JP6544808B2 - 突然変異免疫グロブリン結合ポリペプチド - Google Patents

突然変異免疫グロブリン結合ポリペプチド Download PDF

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JP6544808B2
JP6544808B2 JP2016525329A JP2016525329A JP6544808B2 JP 6544808 B2 JP6544808 B2 JP 6544808B2 JP 2016525329 A JP2016525329 A JP 2016525329A JP 2016525329 A JP2016525329 A JP 2016525329A JP 6544808 B2 JP6544808 B2 JP 6544808B2
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seq
polypeptide
protein
multimer
amino acid
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JP2016523959A (ja
JP2016523959A5 (enExample
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ロドリゴ，グスタフ
アンデル，マッツ
バウレン，ゴラン
ビョルクマン，トマス
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ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2016525329A 2013-07-10 2014-07-08 突然変異免疫グロブリン結合ポリペプチド Active JP6544808B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1350859-3 2013-07-10
SE1350859 2013-07-10
SE1350860-1 2013-07-10
SE1350860 2013-07-10
PCT/SE2014/050872 WO2015005859A1 (en) 2013-07-10 2014-07-08 Mutated immunoglobulin-binding polypeptides

Related Child Applications (1)

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JP2019109474A Division JP6862008B2 (ja) 2013-07-10 2019-06-12 突然変異免疫グロブリン結合ポリペプチド

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JP2016523959A JP2016523959A (ja) 2016-08-12
JP2016523959A5 JP2016523959A5 (enExample) 2017-08-17
JP6544808B2 true JP6544808B2 (ja) 2019-07-17

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JP2016525329A Active JP6544808B2 (ja) 2013-07-10 2014-07-08 突然変異免疫グロブリン結合ポリペプチド
JP2016525330A Active JP6544809B2 (ja) 2013-07-10 2014-07-10 突然変異免疫グロブリン結合ポリペプチド
JP2019109474A Active JP6862008B2 (ja) 2013-07-10 2019-06-12 突然変異免疫グロブリン結合ポリペプチド

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JP2019109474A Active JP6862008B2 (ja) 2013-07-10 2019-06-12 突然変異免疫グロブリン結合ポリペプチド

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US (5) US9896486B2 (enExample)
EP (2) EP3019520B1 (enExample)
JP (3) JP6544808B2 (enExample)
CN (3) CN111848755A (enExample)
WO (2) WO2015005859A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
JP6544808B2 (ja) * 2013-07-10 2019-07-17 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ 突然変異免疫グロブリン結合ポリペプチド
BR112016009051B1 (pt) 2013-10-22 2022-11-01 Renewable Fibers LLC dba RF WasteWater, LLC Sistema para tratar um fluido e método para reduzir a concentração de uma ou mais substâncias presentes em um fluido
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
JP6705806B2 (ja) 2015-03-26 2020-06-03 Jsr株式会社 イムノグロブリン結合タンパク質およびそれを用いたアフィニティー担体
SG11201708170VA (en) 2015-04-13 2017-11-29 Fujifilm Corp Method for producing short-chain peptide-immobilized carrier, and short-chain peptide-immobilized carrier
CN107849095A (zh) * 2015-07-22 2018-03-27 株式会社钟化 酸性pH范围内的抗体结合能力降低的抗体结合性蛋白质
CN107849088A (zh) * 2015-07-22 2018-03-27 株式会社钟化 抗体样蛋白质的纯化方法
EP3330706B1 (en) * 2015-07-28 2023-03-15 JSR Corporation Affinity support and its use in a method for isolating immunoglobulin
JPWO2017022672A1 (ja) * 2015-07-31 2018-07-05 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
JPWO2017022759A1 (ja) * 2015-08-04 2018-05-31 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
EP3455242B1 (en) * 2016-05-11 2021-06-23 Cytiva BioProcess R&D AB Separation method
EP3455241B1 (en) * 2016-05-11 2022-02-23 Cytiva BioProcess R&D AB Method of cleaning and/or sanitizing a separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
JP7122974B2 (ja) * 2016-05-11 2022-08-22 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 変異免疫グロブリン結合ポリペプチド
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
WO2017194592A1 (en) * 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of storing a separation matrix
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US11230576B2 (en) * 2016-08-11 2022-01-25 Navigo Proteins Gmbh Alkaline stable immunoglobulin-binding proteins
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
CN110799521A (zh) * 2017-02-15 2020-02-14 拜奥普罗塞亚科技有限责任公司 具有温和洗脱pH的亲和色谱配体
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
EP3592759A1 (en) * 2017-03-07 2020-01-15 JMVA Biotech AB Modified adsorptive surfaces
GB201708277D0 (en) 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
EP3546476A1 (en) * 2018-03-26 2019-10-02 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP3521304B9 (en) * 2018-02-01 2023-10-04 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
CN111132994B (zh) * 2017-08-07 2024-05-31 瑞普利金公司 在c末端螺旋区中具有半胱氨酸的fc结合蛋白
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
CN112639099B (zh) * 2018-08-24 2024-06-28 Jsr株式会社 免疫球蛋白结合蛋白质以及使用其的亲和载体
GB201904125D0 (en) 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7432813B2 (ja) * 2019-09-10 2024-02-19 東ソー株式会社 免疫グロブリン結合性タンパク質
CN111057153B (zh) 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN111732642B (zh) * 2020-07-30 2020-12-04 苏州纳微科技股份有限公司 免疫球蛋白结合蛋白及其应用
WO2022064447A1 (en) 2020-09-24 2022-03-31 Waters Technologies Corporation Chromatographic hardware improvements for the separation of reactive molecules
KR20230112616A (ko) 2020-10-13 2023-07-27 아비타이드 엘엘씨 3중-나선 번들 단백질들의 친화성 리간드 라이브러리 및 이의 용도
EP4269590A4 (en) * 2020-12-22 2025-01-01 Protenova Co., Ltd. IMMUNOGLOBULIN-BINDING POLYPEPTIDE
EP4294542A1 (en) 2021-02-19 2023-12-27 Avitide LLC Aav2 affinity agents
GB202113626D0 (en) 2021-09-24 2021-11-10 Cytiva Bioprocess R & D Ab FC binding polypeptides
CN116874571A (zh) * 2021-12-17 2023-10-13 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN114315996B (zh) * 2021-12-31 2023-01-17 博格隆(浙江)生物技术有限公司 一种重组ProteinA蛋白及亲和层析介质的制备方法
CN114409748A (zh) * 2022-01-28 2022-04-29 博格隆(浙江)生物技术有限公司 蛋白a的b结构域和z结构域突变体及其应用
GB202203478D0 (en) 2022-03-14 2022-04-27 Cytiva Bioprocess R & D Ab Vh3 binding polypeptides
CN115850408B (zh) * 2022-09-01 2026-07-17 西安蓝晓科技新材料股份有限公司 一种多肽、融合型多聚体蛋白质及其用途
CN117700501A (zh) * 2022-09-13 2024-03-15 普米斯生物技术(珠海)有限公司 免疫球蛋白结合蛋白及其应用
CN116217680B (zh) * 2023-01-10 2024-02-02 珠海冀百康生物科技有限公司 碱稳定性高的免疫球蛋白结合蛋白及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用
WO2026057420A1 (en) 2024-09-10 2026-03-19 Cytiva Bioprocess R&D Ab Affinity ligand for purification of antibodies of isotype iga
CN119708176B (zh) * 2024-12-05 2026-01-06 武汉瑞法医疗器械有限公司 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用
WO2026136802A2 (en) * 2024-12-20 2026-06-25 Repligen Corporation Affinity ligands for purification of herpesvirus vaccine antigens
CN121652245A (zh) * 2024-12-26 2026-03-13 长春金赛药业有限责任公司 一种新型的ProteinA配基突变体及其用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8505922D0 (sv) 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
SE9901379D0 (sv) * 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
US6602977B1 (en) * 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
CA2531238C (en) * 2003-07-04 2015-02-24 Affibody Ab Polypeptides having binding affinity for her2
JP2006304633A (ja) 2005-04-26 2006-11-09 Apro Life Science Institute Inc イムノグロブリン結合タンパク質
WO2007019376A2 (en) * 2005-08-03 2007-02-15 Rq Bioscience, Inc. Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases
WO2007097361A1 (ja) 2006-02-21 2007-08-30 Protenova Co., Ltd. イムノグロブリン親和性リガンド
CN101522278B (zh) 2006-09-29 2016-08-10 通用电气健康护理生物科学股份公司 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体
JP5229888B2 (ja) * 2008-09-30 2013-07-03 独立行政法人産業技術総合研究所 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤
SG195555A1 (en) 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
US20120149875A1 (en) * 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
EP2412809B1 (en) 2009-03-24 2017-08-09 Kaneka Corporation Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand
HRP20160274T1 (hr) 2009-04-03 2016-04-08 University Of Chicago Pripravci i metode vezane za varijante proteina a (spa)
US8859726B2 (en) * 2010-11-29 2014-10-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN103269762B (zh) * 2010-12-20 2016-01-27 通用电气健康护理生物科学股份公司 亲和色谱基质
WO2012083425A1 (en) 2010-12-21 2012-06-28 The University Of Western Ontario Novel alkali-resistant variants of protein a and their use in affinity chromatography
US9040661B2 (en) 2010-12-21 2015-05-26 Jsr Corporation Support for affinity chromatography and method for isolating immunoglobulin
EP2728000B1 (en) * 2011-06-03 2018-12-05 National Institute of Advanced Industrial Science And Technology Protein a mutant protein having reduced affinity in acidic region, and antibody capture agent
SG10201604559TA (en) * 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
DE102013212062B4 (de) 2013-06-25 2017-05-11 Pantrac Gmbh Vorrichtung zur Ableitung von Erdungsströmen, insbesondere in Windkraftanlagen
US9454196B2 (en) 2013-06-27 2016-09-27 Apple Inc. Active peak power management of a high performance embedded microprocessor cluster
JP6544808B2 (ja) * 2013-07-10 2019-07-17 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ 突然変異免疫グロブリン結合ポリペプチド

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US20170320922A1 (en) 2017-11-09
CN111848755A (zh) 2020-10-30
EP3019519A4 (en) 2017-03-08
EP3019520A4 (en) 2017-03-08
WO2015005859A1 (en) 2015-01-15
CN105377881B (zh) 2020-08-07
US9663558B2 (en) 2017-05-30
JP2016523959A (ja) 2016-08-12
JP6862008B2 (ja) 2021-04-21
CN105377880A (zh) 2016-03-02
US20160207966A1 (en) 2016-07-21
US11136359B2 (en) 2021-10-05
WO2015005862A1 (en) 2015-01-15
EP3019520B1 (en) 2019-12-11
EP3019519B1 (en) 2019-04-03
US20180244729A1 (en) 2018-08-30
US20160159857A1 (en) 2016-06-09
US9896486B2 (en) 2018-02-20
JP6544809B2 (ja) 2019-07-17
JP2016525100A (ja) 2016-08-22
US10112980B2 (en) 2018-10-30
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EP3019520A1 (en) 2016-05-18
CN105377881A (zh) 2016-03-02
CN105377880B (zh) 2020-08-07
US20160159855A1 (en) 2016-06-09
US10308690B2 (en) 2019-06-04
JP2019165747A (ja) 2019-10-03

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