RU2016149216A - Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов - Google Patents
Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов Download PDFInfo
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- RU2016149216A RU2016149216A RU2016149216A RU2016149216A RU2016149216A RU 2016149216 A RU2016149216 A RU 2016149216A RU 2016149216 A RU2016149216 A RU 2016149216A RU 2016149216 A RU2016149216 A RU 2016149216A RU 2016149216 A RU2016149216 A RU 2016149216A
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- peptide
- brain barrier
- blood
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- 210000001218 blood-brain barrier Anatomy 0.000 title claims 16
- 238000012360 testing method Methods 0.000 title claims 15
- 238000000034 method Methods 0.000 title claims 8
- 230000003870 intestinal permeability Effects 0.000 title claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 230000008499 blood brain barrier function Effects 0.000 claims 15
- 102100025255 Haptoglobin Human genes 0.000 claims 9
- 108010027843 zonulin Proteins 0.000 claims 9
- 102000023732 binding proteins Human genes 0.000 claims 7
- 108091008324 binding proteins Proteins 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 230000001580 bacterial effect Effects 0.000 claims 6
- 230000004888 barrier function Effects 0.000 claims 6
- 239000002158 endotoxin Substances 0.000 claims 5
- 229920006008 lipopolysaccharide Polymers 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 210000004556 brain Anatomy 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims 3
- 101710176384 Peptide 1 Proteins 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- 108010053256 zonula occludens toxin receptor Proteins 0.000 claims 3
- 108010045403 Calcium-Binding Proteins Proteins 0.000 claims 2
- 102000005701 Calcium-Binding Proteins Human genes 0.000 claims 2
- 102000006386 Myelin Proteins Human genes 0.000 claims 2
- 108010083674 Myelin Proteins Proteins 0.000 claims 2
- 230000002518 glial effect Effects 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- 102000014187 peptide receptors Human genes 0.000 claims 2
- 230000035699 permeability Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 101800000263 Acidic protein Proteins 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims 1
- 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 claims 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000004520 agglutination Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 210000005027 intestinal barrier Anatomy 0.000 claims 1
- 230000007358 intestinal barrier function Effects 0.000 claims 1
- 239000004816 latex Substances 0.000 claims 1
- 229920000126 latex Polymers 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 238000010998 test method Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/709—Toxin induced
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437244P | 2011-01-28 | 2011-01-28 | |
| US61/437,244 | 2011-01-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013139476A Division RU2607479C2 (ru) | 2011-01-28 | 2012-01-26 | Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016149216A true RU2016149216A (ru) | 2018-11-02 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016149216A RU2016149216A (ru) | 2011-01-28 | 2012-01-26 | Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов |
| RU2013139476A RU2607479C2 (ru) | 2011-01-28 | 2012-01-26 | Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013139476A RU2607479C2 (ru) | 2011-01-28 | 2012-01-26 | Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8663911B2 (enExample) |
| EP (1) | EP2668498B1 (enExample) |
| JP (1) | JP6068362B2 (enExample) |
| KR (1) | KR101941308B1 (enExample) |
| CN (2) | CN105823887B (enExample) |
| AU (3) | AU2012211328A1 (enExample) |
| BR (1) | BR112013019380A2 (enExample) |
| CA (2) | CA2964555C (enExample) |
| IL (2) | IL227676A (enExample) |
| MX (1) | MX2013008746A (enExample) |
| RU (2) | RU2016149216A (enExample) |
| WO (1) | WO2012103324A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2628013B1 (en) | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| US9709573B2 (en) | 2012-03-13 | 2017-07-18 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| US20140147856A1 (en) * | 2012-11-29 | 2014-05-29 | Rush University Medical Center | Intestinal Permeability Assay for Neurodegenerative Diseases |
| WO2015009907A1 (en) | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| CN107533048A (zh) | 2015-02-05 | 2018-01-02 | 美国免疫阵列公司 | 用于诊断脑损伤或神经退行性变的方法和组合物 |
| US11131676B2 (en) | 2016-02-25 | 2021-09-28 | The Trustees Of Columbia University In The City Of New York | Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity |
| CN105974105A (zh) * | 2016-05-16 | 2016-09-28 | 河北艾驰生物科技有限公司 | 基质金属蛋白酶-3（mmp3）检测试剂盒 |
| JP6782886B2 (ja) | 2017-01-19 | 2020-11-11 | 国立大学法人島根大学 | 腸粘膜の透過性の診断薬、診断方法、診断装置 |
| CN108191977B (zh) * | 2017-12-25 | 2018-12-18 | 首都医科大学宣武医院 | 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用 |
| CN108152492B (zh) * | 2017-12-25 | 2019-03-08 | 首都医科大学宣武医院 | 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用 |
| US12262983B2 (en) | 2018-02-07 | 2025-04-01 | University Of Cincinnati | System and method for detecting small blood-tissue barrier disruption |
| KR102341906B1 (ko) * | 2018-10-26 | 2021-12-22 | 가천대학교 산학협력단 | 청년기 우울증 동물모델의 제조방법 |
| CN112958172B (zh) * | 2021-02-24 | 2021-12-28 | 北京航空航天大学 | 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片 |
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| US20020028215A1 (en) * | 1999-08-09 | 2002-03-07 | Jagath L. Kadurugamuwa | Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same |
| DE19842609C2 (de) * | 1998-09-17 | 2000-09-21 | Diagnostik Gmbh Leipzig Lab | Salmonellenantigengemisch und Kit zur Bestimmung von Antikörpern gegen Salmonellen |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US6884591B2 (en) * | 2001-06-25 | 2005-04-26 | The Cleveland Clinic Foundation | Peripheral marker of blood brain barrier permeability |
| CN1788017B (zh) * | 2003-02-10 | 2013-04-24 | to-BBB控股股份有限公司 | 炎症状态下在血脑屏障中差异表达的核酸 |
| US20080038843A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Maryland - Baltimore | Method of diagnosing celiac disease |
| CA2651366A1 (en) * | 2005-05-13 | 2006-11-23 | Alessio Fasano | Method for assessing the effectiveness of a treatment regimen |
| US7795314B2 (en) * | 2005-06-01 | 2010-09-14 | Cytokine Pharmasciences, Inc. | Protective role of semapimod in necrotizing enterocolitis |
| EP1757940A1 (en) * | 2005-08-26 | 2007-02-28 | Cézanne S.A.S. | In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC |
| JP4791866B2 (ja) * | 2006-03-24 | 2011-10-12 | 国立大学法人秋田大学 | 下痢原性大腸菌感染症の判別に用いられる固相等 |
| US7892763B2 (en) * | 2009-01-26 | 2011-02-22 | Dodds W Jean | Multi-stage nutrigenomic diagnostic food sensitivity testing in animals |
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- 2012-01-26 MX MX2013008746A patent/MX2013008746A/es unknown
- 2012-01-26 CN CN201610171077.4A patent/CN105823887B/zh active Active
- 2012-01-26 WO PCT/US2012/022706 patent/WO2012103324A2/en not_active Ceased
- 2012-01-26 CA CA2964555A patent/CA2964555C/en active Active
- 2012-01-26 CN CN201280015809.0A patent/CN103460044B/zh active Active
- 2012-01-26 KR KR1020137022644A patent/KR101941308B1/ko active Active
- 2012-01-26 AU AU2012211328A patent/AU2012211328A1/en not_active Abandoned
- 2012-01-26 RU RU2016149216A patent/RU2016149216A/ru not_active Application Discontinuation
- 2012-01-26 JP JP2013551330A patent/JP6068362B2/ja active Active
- 2012-01-26 CA CA2828194A patent/CA2828194A1/en active Pending
- 2012-01-26 BR BR112013019380A patent/BR112013019380A2/pt not_active Application Discontinuation
- 2012-01-26 US US13/359,007 patent/US8663911B2/en active Active
- 2012-01-26 RU RU2013139476A patent/RU2607479C2/ru active
- 2012-01-26 EP EP12739704.0A patent/EP2668498B1/en active Active
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2013
- 2013-07-28 IL IL227676A patent/IL227676A/en active IP Right Grant
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2014
- 2014-03-04 US US14/196,972 patent/US9194867B2/en active Active
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2016
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- 2016-11-24 AU AU2016262726A patent/AU2016262726B2/en active Active
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2017
- 2017-03-01 IL IL250871A patent/IL250871B/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20191216 |