JP2016523959A5 - - Google Patents

Info

Publication number

JP2016523959A5

JP2016523959A5 JP2016525329A JP2016525329A JP2016523959A5 JP 2016523959 A5 JP2016523959 A5 JP 2016523959A5 JP 2016525329 A JP2016525329 A JP 2016525329A JP 2016525329 A JP2016525329 A JP 2016525329A JP 2016523959 A5 JP2016523959 A5 JP 2016523959A5

Authority

JP

Japan

Prior art keywords

amino acid

glutamine

residue

asparagine

cysteine

Prior art date

2014-07-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 235000004554 glutamine Nutrition 0.000 claims 15
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 15
• 125000000539 amino acid group Chemical group 0.000 claims 14
• 229940024606 amino acid Drugs 0.000 claims 13
• 235000001014 amino acid Nutrition 0.000 claims 13
• 150000001413 amino acids Chemical class 0.000 claims 13
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 12
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 12
• 235000009582 asparagine Nutrition 0.000 claims 12
• 229960001230 asparagine Drugs 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 11
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 11
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 11
• 235000018417 cysteine Nutrition 0.000 claims 11
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 11
• 235000013930 proline Nutrition 0.000 claims 11
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 10
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 10
• 235000004279 alanine Nutrition 0.000 claims 10
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 7
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
• 239000011159 matrix material Substances 0.000 claims 6
• 238000000926 separation method Methods 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 4
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
• 239000004473 Threonine Substances 0.000 claims 4
• 238000004140 cleaning Methods 0.000 claims 4
• -1 for example Chemical compound 0.000 claims 4
• 235000008521 threonine Nutrition 0.000 claims 4
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
• 108060003951 Immunoglobulin Proteins 0.000 claims 3
• 235000003704 aspartic acid Nutrition 0.000 claims 3
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
• 235000013922 glutamic acid Nutrition 0.000 claims 3
• 239000004220 glutamic acid Substances 0.000 claims 3
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 3
• 102000018358 immunoglobulin Human genes 0.000 claims 3
• 239000007788 liquid Substances 0.000 claims 3
• 230000035772 mutation Effects 0.000 claims 3
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
• 239000004472 Lysine Substances 0.000 claims 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
• 108010088160 Staphylococcal Protein A Proteins 0.000 claims 2
• 229940072221 immunoglobulins Drugs 0.000 claims 2
• 235000004400 serine Nutrition 0.000 claims 2
• 238000005406 washing Methods 0.000 claims 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241001481833 Coryphaena hippurus Species 0.000 claims 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
• 239000003513 alkali Substances 0.000 claims 1
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 238000010828 elution Methods 0.000 claims 1
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 108010025221 plasma protein Z Proteins 0.000 claims 1
• 230000009145 protein modification Effects 0.000 claims 1
• 102220248493 rs1555542879 Human genes 0.000 claims 1
• 102220186341 rs886053127 Human genes 0.000 claims 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 239000004474 valine Substances 0.000 claims 1