DK3497117T5 - Nye alkalisk stabile immunglobulin-bindende proteiner - Google Patents
Nye alkalisk stabile immunglobulin-bindende proteiner Download PDFInfo
- Publication number
- DK3497117T5 DK3497117T5 DK17752349.5T DK17752349T DK3497117T5 DK 3497117 T5 DK3497117 T5 DK 3497117T5 DK 17752349 T DK17752349 T DK 17752349T DK 3497117 T5 DK3497117 T5 DK 3497117T5
- Authority
- DK
- Denmark
- Prior art keywords
- immunglobulin
- stable
- binding proteins
- new alkaline
- alkaline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183710 | 2016-08-11 | ||
| EP16205707 | 2016-12-21 | ||
| PCT/EP2017/069976 WO2018029157A1 (en) | 2016-08-11 | 2017-08-07 | Novel alkaline stable immunoglobulin-binding proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3497117T3 DK3497117T3 (da) | 2024-04-22 |
| DK3497117T5 true DK3497117T5 (da) | 2024-09-02 |
Family
ID=59631752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17752349.5T DK3497117T5 (da) | 2016-08-11 | 2017-08-07 | Nye alkalisk stabile immunglobulin-bindende proteiner |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11014967B2 (enExample) |
| EP (4) | EP4177260A1 (enExample) |
| JP (3) | JP6951417B2 (enExample) |
| KR (3) | KR20230133943A (enExample) |
| CN (4) | CN117736281A (enExample) |
| AU (2) | AU2017311542B2 (enExample) |
| CA (2) | CA3030208A1 (enExample) |
| DK (1) | DK3497117T5 (enExample) |
| LT (1) | LT3497117T (enExample) |
| SG (1) | SG11201901066UA (enExample) |
| WO (2) | WO2018029158A1 (enExample) |
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| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) * | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| WO2019030156A1 (en) | 2017-08-07 | 2019-02-14 | Repligen Corporation | FC BINDING PROTEINS WITH CYSTEINE IN THE C-TERMINAL HELICAL REGION |
| EP3546476A1 (en) * | 2018-03-26 | 2019-10-02 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| EP4249097A3 (en) | 2018-02-01 | 2024-01-10 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| AU2019380620B2 (en) * | 2018-11-12 | 2022-05-26 | Navigo Proteins Gmbh | Novel triple-helical polypeptides lacking binding affinity for the Fc domain of immunoglobulin and uses thereof |
| EP3650465A1 (en) | 2018-11-12 | 2020-05-13 | Navigo Proteins Gmbh | Novel populations of polypeptides having a triple-helical structure |
| CA3123986A1 (en) | 2018-12-18 | 2020-06-25 | Navigo Proteins Gmbh | Novel folr1 specific binding proteins for cancer diagnosis and treatment |
| BR112021013026A2 (pt) * | 2019-02-01 | 2021-10-13 | Navigo Proteins Gmbh | Proteínas de ligação à imunoglobulina, matriz de separação por afinidade, uso da proteína de ligação à imunoglobulina, e método de purificação por afinidade de uma proteína compreendendo uma sequência de imunoglobulina |
| GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
| JP7432813B2 (ja) * | 2019-09-10 | 2024-02-19 | 東ソー株式会社 | 免疫グロブリン結合性タンパク質 |
| US12286458B2 (en) | 2019-12-17 | 2025-04-29 | Navigo Proteins Gmbh | Binding proteins for the enzyme acid alpha glucosidase (GAA) and uses thereof |
| WO2021165395A1 (en) * | 2020-02-21 | 2021-08-26 | Navigo Proteins Gmbh | Affinity ligand for the soluble part of fibroblast growth factor receptor 3 (sfgfr3) |
| EP3875472A1 (en) | 2020-03-06 | 2021-09-08 | Navigo Proteins Gmbh | Novel immunoglobulin binding polypeptides |
| WO2021260052A1 (en) * | 2020-06-23 | 2021-12-30 | Navigo Proteins Gmbh | Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2) |
| LT4132943T (lt) * | 2020-07-15 | 2024-07-25 | Navigo Proteins Gmbh | Imunoglobulinus surišantys baltymai, skirti giminingumu pagrįstam gryninimui |
| US20230416345A1 (en) * | 2020-11-09 | 2023-12-28 | Navigo Proteins Gmbh | New type ii collagen binding proteins |
| EP4001301A1 (en) * | 2020-11-13 | 2022-05-25 | Navigo Proteins Gmbh | Binding protein for complement factor h (cfh) |
| EP4380955A1 (en) * | 2021-08-06 | 2024-06-12 | Roche Diagnostics GmbH | Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN116925197A (zh) * | 2021-12-21 | 2023-10-24 | 百林科(兰州)新材料有限公司 | 耐碱蛋白A变体在纯化IgG抗体中的应用 |
| CN113999294B (zh) * | 2021-12-30 | 2022-03-29 | 苏州纳微科技股份有限公司 | 免疫球蛋白结合蛋白及其应用 |
| CN114409748A (zh) * | 2022-01-28 | 2022-04-29 | 博格隆(浙江)生物技术有限公司 | 蛋白a的b结构域和z结构域突变体及其应用 |
| GB202203478D0 (en) | 2022-03-14 | 2022-04-27 | Cytiva Bioprocess R & D Ab | Vh3 binding polypeptides |
| JP2025539595A (ja) * | 2022-12-16 | 2025-12-05 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | アフィニティークロマトグラフィーのための新しいリガンド |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| EP4541444A1 (en) * | 2023-10-20 | 2025-04-23 | Cytiva BioProcess R&D AB | Fusion protein for affinity capture |
| WO2025262100A1 (en) * | 2024-06-18 | 2025-12-26 | Navigo Proteins Gmbh | New ligands for the purification of antibodies via affinity chromatography |
| WO2026057420A1 (en) | 2024-09-10 | 2026-03-19 | Cytiva Bioprocess R&D Ab | Affinity ligand for purification of antibodies of isotype iga |
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| JP6881760B2 (ja) | 2015-07-20 | 2021-06-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質に基づくＨｅｒ２結合タンパク質 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| WO2019030156A1 (en) | 2017-08-07 | 2019-02-14 | Repligen Corporation | FC BINDING PROTEINS WITH CYSTEINE IN THE C-TERMINAL HELICAL REGION |
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| EP4249097A3 (en) | 2018-02-01 | 2024-01-10 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
-
2017
- 2017-08-07 CA CA3030208A patent/CA3030208A1/en active Pending
- 2017-08-07 AU AU2017311542A patent/AU2017311542B2/en not_active Ceased
- 2017-08-07 CN CN202311795884.XA patent/CN117736281A/zh active Pending
- 2017-08-07 JP JP2019507171A patent/JP6951417B2/ja active Active
- 2017-08-07 WO PCT/EP2017/069979 patent/WO2018029158A1/en not_active Ceased
- 2017-08-07 AU AU2017311541A patent/AU2017311541B2/en active Active
- 2017-08-07 EP EP22193930.9A patent/EP4177260A1/en active Pending
- 2017-08-07 KR KR1020237030862A patent/KR20230133943A/ko active Pending
- 2017-08-07 KR KR1020197003966A patent/KR102573370B1/ko active Active
- 2017-08-07 LT LTEPPCT/EP2017/069976T patent/LT3497117T/lt unknown
- 2017-08-07 DK DK17752349.5T patent/DK3497117T5/da active
- 2017-08-07 CA CA3031858A patent/CA3031858A1/en active Pending
- 2017-08-07 WO PCT/EP2017/069976 patent/WO2018029157A1/en not_active Ceased
- 2017-08-07 EP EP17752350.3A patent/EP3497118B1/en active Active
- 2017-08-07 CN CN202210871980.7A patent/CN116333065A/zh active Pending
- 2017-08-07 SG SG11201901066UA patent/SG11201901066UA/en unknown
- 2017-08-07 KR KR1020197003790A patent/KR102578256B1/ko active Active
- 2017-08-07 JP JP2019505354A patent/JP7181612B2/ja active Active
- 2017-08-07 EP EP23218805.2A patent/EP4324840A3/en active Pending
- 2017-08-07 EP EP17752349.5A patent/EP3497117B1/en active Active
- 2017-08-07 CN CN201780044905.0A patent/CN109476712B/zh active Active
- 2017-08-07 CN CN201780050413.2A patent/CN109963864B/zh active Active
- 2017-08-07 US US16/324,842 patent/US11014967B2/en active Active
- 2017-08-07 US US16/324,651 patent/US11230576B2/en active Active
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2021
- 2021-03-23 US US17/209,455 patent/US20210206815A1/en not_active Abandoned
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2022
- 2022-07-13 JP JP2022112299A patent/JP2022160444A/ja active Pending
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2024
- 2024-09-03 US US18/822,867 patent/US20250051400A1/en active Pending
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