JP2018514209A5 - - Google Patents
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- Publication number
- JP2018514209A5 JP2018514209A5 JP2017555767A JP2017555767A JP2018514209A5 JP 2018514209 A5 JP2018514209 A5 JP 2018514209A5 JP 2017555767 A JP2017555767 A JP 2017555767A JP 2017555767 A JP2017555767 A JP 2017555767A JP 2018514209 A5 JP2018514209 A5 JP 2018514209A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- signal peptide
- acid construct
- cell
- hydrophobic amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 42
- 150000007523 nucleic acids Chemical group 0.000 claims description 40
- 108020004707 nucleic acids Proteins 0.000 claims description 32
- 102000039446 nucleic acids Human genes 0.000 claims description 32
- 210000004027 cell Anatomy 0.000 claims description 28
- 150000001413 amino acids Chemical class 0.000 claims description 26
- 229940024606 amino acid Drugs 0.000 claims description 22
- 235000001014 amino acid Nutrition 0.000 claims description 22
- 230000002209 hydrophobic effect Effects 0.000 claims description 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 235000018102 proteins Nutrition 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 238000003776 cleavage reaction Methods 0.000 claims description 7
- 230000007017 scission Effects 0.000 claims description 7
- 102000035160 transmembrane proteins Human genes 0.000 claims description 6
- 108091005703 transmembrane proteins Proteins 0.000 claims description 6
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 4
- 229960000310 isoleucine Drugs 0.000 claims description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 239000004474 valine Substances 0.000 claims description 4
- 241000710190 Cardiovirus Species 0.000 claims description 2
- 102000004961 Furin Human genes 0.000 claims description 2
- 108090001126 Furin Proteins 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 241000723792 Tobacco etch virus Species 0.000 claims description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1507108.7A GB201507108D0 (en) | 2015-04-27 | 2015-04-27 | Nucleic acid construct |
| GB1507108.7 | 2015-04-27 | ||
| PCT/GB2016/051165 WO2016174409A1 (en) | 2015-04-27 | 2016-04-26 | Nucleic acid construct |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020117041A Division JP2020182473A (ja) | 2015-04-27 | 2020-07-07 | 核酸構築物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514209A JP2018514209A (ja) | 2018-06-07 |
| JP2018514209A5 true JP2018514209A5 (enExample) | 2019-04-11 |
| JP6836516B2 JP6836516B2 (ja) | 2021-03-03 |
Family
ID=53488690
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555767A Active JP6836516B2 (ja) | 2015-04-27 | 2016-04-26 | 核酸構築物 |
| JP2020117041A Withdrawn JP2020182473A (ja) | 2015-04-27 | 2020-07-07 | 核酸構築物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020117041A Withdrawn JP2020182473A (ja) | 2015-04-27 | 2020-07-07 | 核酸構築物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11613559B2 (enExample) |
| EP (1) | EP3288582B1 (enExample) |
| JP (2) | JP6836516B2 (enExample) |
| CN (1) | CN107532175A (enExample) |
| AU (1) | AU2016254499A1 (enExample) |
| CA (1) | CA2983687A1 (enExample) |
| ES (1) | ES2869971T3 (enExample) |
| GB (1) | GB201507108D0 (enExample) |
| HK (1) | HK1243958A1 (enExample) |
| WO (1) | WO2016174409A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201609118RA (en) | 2014-05-15 | 2016-11-29 | Univ Singapore | Modified natural killer cells and uses thereof |
| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| CN110636851B (zh) | 2017-03-27 | 2023-11-03 | 新加坡国立大学 | 截短的nkg2d嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| WO2019025800A1 (en) * | 2017-08-02 | 2019-02-07 | Autolus Limited | CELLS EXPRESSING A CHIMERIC ANTIGENIC RECEPTOR OR A MANIPULATED TCR AND COMPRISING A SELECTIVELY EXPRESSED SELECTIVE NUCLEOTIDE SEQUENCE |
| CA3089170A1 (en) | 2018-02-09 | 2019-08-15 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| GB201805918D0 (en) | 2018-04-10 | 2018-05-23 | Autolus Ltd | Cell |
| GB201812474D0 (en) | 2018-07-31 | 2018-09-12 | Autolus Ltd | Nucleic acid construct |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| GB201914611D0 (en) | 2019-10-09 | 2019-11-20 | Autolus Ltd | Engineered immune cell |
| GB202007044D0 (en) | 2020-05-13 | 2020-06-24 | Autolus Ltd | Method |
| JP2022072823A (ja) | 2020-10-30 | 2022-05-17 | 藤森工業株式会社 | 包装袋 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| GB202108184D0 (en) | 2021-06-08 | 2021-07-21 | Autolus Ltd | Engineered immune cell |
| WO2023139360A1 (en) | 2022-01-19 | 2023-07-27 | Autolus Limited | Nucleic acid construct |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000063374A1 (en) | 1999-04-16 | 2000-10-26 | Celltech Therapeutics Limited | Synthetic transmembrane components |
| CA2615983A1 (en) * | 2005-07-21 | 2007-02-01 | Abbott Laboratories | Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis |
| ES2636971T3 (es) * | 2009-11-05 | 2017-10-10 | F. Hoffmann-La Roche Ag | Procedimientos y composición para la secreción de polipéptidos heterógenos |
| CN103483452B (zh) * | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| GB201317929D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| RU2717984C2 (ru) | 2013-11-21 | 2020-03-27 | ЮСиЭл БИЗНЕС ЛТД | Клетка |
| GB201507104D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
-
2015
- 2015-04-27 GB GBGB1507108.7A patent/GB201507108D0/en not_active Ceased
-
2016
- 2016-04-26 WO PCT/GB2016/051165 patent/WO2016174409A1/en not_active Ceased
- 2016-04-26 JP JP2017555767A patent/JP6836516B2/ja active Active
- 2016-04-26 CN CN201680022736.6A patent/CN107532175A/zh active Pending
- 2016-04-26 EP EP16720484.1A patent/EP3288582B1/en active Active
- 2016-04-26 HK HK18103620.2A patent/HK1243958A1/zh unknown
- 2016-04-26 CA CA2983687A patent/CA2983687A1/en not_active Abandoned
- 2016-04-26 AU AU2016254499A patent/AU2016254499A1/en not_active Abandoned
- 2016-04-26 US US15/568,862 patent/US11613559B2/en active Active
- 2016-04-26 ES ES16720484T patent/ES2869971T3/es active Active
-
2020
- 2020-07-07 JP JP2020117041A patent/JP2020182473A/ja not_active Withdrawn
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