JP2023058590A5 - - Google Patents
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- JP2023058590A5 JP2023058590A5 JP2023017271A JP2023017271A JP2023058590A5 JP 2023058590 A5 JP2023058590 A5 JP 2023058590A5 JP 2023017271 A JP2023017271 A JP 2023017271A JP 2023017271 A JP2023017271 A JP 2023017271A JP 2023058590 A5 JP2023058590 A5 JP 2023058590A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- poly
- heavy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 5
- 230000003247 decreasing effect Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010065687 Bone loss Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 101500025614 Homo sapiens Transforming growth factor beta-1 Proteins 0.000 claims 1
- 101500025624 Homo sapiens Transforming growth factor beta-2 Proteins 0.000 claims 1
- 101500026551 Homo sapiens Transforming growth factor beta-3 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 229920000805 Polyaspartic acid Polymers 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 230000037182 bone density Effects 0.000 claims 1
- 230000037118 bone strength Effects 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108010064470 polyaspartate Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024205967A JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762448763P | 2017-01-20 | 2017-01-20 | |
| US62/448,763 | 2017-01-20 | ||
| PCT/US2018/014350 WO2018136698A2 (en) | 2017-01-20 | 2018-01-19 | Bone-targeting antibodies |
| JP2019539277A JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539277A Division JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024205967A Division JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023058590A JP2023058590A (ja) | 2023-04-25 |
| JP2023058590A5 true JP2023058590A5 (enExample) | 2023-06-13 |
| JP7597836B2 JP7597836B2 (ja) | 2024-12-10 |
Family
ID=61581744
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539277A Active JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
| JP2023017271A Active JP7597836B2 (ja) | 2017-01-20 | 2023-02-08 | 骨標的抗体 |
| JP2024205967A Pending JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539277A Active JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024205967A Pending JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10844115B2 (enExample) |
| EP (1) | EP3571226A2 (enExample) |
| JP (3) | JP7227138B2 (enExample) |
| KR (3) | KR102755284B1 (enExample) |
| CN (2) | CN118121696A (enExample) |
| AR (1) | AR110755A1 (enExample) |
| AU (1) | AU2018210270A1 (enExample) |
| BR (1) | BR112019013986A2 (enExample) |
| CA (1) | CA3050884A1 (enExample) |
| IL (2) | IL317592A (enExample) |
| MX (2) | MX2019008549A (enExample) |
| MY (2) | MY194819A (enExample) |
| SG (1) | SG11201906663VA (enExample) |
| TW (3) | TW202421659A (enExample) |
| UY (1) | UY37576A (enExample) |
| WO (1) | WO2018136698A2 (enExample) |
| ZA (1) | ZA201907673B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017310344A1 (en) * | 2016-08-11 | 2019-03-07 | Precithera, Inc. | TGF-β antagonist conjugates |
| TWI787230B (zh) | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | 抗ＴＧＦ-β抗體及其用途 |
| TW202421659A (zh) | 2017-01-20 | 2024-06-01 | 美商健臻公司 | 骨靶向抗體 |
| WO2019232280A1 (en) | 2018-05-30 | 2019-12-05 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| AU2019301283B2 (en) * | 2018-07-10 | 2024-12-19 | Sanofi | Combination therapies against cancer targeting CD38 and TGF-beta |
| US20220010368A1 (en) * | 2018-11-19 | 2022-01-13 | Biocartis Nv | Enhanced detection of low-copy-number nucleic acids in an integrated workflow |
| CA3219219A1 (en) | 2021-05-07 | 2022-11-10 | Baylor College Of Medicine | Treatment of moderate-to-severe osteogenesis imperfecta |
| JP2024526920A (ja) * | 2021-07-20 | 2024-07-19 | ウィリアム マーシュ ライス ユニバーシティ | 骨標的療法のための操作された組成物 |
| TW202334209A (zh) * | 2021-11-01 | 2023-09-01 | 美商健臻公司 | 成骨不全症之治療 |
| CN115403657A (zh) * | 2022-06-23 | 2022-11-29 | 浙江大学 | 一种TGF-β3生长因子的亲和多肽及其应用 |
| WO2025184427A1 (en) * | 2024-02-27 | 2025-09-04 | Osteologic Therapeutics, Inc. | Bone-targeted antibodies and methods of use thereof |
| CN120535618B (zh) * | 2025-07-28 | 2025-09-23 | 成都大熊猫繁育研究基地 | 一种抗大熊猫cdv单克隆抗体、杂交瘤细胞株及用途 |
Family Cites Families (54)
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| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US4867973A (en) | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| BRPI9707379C8 (pt) | 1996-02-09 | 2017-12-12 | Abbott Biotech Ltd | composições farmacêuticas compreendendo anticorpo humano recombinante geneticamente engenheirado, e anticorpo humano recombinante geneticamente engenheirado. |
| WO1998035703A2 (en) | 1997-02-14 | 1998-08-20 | The Salk Institute For Biological Studies | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
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| NZ554885A (en) | 2002-12-31 | 2009-07-31 | Altus Pharmaceuticals Inc | Complexes of hgh crystals and protamine polymers |
| JP2006525362A (ja) | 2003-04-30 | 2006-11-09 | ジェンザイム コーポレーション | 腎機能不全を治療するためのＴＧＦ−βアンタゴニストとレニン−アンジオテンシン−アルドステロン系アンタゴニストとの併用 |
| EP1646655A2 (en) | 2003-07-09 | 2006-04-19 | Eli Lilly And Company | Tgf-beta1 ligands |
| WO2005097832A2 (en) | 2004-03-31 | 2005-10-20 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| ES2887039T3 (es) | 2004-04-21 | 2021-12-21 | Alexion Pharma Inc | Conjugados para administración ósea y procedimiento de uso de estos para dirigir proteínas al hueso |
| ES2711213T3 (es) | 2005-02-08 | 2019-04-30 | Genzyme Corp | Anticuerpos de TGFbeta |
| TW200714289A (en) * | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
| CA2632799A1 (en) * | 2005-12-23 | 2007-07-05 | Eli Lilly And Company | Tgf-beta binding compositions |
| CA2688275A1 (en) | 2007-05-31 | 2008-12-04 | Genmab A/S | Stable igg4 antibodies |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| CN115043946A (zh) * | 2008-01-03 | 2022-09-13 | 斯克里普斯研究院 | 通过模块识别结构域的抗体靶向 |
| RS54233B1 (sr) | 2008-08-25 | 2015-12-31 | Amplimmune Inc. | Kompozicije pd-1 antagonista i postupci za njihovu primenu |
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| PL2542590T5 (pl) | 2010-03-05 | 2020-08-10 | The Johns Hopkins University | Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych |
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-
2018
- 2018-01-18 TW TW113101673A patent/TW202421659A/zh unknown
- 2018-01-18 AR ARP180100119A patent/AR110755A1/es unknown
- 2018-01-18 TW TW107101790A patent/TWI788321B/zh active
- 2018-01-18 TW TW111146907A patent/TWI832600B/zh active
- 2018-01-19 CA CA3050884A patent/CA3050884A1/en active Pending
- 2018-01-19 WO PCT/US2018/014350 patent/WO2018136698A2/en not_active Ceased
- 2018-01-19 US US15/875,125 patent/US10844115B2/en active Active
- 2018-01-19 MY MYPI2019006821A patent/MY194819A/en unknown
- 2018-01-19 MX MX2019008549A patent/MX2019008549A/es unknown
- 2018-01-19 MY MYPI2022003998A patent/MY207919A/en unknown
- 2018-01-19 SG SG11201906663VA patent/SG11201906663VA/en unknown
- 2018-01-19 IL IL317592A patent/IL317592A/en unknown
- 2018-01-19 IL IL268114A patent/IL268114B2/en unknown
- 2018-01-19 UY UY0001037576A patent/UY37576A/es not_active Application Discontinuation
- 2018-01-19 CN CN202410319667.1A patent/CN118121696A/zh active Pending
- 2018-01-19 KR KR1020237042558A patent/KR102755284B1/ko active Active
- 2018-01-19 KR KR1020257000987A patent/KR20250012197A/ko active Pending
- 2018-01-19 JP JP2019539277A patent/JP7227138B2/ja active Active
- 2018-01-19 EP EP18709437.0A patent/EP3571226A2/en active Pending
- 2018-01-19 BR BR112019013986-9A patent/BR112019013986A2/pt not_active IP Right Cessation
- 2018-01-19 KR KR1020197024021A patent/KR102613463B1/ko active Active
- 2018-01-19 AU AU2018210270A patent/AU2018210270A1/en not_active Abandoned
- 2018-01-19 CN CN201880007783.2A patent/CN111032690B/zh active Active
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2019
- 2019-07-17 MX MX2022008073A patent/MX2022008073A/es unknown
- 2019-11-20 ZA ZA2019/07673A patent/ZA201907673B/en unknown
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2020
- 2020-10-23 US US17/079,285 patent/US12098194B2/en active Active
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2023
- 2023-02-08 JP JP2023017271A patent/JP7597836B2/ja active Active
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2024
- 2024-08-13 US US18/802,674 patent/US20250074975A1/en active Pending
- 2024-11-27 JP JP2024205967A patent/JP2025028981A/ja active Pending