JP2016501535A5 - - Google Patents
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- Publication number
- JP2016501535A5 JP2016501535A5 JP2015548014A JP2015548014A JP2016501535A5 JP 2016501535 A5 JP2016501535 A5 JP 2016501535A5 JP 2015548014 A JP2015548014 A JP 2015548014A JP 2015548014 A JP2015548014 A JP 2015548014A JP 2016501535 A5 JP2016501535 A5 JP 2016501535A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- nucleic acid
- composition
- recombinant nucleic
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 53
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 51
- 229920001184 polypeptide Polymers 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 239000012634 fragment Substances 0.000 claims 10
- 241000701022 Cytomegalovirus Species 0.000 claims 6
- 108091005804 Peptidases Proteins 0.000 claims 6
- 239000004365 Protease Substances 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 6
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 6
- 238000003776 cleavage reaction Methods 0.000 claims 6
- 230000007017 scission Effects 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 241001502567 Chikungunya virus Species 0.000 claims 3
- 241000725303 Human immunodeficiency virus Species 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 241000725619 Dengue virus Species 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737094P | 2012-12-13 | 2012-12-13 | |
| US61/737,094 | 2012-12-13 | ||
| US201361881376P | 2013-09-23 | 2013-09-23 | |
| US61/881,376 | 2013-09-23 | ||
| US201361896646P | 2013-10-28 | 2013-10-28 | |
| US61/896,646 | 2013-10-28 | ||
| PCT/US2013/075137 WO2014093894A2 (en) | 2012-12-13 | 2013-12-13 | Dna antibody constructs and method of using same |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019061531A Division JP2019115355A (ja) | 2012-12-13 | 2019-03-27 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2021016537A Division JP2021087433A (ja) | 2012-12-13 | 2021-02-04 | Ｄｎａ抗体構築物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016501535A JP2016501535A (ja) | 2016-01-21 |
| JP2016501535A5 true JP2016501535A5 (enExample) | 2017-02-02 |
| JP6898060B2 JP6898060B2 (ja) | 2021-07-07 |
Family
ID=50935092
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548014A Active JP6898060B2 (ja) | 2012-12-13 | 2013-12-13 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2019061531A Pending JP2019115355A (ja) | 2012-12-13 | 2019-03-27 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2020035240A Pending JP2020108381A (ja) | 2012-12-13 | 2020-03-02 | Ｄｎａ抗体構築物及びその使用方法 |
| JP2021016537A Withdrawn JP2021087433A (ja) | 2012-12-13 | 2021-02-04 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023040876A Pending JP2023080085A (ja) | 2012-12-13 | 2023-03-15 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023108341A Pending JP2023138998A (ja) | 2012-12-13 | 2023-06-30 | Ｄｎａ抗体構築物及びその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019061531A Pending JP2019115355A (ja) | 2012-12-13 | 2019-03-27 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2020035240A Pending JP2020108381A (ja) | 2012-12-13 | 2020-03-02 | Ｄｎａ抗体構築物及びその使用方法 |
| JP2021016537A Withdrawn JP2021087433A (ja) | 2012-12-13 | 2021-02-04 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023040876A Pending JP2023080085A (ja) | 2012-12-13 | 2023-03-15 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023108341A Pending JP2023138998A (ja) | 2012-12-13 | 2023-06-30 | Ｄｎａ抗体構築物及びその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US9994629B2 (enExample) |
| EP (1) | EP2931318A4 (enExample) |
| JP (6) | JP6898060B2 (enExample) |
| KR (4) | KR20150093834A (enExample) |
| CN (1) | CN104853782A (enExample) |
| AU (7) | AU2013358944B2 (enExample) |
| BR (2) | BR112015013700A8 (enExample) |
| CA (1) | CA2889723A1 (enExample) |
| EA (1) | EA201591131A1 (enExample) |
| HK (1) | HK1213481A1 (enExample) |
| MX (4) | MX2015007575A (enExample) |
| MY (1) | MY175708A (enExample) |
| SG (1) | SG10202002718RA (enExample) |
| WO (1) | WO2014093894A2 (enExample) |
| ZA (1) | ZA201503583B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201591131A1 (ru) | 2012-12-13 | 2015-12-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Днк-конструкции антитела и способ их применения |
| US10087240B2 (en) * | 2013-12-13 | 2018-10-02 | Inovio Pharmaceuticals, Inc. | DNA antibody constructs and method of using same |
| KR20230145241A (ko) * | 2014-10-01 | 2023-10-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신 |
| KR20170085131A (ko) * | 2014-12-01 | 2017-07-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Dna 항체 작제물 및 그 이용 방법 |
| AU2016347058B2 (en) | 2015-10-25 | 2023-11-09 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of HIV infection |
| WO2017106326A1 (en) * | 2015-12-14 | 2017-06-22 | The Trustees Of The University Of Pennsylvania | Aav-anti pcsk9 antibody constructs and uses thereof |
| KR20230012070A (ko) * | 2016-03-21 | 2023-01-25 | 데이비드 비. 웨이너 | Dna 항체 작제물 및 이의 사용 방법 |
| EP4257193B1 (en) | 2016-04-13 | 2025-12-31 | Sanofi | TRISPECIFIC AND/OR TRIVALENT LINKING PROTEINS |
| WO2017192933A1 (en) * | 2016-05-05 | 2017-11-09 | Weiner, David | Dna monoclonal antibodies targeting il-6 and cd126 |
| CN120366325A (zh) * | 2016-05-05 | 2025-07-25 | 宾夕法尼亚大学理事会 | 靶向检查点分子的dna单克隆抗体 |
| JP2019520085A (ja) * | 2016-05-05 | 2019-07-18 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａに対して使用するためのｄｎａ抗体構築物 |
| CN118109478A (zh) * | 2016-05-05 | 2024-05-31 | 宾夕法尼亚大学理事会 | 靶向流感病毒的dna单克隆抗体 |
| CA3037486A1 (en) | 2016-09-19 | 2018-03-22 | The Trustees Of The University Of Pennsylvania | Combination of novel vaccines against zika virus and dna antibody constructs for use against zika virus |
| TWI778985B (zh) | 2016-10-20 | 2022-10-01 | 法商賽諾菲公司 | 抗chikv抗體及其用途 |
| EP3534941A4 (en) * | 2016-11-07 | 2020-07-08 | The Wistar Institute Of Anatomy And Biology | CONSTRUCTIONS OF ANTI-DNA ANTIBODIES FOR USE AGAINST LYME DISEASE |
| EP3606552A4 (en) | 2017-04-07 | 2020-08-05 | The Rockefeller University | COMPOSITIONS AND METHODS RELATING TO HUMAN NEUTRALIZING ANTIBODIES DIRECTED AGAINST ZIKA VIRUS AND DENGUE VIRUS 1 |
| WO2018217681A1 (en) * | 2017-05-22 | 2018-11-29 | National Cheng Kung University | Anti-dengue virus antibody, pharmaceutical composition comprising the same, and uses thereof |
| US11230592B2 (en) * | 2017-09-27 | 2022-01-25 | The Wistar Institute Of Anatomy And Biology | DNA antibody constructs for use against middle east respiratory syndrome coronavirus |
| WO2019152602A1 (en) * | 2018-01-31 | 2019-08-08 | The Wistar Institute Of Anatomy And Biology | Structurally modified flavivirus dmabs |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| EP4003421A4 (en) * | 2019-07-31 | 2023-11-08 | The Wistar Institute of Anatomy and Biology | Multivalent dna antibody constructs and use thereof |
| MX2022003291A (es) | 2019-09-18 | 2022-09-09 | Intergalactic Therapeutics Inc | Vectores de adn sinteticos y metodos de uso. |
| SE544001C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequences, signal peptide sequences and nucleic acid sequences encoding heavy and light chains of an antibody |
| SE544000C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequence, signal peptide sequence and nucleic acid sequence encoding a recombinant protein |
| US20230136960A1 (en) * | 2020-03-19 | 2023-05-04 | Nature's Toolbox, Inc. | Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same |
| IL297903A (en) | 2020-05-14 | 2023-01-01 | Inovio Pharmaceuticals Inc | Vaccines for multiple recurrent respiratory papillomas and methods of their use |
| WO2022120010A1 (en) * | 2020-12-02 | 2022-06-09 | Thomas Jefferson University | Desmoglein 2-directed chimeric antigen receptor (car) constructs and methods of use |
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| FI46572C (fi) * | 1972-04-07 | 1973-04-10 | Stroemberg Oy Ab | Jännitemuuntaja. |
| US7276488B2 (en) | 1997-06-04 | 2007-10-02 | Oxford Biomedica (Uk) Limited | Vector system |
| US20030039635A1 (en) | 1998-09-30 | 2003-02-27 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| CN1334343A (zh) * | 2000-07-14 | 2002-02-06 | 中国医学科学院肿瘤医院肿瘤研究所 | 抑制肿瘤生长的新抗体、其衍生物及其应用 |
| US20070037165A1 (en) | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| WO2004013278A2 (en) * | 2002-08-02 | 2004-02-12 | Yuhan Corporation | Expression vectors |
| WO2005017149A1 (en) * | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| CN1480215A (zh) | 2003-07-07 | 2004-03-10 | 叶新新 | Sars病毒抗原抗体复合疫苗及实验动物模型与方法 |
| MXPA06013834A (es) | 2004-05-28 | 2007-03-01 | Agensys Inc | Anticuerpos y moleculas relacionadas que enlazan a proteinas psca. |
| BRPI0511624B1 (pt) * | 2004-05-28 | 2022-02-08 | Agensys, Inc | Anticorpo monoclonal que se liga à proteína psca, uso do mesmo, hibridoma, vetor, composição farmacêutica, bem como ensaio e método para detecção da presença de uma proteína psca em uma amostra biológica |
| US7714119B2 (en) * | 2004-07-13 | 2010-05-11 | Biosante Pharmaceuticals, Inc. | AAV vector compositions and methods for enhanced expression of immunoglobulins using the same |
| KR20190035967A (ko) | 2004-07-22 | 2019-04-03 | 제넨테크, 인크. | Ｈｅｒ２ 항체 조성물 |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| KR101291640B1 (ko) | 2005-02-18 | 2013-08-05 | 메다렉스, 엘.엘.시. | 푸코실 잔기가 결핍된 전립선 특이적 막 항원(ｐｓｍａ)에대한 단클론성 항체 |
| US20060216722A1 (en) | 2005-03-25 | 2006-09-28 | Christer Betsholtz | Glomerular expression profiling |
| RU2478709C2 (ru) | 2005-07-21 | 2013-04-10 | Эбботт Лэборетриз | ЭКСПРЕССИЯ МНОЖЕСТВА ГЕНОВ, ВКЛЮЧАЯ sORF-КОНСТРУКЦИИ, И СПОСОБЫ ЭКСПРЕССИРОВАНИЯ ИММУНОГЛОБУЛИНА |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| CA2598966A1 (en) | 2007-09-07 | 2009-03-07 | Institut Pasteur | Anti-chikungunya monoclonal antibodies and uses thereof |
| JP2009171880A (ja) | 2008-01-23 | 2009-08-06 | Yokohama City Univ | アルツハイマー病における次世代遺伝子治療法・免疫治療法の開発 |
| NZ587830A (en) | 2008-03-14 | 2012-08-31 | Transgene Sa | Antibody against the colony-stimulating factor-1 receptor (CSF-1R) |
| CA2720166A1 (en) | 2008-04-04 | 2009-10-08 | David B. Weiner | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| MX2011003588A (es) | 2008-10-13 | 2011-10-14 | Inst Research In Biomedicine | Anticuerpos neutralizadores del virus del dengue y uso de los mismos. |
| SG177560A1 (en) * | 2009-07-06 | 2012-03-29 | Hoffmann La Roche | Bi-specific digoxigenin binding antibodies |
| RU2553331C2 (ru) | 2009-07-13 | 2015-06-10 | Бхарат Байотек Интернэшнл Лимитед | Композиция, применимая в качестве ротавирусной вакцины, и способ ее получения |
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| AU2010298025B2 (en) * | 2009-09-25 | 2016-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to HIV-1 and their use |
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| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| BR112013000603A2 (pt) * | 2010-07-09 | 2016-07-05 | Jv Bio Srl | anticorpos conjugados com lipídios |
| NZ703035A (en) | 2010-07-09 | 2016-06-24 | Crucell Holland Bv | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| US8637035B2 (en) | 2010-07-16 | 2014-01-28 | Academia Sinica | Anti-dengue virus antibodies |
| CA2817709C (en) | 2010-11-12 | 2021-06-01 | The Trustees Of The University Of Pennsylvania | Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same |
| EA033467B1 (ru) * | 2011-01-31 | 2019-10-31 | Univ Pennsylvania | Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение |
| WO2012106578A1 (en) | 2011-02-04 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc) |
| WO2012115980A1 (en) | 2011-02-22 | 2012-08-30 | California Institute Of Technology | Delivery of proteins using adeno-associated virus (aav) vectors |
| CN102199218A (zh) * | 2011-04-29 | 2011-09-28 | 中国人民解放军军事医学科学院基础医学研究所 | 一种抗Her2抗体-白细胞介素2融合蛋白及其用途 |
| US9540657B2 (en) | 2012-05-25 | 2017-01-10 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
| JP7078350B2 (ja) * | 2013-10-28 | 2022-05-31 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｄｎａ抗体構築物及びその使用方法 |
| EA201591131A1 (ru) | 2012-12-13 | 2015-12-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Днк-конструкции антитела и способ их применения |
| PL2931304T3 (pl) | 2012-12-13 | 2021-11-08 | The Trustees Of The University Of Pennsylvania | Szczepionka wt1 |
| WO2014100490A1 (en) | 2012-12-19 | 2014-06-26 | Adimab, Llc | Multivalent antibody analogs, and methods of their preparation and use |
| US10087240B2 (en) | 2013-12-13 | 2018-10-02 | Inovio Pharmaceuticals, Inc. | DNA antibody constructs and method of using same |
-
2013
- 2013-12-13 EA EA201591131A patent/EA201591131A1/ru unknown
- 2013-12-13 JP JP2015548014A patent/JP6898060B2/ja active Active
- 2013-12-13 CN CN201380065674.3A patent/CN104853782A/zh active Pending
- 2013-12-13 WO PCT/US2013/075137 patent/WO2014093894A2/en not_active Ceased
- 2013-12-13 AU AU2013358944A patent/AU2013358944B2/en active Active
- 2013-12-13 BR BR112015013700A patent/BR112015013700A8/pt not_active Application Discontinuation
- 2013-12-13 CA CA2889723A patent/CA2889723A1/en active Pending
- 2013-12-13 KR KR1020157018712A patent/KR20150093834A/ko not_active Ceased
- 2013-12-13 HK HK16101459.4A patent/HK1213481A1/zh unknown
- 2013-12-13 KR KR1020237036307A patent/KR20230156146A/ko not_active Ceased
- 2013-12-13 US US14/651,740 patent/US9994629B2/en active Active
- 2013-12-13 MX MX2015007575A patent/MX2015007575A/es unknown
- 2013-12-13 EP EP13863143.7A patent/EP2931318A4/en active Pending
- 2013-12-13 KR KR1020217020972A patent/KR20210088741A/ko not_active Ceased
-
2014
- 2014-12-13 MY MYPI2016702163A patent/MY175708A/en unknown
- 2014-12-13 AU AU2014361811A patent/AU2014361811B2/en active Active
- 2014-12-13 SG SG10202002718RA patent/SG10202002718RA/en unknown
- 2014-12-13 MX MX2016007722A patent/MX388911B/es unknown
- 2014-12-13 KR KR1020167018560A patent/KR102454610B1/ko active Active
- 2014-12-13 BR BR112016013493-1A patent/BR112016013493B1/pt not_active IP Right Cessation
-
2015
- 2015-05-21 ZA ZA2015/03583A patent/ZA201503583B/en unknown
- 2015-06-12 MX MX2022016002A patent/MX2022016002A/es unknown
-
2016
- 2016-06-13 MX MX2021015971A patent/MX2021015971A/es unknown
- 2016-11-18 AU AU2016259451A patent/AU2016259451A1/en not_active Abandoned
-
2018
- 2018-04-30 AU AU2018202997A patent/AU2018202997A1/en not_active Abandoned
- 2018-06-12 US US16/005,997 patent/US20180346554A1/en not_active Abandoned
- 2018-09-26 US US16/142,457 patent/US11208470B2/en active Active
-
2019
- 2019-03-27 JP JP2019061531A patent/JP2019115355A/ja active Pending
- 2019-04-04 AU AU2019202343A patent/AU2019202343B2/en active Active
-
2020
- 2020-03-02 JP JP2020035240A patent/JP2020108381A/ja active Pending
- 2020-03-13 AU AU2020201853A patent/AU2020201853B2/en active Active
-
2021
- 2021-02-04 JP JP2021016537A patent/JP2021087433A/ja not_active Withdrawn
- 2021-06-03 AU AU2021203643A patent/AU2021203643A1/en not_active Abandoned
- 2021-12-17 US US17/554,642 patent/US20220112273A1/en not_active Abandoned
-
2023
- 2023-03-15 JP JP2023040876A patent/JP2023080085A/ja active Pending
- 2023-06-30 JP JP2023108341A patent/JP2023138998A/ja active Pending
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