SG11201901066UA - Novel alkaline stable immunoglobulin-binding proteins - Google Patents
Novel alkaline stable immunoglobulin-binding proteinsInfo
- Publication number
- SG11201901066UA SG11201901066UA SG11201901066UA SG11201901066UA SG11201901066UA SG 11201901066U A SG11201901066U A SG 11201901066UA SG 11201901066U A SG11201901066U A SG 11201901066UA SG 11201901066U A SG11201901066U A SG 11201901066UA SG 11201901066U A SG11201901066U A SG 11201901066UA
- Authority
- SG
- Singapore
- Prior art keywords
- proteins
- damerow
- navigo
- saale
- halle
- Prior art date
Links
- 102000028557 immunoglobulin binding proteins Human genes 0.000 title abstract 2
- 108091009323 immunoglobulin binding proteins Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000023732 binding proteins Human genes 0.000 abstract 3
- 108091008324 binding proteins Proteins 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 238000001261 affinity purification Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 01E101011M vu H 1 0 011101 OHM 3100111111110111011 lil Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/029157 Al 15 February 2018 (15.02.2018) W I P0 I P C T (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) (72) (74) (81) Designated States International Patent Classification: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, C07K 14/31 (2006.01) CO7K 1/22 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PCT/EP2017/069976 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 07 August 2017 (07.08.2017) (84) Designated States (unless otherwise indicated, for every English kind of regional protection available): ARIPO (BW, GH, English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Priority Data: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 16183710.9 11 August 2016 (11.08.2016) EP EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 16205707.9 21 December 2016 (21.12.2016) EP MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Applicant: NAVIGO PROTEINS GMBH [DE/DE]; KM, ML, MR, NE, SN, TD, TG). Heinrich Damerow Str. 1, 06120 Halle/Saale (DE). Inventors: KNICK, Paul; Navigo Proteins GmbH Hein- Published: rich-Damerow-Str. 1, 06120 Halle/Saale (DE). FIEDLER, — with international search report (Art. 21(3)) Erik; Navigo Proteins GmbH Heinrich Damerow Str. 1, — before the expiration of the time limit for amending the 06120 Halle/Saale (DE). HAUPTS, Ulrich; Navigo Pro- claims and to be republished in the event of receipt of teins GmbH Heinrich Damerow Str. 1, 06120 Halle/Saale amendments (Rule 48.2(h)) (DE). MEYSING, Maren; Navigo Proteins GmbH Hein- — with sequence listing part of description (Rule 5.2(a)) rich-Damerow-Str. 1, 06120 Halle/Saale (DE). Agent: HAUCKE, Kerstin; Navigo Proteins GmbH Hein- rich Damerow Str. 1, 06120 Halle/Saale (DE). (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Title: NOVEL ALKALINE STABLE IMMUNOGLOBULIN-BINDING PROTEINS : The present invention relates to immunoglobulin (Ig) binding proteins comprising amino acids selected from the group consisting at least of 1I, 11A, 11E, 11I, 35R, 35I, and matrices comprising the Ig binding proteins of the invention. The invention also relates affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification the invention. FIG. 4. cs27 with at least 11, 11A, 35R 250 200 at c 150 t 100 T < 50 I I827 cs27-1 cs27-2 one or more Ig binding domains 42L. The invention further relates to to a use of these Ig binding5 proteins using the Ig binding proteins = (54) 11 Ir ----- ir) 1-1 cT ei © p i p (57) - with 0 el affinity or 0 of
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183710 | 2016-08-11 | ||
| EP16205707 | 2016-12-21 | ||
| PCT/EP2017/069976 WO2018029157A1 (en) | 2016-08-11 | 2017-08-07 | Novel alkaline stable immunoglobulin-binding proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201901066UA true SG11201901066UA (en) | 2019-03-28 |
Family
ID=59631752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901066UA SG11201901066UA (en) | 2016-08-11 | 2017-08-07 | Novel alkaline stable immunoglobulin-binding proteins |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11230576B2 (en) |
| EP (4) | EP4177260A1 (en) |
| JP (3) | JP6951417B2 (en) |
| KR (3) | KR20230133943A (en) |
| CN (4) | CN109476712B (en) |
| AU (2) | AU2017311541B2 (en) |
| CA (2) | CA3030208A1 (en) |
| DK (1) | DK3497117T3 (en) |
| LT (1) | LT3497117T (en) |
| SG (1) | SG11201901066UA (en) |
| WO (2) | WO2018029157A1 (en) |
Families Citing this family (24)
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| US10858405B2 (en) | 2015-02-06 | 2020-12-08 | Navigo Proteins Gmbh | EGFR binding proteins |
| US10808042B2 (en) | 2015-07-16 | 2020-10-20 | Navigo Proteins Gmbh | Immunoglobulin-binding proteins and their use in affinity purification |
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| WO2017191252A1 (en) | 2016-05-04 | 2017-11-09 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| EP3546476A1 (en) * | 2018-03-26 | 2019-10-02 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| AU2018314651B2 (en) * | 2017-08-07 | 2022-12-15 | Repligen Corporation | Fc binding proteins with Cysteine in the C-terminal helical region |
| EP3521304B9 (en) | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
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| WO2020157281A1 (en) * | 2019-02-01 | 2020-08-06 | Navigo Proteins Gmbh | Immunoglobulin binding proteins for affinity purification |
| GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
| JP7432813B2 (en) | 2019-09-10 | 2024-02-19 | 東ソー株式会社 | immunoglobulin binding protein |
| JP2023507268A (en) * | 2019-12-17 | 2023-02-22 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Binding protein of the enzyme acid alpha-glucosidase (GAA) and uses thereof |
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| EP3875472A1 (en) * | 2020-03-06 | 2021-09-08 | Navigo Proteins Gmbh | Novel immunoglobulin binding polypeptides |
| JP2023533529A (en) * | 2020-07-15 | 2023-08-03 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Immunoglobulin binding proteins for affinity purification |
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| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
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| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
-
2017
- 2017-08-07 CA CA3030208A patent/CA3030208A1/en active Pending
- 2017-08-07 EP EP22193930.9A patent/EP4177260A1/en active Pending
- 2017-08-07 WO PCT/EP2017/069976 patent/WO2018029157A1/en unknown
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