CA2964555C - Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto - Google Patents

Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto Download PDF

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Publication number
CA2964555C
CA2964555C CA2964555A CA2964555A CA2964555C CA 2964555 C CA2964555 C CA 2964555C CA 2964555 A CA2964555 A CA 2964555A CA 2964555 A CA2964555 A CA 2964555A CA 2964555 C CA2964555 C CA 2964555C
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Prior art keywords
bbb
protein
blood
brain barrier
intestinal
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CA2964555A
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English (en)
French (fr)
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CA2964555A1 (en
Inventor
Aristo Vojdani
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CYREX LABORATORIES LLC
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CYREX LABORATORIES LLC
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Publication of CA2964555A1 publication Critical patent/CA2964555A1/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/709Toxin induced

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2964555A 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto Active CA2964555C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437244P 2011-01-28 2011-01-28
US61/437,244 2011-01-28
CA2828194A CA2828194A1 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2828194A Division CA2828194A1 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Publications (2)

Publication Number Publication Date
CA2964555A1 CA2964555A1 (en) 2012-08-02
CA2964555C true CA2964555C (en) 2024-05-14

Family

ID=46577669

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2964555A Active CA2964555C (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
CA2828194A Pending CA2828194A1 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2828194A Pending CA2828194A1 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Country Status (12)

Country Link
US (2) US8663911B2 (enExample)
EP (1) EP2668498B1 (enExample)
JP (1) JP6068362B2 (enExample)
KR (1) KR101941308B1 (enExample)
CN (2) CN105823887B (enExample)
AU (3) AU2012211328A1 (enExample)
BR (1) BR112013019380A2 (enExample)
CA (2) CA2964555C (enExample)
IL (2) IL227676A (enExample)
MX (1) MX2013008746A (enExample)
RU (2) RU2016149216A (enExample)
WO (1) WO2012103324A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
US9709573B2 (en) 2012-03-13 2017-07-18 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
US20140147856A1 (en) * 2012-11-29 2014-05-29 Rush University Medical Center Intestinal Permeability Assay for Neurodegenerative Diseases
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
CN107533048A (zh) 2015-02-05 2018-01-02 美国免疫阵列公司 用于诊断脑损伤或神经退行性变的方法和组合物
US11131676B2 (en) 2016-02-25 2021-09-28 The Trustees Of Columbia University In The City Of New York Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity
CN105974105A (zh) * 2016-05-16 2016-09-28 河北艾驰生物科技有限公司 基质金属蛋白酶-3(mmp3)检测试剂盒
JP6782886B2 (ja) 2017-01-19 2020-11-11 国立大学法人島根大学 腸粘膜の透過性の診断薬、診断方法、診断装置
CN108191977B (zh) * 2017-12-25 2018-12-18 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
CN108152492B (zh) * 2017-12-25 2019-03-08 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
US12262983B2 (en) 2018-02-07 2025-04-01 University Of Cincinnati System and method for detecting small blood-tissue barrier disruption
KR102341906B1 (ko) * 2018-10-26 2021-12-22 가천대학교 산학협력단 청년기 우울증 동물모델의 제조방법
CN112958172B (zh) * 2021-02-24 2021-12-28 北京航空航天大学 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028215A1 (en) * 1999-08-09 2002-03-07 Jagath L. Kadurugamuwa Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
DE19842609C2 (de) * 1998-09-17 2000-09-21 Diagnostik Gmbh Leipzig Lab Salmonellenantigengemisch und Kit zur Bestimmung von Antikörpern gegen Salmonellen
US6958324B2 (en) * 1998-12-02 2005-10-25 Inotek Pharmaceuticals Corporation Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
US6884591B2 (en) * 2001-06-25 2005-04-26 The Cleveland Clinic Foundation Peripheral marker of blood brain barrier permeability
CN1788017B (zh) * 2003-02-10 2013-04-24 to-BBB控股股份有限公司 炎症状态下在血脑屏障中差异表达的核酸
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
CA2651366A1 (en) * 2005-05-13 2006-11-23 Alessio Fasano Method for assessing the effectiveness of a treatment regimen
US7795314B2 (en) * 2005-06-01 2010-09-14 Cytokine Pharmasciences, Inc. Protective role of semapimod in necrotizing enterocolitis
EP1757940A1 (en) * 2005-08-26 2007-02-28 Cézanne S.A.S. In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC
JP4791866B2 (ja) * 2006-03-24 2011-10-12 国立大学法人秋田大学 下痢原性大腸菌感染症の判別に用いられる固相等
US7892763B2 (en) * 2009-01-26 2011-02-22 Dodds W Jean Multi-stage nutrigenomic diagnostic food sensitivity testing in animals

Also Published As

Publication number Publication date
IL227676A (en) 2017-03-30
CA2828194A1 (en) 2012-08-02
IL227676A0 (en) 2013-09-30
US8663911B2 (en) 2014-03-04
RU2607479C2 (ru) 2017-01-10
AU2016259430A1 (en) 2016-12-08
KR101941308B1 (ko) 2019-01-22
JP6068362B2 (ja) 2017-01-25
US9194867B2 (en) 2015-11-24
KR20140052941A (ko) 2014-05-07
US20120196299A1 (en) 2012-08-02
CN103460044A (zh) 2013-12-18
JP2014503829A (ja) 2014-02-13
WO2012103324A2 (en) 2012-08-02
RU2016149216A (ru) 2018-11-02
MX2013008746A (es) 2014-06-23
CN103460044B (zh) 2016-04-20
EP2668498B1 (en) 2019-10-02
IL250871B (en) 2021-05-31
CA2964555A1 (en) 2012-08-02
AU2016262726A1 (en) 2016-12-15
CN105823887B (zh) 2018-06-12
AU2016262726B2 (en) 2018-12-06
HK1189938A1 (zh) 2014-06-20
BR112013019380A2 (pt) 2019-10-01
EP2668498A4 (en) 2015-05-20
WO2012103324A3 (en) 2012-11-01
CN105823887A (zh) 2016-08-03
IL250871A0 (en) 2017-04-30
RU2013139476A (ru) 2015-03-10
US20140186855A1 (en) 2014-07-03
AU2012211328A1 (en) 2013-09-19
NZ614707A (en) 2015-04-24
AU2016259430B2 (en) 2019-01-03
EP2668498A2 (en) 2013-12-04

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CA2964555C (en) Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
AU2017201908B2 (en) Methods and apparatus for detection of gluten sensitivity, and its differentiation from celiac disease
NZ614707B2 (en) Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
HK1189938B (en) Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
NZ614464B2 (en) Methods and apparatus for detection of gluten sensitivity, and its differentiation from celiac disease

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