CN111848755A - 突变的免疫球蛋白结合多肽 - Google Patents

突变的免疫球蛋白结合多肽 Download PDF

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Publication number
CN111848755A
CN111848755A CN202010728898.XA CN202010728898A CN111848755A CN 111848755 A CN111848755 A CN 111848755A CN 202010728898 A CN202010728898 A CN 202010728898A CN 111848755 A CN111848755 A CN 111848755A
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ala
polypeptide
amino acid
lys
leu
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Chinese (zh)
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G.罗德里戈
M.安德
G.鲍伦
T.布杰克曼
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Global Life Sciences Solutions USA LLC
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GE Healthcare Bio Sciences Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN202010728898.XA 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽 Pending CN111848755A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1350860-1 2013-07-10
SE1350859-3 2013-07-10
SE1350860 2013-07-10
SE1350859 2013-07-10
CN201480039292.8A CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽

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CN202010728898.XA Pending CN111848755A (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039292.8A Active CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039299.XA Active CN105377881B (zh) 2013-07-10 2014-07-10 突变的免疫球蛋白结合多肽

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CN201480039299.XA Active CN105377881B (zh) 2013-07-10 2014-07-10 突变的免疫球蛋白结合多肽

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US (5) US9896486B2 (enExample)
EP (2) EP3019520B1 (enExample)
JP (3) JP6544808B2 (enExample)
CN (3) CN111848755A (enExample)
WO (2) WO2015005859A1 (enExample)

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CN114149495A (zh) * 2021-12-17 2022-03-08 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules

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CN110372086B (zh) 2013-10-22 2022-12-06 那沃达有限责任公司 使用天然产生的生物生长培养基减少被污染流体中的物质
US11566082B2 (en) * 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3276002B1 (en) * 2015-03-26 2020-04-29 JSR Corporation Immunoglobulin-binding protein and affinity carrier using same
KR20170121746A (ko) * 2015-04-13 2017-11-02 후지필름 가부시키가이샤 단쇄 펩타이드 고정화 담체의 제조 방법 및 단쇄 펩타이드 고정화 담체
WO2017014261A1 (ja) * 2015-07-22 2017-01-26 株式会社カネカ 抗体様タンパク質の精製方法
CN107849095A (zh) * 2015-07-22 2018-03-27 株式会社钟化 酸性pH范围内的抗体结合能力降低的抗体结合性蛋白质
US10766924B2 (en) 2015-07-28 2020-09-08 Jsr Corporation Affinity support and method for isolating immunoglobulin
WO2017022672A1 (ja) * 2015-07-31 2017-02-09 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
JPWO2017022759A1 (ja) * 2015-08-04 2018-05-31 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
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WO2020040307A1 (ja) * 2018-08-24 2020-02-27 Jsr株式会社 イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体
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JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7432813B2 (ja) * 2019-09-10 2024-02-19 東ソー株式会社 免疫グロブリン結合性タンパク質
CN111057153B (zh) 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用
CN111732642B (zh) * 2020-07-30 2020-12-04 苏州纳微科技股份有限公司 免疫球蛋白结合蛋白及其应用
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CN117700501A (zh) * 2022-09-13 2024-03-15 普米斯生物技术(珠海)有限公司 免疫球蛋白结合蛋白及其应用
CN116217680B (zh) * 2023-01-10 2024-02-02 珠海冀百康生物科技有限公司 碱稳定性高的免疫球蛋白结合蛋白及其应用
CN119708176B (zh) * 2024-12-05 2026-01-06 武汉瑞法医疗器械有限公司 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用

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