ES2994790T3 - Modified-igg antibodies that bind transforming growth factor-beta1 with high affinity, avidity and specificity - Google Patents
Modified-igg antibodies that bind transforming growth factor-beta1 with high affinity, avidity and specificity Download PDFInfo
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- ES2994790T3 ES2994790T3 ES22180865T ES22180865T ES2994790T3 ES 2994790 T3 ES2994790 T3 ES 2994790T3 ES 22180865 T ES22180865 T ES 22180865T ES 22180865 T ES22180865 T ES 22180865T ES 2994790 T3 ES2994790 T3 ES 2994790T3
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- C07K—PEPTIDES
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- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K—PEPTIDES
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- C07K2317/522—CH1 domain
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- C07K—PEPTIDES
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
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- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Health & Medical Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| MX2018010948A (es) | 2016-03-11 | 2019-06-20 | Scholar Rock Inc | INMUNOGLOBULINAS DE ENLACE A TGFß1 Y USOS DE LAS MISMAS. |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| TWI787230B (zh) | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | 抗ＴＧＦ-β抗體及其用途 |
| TWI788321B (zh) | 2017-01-20 | 2023-01-01 | 美商健臻公司 | 骨靶向抗體 |
| JP7384415B2 (ja) * | 2018-05-10 | 2023-11-21 | ミラバイオロジクス株式会社 | 抗体の抗原結合領域を含み、生理活性ペプチドを融合する人工タンパク質 |
| MA53125A (fr) | 2018-07-11 | 2021-05-19 | Scholar Rock Inc | Inhibiteurs de tgf?1 sélectifs selon l'isoforme à affinité élevée |
| US20220119513A1 (en) * | 2020-06-08 | 2022-04-21 | Zoetis Services Llc | Anti-tgfb antibodies and therapeutic uses thereof |
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| US20020099179A1 (en) | 1989-12-21 | 2002-07-25 | Linda K. Jolliffe | Cdr-grafted antibodies |
| US5616561A (en) | 1995-03-31 | 1997-04-01 | Regents Of The University Of California | TGF-β antagonists as mitigators of radiation-induced tissue damage |
| EP1486560A3 (en) | 1999-04-30 | 2005-02-09 | Cambridge Antibody Technology LTD | Specific antibodies and antibody fragments for TGFBETA1 |
| US6492497B1 (en) * | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| JP2006525362A (ja) | 2003-04-30 | 2006-11-09 | ジェンザイム コーポレーション | 腎機能不全を治療するためのＴＧＦ−βアンタゴニストとレニン−アンジオテンシン−アルドステロン系アンタゴニストとの併用 |
| KR101245983B1 (ko) | 2004-03-31 | 2013-06-28 | 제넨테크, 인크. | 인간화 항-ｔｇｆ-베타 항체 |
| US7867496B2 (en) * | 2004-09-22 | 2011-01-11 | Genzyme Corporation | Use of TGF-β antagonists to limit nephrotoxicity of immunosuppressive agents |
| US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| EA016038B1 (ru) | 2005-04-22 | 2012-01-30 | Эли Лилли Энд Компани | Антитело к tgf-бета и его применение |
| CA2632799A1 (en) | 2005-12-23 | 2007-07-05 | Eli Lilly And Company | Tgf-beta binding compositions |
| KR101516823B1 (ko) | 2006-03-17 | 2015-05-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 안정화된 폴리펩티드 조성물 |
| CA2644663A1 (en) | 2006-03-23 | 2007-09-27 | Kirin Pharma Kabushiki Kaisha | Agonist antibody to human thrombopoietin receptor |
| CN104645328A (zh) | 2006-10-03 | 2015-05-27 | 建新公司 | TGF-β拮抗物治疗具有罹患支气管肺发育不良风险的婴儿的用途 |
| EP2313109A2 (en) | 2008-07-02 | 2011-04-27 | Emergent Product Development Seattle, LLC | Il6 immunotherapeutics |
| US20120294868A1 (en) * | 2009-04-24 | 2012-11-22 | Edwards James R | Anti-tgf-beta induction of bone cell function and bone growth |
| EP2655624B1 (en) | 2010-12-23 | 2017-11-29 | Biogen MA Inc. | Linker peptides and polypeptides comprising same |
| TWI743461B (zh) | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| HRP20211582T1 (hr) * | 2011-06-03 | 2022-01-07 | Xoma Technology Ltd. | Protutijela specifična za tgf-beta |
| CN104640561A (zh) | 2012-07-23 | 2015-05-20 | 酵活有限公司 | 包含轻链和重链的选择性配对的免疫球蛋白构建体 |
| TWI664979B (zh) | 2013-03-11 | 2019-07-11 | 健臻公司 | 經生物工程之抗-ＴＧＦ-β抗體及抗原結合片段 |
| KR102257138B1 (ko) * | 2013-03-20 | 2021-05-26 | 젠자임 코포레이션 | 불완전 골형성증의 치료 방법 |
| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
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2016
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