MX2022008073A - Anticuerpos dirigidos a los huesos. - Google Patents
Anticuerpos dirigidos a los huesos.Info
- Publication number
- MX2022008073A MX2022008073A MX2022008073A MX2022008073A MX2022008073A MX 2022008073 A MX2022008073 A MX 2022008073A MX 2022008073 A MX2022008073 A MX 2022008073A MX 2022008073 A MX2022008073 A MX 2022008073A MX 2022008073 A MX2022008073 A MX 2022008073A
- Authority
- MX
- Mexico
- Prior art keywords
- bone
- antibodies
- targeting antibodies
- fragments
- poly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Se proporcionan anticuerpos recombinantes y conjugados químicamente y fragmentos de los mismos modificados con uno o más péptidos poli-aspartato (poli-D) (p. ej., una secuencia D10) para mejorar la localización de los anticuerpos o fragmentos en hueso. También se describen métodos de fabricación y uso de estos anticuerpos y fragmentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762448763P | 2017-01-20 | 2017-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022008073A true MX2022008073A (es) | 2022-07-27 |
Family
ID=61581744
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019008549A MX2019008549A (es) | 2017-01-20 | 2018-01-19 | Anticuerpos dirigidos a los huesos. |
MX2022008073A MX2022008073A (es) | 2017-01-20 | 2019-07-17 | Anticuerpos dirigidos a los huesos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019008549A MX2019008549A (es) | 2017-01-20 | 2018-01-19 | Anticuerpos dirigidos a los huesos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US10844115B2 (es) |
EP (1) | EP3571226A2 (es) |
JP (2) | JP7227138B2 (es) |
KR (2) | KR102613463B1 (es) |
CN (1) | CN111032690B (es) |
AR (1) | AR110755A1 (es) |
AU (1) | AU2018210270A1 (es) |
BR (1) | BR112019013986A2 (es) |
CA (1) | CA3050884A1 (es) |
IL (1) | IL268114A (es) |
MX (2) | MX2019008549A (es) |
MY (1) | MY194819A (es) |
SG (1) | SG11201906663VA (es) |
TW (1) | TWI788321B (es) |
UY (1) | UY37576A (es) |
WO (1) | WO2018136698A2 (es) |
ZA (1) | ZA201907673B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019533003A (ja) * | 2016-08-11 | 2019-11-14 | プレシセラ,インコーポレイテッド | TGF−βアンタゴニストコンジュゲート |
KR20240018471A (ko) | 2021-05-07 | 2024-02-13 | 베이롤 칼리지 오브 메드신 | 중등증 내지 중증 불완전 골형성증의 치료 |
WO2023004348A1 (en) * | 2021-07-20 | 2023-01-26 | William Marsh Rice University | Engineered compositions for bone-targeted therapy |
WO2023077131A1 (en) | 2021-11-01 | 2023-05-04 | Genzyme Corporation | Treatment of osteogenesis imperfecta |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4867973A (en) | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
AU690528B2 (en) | 1992-12-04 | 1998-04-30 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
HU228630B1 (en) | 1996-02-09 | 2013-04-29 | Abbott Biotech Ltd | Use of human anti bodies that bind human tnf-alpha and process for inhibiting of human tnf-alpha activity |
WO1998035703A2 (en) | 1997-02-14 | 1998-08-20 | The Salk Institute For Biological Studies | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
EP1074563A1 (en) * | 1999-08-02 | 2001-02-07 | F. Hoffmann-La Roche Ag | Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof |
US20030224501A1 (en) | 2000-03-17 | 2003-12-04 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
NZ571243A (en) | 2002-12-31 | 2010-04-30 | Altus Pharmaceuticals Inc | Complexes of protein crystals and ionic polymers comprising human growth hormone and protamine |
WO2004098637A1 (en) | 2003-04-30 | 2004-11-18 | Genzyme Corporation | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
EP1646655A2 (en) | 2003-07-09 | 2006-04-19 | Eli Lilly And Company | Tgf-beta1 ligands |
ZA200608130B (en) | 2004-03-31 | 2008-12-31 | Genentech Inc | Humanized anti-TGF-beta antibodies |
EP3404102B1 (en) | 2004-04-21 | 2021-08-11 | Alexion Pharmaceuticals, Inc. | Bone delivery conjugates and method of using same to target proteins to bone |
TR201901929T4 (tr) | 2005-02-08 | 2019-03-21 | Genzyme Corp | TGFBeta'ya antikorlar. |
TW200714289A (en) * | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
GEP20156390B (en) | 2008-01-03 | 2015-11-10 | Scripps Research Inst | Antibody targeting through a modular recognition domain |
US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
DK2350129T3 (en) | 2008-08-25 | 2015-08-31 | Amplimmune Inc | PREPARATIONS WITH PD-1 ANTAGONISTS AND PROCEDURES FOR USE THEREOF |
JP5714505B2 (ja) | 2008-12-22 | 2015-05-07 | ノヴォ ノルディスク アー/エス | 組織因子経路阻害因子に対する抗体 |
WO2010124276A2 (en) | 2009-04-24 | 2010-10-28 | Vanderbilt Universtiy | Anti-tgf-beta induction of bone cell function and bone growth |
PL2542590T5 (pl) | 2010-03-05 | 2020-08-10 | The Johns Hopkins University | Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych |
HUE037651T2 (hu) | 2011-04-20 | 2018-09-28 | Medimmune Llc | B7-Hl-et és PD-l-et kötõ ellenanyagok és más molekulák |
SG10201902706VA (en) | 2011-06-03 | 2019-04-29 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
CN108892726A (zh) | 2011-06-13 | 2018-11-27 | 艾比吉诺米克斯合作公司 | 抗psgl-1抗体及其用途 |
WO2013058833A1 (en) | 2011-10-19 | 2013-04-25 | Enobia Canada Limited Partnership | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
US10052366B2 (en) * | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
EP2855527B1 (en) | 2012-05-31 | 2018-08-01 | Innate Pharma | Tlr3 binding agents |
US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
AU2013331154B2 (en) | 2012-10-17 | 2018-02-01 | Cedars-Sinai Medical Center | Molecular signatures of ovarian cancer |
DK3312195T3 (da) * | 2013-03-20 | 2020-01-06 | Genzyme Corp | Fremgangsmåder til behandling af osteogenesis imperfecta |
LT2981822T (lt) | 2013-05-06 | 2020-12-28 | Scholar Rock, Inc. | Kompozicijos ir būdai, skirti augimo faktoriaus moduliacijai |
HUE049281T2 (hu) | 2013-09-13 | 2020-09-28 | Beigene Switzerland Gmbh | Anti-PD1 antitestek, valamint terapeutikumként és diagnosztikumként történõ alkalmazásuk |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
US20170216401A1 (en) | 2014-03-17 | 2017-08-03 | Piotr Jachimczak | Combination for use in a method of treating cancer |
CN107428825A (zh) | 2014-10-10 | 2017-12-01 | 创祐生技股份有限公司 | 治疗及/或预防肿瘤生长、侵袭及/或转移的方法 |
TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
EA201792273A1 (ru) | 2015-04-17 | 2018-04-30 | Бристол-Маерс Сквибб Компани | Композиции, содержащие комбинацию анти-pd-1 антитела и другого антитела |
WO2017011773A2 (en) | 2015-07-15 | 2017-01-19 | Modernatx, Inc. | Codon-optimized nucleic acids encoding antibodies |
CA2996996A1 (en) | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof |
JP2019533003A (ja) | 2016-08-11 | 2019-11-14 | プレシセラ,インコーポレイテッド | TGF−βアンタゴニストコンジュゲート |
-
2018
- 2018-01-18 TW TW107101790A patent/TWI788321B/zh active
- 2018-01-18 AR ARP180100119A patent/AR110755A1/es unknown
- 2018-01-19 MY MYPI2019006821A patent/MY194819A/en unknown
- 2018-01-19 CN CN201880007783.2A patent/CN111032690B/zh active Active
- 2018-01-19 BR BR112019013986-9A patent/BR112019013986A2/pt not_active IP Right Cessation
- 2018-01-19 KR KR1020197024021A patent/KR102613463B1/ko active IP Right Grant
- 2018-01-19 CA CA3050884A patent/CA3050884A1/en active Pending
- 2018-01-19 US US15/875,125 patent/US10844115B2/en active Active
- 2018-01-19 SG SG11201906663VA patent/SG11201906663VA/en unknown
- 2018-01-19 KR KR1020237042558A patent/KR20230172039A/ko not_active Application Discontinuation
- 2018-01-19 AU AU2018210270A patent/AU2018210270A1/en not_active Abandoned
- 2018-01-19 EP EP18709437.0A patent/EP3571226A2/en active Pending
- 2018-01-19 MX MX2019008549A patent/MX2019008549A/es unknown
- 2018-01-19 WO PCT/US2018/014350 patent/WO2018136698A2/en unknown
- 2018-01-19 UY UY0001037576A patent/UY37576A/es not_active Application Discontinuation
- 2018-01-19 JP JP2019539277A patent/JP7227138B2/ja active Active
-
2019
- 2019-07-16 IL IL268114A patent/IL268114A/en unknown
- 2019-07-17 MX MX2022008073A patent/MX2022008073A/es unknown
- 2019-11-20 ZA ZA2019/07673A patent/ZA201907673B/en unknown
-
2020
- 2020-10-23 US US17/079,285 patent/US20210163584A1/en active Pending
-
2023
- 2023-02-08 JP JP2023017271A patent/JP2023058590A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US10844115B2 (en) | 2020-11-24 |
AU2018210270A1 (en) | 2019-09-05 |
CA3050884A1 (en) | 2018-07-26 |
JP2023058590A (ja) | 2023-04-25 |
KR102613463B1 (ko) | 2023-12-15 |
BR112019013986A2 (pt) | 2020-03-03 |
TW202330597A (zh) | 2023-08-01 |
TWI788321B (zh) | 2023-01-01 |
AR110755A1 (es) | 2019-05-02 |
KR20230172039A (ko) | 2023-12-21 |
ZA201907673B (en) | 2021-05-26 |
RU2019126026A (ru) | 2021-02-20 |
WO2018136698A3 (en) | 2018-08-30 |
UY37576A (es) | 2018-10-31 |
WO2018136698A2 (en) | 2018-07-26 |
SG11201906663VA (en) | 2019-08-27 |
TW201839013A (zh) | 2018-11-01 |
US20210163584A1 (en) | 2021-06-03 |
RU2019126026A3 (es) | 2021-11-09 |
JP7227138B2 (ja) | 2023-02-21 |
JP2020505919A (ja) | 2020-02-27 |
IL268114A (en) | 2019-09-26 |
CN111032690A (zh) | 2020-04-17 |
KR20190105236A (ko) | 2019-09-16 |
US20180208650A1 (en) | 2018-07-26 |
EP3571226A2 (en) | 2019-11-27 |
CN111032690B (zh) | 2024-03-26 |
MY194819A (en) | 2022-12-17 |
MX2019008549A (es) | 2019-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022008073A (es) | Anticuerpos dirigidos a los huesos. | |
AU2019284081A1 (en) | Food compositions comprising recombinant milk proteins and methods of producing the same | |
MX2016017311A (es) | Composiciones de portador-anticuerpo y metodos para realizarlas y utilizarlas. | |
PH12018501281A1 (en) | Human immunodeficiency virus neutralizing antibodies | |
ZA201904725B (en) | Personalised immunogenic peptide identification platform | |
MX2022005291A (es) | Vacunas para el tratamiento y prevencion del cancer. | |
GEP20217326B (en) | Constructs having a sirp-alpha domain or variant thereof | |
MX2020004073A (es) | Procesos de siembra en serie y usos de los mismos. | |
MX2019007020A (es) | Anticuerpos il-11. | |
MX2018014456A (es) | Anticuerpos contra alfa-sinucleina y sus usos. | |
PH12017502207A1 (en) | Tau-binding antibodies | |
MX2016002937A (es) | Vacuna oncologica. | |
MX2021001460A (es) | Metodos y composiciones para secrecion de polipeptidos heterologos. | |
MX2019003970A (es) | Péptidos de arginasa inmunogénicos. | |
EP4219540A3 (en) | Ctla-4 variant immunomodulatory proteins and uses thereof | |
MY182046A (en) | Interferon alpha and omega antibody antagonists | |
MY194084A (en) | Interferon beta antibodies and uses thereof | |
MY195726A (en) | Steviol Glycoside Transport | |
SG11202001602QA (en) | Peptide conjugates, conjugation process, and uses thereof | |
MX2018000023A (es) | Particulas semejantes a virus recombinantes que utilizan la proteina gag del virus de inmunodeficiencia bovina. | |
PH12019502449A1 (en) | Anti-jagged1 antigen binding proteins | |
PH12018500468A1 (en) | Fusion protein | |
MX2021015766A (es) | Nuevos antigenos y metodos contra el cancer. | |
SG11201907914QA (en) | Polypeptide, polypeptide fragment, derivative thereof, and applications thereof | |
AU2017305946A8 (en) | C1q and HMGB1 fusion proteins and uses thereof |