RU2607479C2 - Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов - Google Patents

Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов Download PDF

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RU2607479C2
RU2607479C2 RU2013139476A RU2013139476A RU2607479C2 RU 2607479 C2 RU2607479 C2 RU 2607479C2 RU 2013139476 A RU2013139476 A RU 2013139476A RU 2013139476 A RU2013139476 A RU 2013139476A RU 2607479 C2 RU2607479 C2 RU 2607479C2
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intestinal
blood
protein
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RU2013139476A (ru
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Аристо ВОЖДАНИ
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САЙРЕКС ЛАБОРАТОРИЗ, ЭлЭлСи
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/709—Toxin induced

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  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
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  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013139476A 2011-01-28 2012-01-26 Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов RU2607479C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437244P 2011-01-28 2011-01-28
US61/437,244 2011-01-28
PCT/US2012/022706 WO2012103324A2 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Related Child Applications (1)

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RU2016149216A Division RU2016149216A (ru) 2011-01-28 2012-01-26 Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов

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RU2013139476A RU2013139476A (ru) 2015-03-10
RU2607479C2 true RU2607479C2 (ru) 2017-01-10

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RU2013139476A RU2607479C2 (ru) 2011-01-28 2012-01-26 Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов
RU2016149216A RU2016149216A (ru) 2011-01-28 2012-01-26 Способ обнаружения проницаемости кишечного, а также гематоэнцефалического барьера и материалы для соответствующих тестов

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US (2) US8663911B2 (enExample)
EP (1) EP2668498B1 (enExample)
JP (1) JP6068362B2 (enExample)
KR (1) KR101941308B1 (enExample)
CN (2) CN105823887B (enExample)
AU (3) AU2012211328A1 (enExample)
BR (1) BR112013019380A2 (enExample)
CA (2) CA2964555C (enExample)
IL (2) IL227676A (enExample)
MX (1) MX2013008746A (enExample)
RU (2) RU2607479C2 (enExample)
WO (1) WO2012103324A2 (enExample)

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EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
US9709573B2 (en) 2012-03-13 2017-07-18 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
US20140147856A1 (en) * 2012-11-29 2014-05-29 Rush University Medical Center Intestinal Permeability Assay for Neurodegenerative Diseases
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
WO2016125148A1 (en) 2015-02-05 2016-08-11 Immunarray Ltd. Methods and compositions for diagnosing brain injury or neurodegeneration
WO2017147378A1 (en) * 2016-02-25 2017-08-31 The Trustees Of Columbia University In The City Of New York Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity
CN105974105A (zh) * 2016-05-16 2016-09-28 河北艾驰生物科技有限公司 基质金属蛋白酶-3（mmp3）检测试剂盒
CN110312937B (zh) 2017-01-19 2023-01-10 和田孝一郎 诊断肠黏膜通透性的诊断药、诊断方法及诊断装置
CN108191977B (zh) * 2017-12-25 2018-12-18 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
CN108152492B (zh) * 2017-12-25 2019-03-08 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
WO2019157119A1 (en) 2018-02-07 2019-08-15 University Of Cincinnati System and method for detecting small blood-tissue barrier disruption
KR102341906B1 (ko) * 2018-10-26 2021-12-22 가천대학교 산학협력단 청년기 우울증 동물모델의 제조방법
CN112958172B (zh) * 2021-02-24 2021-12-28 北京航空航天大学 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片

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US20030170747A1 (en) * 2001-06-25 2003-09-11 Damir Janigro Peripheral marker of blood brain barrier permeability
US20100190191A1 (en) * 2009-01-26 2010-07-29 Dodds W Jean Multi-stage nutrigenomic diagnostic food sensitivity testing in animals

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US20100190191A1 (en) * 2009-01-26 2010-07-29 Dodds W Jean Multi-stage nutrigenomic diagnostic food sensitivity testing in animals

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Also Published As

Publication number Publication date
US8663911B2 (en) 2014-03-04
RU2013139476A (ru) 2015-03-10
JP2014503829A (ja) 2014-02-13
IL227676A (en) 2017-03-30
RU2016149216A (ru) 2018-11-02
IL250871A0 (en) 2017-04-30
CN103460044A (zh) 2013-12-18
WO2012103324A2 (en) 2012-08-02
HK1189938A1 (zh) 2014-06-20
AU2016259430B2 (en) 2019-01-03
JP6068362B2 (ja) 2017-01-25
KR20140052941A (ko) 2014-05-07
CA2828194A1 (en) 2012-08-02
MX2013008746A (es) 2014-06-23
EP2668498A2 (en) 2013-12-04
WO2012103324A3 (en) 2012-11-01
IL250871B (en) 2021-05-31
NZ614707A (en) 2015-04-24
AU2016262726A1 (en) 2016-12-15
CN105823887B (zh) 2018-06-12
AU2016262726B2 (en) 2018-12-06
US9194867B2 (en) 2015-11-24
AU2012211328A1 (en) 2013-09-19
CN103460044B (zh) 2016-04-20
CA2964555C (en) 2024-05-14
AU2016259430A1 (en) 2016-12-08
CN105823887A (zh) 2016-08-03
CA2964555A1 (en) 2012-08-02
KR101941308B1 (ko) 2019-01-22
IL227676A0 (en) 2013-09-30
BR112013019380A2 (pt) 2019-10-01
US20140186855A1 (en) 2014-07-03
US20120196299A1 (en) 2012-08-02
EP2668498B1 (en) 2019-10-02
EP2668498A4 (en) 2015-05-20

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