CN111848755A - 突变的免疫球蛋白结合多肽 - Google Patents

突变的免疫球蛋白结合多肽 Download PDF

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Publication number
CN111848755A
CN111848755A CN202010728898.XA CN202010728898A CN111848755A CN 111848755 A CN111848755 A CN 111848755A CN 202010728898 A CN202010728898 A CN 202010728898A CN 111848755 A CN111848755 A CN 111848755A
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ala
polypeptide
amino acid
lys
leu
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Chinese (zh)
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G.罗德里戈
M.安德
G.鲍伦
T.布杰克曼
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Global Life Sciences Solutions USA LLC
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GE Healthcare Bio Sciences Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN202010728898.XA 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽 Pending CN111848755A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1350860 2013-07-10
SE1350859 2013-07-10
SE1350860-1 2013-07-10
SE1350859-3 2013-07-10
CN201480039292.8A CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽

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CN202010728898.XA Pending CN111848755A (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039292.8A Active CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039299.XA Active CN105377881B (zh) 2013-07-10 2014-07-10 突变的免疫球蛋白结合多肽

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CN201480039299.XA Active CN105377881B (zh) 2013-07-10 2014-07-10 突变的免疫球蛋白结合多肽

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US (5) US9896486B2 (enExample)
EP (2) EP3019520B1 (enExample)
JP (3) JP6544808B2 (enExample)
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WO (2) WO2015005859A1 (enExample)

Cited By (8)

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CN114149495A (zh) * 2021-12-17 2022-03-08 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
JP6544808B2 (ja) * 2013-07-10 2019-07-17 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ 突然変異免疫グロブリン結合ポリペプチド
ES2733290T3 (es) 2013-10-22 2019-11-28 Nuvoda Llc Reducción de sustancias en fluidos contaminados utilizando medio de crecimiento biológico producido de forma natural
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
TWI709571B (zh) * 2015-03-26 2020-11-11 日商Ｊｓｒ股份有限公司 免疫球蛋白結合蛋白質及使用此之親和性載體
CN107531799B (zh) * 2015-04-13 2021-11-26 富士胶片株式会社 短链肽固定化载体的制造方法及短链肽固定化载体
JPWO2017014261A1 (ja) * 2015-07-22 2018-04-26 株式会社カネカ 抗体様タンパク質の精製方法
EP3327029A4 (en) * 2015-07-22 2018-10-31 Kaneka Corporation ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY-BINDING CAPACITY IN ACIDIC pH REGIONS
JP6722187B2 (ja) * 2015-07-28 2020-07-15 Jsr株式会社 アフィニティー担体およびイムノグロブリンを単離する方法
JPWO2017022672A1 (ja) * 2015-07-31 2018-07-05 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
JPWO2017022759A1 (ja) * 2015-08-04 2018-05-31 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3455240B1 (en) * 2016-05-11 2025-01-01 Cytiva BioProcess R&D AB Method of storing a separation matrix
CN109311948B (zh) * 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 清洁和/或消毒分离基质的方法
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
EP3455242B1 (en) * 2016-05-11 2021-06-23 Cytiva BioProcess R&D AB Separation method
JP7031934B2 (ja) * 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
CN109071612B (zh) * 2016-05-11 2022-10-25 思拓凡生物工艺研发有限公司 突变的免疫球蛋白结合多肽
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
EP3455243B1 (en) 2016-05-11 2021-03-24 Cytiva BioProcess R&D AB Separation matrix
AU2017311541B2 (en) 2016-08-11 2020-08-13 Navigo Proteins Gmbh Novel alkaline stable immunoglobulin-binding proteins
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
WO2018151743A1 (en) * 2017-02-15 2018-08-23 Bioprocessia Technologies Llc Affinity chromatography ligands with mild elution ph
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
WO2018162501A1 (en) * 2017-03-07 2018-09-13 Jmva Biotech Ab Modified adsorptive surfaces
GB201708277D0 (en) 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
JP7355729B2 (ja) 2017-08-07 2023-10-03 レプリゲン・コーポレイション Ｃ末端ヘリカル領域にシステインを有するｆｃ結合タンパク質
EP3546476A1 (en) * 2018-03-26 2019-10-02 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP4249097A3 (en) * 2018-02-01 2024-01-10 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
JP7335881B2 (ja) * 2018-08-24 2023-08-30 Jsr株式会社 イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体
GB201904125D0 (en) 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7432813B2 (ja) * 2019-09-10 2024-02-19 東ソー株式会社 免疫グロブリン結合性タンパク質
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CN111732642B (zh) * 2020-07-30 2020-12-04 苏州纳微科技股份有限公司 免疫球蛋白结合蛋白及其应用
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CN119708176A (zh) * 2024-12-05 2025-03-28 武汉瑞法医疗器械有限公司 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063243A1 (en) * 1999-04-19 2000-10-26 Biovitrum Ab Derivatives of the b or z domain from staphylococcal protein a (spa) interacting with at least one domain of human factor viii
CN1642976A (zh) * 2002-03-25 2005-07-20 阿默森生物科学有限公司 一种突变的免疫球蛋白－结合蛋白
CN101775069A (zh) * 2008-12-24 2010-07-14 米利波尔公司 腐蚀稳定性色谱分析用配体
WO2012074463A1 (en) * 2010-11-29 2012-06-07 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
US20120149875A1 (en) * 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN105377881B (zh) * 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8505922D0 (sv) 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
US6602977B1 (en) * 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
AU2004253835B2 (en) * 2003-07-04 2009-01-29 Affibody Ab Polypeptides having binding affinity for HER2
JP2006304633A (ja) 2005-04-26 2006-11-09 Apro Life Science Institute Inc イムノグロブリン結合タンパク質
EP1933883B1 (en) * 2005-08-03 2015-10-07 Rq Bioscience, Inc. Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases
EP1992692B1 (en) 2006-02-21 2013-01-09 Protenova Co., Ltd. Immunoglobulin affinity ligand
JP5345539B2 (ja) 2006-09-29 2013-11-20 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー 抗体単離のためのスタフィロコッカスアウレウス由来のドメインｃを含むクロマトグラフィーリガンド
JP5229888B2 (ja) * 2008-09-30 2013-07-03 独立行政法人産業技術総合研究所 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤
WO2010110288A1 (ja) 2009-03-24 2010-09-30 株式会社カネカ 免疫グロブリンに親和性を有するタンパク質および免疫グロブリン結合性アフィニティーリガンド
JP5789250B2 (ja) * 2009-04-03 2015-10-07 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ プロテインＡ（ＳｐＡ）変種に関連する組成物および方法
US9187555B2 (en) 2010-12-20 2015-11-17 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN103270044B (zh) 2010-12-21 2016-03-09 Jsr株式会社 亲和色谱用载体和分离免疫球蛋白的方法
JP5997176B2 (ja) 2010-12-21 2016-09-28 ザ ユニバーシティ オブ ウエスタン オンタリオＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｗｅｓｔｅｒｎ Ｏｎｔａｒｉｏ プロテインａの新規アルカリ抵抗性変異体及びアフィニティークロマトグラフィーにおけるその使用
EP2728000B1 (en) * 2011-06-03 2018-12-05 National Institute of Advanced Industrial Science And Technology Protein a mutant protein having reduced affinity in acidic region, and antibody capture agent
SG186552A1 (en) * 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
DE102013212062B4 (de) * 2013-06-25 2017-05-11 Pantrac Gmbh Vorrichtung zur Ableitung von Erdungsströmen, insbesondere in Windkraftanlagen
US9454196B2 (en) * 2013-06-27 2016-09-27 Apple Inc. Active peak power management of a high performance embedded microprocessor cluster

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063243A1 (en) * 1999-04-19 2000-10-26 Biovitrum Ab Derivatives of the b or z domain from staphylococcal protein a (spa) interacting with at least one domain of human factor viii
CN1642976A (zh) * 2002-03-25 2005-07-20 阿默森生物科学有限公司 一种突变的免疫球蛋白－结合蛋白
CN101775069A (zh) * 2008-12-24 2010-07-14 米利波尔公司 腐蚀稳定性色谱分析用配体
US20120149875A1 (en) * 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
WO2012074463A1 (en) * 2010-11-29 2012-06-07 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN105377881B (zh) * 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽
CN105377880B (zh) * 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽

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US12416607B2 (en) 2017-09-18 2025-09-16 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules
CN114149495A (zh) * 2021-12-17 2022-03-08 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用

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