JP6851200B2 - 多量体Fcタンパク質 - Google Patents

多量体Fcタンパク質 Download PDF

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Publication number
JP6851200B2
JP6851200B2 JP2016555527A JP2016555527A JP6851200B2 JP 6851200 B2 JP6851200 B2 JP 6851200B2 JP 2016555527 A JP2016555527 A JP 2016555527A JP 2016555527 A JP2016555527 A JP 2016555527A JP 6851200 B2 JP6851200 B2 JP 6851200B2
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Japan
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residue
fusion protein
domain
replaced
igg4
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JP2016555527A
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JP2017512063A5 (enExample
JP2017512063A (ja
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− アラニ、ファルナツ ファラー
− アラニ、ファルナツ ファラー
アンソニー グリフィン、ロバート
アンソニー グリフィン、ロバート
ポール ハンフリーズ、デイヴィッド
ポール ハンフリーズ、デイヴィッド
ジェイン ピーターズ、シャーリー
ジェイン ピーターズ、シャーリー
ジョン スミス、ブライアン
ジョン スミス、ブライアン
エドワード スティーブンス、ポール
エドワード スティーブンス、ポール
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ユーシービー バイオファルマ エスアールエル
ユーシービー バイオファルマ エスアールエル
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Priority claimed from GB201403912A external-priority patent/GB201403912D0/en
Priority claimed from GB201403913A external-priority patent/GB201403913D0/en
Priority claimed from GB201405952A external-priority patent/GB201405952D0/en
Priority claimed from GB201412646A external-priority patent/GB201412646D0/en
Application filed by ユーシービー バイオファルマ エスアールエル, ユーシービー バイオファルマ エスアールエル filed Critical ユーシービー バイオファルマ エスアールエル
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/524CH2 domain
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    • C07ORGANIC CHEMISTRY
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    • C07KPEPTIDES
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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JP2016555527A 2014-03-05 2015-03-05 多量体Fcタンパク質 Expired - Fee Related JP6851200B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB201403912A GB201403912D0 (en) 2014-03-05 2014-03-05 Proteins
GB1403913.5 2014-03-05
GB201403913A GB201403913D0 (en) 2014-03-05 2014-03-05 Proteins
GB1403912.7 2014-03-05
GB201405952A GB201405952D0 (en) 2014-04-02 2014-04-02 Proteins
GB1405952.1 2014-04-02
GB201412646A GB201412646D0 (en) 2014-07-16 2014-07-16 Proteins
GB1412646.0 2014-07-16
PCT/EP2015/054687 WO2015132364A1 (en) 2014-03-05 2015-03-05 Multimeric fc proteins

Publications (3)

Publication Number Publication Date
JP2017512063A JP2017512063A (ja) 2017-05-18
JP2017512063A5 JP2017512063A5 (enExample) 2018-04-12
JP6851200B2 true JP6851200B2 (ja) 2021-03-31

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JP2016555527A Expired - Fee Related JP6851200B2 (ja) 2014-03-05 2015-03-05 多量体Fcタンパク質

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US (1) US11352414B2 (enExample)
EP (1) EP3114143B1 (enExample)
JP (1) JP6851200B2 (enExample)
KR (1) KR20160130463A (enExample)
CN (1) CN106068274A (enExample)
AU (1) AU2015226100B2 (enExample)
BR (1) BR112016020368A2 (enExample)
CA (1) CA2939198A1 (enExample)
IL (1) IL247096A0 (enExample)
MX (1) MX2016010951A (enExample)
RU (1) RU2016139006A (enExample)
SG (1) SG11201606597QA (enExample)
TW (1) TW201619188A (enExample)
UY (1) UY36021A (enExample)
WO (1) WO2015132364A1 (enExample)

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EP3114143B1 (en) 2014-03-05 2020-07-08 UCB Biopharma SRL Multimeric fc proteins
AU2015226101B2 (en) 2014-03-05 2019-08-22 Ucb Biopharma Sprl Multimeric Fc proteins
BR112016023948A2 (pt) 2014-04-16 2018-01-30 Ucb Biopharma Sprl proteínas fc multiméricas
JP2017518965A (ja) 2014-05-02 2017-07-13 モメンタ ファーマシューティカルズ インコーポレイテッ エンジニアリングされたFc構築物に関連する組成物および方法
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GB201511787D0 (en) 2015-07-06 2015-08-19 Ucb Biopharma Sprl Proteins

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MX2016010951A (es) 2016-11-29
AU2015226100A1 (en) 2016-08-25
IL247096A0 (en) 2016-09-29
UY36021A (es) 2015-09-30
EP3114143A1 (en) 2017-01-11
CN106068274A (zh) 2016-11-02
SG11201606597QA (en) 2016-09-29
RU2016139006A (ru) 2018-04-05
CA2939198A1 (en) 2015-09-11
BR112016020368A2 (pt) 2018-01-23
US20170088603A1 (en) 2017-03-30
KR20160130463A (ko) 2016-11-11
AU2015226100B2 (en) 2020-05-07
US11352414B2 (en) 2022-06-07
JP2017512063A (ja) 2017-05-18
WO2015132364A1 (en) 2015-09-11
EP3114143B1 (en) 2020-07-08

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