JO3744B1 - مواد ربط لـpd1 و/ أو lag3 - Google Patents

مواد ربط لـpd1 و/ أو lag3

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Publication number
JO3744B1
JO3744B1 JOP/2016/0244A JOP20160244A JO3744B1 JO 3744 B1 JO3744 B1 JO 3744B1 JO P20160244 A JOP20160244 A JO P20160244A JO 3744 B1 JO3744 B1 JO 3744B1
Authority
JO
Jordan
Prior art keywords
molecules
lag3
treat
lag3 binders
isvds
Prior art date
Application number
JOP/2016/0244A
Other languages
English (en)
Inventor
Bowman Edward
A Kastelein Robert
Vlerick David
Beaumont Maribel
Buyse Marie-Ange
Boutton Carlo
Dombrecht Bruno
Original Assignee
Merck Sharp & Dohme
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Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of JO3744B1 publication Critical patent/JO3744B1/ar

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Communicable Diseases (AREA)
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  • Mycology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Ceramic Products (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بجزيئات، مثل ISVDs وأجسام بحجم النانو، ترتبط بـ PD1 وLAG3 و، اختياريًا بألبيومين المصل البشري. تمت معالجة هذه الجزيئات وراثيًا لخفض حدوث الارتباط بواسطة أجسام مضادة موجودة مسبقًا في أجسام خاضع تم إعطاؤه هذا الجزيء. يتم توفير طرق لزيادة الاستجابة المناعية و/ أو علاج سرطان و/ أو علاج مرض معدي بهذه الجزيئات.
JOP/2016/0244A 2015-11-18 2016-11-17 مواد ربط لـpd1 و/ أو lag3 JO3744B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562257009P 2015-11-18 2015-11-18

Publications (1)

Publication Number Publication Date
JO3744B1 true JO3744B1 (ar) 2021-01-31

Family

ID=57472067

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0244A JO3744B1 (ar) 2015-11-18 2016-11-17 مواد ربط لـpd1 و/ أو lag3

Country Status (30)

Country Link
US (5) US10323090B2 (ar)
EP (1) EP3377531A2 (ar)
JP (3) JP6817302B2 (ar)
KR (3) KR102194188B1 (ar)
CN (1) CN108473585B (ar)
AR (1) AR106754A1 (ar)
AU (3) AU2016355570B2 (ar)
CA (3) CA3132021C (ar)
CL (3) CL2018001327A1 (ar)
CO (1) CO2018005126A2 (ar)
CR (1) CR20180278A (ar)
DO (2) DOP2018000126A (ar)
EA (1) EA201891165A1 (ar)
EC (1) ECSP18045468A (ar)
GE (1) GEP20217220B (ar)
HK (1) HK1254951A1 (ar)
IL (2) IL300122A (ar)
JO (1) JO3744B1 (ar)
MA (1) MA43260A (ar)
MX (2) MX2018006245A (ar)
MY (1) MY189018A (ar)
NI (1) NI201800061A (ar)
PE (1) PE20181532A1 (ar)
PH (1) PH12018501080A1 (ar)
SG (2) SG11201804178YA (ar)
SV (1) SV2018005694A (ar)
TN (1) TN2018000172A1 (ar)
TW (2) TWI754621B (ar)
UA (1) UA121914C2 (ar)
WO (1) WO2017087589A2 (ar)

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JP2019506137A (ja) 2019-03-07
WO2017087589A3 (en) 2017-07-13
KR102220275B1 (ko) 2021-02-26
KR102194188B1 (ko) 2020-12-24
KR102317574B1 (ko) 2021-10-26
KR20180081592A (ko) 2018-07-16
IL259224B2 (en) 2023-07-01
AU2020202238B2 (en) 2022-07-28
US12351630B2 (en) 2025-07-08
CN108473585B (zh) 2022-04-05
SG11201804178YA (en) 2018-06-28
US20190338025A1 (en) 2019-11-07
EA201891165A1 (ru) 2018-11-30
US10323090B2 (en) 2019-06-18
CO2018005126A2 (es) 2018-11-30
DOP2021000005A (es) 2021-04-15
CA3131983A1 (en) 2017-05-26
US20170137517A1 (en) 2017-05-18
AU2020202177B2 (en) 2022-07-28
MA43260A (fr) 2018-09-26
US11155619B2 (en) 2021-10-26
IL259224B1 (en) 2023-03-01
JP2021058197A (ja) 2021-04-15
SG10201911035QA (en) 2020-01-30
WO2017087589A2 (en) 2017-05-26
MY189018A (en) 2022-01-19
TW202216787A (zh) 2022-05-01
US20190330339A1 (en) 2019-10-31
MX2018006245A (es) 2018-08-01
JP6845905B2 (ja) 2021-03-24
US11168136B2 (en) 2021-11-09
PE20181532A1 (es) 2018-09-26
CL2020002521A1 (es) 2021-01-29
JP6817302B2 (ja) 2021-01-20
AU2020202177A1 (en) 2020-04-16
EP3377531A2 (en) 2018-09-26
KR20190116546A (ko) 2019-10-14
GEP20217220B (en) 2021-02-10
TW201726740A (zh) 2017-08-01
CA3131983C (en) 2023-12-05
TN2018000172A1 (en) 2019-10-04
MX2023001356A (es) 2023-02-27
ECSP18045468A (es) 2018-10-31

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