CN104853782A - Dna抗体构建体及其使用方法 - Google Patents

Dna抗体构建体及其使用方法 Download PDF

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Publication number
CN104853782A
CN104853782A CN201380065674.3A CN201380065674A CN104853782A CN 104853782 A CN104853782 A CN 104853782A CN 201380065674 A CN201380065674 A CN 201380065674A CN 104853782 A CN104853782 A CN 104853782A
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Prior art keywords
acid sequence
nucleic acid
recombinant nucleic
env
subject
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Pending
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CN201380065674.3A
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Chinese (zh)
Inventor
大卫·B·韦纳
卡鲁皮亚·穆苏马尼
尼兰詹·萨尔德赛
塞利克·夫林盖
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University of Pennsylvania Penn
Inovio Pharmaceuticals Inc
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University of Pennsylvania Penn
Inovio Pharmaceuticals Inc
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Publication of CN104853782A publication Critical patent/CN104853782A/zh
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    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
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    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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CN201380065674.3A 2012-12-13 2013-12-13 Dna抗体构建体及其使用方法 Pending CN104853782A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261737094P 2012-12-13 2012-12-13
US61/737,094 2012-12-13
US201361881376P 2013-09-23 2013-09-23
US61/881,376 2013-09-23
US201361896646P 2013-10-28 2013-10-28
US61/896,646 2013-10-28
PCT/US2013/075137 WO2014093894A2 (en) 2012-12-13 2013-12-13 Dna antibody constructs and method of using same

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CN104853782A true CN104853782A (zh) 2015-08-19

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EP (1) EP2931318A4 (enExample)
JP (6) JP6898060B2 (enExample)
KR (4) KR20150093834A (enExample)
CN (1) CN104853782A (enExample)
AU (7) AU2013358944B2 (enExample)
BR (2) BR112015013700A8 (enExample)
CA (1) CA2889723A1 (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427566A (zh) * 2014-12-01 2017-12-01 宾夕法尼亚大学理事会 Dna抗体构建体及其使用方法
CN109789224A (zh) * 2016-05-05 2019-05-21 宾夕法尼亚大学理事会 靶向il-6和cd126的dna单克隆抗体
CN109890407A (zh) * 2016-03-21 2019-06-14 大卫·B·韦纳 Dna抗体构建体和其使用方法
CN110167584A (zh) * 2016-11-07 2019-08-23 威斯塔解剖学和生物学研究所 用于针对莱姆病的dna抗体构建体
CN110325546A (zh) * 2016-05-05 2019-10-11 宾夕法尼亚大学理事会 靶向流感病毒的dna单克隆抗体

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2931318A4 (en) * 2012-12-13 2016-07-20 Univ Pennsylvania DNA ANTIBODY CONSTRUCTS AND METHODS FOR USE THEREOF
SG11201604719WA (en) 2013-12-13 2016-07-28 Univ Pennsylvania Dna antibody constructs and method of using same
KR102586707B1 (ko) * 2014-10-01 2023-10-11 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신
ES2894304T3 (es) 2015-10-25 2022-02-14 Sanofi Sa Proteínas de unión triespecíficas y/o trivalentes para la prevención o tratamiento de infección por VIH
US20180363000A1 (en) * 2015-12-14 2018-12-20 The Trustees Of The University Of Pennsylvania Aav-anti pcsk9 antibody constructs and uses thereof
EP4257193A3 (en) 2016-04-13 2024-01-24 Sanofi Trispecific and/or trivalent binding proteins
KR20190025826A (ko) * 2016-05-05 2019-03-12 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 슈도모나스 에루지노사에 대해 사용하기 위한 dna 항체 작제물
CN120400172A (zh) * 2016-05-05 2025-08-01 宾夕法尼亚大学理事会 靶向检查点分子的dna单克隆抗体
EP3515482A4 (en) * 2016-09-19 2020-09-30 The Wistar Institute Of Anatomy And Biology ASSOCIATION OF NEW ZIKA VIRUS VACCINES AND ANTI-DNA ANTIBODY CONSTRUCTIONS FOR USE AGAINST ZIKA VIRUS
TWI778985B (zh) 2016-10-20 2022-10-01 法商賽諾菲公司 抗chikv抗體及其用途
US11370830B2 (en) 2017-04-07 2022-06-28 The Rockefeller University Neutralizing antibodies that bind to the zika virus domain III envelope region
CN111032077A (zh) * 2017-05-22 2020-04-17 叶才明 抗-登革热病毒抗体、包含该抗体的药学组合物及其用途
US11230592B2 (en) 2017-09-27 2022-01-25 The Wistar Institute Of Anatomy And Biology DNA antibody constructs for use against middle east respiratory syndrome coronavirus
WO2019152602A1 (en) * 2018-01-31 2019-08-08 The Wistar Institute Of Anatomy And Biology Structurally modified flavivirus dmabs
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof
AU2020323601A1 (en) * 2019-07-31 2022-03-03 The Wistar Institute Of Anatomy And Biology Multivalent DNA antibody constructs and use thereof
CN115066255A (zh) 2019-09-18 2022-09-16 星际治疗有限公司 合成的dna载体和使用方法
SE544001C2 (en) * 2020-03-17 2021-10-26 Xbrane Biopharma Ab Novel combination of tis sequences, signal peptide sequences and nucleic acid sequences encoding heavy and light chains of an antibody
SE544000C2 (en) * 2020-03-17 2021-10-26 Xbrane Biopharma Ab Novel combination of tis sequence, signal peptide sequence and nucleic acid sequence encoding a recombinant protein
WO2021188906A1 (en) * 2020-03-19 2021-09-23 Nature's Toolbox, Inc. Novel mrna-based covid-19 multi-valent vaccine and methods of scaled production of the same
PE20230349A1 (es) * 2020-05-14 2023-03-02 Inovio Pharmaceuticals Inc Vacunas para la papilomatosis respiratoria recurrente y metodos para usar estas
EP4255484A4 (en) * 2020-12-02 2025-02-26 Thomas Jefferson University DESMOGLEIN-2-TARGETED CHIMERIC ANTIGEN RECEPTOR CONSTRUCTS AND METHODS OF USE

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1334343A (zh) * 2000-07-14 2002-02-06 中国医学科学院肿瘤医院肿瘤研究所 抑制肿瘤生长的新抗体、其衍生物及其应用
CN101084015A (zh) * 2004-10-20 2007-12-05 健泰科生物技术公司 组氨酸－醋酸盐缓冲液中的抗体制剂
CN102199218A (zh) * 2011-04-29 2011-09-28 中国人民解放军军事医学科学院基础医学研究所 一种抗Her2抗体-白细胞介素2融合蛋白及其用途
CN102344493A (zh) * 2004-05-28 2012-02-08 艾更斯司股份有限公司 结合于psca蛋白的用于癌症诊断的抗体
CN102470171A (zh) * 2009-07-06 2012-05-23 弗·哈夫曼-拉罗切有限公司 双特异性抗体和与治疗或诊断剂缀合的地高辛配基的复合物
US20120282264A1 (en) * 2009-09-25 2012-11-08 The Gov of the USA as Represented by the Secretary Dept.of Health and Human Services&University of W Neutralizing antibodies to hiv-1 and their use

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI46572C (fi) * 1972-04-07 1973-04-10 Stroemberg Oy Ab Jännitemuuntaja.
US7276488B2 (en) 1997-06-04 2007-10-02 Oxford Biomedica (Uk) Limited Vector system
US20030039635A1 (en) 1998-09-30 2003-02-27 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20070037165A1 (en) 2000-09-08 2007-02-15 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
AU2003253447A1 (en) * 2002-08-02 2004-02-23 Yuhan Corporation Expression vectors
WO2005017149A1 (en) * 2003-06-03 2005-02-24 Cell Genesys, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
CN1480215A (zh) 2003-07-07 2004-03-10 叶新新 Sars病毒抗原抗体复合疫苗及实验动物模型与方法
PL1753871T3 (pl) 2004-05-28 2016-01-29 Agensys Inc Przeciwciała i powiązane cząsteczki, które wiążą się z antygenem komórek macierzystych prostaty (PSCA)
JP2008506389A (ja) 2004-07-13 2008-03-06 セル ジェネシス インコーポレイテッド Ａａｖベクター組成物および免疫グロブリンの発現の増強のための方法ならびにその使用方法
RS53594B1 (sr) 2004-07-22 2015-02-27 Genentech, Inc. Preparat her2 antitela
EP1851251A2 (en) 2005-02-18 2007-11-07 Medarex, Inc. Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues
US20060216722A1 (en) 2005-03-25 2006-09-28 Christer Betsholtz Glomerular expression profiling
KR20080031024A (ko) 2005-07-21 2008-04-07 아보트 러보러터리즈 폴리단백질, 프로단백질 및 단백질분해를 사용한 ｓＯＲＦ작제물 포함 다중 유전자 발현 및 방법
US8865875B2 (en) 2007-08-22 2014-10-21 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
CA2598966A1 (en) 2007-09-07 2009-03-07 Institut Pasteur Anti-chikungunya monoclonal antibodies and uses thereof
JP2009171880A (ja) 2008-01-23 2009-08-06 Yokohama City Univ アルツハイマー病における次世代遺伝子治療法・免疫治療法の開発
JP5805393B2 (ja) 2008-03-14 2015-11-04 トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． Ｃｓｆ−１ｒに対する抗体
KR101589511B1 (ko) 2008-04-04 2016-02-01 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 치쿤구니야 바이러스 단백질의 공통 서열, 이를 인코딩하는 핵산 분자, 조성물 및 이를 이용하는 방법
WO2010043977A2 (en) 2008-10-13 2010-04-22 Institute For Research In Biomedicine Dengue virus neutralizing antibodies and uses thereof
MY162326A (en) 2009-07-13 2017-05-31 Bharat Biotech Int Ltd A composition useful as rotavirus vaccine and a method therefor
US20110045534A1 (en) 2009-08-20 2011-02-24 Cell Signaling Technology, Inc. Nucleic Acid Cassette For Producing Recombinant Antibodies
JP2013508287A (ja) * 2009-10-14 2013-03-07 ヤンセン バイオテツク，インコーポレーテツド 抗体を親和性成熟する方法
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
US20130150563A1 (en) * 2010-07-09 2013-06-13 Jv Bio Srl Lipid-conjugated antibodies
BR112012031638B1 (pt) 2010-07-09 2021-01-12 Janssen Vaccines & Prevention B.V. anticorpo anti-rsv ou fragmento de ligação de antígeno do mesmo, anticorpo multivalente, composição farmacêutica, uso de anticorpo ou fragmento de ligação de antígeno, método de detectar infecção por rsv, e, ácido nucleico isolado
US8637035B2 (en) 2010-07-16 2014-01-28 Academia Sinica Anti-dengue virus antibodies
WO2012065164A2 (en) * 2010-11-12 2012-05-18 The Trustees Of The University Of Pennsylvania Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same
EA033467B1 (ru) 2011-01-31 2019-10-31 Univ Pennsylvania Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение
WO2012106578A1 (en) 2011-02-04 2012-08-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc)
WO2012115980A1 (en) 2011-02-22 2012-08-30 California Institute Of Technology Delivery of proteins using adeno-associated virus (aav) vectors
US9540657B2 (en) 2012-05-25 2017-01-10 California Institute Of Technology Expression of secreted and cell-surface polypeptides
EP2931318A4 (en) 2012-12-13 2016-07-20 Univ Pennsylvania DNA ANTIBODY CONSTRUCTS AND METHODS FOR USE THEREOF
JP7078350B2 (ja) * 2013-10-28 2022-05-31 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｄｎａ抗体構築物及びその使用方法
MX364732B (es) 2012-12-13 2019-05-06 Univ Pennsylvania Vacuna contra el tumor de wilms 1.
US20140377269A1 (en) 2012-12-19 2014-12-25 Adimab, Llc Multivalent antibody analogs, and methods of their preparation and use
SG11201604719WA (en) 2013-12-13 2016-07-28 Univ Pennsylvania Dna antibody constructs and method of using same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1334343A (zh) * 2000-07-14 2002-02-06 中国医学科学院肿瘤医院肿瘤研究所 抑制肿瘤生长的新抗体、其衍生物及其应用
CN102344493A (zh) * 2004-05-28 2012-02-08 艾更斯司股份有限公司 结合于psca蛋白的用于癌症诊断的抗体
CN101084015A (zh) * 2004-10-20 2007-12-05 健泰科生物技术公司 组氨酸－醋酸盐缓冲液中的抗体制剂
CN102470171A (zh) * 2009-07-06 2012-05-23 弗·哈夫曼-拉罗切有限公司 双特异性抗体和与治疗或诊断剂缀合的地高辛配基的复合物
US20120282264A1 (en) * 2009-09-25 2012-11-08 The Gov of the USA as Represented by the Secretary Dept.of Health and Human Services&University of W Neutralizing antibodies to hiv-1 and their use
CN102199218A (zh) * 2011-04-29 2011-09-28 中国人民解放军军事医学科学院基础医学研究所 一种抗Her2抗体-白细胞介素2融合蛋白及其用途

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JAY W.ELLISON等: "The nncleotide sequence of a human immunoglobulin Cr1 gene", 《NUCLEIC ACIDS RESEARCH》 *
JIANMIN FANG等: "An Antibody Delivery System for Regulated Expression of Therapeutic Levels of Monoclonal Antibodies In Vivo", 《MOLECULAR THERAPY》 *
JOHN LUND等: "Expression and characterization of truncated forms of humanized L243 IgG1", 《EUR. J. BIOCHEM.》 *
KYUNG-JIN KIM等: "Two-promoter vector is highly efficient for overproduction of protein complexes", 《PROTEIN SCIENCE》 *
WEI CAO等: "Oligomerization is required for the activity of recombinantsoluble LOX-1", 《FEBS JOURNAL》 *
胡迪超等: "人鼠嵌合抗体的基因构建", 《中国生物制品学杂志》 *

Cited By (9)

* Cited by examiner, † Cited by third party
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CN110167584B (zh) * 2016-11-07 2024-06-07 威斯塔解剖学和生物学研究所 用于针对莱姆病的dna抗体构建体

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