JP2018526642A5 - - Google Patents
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- Publication number
- JP2018526642A5 JP2018526642A5 JP2018510519A JP2018510519A JP2018526642A5 JP 2018526642 A5 JP2018526642 A5 JP 2018526642A5 JP 2018510519 A JP2018510519 A JP 2018510519A JP 2018510519 A JP2018510519 A JP 2018510519A JP 2018526642 A5 JP2018526642 A5 JP 2018526642A5
- Authority
- JP
- Japan
- Prior art keywords
- synuclein
- alpha
- sample
- antibody
- capture antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 102000003802 alpha-Synuclein Human genes 0.000 claims 12
- 108090000185 alpha-Synuclein Proteins 0.000 claims 12
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- 102000019355 Synuclein Human genes 0.000 claims 2
- 108050006783 Synuclein Proteins 0.000 claims 2
- 229920004896 Triton X-405 Polymers 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021122883A JP7244949B2 (ja) | 2015-08-25 | 2021-07-28 | リン酸化アルファ－シヌクレインを検出するための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562209800P | 2015-08-25 | 2015-08-25 | |
| US62/209,800 | 2015-08-25 | ||
| US201662297777P | 2016-02-19 | 2016-02-19 | |
| US62/297,777 | 2016-02-19 | ||
| PCT/IB2016/055088 WO2017033152A1 (en) | 2015-08-25 | 2016-08-25 | Methods for detecting phosphorylated alpha-synuclein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021122883A Division JP7244949B2 (ja) | 2015-08-25 | 2021-07-28 | リン酸化アルファ－シヌクレインを検出するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526642A JP2018526642A (ja) | 2018-09-13 |
| JP2018526642A5 true JP2018526642A5 (enExample) | 2019-10-03 |
| JP6989927B2 JP6989927B2 (ja) | 2022-02-03 |
Family
ID=56926235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510519A Active JP6989927B2 (ja) | 2015-08-25 | 2016-08-25 | リン酸化アルファ－シヌクレインを検出するための方法 |
| JP2021122883A Active JP7244949B2 (ja) | 2015-08-25 | 2021-07-28 | リン酸化アルファ－シヌクレインを検出するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021122883A Active JP7244949B2 (ja) | 2015-08-25 | 2021-07-28 | リン酸化アルファ－シヌクレインを検出するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10852309B2 (enExample) |
| EP (1) | EP3341725B1 (enExample) |
| JP (2) | JP6989927B2 (enExample) |
| CA (1) | CA2994518C (enExample) |
| DK (1) | DK3341725T3 (enExample) |
| ES (1) | ES2890073T3 (enExample) |
| HU (1) | HUE056054T2 (enExample) |
| PT (1) | PT3341725T (enExample) |
| WO (1) | WO2017033152A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3341725T (pt) | 2015-08-25 | 2021-09-21 | Prothena Biosciences Ltd | Métodos para detetar alfa-sinucleína fosforilada |
| AU2017359944B2 (en) | 2016-11-15 | 2024-07-18 | H. Lundbeck A/S | Agents, uses and methods for the treatment of synucleinopathy |
| US11237176B2 (en) | 2016-12-02 | 2022-02-01 | Prothena Biosciences Limited | Infrared assay detecting secondary structure profiles of alpha-synuclein |
| ES3008133T3 (en) | 2016-12-16 | 2025-03-21 | H Lundbeck As | Agents, uses and methods |
| KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| EP3729088B1 (en) * | 2017-12-21 | 2021-10-20 | H. Lundbeck A/S | Diagnosis and treatment of alpha-synucleinopathies |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| WO2020146497A1 (en) * | 2019-01-09 | 2020-07-16 | The Regents Of The University Of California | An electrochemiluminescence elisa for ps129-a-synuclein |
| JP2023504699A (ja) * | 2019-12-04 | 2023-02-06 | エイシー イミューン ソシエテ アノニム | 治療および診断のための新規な分子 |
| CN112710850A (zh) * | 2020-12-29 | 2021-04-27 | 苏州百志生物科技有限公司 | 一种检测人体液中α-突触核蛋白含量的试剂盒 |
| WO2024163454A1 (en) * | 2023-01-30 | 2024-08-08 | The Regents Of The University Of California | A duplex electrochemiluminescence immunoassay for total α-synuclein and ps129-α-synuclein |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| AU8081491A (en) | 1990-06-01 | 1991-12-31 | Cetus Corporation | Compositions and methods for identifying biologically active molecules |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| DK0667959T3 (da) * | 1992-10-26 | 2003-12-08 | Elan Pharm Inc | Fremgangsmåder til identificering af inhibitorer af produktionen af beta-amyloidpeptid |
| US5914241A (en) | 1993-01-19 | 1999-06-22 | Biosite Diagnostics, Inc. | Assays and kits for detecting analytes in the presence of cross-reacting substances |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5965375A (en) | 1997-04-04 | 1999-10-12 | Biosite Diagnostics | Diagnostic tests and kits for Clostridium difficile |
| US20080014194A1 (en) * | 2003-10-31 | 2008-01-17 | Elan Pharmaceuticals, Inc. | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| US8506959B2 (en) * | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| WO2005047860A2 (en) * | 2003-11-08 | 2005-05-26 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| EP2527369A3 (en) * | 2007-09-13 | 2012-12-19 | University Of Zurich Prorektorat Forschung | Monoclonal amyloid beta (abeta)-specific antibody and uses thereof |
| RU2014105172A (ru) * | 2011-07-13 | 2015-08-20 | Мерк Шарп И Доум Корп. | Способ обнаружения олигомеров бета-амилоида в образце жидкости организма и варианты его применения |
| PT3341725T (pt) | 2015-08-25 | 2021-09-21 | Prothena Biosciences Ltd | Métodos para detetar alfa-sinucleína fosforilada |
-
2016
- 2016-08-25 PT PT167660885T patent/PT3341725T/pt unknown
- 2016-08-25 US US15/247,598 patent/US10852309B2/en active Active
- 2016-08-25 DK DK16766088.5T patent/DK3341725T3/da active
- 2016-08-25 CA CA2994518A patent/CA2994518C/en active Active
- 2016-08-25 HU HUE16766088A patent/HUE056054T2/hu unknown
- 2016-08-25 WO PCT/IB2016/055088 patent/WO2017033152A1/en not_active Ceased
- 2016-08-25 EP EP16766088.5A patent/EP3341725B1/en active Active
- 2016-08-25 ES ES16766088T patent/ES2890073T3/es active Active
- 2016-08-25 JP JP2018510519A patent/JP6989927B2/ja active Active
-
2020
- 2020-10-30 US US17/086,158 patent/US20210165000A1/en not_active Abandoned
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2021
- 2021-07-28 JP JP2021122883A patent/JP7244949B2/ja active Active
-
2023
- 2023-01-26 US US18/160,270 patent/US20230228772A1/en active Pending