CN113316591A - Cd73抗体及其制备方法和应用 - Google Patents

Cd73抗体及其制备方法和应用 Download PDF

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CN113316591A
CN113316591A CN202080008682.4A CN202080008682A CN113316591A CN 113316591 A CN113316591 A CN 113316591A CN 202080008682 A CN202080008682 A CN 202080008682A CN 113316591 A CN113316591 A CN 113316591A
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antibody
variable region
chain variable
light chain
heavy chain
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CN113316591B (zh
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王冬旭
段清
刘礼乐
杨达志
刘虎
韩烨
谢荣荣
邵晓慧
王鹏
钟勤
黄亚珺
吴建
王美玲
王远东
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Shanghai Pharmaexplorer Co Ltd
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract

提供了一种靶向CD73的抗体、其制备方法和用途。提供的单克隆抗体能够高特异性地结合CD73抗原，其具有很高的亲和力并且具有显著抗肿瘤等活性。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN202080008682.4A 2019-01-11 2020-01-13 Cd73抗体及其制备方法和应用 Active CN113316591B (zh)

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CN201910028562.XA CN111434688A (zh) 2019-01-11 2019-01-11 Cd73抗体及其制备方法和应用
CN201910028562X 2019-01-11
PCT/CN2020/071838 WO2020143836A1 (zh) 2019-01-11 2020-01-13 Cd73抗体及其制备方法和应用

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CN114456267B (zh) * 2020-11-03 2023-12-01 浙江大学医学院附属第二医院 一种抗cd73人源化单克隆抗体及其应用
TW202222840A (zh) * 2020-12-11 2022-06-16 大陸商上海華奧泰生物藥業股份有限公司 Ｃｄ７３的抗原結合蛋白及其應用
CN113045659B (zh) * 2021-03-18 2022-03-18 上海近岸科技有限公司 抗cd73人源化抗体
WO2022179039A1 (zh) * 2021-02-24 2022-09-01 苏州近岸蛋白质科技股份有限公司 抗人cd73抗体及其应用
EP4388012A1 (en) * 2021-08-20 2024-06-26 Duke University Antibodies that target hla-e-host peptide complexes and uses thereof
WO2023167680A1 (en) * 2022-03-04 2023-09-07 Development Center For Biotechnology Anti-cd73 antibodies and use thereof
TW202400242A (zh) * 2022-03-14 2024-01-01 大陸商上海華奧泰生物藥業股份有限公司 抗體藥物偶聯物及其應用
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2023206242A1 (zh) * 2022-04-28 2023-11-02 江苏中新医药有限公司 无钩状效应的抗人cd73单克隆抗体
CN117304316A (zh) * 2022-06-22 2023-12-29 复旦大学 靶向cd73的纳米抗体及纳米抗体-药物偶联物、其制备方法和用途
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

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