JP2014503829A5 - - Google Patents
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- Publication number
- JP2014503829A5 JP2014503829A5 JP2013551330A JP2013551330A JP2014503829A5 JP 2014503829 A5 JP2014503829 A5 JP 2014503829A5 JP 2013551330 A JP2013551330 A JP 2013551330A JP 2013551330 A JP2013551330 A JP 2013551330A JP 2014503829 A5 JP2014503829 A5 JP 2014503829A5
- Authority
- JP
- Japan
- Prior art keywords
- macromolecule
- igm
- resulting
- immune system
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003870 intestinal permeability Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 230000003959 neuroinflammation Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437244P | 2011-01-28 | 2011-01-28 | |
| US61/437,244 | 2011-01-28 | ||
| PCT/US2012/022706 WO2012103324A2 (en) | 2011-01-28 | 2012-01-26 | Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503829A JP2014503829A (ja) | 2014-02-13 |
| JP2014503829A5 true JP2014503829A5 (enExample) | 2016-02-04 |
| JP6068362B2 JP6068362B2 (ja) | 2017-01-25 |
Family
ID=46577669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551330A Active JP6068362B2 (ja) | 2011-01-28 | 2012-01-26 | 腸および血液脳関門の透過性を検出する方法、およびその試験材料 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8663911B2 (enExample) |
| EP (1) | EP2668498B1 (enExample) |
| JP (1) | JP6068362B2 (enExample) |
| KR (1) | KR101941308B1 (enExample) |
| CN (2) | CN105823887B (enExample) |
| AU (3) | AU2012211328A1 (enExample) |
| BR (1) | BR112013019380A2 (enExample) |
| CA (2) | CA2964555C (enExample) |
| IL (2) | IL227676A (enExample) |
| MX (1) | MX2013008746A (enExample) |
| RU (2) | RU2016149216A (enExample) |
| WO (1) | WO2012103324A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2628013B1 (en) | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| US9709573B2 (en) | 2012-03-13 | 2017-07-18 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| US20140147856A1 (en) * | 2012-11-29 | 2014-05-29 | Rush University Medical Center | Intestinal Permeability Assay for Neurodegenerative Diseases |
| WO2015009907A1 (en) | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| CN107533048A (zh) | 2015-02-05 | 2018-01-02 | 美国免疫阵列公司 | 用于诊断脑损伤或神经退行性变的方法和组合物 |
| US11131676B2 (en) | 2016-02-25 | 2021-09-28 | The Trustees Of Columbia University In The City Of New York | Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity |
| CN105974105A (zh) * | 2016-05-16 | 2016-09-28 | 河北艾驰生物科技有限公司 | 基质金属蛋白酶-3（mmp3）检测试剂盒 |
| JP6782886B2 (ja) | 2017-01-19 | 2020-11-11 | 国立大学法人島根大学 | 腸粘膜の透過性の診断薬、診断方法、診断装置 |
| CN108191977B (zh) * | 2017-12-25 | 2018-12-18 | 首都医科大学宣武医院 | 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用 |
| CN108152492B (zh) * | 2017-12-25 | 2019-03-08 | 首都医科大学宣武医院 | 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用 |
| US12262983B2 (en) | 2018-02-07 | 2025-04-01 | University Of Cincinnati | System and method for detecting small blood-tissue barrier disruption |
| KR102341906B1 (ko) * | 2018-10-26 | 2021-12-22 | 가천대학교 산학협력단 | 청년기 우울증 동물모델의 제조방법 |
| CN112958172B (zh) * | 2021-02-24 | 2021-12-28 | 北京航空航天大学 | 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020028215A1 (en) * | 1999-08-09 | 2002-03-07 | Jagath L. Kadurugamuwa | Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same |
| DE19842609C2 (de) * | 1998-09-17 | 2000-09-21 | Diagnostik Gmbh Leipzig Lab | Salmonellenantigengemisch und Kit zur Bestimmung von Antikörpern gegen Salmonellen |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US6884591B2 (en) * | 2001-06-25 | 2005-04-26 | The Cleveland Clinic Foundation | Peripheral marker of blood brain barrier permeability |
| CN1788017B (zh) * | 2003-02-10 | 2013-04-24 | to-BBB控股股份有限公司 | 炎症状态下在血脑屏障中差异表达的核酸 |
| US20080038843A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Maryland - Baltimore | Method of diagnosing celiac disease |
| CA2651366A1 (en) * | 2005-05-13 | 2006-11-23 | Alessio Fasano | Method for assessing the effectiveness of a treatment regimen |
| US7795314B2 (en) * | 2005-06-01 | 2010-09-14 | Cytokine Pharmasciences, Inc. | Protective role of semapimod in necrotizing enterocolitis |
| EP1757940A1 (en) * | 2005-08-26 | 2007-02-28 | Cézanne S.A.S. | In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC |
| JP4791866B2 (ja) * | 2006-03-24 | 2011-10-12 | 国立大学法人秋田大学 | 下痢原性大腸菌感染症の判別に用いられる固相等 |
| US7892763B2 (en) * | 2009-01-26 | 2011-02-22 | Dodds W Jean | Multi-stage nutrigenomic diagnostic food sensitivity testing in animals |
-
2012
- 2012-01-26 MX MX2013008746A patent/MX2013008746A/es unknown
- 2012-01-26 CN CN201610171077.4A patent/CN105823887B/zh active Active
- 2012-01-26 WO PCT/US2012/022706 patent/WO2012103324A2/en not_active Ceased
- 2012-01-26 CA CA2964555A patent/CA2964555C/en active Active
- 2012-01-26 CN CN201280015809.0A patent/CN103460044B/zh active Active
- 2012-01-26 KR KR1020137022644A patent/KR101941308B1/ko active Active
- 2012-01-26 AU AU2012211328A patent/AU2012211328A1/en not_active Abandoned
- 2012-01-26 RU RU2016149216A patent/RU2016149216A/ru not_active Application Discontinuation
- 2012-01-26 JP JP2013551330A patent/JP6068362B2/ja active Active
- 2012-01-26 CA CA2828194A patent/CA2828194A1/en active Pending
- 2012-01-26 BR BR112013019380A patent/BR112013019380A2/pt not_active Application Discontinuation
- 2012-01-26 US US13/359,007 patent/US8663911B2/en active Active
- 2012-01-26 RU RU2013139476A patent/RU2607479C2/ru active
- 2012-01-26 EP EP12739704.0A patent/EP2668498B1/en active Active
-
2013
- 2013-07-28 IL IL227676A patent/IL227676A/en active IP Right Grant
-
2014
- 2014-03-04 US US14/196,972 patent/US9194867B2/en active Active
-
2016
- 2016-11-18 AU AU2016259430A patent/AU2016259430B2/en active Active
- 2016-11-24 AU AU2016262726A patent/AU2016262726B2/en active Active
-
2017
- 2017-03-01 IL IL250871A patent/IL250871B/en active IP Right Grant
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