care D/b/a Children's Minnesota
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Childrens Health Care D/b/a Childrens Minnesota
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Assigned to CHILDREN'S HEALTH CARE D/B/A CHILDREN'S MINNESOTA reassignment CHILDREN'S HEALTH CARE D/B/A CHILDREN'S MINNESOTA Request for Assignment Assignors: I2 PHARMACEUTICALS, INC.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2016215676A 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies Active AU2016215676B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562111018P 2015-02-02 2015-02-02
US62/111,018 2015-02-02
PCT/US2016/015166 WO2016126488A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Publications (2)

Publication Number Publication Date
AU2016215676A1 AU2016215676A1 (en) 2017-08-10
AU2016215676B2 true AU2016215676B2 (en) 2021-12-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016215676A Active AU2016215676B2 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Country Status (10)

Country Link
US (1) US10858448B2 (enExample)
EP (2) EP3253793A4 (enExample)
JP (1) JP2018507254A (enExample)
KR (1) KR102590740B1 (enExample)
CN (1) CN107849123A (enExample)
AU (1) AU2016215676B2 (enExample)
CA (2) CA2975346A1 (enExample)
HK (1) HK1247941A1 (enExample)
IL (1) IL253579A0 (enExample)
WO (1) WO2016126488A1 (enExample)

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* Cited by examiner, † Cited by third party
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WO2016126488A1 (en) 2015-02-02 2016-08-11 Sea Lane Biotechnologies, Llc Anti-surrogate light chain antibodies
AU2016215110A1 (en) 2015-02-05 2017-09-21 Stc.Unm Anti-pre-BCR antagonists and methods
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
JP7840511B2 (ja) * 2019-02-01 2026-04-06 石▲薬▼集▲団▼巨石生物制▲薬▼有限公司 抗クローディン１８抗体及びそれらの使用の方法
AU2020266560A1 (en) * 2019-04-30 2021-11-25 Absci Corporation Cancer associated antibody compositions and methods of use
CN112300282A (zh) * 2020-11-03 2021-02-02 南京北恒生物科技有限公司 靶向cd7的人源化抗体及其用途
MX2023009433A (es) 2021-02-16 2023-11-29 Children´S Health Care D/B/A/ Children´S Minnesota Metodos para el tratamiento de b-all mediante la administracion de un antagonista del complejo pre-bcr.
US20260124303A1 (en) * 2022-10-04 2026-05-07 Mink Therapeutics, Inc. Fibroblast activation protein (fap) car-invariant natural killer t cells and uses thereof
WO2025212740A1 (en) * 2024-04-03 2025-10-09 Mink Therapeutics, Inc. Composition and methods for treating colorectal cancer liver metastasis (crc liver mets)

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Also Published As

Publication number Publication date
HK1247941A1 (zh) 2018-10-05
CA2975346A1 (en) 2016-08-11
EP3253793A1 (en) 2017-12-13
IL253579A0 (en) 2017-09-28
KR102590740B1 (ko) 2023-10-18
EP4177267A1 (en) 2023-05-10
AU2016215676A1 (en) 2017-08-10
WO2016126488A1 (en) 2016-08-11
JP2018507254A (ja) 2018-03-15
KR20170120120A (ko) 2017-10-30
CA3185253A1 (en) 2016-08-11
US10858448B2 (en) 2020-12-08
US20180265594A1 (en) 2018-09-20
CN107849123A (zh) 2018-03-27
EP3253793A4 (en) 2018-11-14

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Owner name: CHILDREN'S HEALTH CARE D/B/A CHILDREN'S MINNESOTA

Free format text: FORMER APPLICANT(S): I2 PHARMACEUTICALS, INC.

FGA Letters patent sealed or granted (standard patent)