JP2021087433A5 - - Google Patents
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- JP2021087433A5 JP2021087433A5 JP2021016537A JP2021016537A JP2021087433A5 JP 2021087433 A5 JP2021087433 A5 JP 2021087433A5 JP 2021016537 A JP2021016537 A JP 2021016537A JP 2021016537 A JP2021016537 A JP 2021016537A JP 2021087433 A5 JP2021087433 A5 JP 2021087433A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- pharmaceutical composition
- nucleic acid
- composition according
- recombinant nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 56
- 150000007523 nucleic acids Chemical group 0.000 claims 55
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 51
- 229920001184 polypeptide Polymers 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 239000012634 fragment Substances 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 10
- 241000701022 Cytomegalovirus Species 0.000 claims 6
- 108091005804 Peptidases Proteins 0.000 claims 6
- 239000004365 Protease Substances 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 6
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 241001502567 Chikungunya virus Species 0.000 claims 3
- 241000725303 Human immunodeficiency virus Species 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 241000725619 Dengue virus Species 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023040876A JP2023080085A (ja) | 2012-12-13 | 2023-03-15 | Ｄｎａ抗体構築物およびその使用方法 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737094P | 2012-12-13 | 2012-12-13 | |
| US61/737,094 | 2012-12-13 | ||
| US201361881376P | 2013-09-23 | 2013-09-23 | |
| US61/881,376 | 2013-09-23 | ||
| US201361896646P | 2013-10-28 | 2013-10-28 | |
| US61/896,646 | 2013-10-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548014A Division JP6898060B2 (ja) | 2012-12-13 | 2013-12-13 | Ｄｎａ抗体構築物およびその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023040876A Division JP2023080085A (ja) | 2012-12-13 | 2023-03-15 | Ｄｎａ抗体構築物およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021087433A JP2021087433A (ja) | 2021-06-10 |
| JP2021087433A5 true JP2021087433A5 (enExample) | 2021-07-26 |
Family
ID=50935092
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548014A Expired - Fee Related JP6898060B2 (ja) | 2012-12-13 | 2013-12-13 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2019061531A Pending JP2019115355A (ja) | 2012-12-13 | 2019-03-27 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2020035240A Pending JP2020108381A (ja) | 2012-12-13 | 2020-03-02 | Ｄｎａ抗体構築物及びその使用方法 |
| JP2021016537A Withdrawn JP2021087433A (ja) | 2012-12-13 | 2021-02-04 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023040876A Pending JP2023080085A (ja) | 2012-12-13 | 2023-03-15 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023108341A Pending JP2023138998A (ja) | 2012-12-13 | 2023-06-30 | Ｄｎａ抗体構築物及びその使用方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548014A Expired - Fee Related JP6898060B2 (ja) | 2012-12-13 | 2013-12-13 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2019061531A Pending JP2019115355A (ja) | 2012-12-13 | 2019-03-27 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2020035240A Pending JP2020108381A (ja) | 2012-12-13 | 2020-03-02 | Ｄｎａ抗体構築物及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023040876A Pending JP2023080085A (ja) | 2012-12-13 | 2023-03-15 | Ｄｎａ抗体構築物およびその使用方法 |
| JP2023108341A Pending JP2023138998A (ja) | 2012-12-13 | 2023-06-30 | Ｄｎａ抗体構築物及びその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US9994629B2 (enExample) |
| EP (1) | EP2931318A4 (enExample) |
| JP (6) | JP6898060B2 (enExample) |
| KR (4) | KR20230156146A (enExample) |
| CN (1) | CN104853782A (enExample) |
| AU (7) | AU2013358944B2 (enExample) |
| BR (2) | BR112015013700A8 (enExample) |
| CA (1) | CA2889723A1 (enExample) |
| EA (1) | EA201591131A1 (enExample) |
| HK (1) | HK1213481A1 (enExample) |
| MX (4) | MX2015007575A (enExample) |
| MY (1) | MY175708A (enExample) |
| SG (1) | SG10202002718RA (enExample) |
| WO (1) | WO2014093894A2 (enExample) |
| ZA (1) | ZA201503583B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015089492A2 (en) | 2013-12-13 | 2015-06-18 | The Trustees Of The University Of Pennsylvania | Dna antibody constructs and method of using same |
| KR20230156146A (ko) * | 2012-12-13 | 2023-11-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ｄｎａ 항체 작제물 및 그 이용 방법 |
| KR20250108761A (ko) * | 2014-10-01 | 2025-07-15 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신 |
| BR112017011556A2 (en) * | 2014-12-01 | 2018-03-06 | The Trustees Of The University Of Pennsylvania | methods for generating a synthetic antibody, preventing or treating a disease, treating a subject of pathogen infection and a subject with cancer, product, nucleic acid molecule, and composition. |
| KR102687212B1 (ko) | 2015-10-25 | 2024-07-19 | 사노피 | Hiv 감염의 예방 또는 치료를 위한 3특이성 및/또는 3가 결합 단백질 |
| WO2017106326A1 (en) * | 2015-12-14 | 2017-06-22 | The Trustees Of The University Of Pennsylvania | Aav-anti pcsk9 antibody constructs and uses thereof |
| KR20230012070A (ko) * | 2016-03-21 | 2023-01-25 | 데이비드 비. 웨이너 | Dna 항체 작제물 및 이의 사용 방법 |
| TN2020000058A1 (en) | 2016-04-13 | 2022-01-06 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
| AU2017261292B2 (en) * | 2016-05-05 | 2024-06-06 | The Trustees Of The University Of Pennsylvania | DNA monoclonal antibodies targeting IL-6 and CD126 |
| EA201892525A1 (ru) * | 2016-05-05 | 2019-04-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Конструкции днк-антител для применения против pseudomonas aeruginosa |
| EP3452504A4 (en) * | 2016-05-05 | 2020-07-29 | The Trustees of The University of Pennsylvania | MONOCLONAL DNA ANTIBODIES TARGETING INFLUENZA VIRUS |
| CN120366326A (zh) * | 2016-05-05 | 2025-07-25 | 宾夕法尼亚大学理事会 | 靶向检查点分子的dna单克隆抗体 |
| EP3515482A4 (en) * | 2016-09-19 | 2020-09-30 | The Wistar Institute Of Anatomy And Biology | ASSOCIATION OF NEW ZIKA VIRUS VACCINES AND ANTI-DNA ANTIBODY CONSTRUCTIONS FOR USE AGAINST ZIKA VIRUS |
| TW202300515A (zh) | 2016-10-20 | 2023-01-01 | 法商賽諾菲公司 | 抗ｃｈｉｋｖ抗體及其用途 |
| KR20210117359A (ko) * | 2016-11-07 | 2021-09-28 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | 라임병에 사용하기 위한 dna 항체 작제물 |
| EP3606552A4 (en) | 2017-04-07 | 2020-08-05 | The Rockefeller University | COMPOSITIONS AND METHODS RELATING TO HUMAN NEUTRALIZING ANTIBODIES DIRECTED AGAINST ZIKA VIRUS AND DENGUE VIRUS 1 |
| BR112019024643A2 (pt) * | 2017-05-22 | 2020-06-23 | National Cheng Kung University | Anticorpo contra vírus da dengue, composição farmacêutica compreendendo o mesmo e seus usos |
| WO2019067671A1 (en) * | 2017-09-27 | 2019-04-04 | David Weiner | DNA ANTIBODY CONSTRUCTS FOR USE IN CORONAVIRUS RESPIRATORY SYNDROME OF THE MIDDLE EAST |
| SG11202007241WA (en) | 2018-01-31 | 2020-08-28 | Wistar Inst | Nucleic acid antibody constructs for use against respiratory syncytial virus |
| WO2019152602A1 (en) * | 2018-01-31 | 2019-08-08 | The Wistar Institute Of Anatomy And Biology | Structurally modified flavivirus dmabs |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| US12606612B2 (en) | 2019-07-31 | 2026-04-21 | The Wistar Institute Of Anatomy And Biology | Multivalent DNA antibody constructs and use thereof |
| GB2606844B (en) | 2019-09-18 | 2025-08-06 | Aldevron Llc | Synthetic DNA vectors and methods of use |
| SE544001C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequences, signal peptide sequences and nucleic acid sequences encoding heavy and light chains of an antibody |
| SE544000C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequence, signal peptide sequence and nucleic acid sequence encoding a recombinant protein |
| WO2021188906A1 (en) * | 2020-03-19 | 2021-09-23 | Nature's Toolbox, Inc. | Novel mrna-based covid-19 multi-valent vaccine and methods of scaled production of the same |
| PH12022553102A1 (en) | 2020-05-14 | 2023-11-20 | Inovio Pharmaceuticals Inc | Vaccines for recurrent respiratory papillomatosis and methods of using the same |
| IL303262A (en) * | 2020-12-02 | 2023-07-01 | Univ Jefferson | Desmoglein 2-directed chimeric antigen receptor (car) constructs and methods of use |
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| US7276488B2 (en) | 1997-06-04 | 2007-10-02 | Oxford Biomedica (Uk) Limited | Vector system |
| US20030039635A1 (en) | 1998-09-30 | 2003-02-27 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| CN1334343A (zh) * | 2000-07-14 | 2002-02-06 | 中国医学科学院肿瘤医院肿瘤研究所 | 抑制肿瘤生长的新抗体、其衍生物及其应用 |
| US20070037165A1 (en) | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| WO2004013278A2 (en) * | 2002-08-02 | 2004-02-12 | Yuhan Corporation | Expression vectors |
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| CN1480215A (zh) | 2003-07-07 | 2004-03-10 | 叶新新 | Sars病毒抗原抗体复合疫苗及实验动物模型与方法 |
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| BRPI0520902B1 (pt) * | 2004-05-28 | 2021-11-30 | Agensys, Inc | Anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo que se liga a proteínas psca para diagnóstico de câncer, método para produção dos mesmos, hibridoma, polinucleotídeo, vetor, composição, ensaio para detectar a presença de uma proteína psca e método de detecção de uma proteína psca |
| EP1765846A4 (en) | 2004-07-13 | 2010-02-17 | Cell Genesys Inc | AAV VECTOR COMPOSITIONS AND ITS USE IN PROCESSES FOR INCREASING IMMUNOGLOBULIN EXPRESSION |
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| CA2598966A1 (en) | 2007-09-07 | 2009-03-07 | Institut Pasteur | Anti-chikungunya monoclonal antibodies and uses thereof |
| JP2009171880A (ja) | 2008-01-23 | 2009-08-06 | Yokohama City Univ | アルツハイマー病における次世代遺伝子治療法・免疫治療法の開発 |
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| BR112012000588A2 (pt) | 2009-07-13 | 2020-08-11 | Bharat Biotech International Limited | composição, composição líquida, composição liofilizada e método para produzir um rotavirus atenuado |
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| US8637035B2 (en) | 2010-07-16 | 2014-01-28 | Academia Sinica | Anti-dengue virus antibodies |
| MX346784B (es) | 2010-11-12 | 2017-03-31 | Inovio Pharmaceuticals Inc | Antigenos prostaticos de consenso, molecula de acido nucleico que los codifica y vacuna y usos que los comprenden. |
| EA033467B1 (ru) * | 2011-01-31 | 2019-10-31 | Univ Pennsylvania | Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение |
| WO2012106578A1 (en) | 2011-02-04 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc) |
| US8865881B2 (en) * | 2011-02-22 | 2014-10-21 | California Institute Of Technology | Delivery of proteins using adeno-associated virus (AAV) vectors |
| CN102199218A (zh) * | 2011-04-29 | 2011-09-28 | 中国人民解放军军事医学科学院基础医学研究所 | 一种抗Her2抗体-白细胞介素2融合蛋白及其用途 |
| WO2013177533A1 (en) | 2012-05-25 | 2013-11-28 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
| JP7078350B2 (ja) * | 2013-10-28 | 2022-05-31 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｄｎａ抗体構築物及びその使用方法 |
| PL2931304T3 (pl) | 2012-12-13 | 2021-11-08 | The Trustees Of The University Of Pennsylvania | Szczepionka wt1 |
| KR20230156146A (ko) | 2012-12-13 | 2023-11-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ｄｎａ 항체 작제물 및 그 이용 방법 |
| WO2015089492A2 (en) | 2013-12-13 | 2015-06-18 | The Trustees Of The University Of Pennsylvania | Dna antibody constructs and method of using same |
| US20140377269A1 (en) | 2012-12-19 | 2014-12-25 | Adimab, Llc | Multivalent antibody analogs, and methods of their preparation and use |
-
2013
- 2013-12-13 KR KR1020237036307A patent/KR20230156146A/ko not_active Ceased
- 2013-12-13 HK HK16101459.4A patent/HK1213481A1/zh unknown
- 2013-12-13 BR BR112015013700A patent/BR112015013700A8/pt not_active Application Discontinuation
- 2013-12-13 KR KR1020217020972A patent/KR20210088741A/ko not_active Ceased
- 2013-12-13 EA EA201591131A patent/EA201591131A1/ru unknown
- 2013-12-13 CN CN201380065674.3A patent/CN104853782A/zh active Pending
- 2013-12-13 KR KR1020157018712A patent/KR20150093834A/ko not_active Ceased
- 2013-12-13 US US14/651,740 patent/US9994629B2/en active Active
- 2013-12-13 AU AU2013358944A patent/AU2013358944B2/en active Active
- 2013-12-13 JP JP2015548014A patent/JP6898060B2/ja not_active Expired - Fee Related
- 2013-12-13 CA CA2889723A patent/CA2889723A1/en active Pending
- 2013-12-13 WO PCT/US2013/075137 patent/WO2014093894A2/en not_active Ceased
- 2013-12-13 MX MX2015007575A patent/MX2015007575A/es unknown
- 2013-12-13 EP EP13863143.7A patent/EP2931318A4/en active Pending
-
2014
- 2014-12-13 AU AU2014361811A patent/AU2014361811B2/en active Active
- 2014-12-13 MX MX2016007722A patent/MX388911B/es unknown
- 2014-12-13 MY MYPI2016702163A patent/MY175708A/en unknown
- 2014-12-13 KR KR1020167018560A patent/KR102454610B1/ko active Active
- 2014-12-13 BR BR112016013493-1A patent/BR112016013493B1/pt not_active IP Right Cessation
- 2014-12-13 SG SG10202002718RA patent/SG10202002718RA/en unknown
-
2015
- 2015-05-21 ZA ZA2015/03583A patent/ZA201503583B/en unknown
- 2015-06-12 MX MX2022016002A patent/MX2022016002A/es unknown
-
2016
- 2016-06-13 MX MX2021015971A patent/MX2021015971A/es unknown
- 2016-11-18 AU AU2016259451A patent/AU2016259451A1/en not_active Abandoned
-
2018
- 2018-04-30 AU AU2018202997A patent/AU2018202997A1/en not_active Abandoned
- 2018-06-12 US US16/005,997 patent/US20180346554A1/en not_active Abandoned
- 2018-09-26 US US16/142,457 patent/US11208470B2/en active Active
-
2019
- 2019-03-27 JP JP2019061531A patent/JP2019115355A/ja active Pending
- 2019-04-04 AU AU2019202343A patent/AU2019202343B2/en active Active
-
2020
- 2020-03-02 JP JP2020035240A patent/JP2020108381A/ja active Pending
- 2020-03-13 AU AU2020201853A patent/AU2020201853B2/en active Active
-
2021
- 2021-02-04 JP JP2021016537A patent/JP2021087433A/ja not_active Withdrawn
- 2021-06-03 AU AU2021203643A patent/AU2021203643A1/en not_active Abandoned
- 2021-12-17 US US17/554,642 patent/US20220112273A1/en not_active Abandoned
-
2023
- 2023-03-15 JP JP2023040876A patent/JP2023080085A/ja active Pending
- 2023-06-30 JP JP2023108341A patent/JP2023138998A/ja active Pending
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