JP2018512124A5 - - Google Patents
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- Publication number
- JP2018512124A5 JP2018512124A5 JP2017546179A JP2017546179A JP2018512124A5 JP 2018512124 A5 JP2018512124 A5 JP 2018512124A5 JP 2017546179 A JP2017546179 A JP 2017546179A JP 2017546179 A JP2017546179 A JP 2017546179A JP 2018512124 A5 JP2018512124 A5 JP 2018512124A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- independently
- linker
- amino acid
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128149P | 2015-03-04 | 2015-03-04 | |
| US62/128,149 | 2015-03-04 | ||
| PCT/US2016/020780 WO2016141245A1 (en) | 2015-03-04 | 2016-03-03 | Modified-igg antibodies that bind transforming growth factor-beta1 with high affinity, avidity and specificity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512124A JP2018512124A (ja) | 2018-05-17 |
| JP2018512124A5 true JP2018512124A5 (enExample) | 2019-03-28 |
| JP6745275B2 JP6745275B2 (ja) | 2020-08-26 |
Family
ID=55524479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546179A Active JP6745275B2 (ja) | 2015-03-04 | 2016-03-03 | トランスフォーミング増殖因子β１に高親和性、アビディティおよび特異性で結合する修飾ＩｇＧ抗体 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US11325970B2 (enExample) |
| EP (3) | EP3265487B1 (enExample) |
| JP (1) | JP6745275B2 (enExample) |
| KR (3) | KR20240076851A (enExample) |
| CN (1) | CN107787329B (enExample) |
| AR (1) | AR103840A1 (enExample) |
| AU (1) | AU2016226098B2 (enExample) |
| DK (1) | DK3265487T3 (enExample) |
| ES (2) | ES2994790T3 (enExample) |
| HR (1) | HRP20221142T1 (enExample) |
| HU (1) | HUE059644T2 (enExample) |
| IL (1) | IL254239B2 (enExample) |
| LT (1) | LT3265487T (enExample) |
| MX (1) | MX382703B (enExample) |
| PL (1) | PL3265487T3 (enExample) |
| PT (1) | PT3265487T (enExample) |
| RS (1) | RS63589B1 (enExample) |
| RU (1) | RU2728858C2 (enExample) |
| SG (2) | SG10201908019UA (enExample) |
| SI (1) | SI3265487T1 (enExample) |
| TW (1) | TWI733661B (enExample) |
| WO (1) | WO2016141245A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| PL3365368T3 (pl) | 2016-03-11 | 2023-08-21 | Scholar Rock, Inc. | Immunoglobuliny wiążące tgfbeta1 i ich zastosowanie |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| TWI788321B (zh) | 2017-01-20 | 2023-01-01 | 美商健臻公司 | 骨靶向抗體 |
| TWI787230B (zh) * | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | 抗ＴＧＦ-β抗體及其用途 |
| SG11202100087WA (en) * | 2018-05-10 | 2021-02-25 | Mirabiologics Inc | Artificial protein containing an antibody antigen-binding region, fused with bioactive peptides |
| US12252531B2 (en) | 2018-07-11 | 2025-03-18 | Scholar Rock, Inc. | Methods of screening for high-affinity, isoform-selective TGFβ1 inhibitors |
| US20250270325A1 (en) * | 2020-03-31 | 2025-08-28 | Medimmune, Llc | Stabilized igg4 antibodies and uses thereof |
| US20220119513A1 (en) * | 2020-06-08 | 2022-04-21 | Zoetis Services Llc | Anti-tgfb antibodies and therapeutic uses thereof |
| JP7798806B2 (ja) * | 2020-06-12 | 2026-01-14 | ブリストル－マイヤーズ・スクイブ・ティージーエフ・ベータ・インコーポレイテッド | 形質転換成長因子β（ＴＧＦβ）結合剤及びその使用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020099179A1 (en) | 1989-12-21 | 2002-07-25 | Linda K. Jolliffe | Cdr-grafted antibodies |
| US5616561A (en) | 1995-03-31 | 1997-04-01 | Regents Of The University Of California | TGF-β antagonists as mitigators of radiation-induced tissue damage |
| US6492497B1 (en) * | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| EP1486560A3 (en) | 1999-04-30 | 2005-02-09 | Cambridge Antibody Technology LTD | Specific antibodies and antibody fragments for TGFBETA1 |
| US20060286105A1 (en) | 2003-04-30 | 2006-12-21 | Steven Ledbetter | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
| CA2561686C (en) * | 2004-03-31 | 2014-12-02 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| EP1796715A2 (en) | 2004-09-22 | 2007-06-20 | Genzyme Corporation | USE OF TGF-ß ANTAGONISTS TO LIMIT NEPHROTOXICITY OF IMMUNOSUPPRESSIVE AGENTS |
| US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| CA2607448C (en) | 2005-04-22 | 2014-11-18 | Eli Lilly And Company | Tgf beta 1 specific antibodies |
| ES2379194T3 (es) | 2005-12-23 | 2012-04-23 | Eli Lilly And Company | Anticuerpos de unión a TGF-beta |
| CN103073639A (zh) | 2006-03-17 | 2013-05-01 | 比奥根艾迪克Ma公司 | 稳定的多肽组合物 |
| TW200808347A (en) | 2006-03-23 | 2008-02-16 | Kirin Brewery | Agonistic antibody directed against human thrombopoietin receptor |
| EP2918288B1 (en) | 2006-10-03 | 2017-08-16 | Genzyme Corporation | Use of TGF beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia |
| EA019512B1 (ru) | 2008-07-02 | 2014-04-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | Il-6-опосредованная иммунотерапия |
| US20120294868A1 (en) * | 2009-04-24 | 2012-11-22 | Edwards James R | Anti-tgf-beta induction of bone cell function and bone growth |
| EP2655624B1 (en) | 2010-12-23 | 2017-11-29 | Biogen MA Inc. | Linker peptides and polypeptides comprising same |
| TWI838039B (zh) * | 2011-03-28 | 2024-04-01 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| PH12013502489B1 (en) * | 2011-06-03 | 2019-04-24 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
| CA2878587A1 (en) | 2012-07-23 | 2014-01-30 | Zymeworks Inc. | Immunoglobulin constructs comprising selective pairing of the light and heavy chains |
| PL2971048T4 (pl) | 2013-03-11 | 2019-05-31 | Genzyme Corp | Zmodyfikowane przeciwciała anty-TGF-beta i fragmenty wiążące antygen |
| SI3312195T1 (sl) * | 2013-03-20 | 2020-02-28 | Genzyme Corporation | Postopki zdravljenja osteogeneze imperfecta |
| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
-
2016
- 2016-03-02 TW TW105106247A patent/TWI733661B/zh active
- 2016-03-03 SG SG10201908019U patent/SG10201908019UA/en unknown
- 2016-03-03 ES ES22180865T patent/ES2994790T3/es active Active
- 2016-03-03 JP JP2017546179A patent/JP6745275B2/ja active Active
- 2016-03-03 WO PCT/US2016/020780 patent/WO2016141245A1/en not_active Ceased
- 2016-03-03 SI SI201631598T patent/SI3265487T1/sl unknown
- 2016-03-03 CN CN201680025633.5A patent/CN107787329B/zh active Active
- 2016-03-03 SG SG11201707109XA patent/SG11201707109XA/en unknown
- 2016-03-03 EP EP16709666.8A patent/EP3265487B1/en active Active
- 2016-03-03 RU RU2017134043A patent/RU2728858C2/ru active
- 2016-03-03 PL PL16709666.8T patent/PL3265487T3/pl unknown
- 2016-03-03 EP EP22180865.2A patent/EP4163299B1/en active Active
- 2016-03-03 DK DK16709666.8T patent/DK3265487T3/da active
- 2016-03-03 ES ES16709666T patent/ES2927297T3/es active Active
- 2016-03-03 EP EP24203381.9A patent/EP4495137A3/en not_active Withdrawn
- 2016-03-03 KR KR1020247016764A patent/KR20240076851A/ko not_active Ceased
- 2016-03-03 US US15/555,500 patent/US11325970B2/en active Active
- 2016-03-03 LT LTEPPCT/US2016/020780T patent/LT3265487T/lt unknown
- 2016-03-03 AU AU2016226098A patent/AU2016226098B2/en active Active
- 2016-03-03 AR ARP160100560A patent/AR103840A1/es unknown
- 2016-03-03 HR HRP20221142TT patent/HRP20221142T1/hr unknown
- 2016-03-03 MX MX2017011252A patent/MX382703B/es unknown
- 2016-03-03 PT PT167096668T patent/PT3265487T/pt unknown
- 2016-03-03 HU HUE16709666A patent/HUE059644T2/hu unknown
- 2016-03-03 KR KR1020177027372A patent/KR102560072B1/ko active Active
- 2016-03-03 KR KR1020237024971A patent/KR102668864B1/ko active Active
- 2016-03-03 RS RS20220886A patent/RS63589B1/sr unknown
-
2017
- 2017-08-31 IL IL254239A patent/IL254239B2/en unknown
-
2022
- 2022-04-11 US US17/717,967 patent/US11834495B2/en active Active
-
2023
- 2023-10-23 US US18/492,150 patent/US12162933B2/en active Active
-
2024
- 2024-11-06 US US18/939,307 patent/US20250179163A1/en active Pending
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