JP2016523959A5 - - Google Patents
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- Publication number
- JP2016523959A5 JP2016523959A5 JP2016525329A JP2016525329A JP2016523959A5 JP 2016523959 A5 JP2016523959 A5 JP 2016523959A5 JP 2016525329 A JP2016525329 A JP 2016525329A JP 2016525329 A JP2016525329 A JP 2016525329A JP 2016523959 A5 JP2016523959 A5 JP 2016523959A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- glutamine
- residue
- asparagine
- cysteine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000004554 glutamine Nutrition 0.000 claims 15
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 15
- 125000000539 amino acid group Chemical group 0.000 claims 14
- 229940024606 amino acid Drugs 0.000 claims 13
- 235000001014 amino acid Nutrition 0.000 claims 13
- 150000001413 amino acids Chemical class 0.000 claims 13
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 12
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 12
- 235000009582 asparagine Nutrition 0.000 claims 12
- 229960001230 asparagine Drugs 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 11
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 11
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 11
- 235000018417 cysteine Nutrition 0.000 claims 11
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 11
- 235000013930 proline Nutrition 0.000 claims 11
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 10
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 10
- 235000004279 alanine Nutrition 0.000 claims 10
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 6
- 238000000926 separation method Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
- 239000004473 Threonine Substances 0.000 claims 4
- 238000004140 cleaning Methods 0.000 claims 4
- -1 for example Chemical compound 0.000 claims 4
- 235000008521 threonine Nutrition 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 2
- 229940072221 immunoglobulins Drugs 0.000 claims 2
- 235000004400 serine Nutrition 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241001481833 Coryphaena hippurus Species 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 230000009145 protein modification Effects 0.000 claims 1
- 102220248493 rs1555542879 Human genes 0.000 claims 1
- 102220186341 rs886053127 Human genes 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1350860 | 2013-07-10 | ||
| SE1350859 | 2013-07-10 | ||
| SE1350859-3 | 2013-07-10 | ||
| SE1350860-1 | 2013-07-10 | ||
| PCT/SE2014/050872 WO2015005859A1 (en) | 2013-07-10 | 2014-07-08 | Mutated immunoglobulin-binding polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019109474A Division JP6862008B2 (ja) | 2013-07-10 | 2019-06-12 | 突然変異免疫グロブリン結合ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523959A JP2016523959A (ja) | 2016-08-12 |
| JP2016523959A5 true JP2016523959A5 (enExample) | 2017-08-17 |
| JP6544808B2 JP6544808B2 (ja) | 2019-07-17 |
Family
ID=52280382
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525329A Active JP6544808B2 (ja) | 2013-07-10 | 2014-07-08 | 突然変異免疫グロブリン結合ポリペプチド |
| JP2016525330A Active JP6544809B2 (ja) | 2013-07-10 | 2014-07-10 | 突然変異免疫グロブリン結合ポリペプチド |
| JP2019109474A Active JP6862008B2 (ja) | 2013-07-10 | 2019-06-12 | 突然変異免疫グロブリン結合ポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525330A Active JP6544809B2 (ja) | 2013-07-10 | 2014-07-10 | 突然変異免疫グロブリン結合ポリペプチド |
| JP2019109474A Active JP6862008B2 (ja) | 2013-07-10 | 2019-06-12 | 突然変異免疫グロブリン結合ポリペプチド |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US9896486B2 (enExample) |
| EP (2) | EP3019520B1 (enExample) |
| JP (3) | JP6544808B2 (enExample) |
| CN (3) | CN105377880B (enExample) |
| WO (2) | WO2015005859A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| CN105377880B (zh) | 2013-07-10 | 2020-08-07 | 通用电气医疗集团生物工艺研发股份公司 | 突变的免疫球蛋白结合多肽 |
| WO2015061340A1 (en) | 2013-10-22 | 2015-04-30 | Renewable Fibers LLC dba RF WasteWater, LLC | Reduction of substances in contaminated fluids using a naturally occurring biological growth media |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| TWI709571B (zh) * | 2015-03-26 | 2020-11-11 | 日商Ｊｓｒ股份有限公司 | 免疫球蛋白結合蛋白質及使用此之親和性載體 |
| KR20170121746A (ko) | 2015-04-13 | 2017-11-02 | 후지필름 가부시키가이샤 | 단쇄 펩타이드 고정화 담체의 제조 방법 및 단쇄 펩타이드 고정화 담체 |
| EP3327029A4 (en) * | 2015-07-22 | 2018-10-31 | Kaneka Corporation | ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY-BINDING CAPACITY IN ACIDIC pH REGIONS |
| CN107849088A (zh) * | 2015-07-22 | 2018-03-27 | 株式会社钟化 | 抗体样蛋白质的纯化方法 |
| US10766924B2 (en) | 2015-07-28 | 2020-09-08 | Jsr Corporation | Affinity support and method for isolating immunoglobulin |
| WO2017022672A1 (ja) * | 2015-07-31 | 2017-02-09 | 株式会社カネカ | 免疫グロブリン結合性改変型タンパク質 |
| WO2017022759A1 (ja) * | 2015-08-04 | 2017-02-09 | 株式会社カネカ | 免疫グロブリン結合性改変型タンパク質 |
| GB201515339D0 (en) * | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| DK3455244T3 (da) * | 2016-05-11 | 2022-06-07 | Cytiva Bioprocess R & D Ab | Muterede immunoglobulin-bindende polypeptider |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| ES2909833T3 (es) * | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| JP7106187B2 (ja) * | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
| CN109219613B (zh) * | 2016-05-11 | 2022-09-23 | 思拓凡生物工艺研发有限公司 | 分离方法 |
| ES2874974T3 (es) | 2016-05-11 | 2021-11-05 | Cytiva Bioprocess R & D Ab | Matriz de separación |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
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| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
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| US11660550B2 (en) * | 2017-03-07 | 2023-05-30 | Jmva Biotech Ab | Modified adsorptive surfaces |
| GB201708277D0 (en) | 2017-05-24 | 2017-07-05 | Ge Healthcare | A Recombinant protein |
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| WO2019030156A1 (en) | 2017-08-07 | 2019-02-14 | Repligen Corporation | FC BINDING PROTEINS WITH CYSTEINE IN THE C-TERMINAL HELICAL REGION |
| US12180581B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US12181452B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709155B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
| EP4249097A3 (en) | 2018-02-01 | 2024-01-10 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| WO2020040307A1 (ja) * | 2018-08-24 | 2020-02-27 | Jsr株式会社 | イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体 |
| GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
| JP6927247B2 (ja) * | 2019-04-08 | 2021-08-25 | 昭和電工マテリアルズ株式会社 | 抗体の精製方法 |
| JP7432813B2 (ja) * | 2019-09-10 | 2024-02-19 | 東ソー株式会社 | 免疫グロブリン結合性タンパク質 |
| CN111057153B (zh) | 2019-12-06 | 2021-09-07 | 广州康盛生物科技股份有限公司 | 一种免疫球蛋白结合蛋白及其制备方法和应用 |
| US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
| CN111732642B (zh) * | 2020-07-30 | 2020-12-04 | 苏州纳微科技股份有限公司 | 免疫球蛋白结合蛋白及其应用 |
| EP4628889A3 (en) | 2020-09-24 | 2025-12-10 | Waters Technologies Corporation | Chromatographic hardware improvements for the separation of reactive molecules |
| WO2022081779A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
| JP7854191B2 (ja) * | 2020-12-22 | 2026-05-01 | プロテノバ株式会社 | イムノグロブリン結合ポリペプチド |
| CN117241866A (zh) | 2021-02-19 | 2023-12-15 | 艾维泰有限责任公司 | Aav2亲和剂 |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN116874571A (zh) * | 2021-12-17 | 2023-10-13 | 博格隆(上海)生物技术有限公司 | 突变的蛋白a结构域c及其应用 |
| CN114315996B (zh) * | 2021-12-31 | 2023-01-17 | 博格隆(浙江)生物技术有限公司 | 一种重组ProteinA蛋白及亲和层析介质的制备方法 |
| CN114409748A (zh) * | 2022-01-28 | 2022-04-29 | 博格隆(浙江)生物技术有限公司 | 蛋白a的b结构域和z结构域突变体及其应用 |
| GB202203478D0 (en) | 2022-03-14 | 2022-04-27 | Cytiva Bioprocess R & D Ab | Vh3 binding polypeptides |
| CN115850408A (zh) * | 2022-09-01 | 2023-03-28 | 西安蓝晓科技新材料股份有限公司 | 一种多肽、融合型多聚体蛋白质及其用途 |
| CN117700501A (zh) * | 2022-09-13 | 2024-03-15 | 普米斯生物技术(珠海)有限公司 | 免疫球蛋白结合蛋白及其应用 |
| CN116217680B (zh) * | 2023-01-10 | 2024-02-02 | 珠海冀百康生物科技有限公司 | 碱稳定性高的免疫球蛋白结合蛋白及其应用 |
| CN116333056A (zh) * | 2023-02-09 | 2023-06-27 | 西宝生物科技（上海）股份有限公司 | 一种高结合容量的耐碱重组Protein A及其制备方法和应用 |
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| CN119708176B (zh) * | 2024-12-05 | 2026-01-06 | 武汉瑞法医疗器械有限公司 | 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用 |
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| DE102013212062B4 (de) * | 2013-06-25 | 2017-05-11 | Pantrac Gmbh | Vorrichtung zur Ableitung von Erdungsströmen, insbesondere in Windkraftanlagen |
| US9454196B2 (en) * | 2013-06-27 | 2016-09-27 | Apple Inc. | Active peak power management of a high performance embedded microprocessor cluster |
| CN105377880B (zh) | 2013-07-10 | 2020-08-07 | 通用电气医疗集团生物工艺研发股份公司 | 突变的免疫球蛋白结合多肽 |
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2014
- 2014-07-08 CN CN201480039292.8A patent/CN105377880B/zh active Active
- 2014-07-08 CN CN202010728898.XA patent/CN111848755A/zh active Pending
- 2014-07-08 WO PCT/SE2014/050872 patent/WO2015005859A1/en not_active Ceased
- 2014-07-08 JP JP2016525329A patent/JP6544808B2/ja active Active
- 2014-07-08 EP EP14823829.8A patent/EP3019520B1/en active Active
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- 2014-07-10 CN CN201480039299.XA patent/CN105377881B/zh active Active
- 2014-07-10 JP JP2016525330A patent/JP6544809B2/ja active Active
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