BR112013019380A2 - método para detecção de permeabilidade da barreira hematoencefálica, e intestinal e materiais de teste da mesma - Google Patents

método para detecção de permeabilidade da barreira hematoencefálica, e intestinal e materiais de teste da mesma Download PDF

Info

Publication number
BR112013019380A2
BR112013019380A2 BR112013019380A BR112013019380A BR112013019380A2 BR 112013019380 A2 BR112013019380 A2 BR 112013019380A2 BR 112013019380 A BR112013019380 A BR 112013019380A BR 112013019380 A BR112013019380 A BR 112013019380A BR 112013019380 A2 BR112013019380 A2 BR 112013019380A2
Authority
BR
Brazil
Prior art keywords
igg
iga
igm
blood
protein
Prior art date
Application number
BR112013019380A
Other languages
English (en)
Portuguese (pt)
Inventor
Vojdani Aristo
Original Assignee
Immunosciences Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunosciences Lab Inc filed Critical Immunosciences Lab Inc
Publication of BR112013019380A2 publication Critical patent/BR112013019380A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/709Toxin induced

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112013019380A 2011-01-28 2012-01-26 método para detecção de permeabilidade da barreira hematoencefálica, e intestinal e materiais de teste da mesma BR112013019380A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437244P 2011-01-28 2011-01-28
PCT/US2012/022706 WO2012103324A2 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Publications (1)

Publication Number Publication Date
BR112013019380A2 true BR112013019380A2 (pt) 2019-10-01

Family

ID=46577669

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013019380A BR112013019380A2 (pt) 2011-01-28 2012-01-26 método para detecção de permeabilidade da barreira hematoencefálica, e intestinal e materiais de teste da mesma

Country Status (12)

Country Link
US (2) US8663911B2 (enExample)
EP (1) EP2668498B1 (enExample)
JP (1) JP6068362B2 (enExample)
KR (1) KR101941308B1 (enExample)
CN (2) CN105823887B (enExample)
AU (3) AU2012211328A1 (enExample)
BR (1) BR112013019380A2 (enExample)
CA (2) CA2964555C (enExample)
IL (2) IL227676A (enExample)
MX (1) MX2013008746A (enExample)
RU (2) RU2016149216A (enExample)
WO (1) WO2012103324A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
US9709573B2 (en) 2012-03-13 2017-07-18 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
US20140147856A1 (en) * 2012-11-29 2014-05-29 Rush University Medical Center Intestinal Permeability Assay for Neurodegenerative Diseases
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
CN107533048A (zh) 2015-02-05 2018-01-02 美国免疫阵列公司 用于诊断脑损伤或神经退行性变的方法和组合物
US11131676B2 (en) 2016-02-25 2021-09-28 The Trustees Of Columbia University In The City Of New York Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity
CN105974105A (zh) * 2016-05-16 2016-09-28 河北艾驰生物科技有限公司 基质金属蛋白酶-3(mmp3)检测试剂盒
JP6782886B2 (ja) 2017-01-19 2020-11-11 国立大学法人島根大学 腸粘膜の透過性の診断薬、診断方法、診断装置
CN108191977B (zh) * 2017-12-25 2018-12-18 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
CN108152492B (zh) * 2017-12-25 2019-03-08 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
US12262983B2 (en) 2018-02-07 2025-04-01 University Of Cincinnati System and method for detecting small blood-tissue barrier disruption
KR102341906B1 (ko) * 2018-10-26 2021-12-22 가천대학교 산학협력단 청년기 우울증 동물모델의 제조방법
CN112958172B (zh) * 2021-02-24 2021-12-28 北京航空航天大学 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028215A1 (en) * 1999-08-09 2002-03-07 Jagath L. Kadurugamuwa Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
DE19842609C2 (de) * 1998-09-17 2000-09-21 Diagnostik Gmbh Leipzig Lab Salmonellenantigengemisch und Kit zur Bestimmung von Antikörpern gegen Salmonellen
US6958324B2 (en) * 1998-12-02 2005-10-25 Inotek Pharmaceuticals Corporation Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
US6884591B2 (en) * 2001-06-25 2005-04-26 The Cleveland Clinic Foundation Peripheral marker of blood brain barrier permeability
CN1788017B (zh) * 2003-02-10 2013-04-24 to-BBB控股股份有限公司 炎症状态下在血脑屏障中差异表达的核酸
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
CA2651366A1 (en) * 2005-05-13 2006-11-23 Alessio Fasano Method for assessing the effectiveness of a treatment regimen
US7795314B2 (en) * 2005-06-01 2010-09-14 Cytokine Pharmasciences, Inc. Protective role of semapimod in necrotizing enterocolitis
EP1757940A1 (en) * 2005-08-26 2007-02-28 Cézanne S.A.S. In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC
JP4791866B2 (ja) * 2006-03-24 2011-10-12 国立大学法人秋田大学 下痢原性大腸菌感染症の判別に用いられる固相等
US7892763B2 (en) * 2009-01-26 2011-02-22 Dodds W Jean Multi-stage nutrigenomic diagnostic food sensitivity testing in animals

Also Published As

Publication number Publication date
IL227676A (en) 2017-03-30
CA2828194A1 (en) 2012-08-02
IL227676A0 (en) 2013-09-30
US8663911B2 (en) 2014-03-04
RU2607479C2 (ru) 2017-01-10
AU2016259430A1 (en) 2016-12-08
KR101941308B1 (ko) 2019-01-22
JP6068362B2 (ja) 2017-01-25
US9194867B2 (en) 2015-11-24
KR20140052941A (ko) 2014-05-07
US20120196299A1 (en) 2012-08-02
CN103460044A (zh) 2013-12-18
JP2014503829A (ja) 2014-02-13
WO2012103324A2 (en) 2012-08-02
RU2016149216A (ru) 2018-11-02
MX2013008746A (es) 2014-06-23
CA2964555C (en) 2024-05-14
CN103460044B (zh) 2016-04-20
EP2668498B1 (en) 2019-10-02
IL250871B (en) 2021-05-31
CA2964555A1 (en) 2012-08-02
AU2016262726A1 (en) 2016-12-15
CN105823887B (zh) 2018-06-12
AU2016262726B2 (en) 2018-12-06
HK1189938A1 (zh) 2014-06-20
EP2668498A4 (en) 2015-05-20
WO2012103324A3 (en) 2012-11-01
CN105823887A (zh) 2016-08-03
IL250871A0 (en) 2017-04-30
RU2013139476A (ru) 2015-03-10
US20140186855A1 (en) 2014-07-03
AU2012211328A1 (en) 2013-09-19
NZ614707A (en) 2015-04-24
AU2016259430B2 (en) 2019-01-03
EP2668498A2 (en) 2013-12-04

Similar Documents

Publication Publication Date Title
BR112013019380A2 (pt) método para detecção de permeabilidade da barreira hematoencefálica, e intestinal e materiais de teste da mesma
KR102047141B1 (ko) 글루텐 과민성 검출 및 만성소화장애증과의 구별 방법 및 장치
Carroccio et al. Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome
Lagercrantz et al. Immunological studies in ulcerative colitis: v. family studies
HK1189938B (en) Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
NZ614707B2 (en) Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
de Castro Measurement of anti-bovine serum albumin antibodies in dogs with chronic enteropathy
WAKEFIELD et al. RETRACTED: Ileal-Lymphoid-Nodular Hyperplasia, Non-Specific Colitis, and Pervasive Developmental
Ajamian Investigating Markers of Intestinal Barrier Dysfunction in Gastrointestinal Diseases
None-Mod Stool Chemistry
NZ614464B2 (en) Methods and apparatus for detection of gluten sensitivity, and its differentiation from celiac disease

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: CYREX LABORATORIES, LLC (US)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]