BR112015013700A2 - composição, sequência nucleotídica, anticorpo sintético, e, uso da composição - Google Patents

composição, sequência nucleotídica, anticorpo sintético, e, uso da composição

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Publication number
BR112015013700A2
BR112015013700A2 BR112015013700A BR112015013700A BR112015013700A2 BR 112015013700 A2 BR112015013700 A2 BR 112015013700A2 BR 112015013700 A BR112015013700 A BR 112015013700A BR 112015013700 A BR112015013700 A BR 112015013700A BR 112015013700 A2 BR112015013700 A2 BR 112015013700A2
Authority
BR
Brazil
Prior art keywords
composition
synthetic antibody
subject
nucleotide sequence
antibody
Prior art date
Application number
BR112015013700A
Other languages
English (en)
Other versions
BR112015013700A8 (pt
Inventor
B Weiner David
Muthumani Karuppiah
Sardesai Niranjan
Flingai Seleeke
Original Assignee
The Trustees Of The Univ Of Pennsylvania E Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The Univ Of Pennsylvania E Inovio Pharmaceuticals Inc filed Critical The Trustees Of The Univ Of Pennsylvania E Inovio Pharmaceuticals Inc
Publication of BR112015013700A2 publication Critical patent/BR112015013700A2/pt
Publication of BR112015013700A8 publication Critical patent/BR112015013700A8/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
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    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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Abstract

1 / 1 resumo “mã‰todos para gerar um anticorpo sintã‰tico, para prevenir ou tratar uma doenã‡a, e para tratar um sujeito de infecã‡ãƒo por um patã“geno” ㉠divulgado neste documento uma composiã§ã£o incluindo uma sequãªncia de ã¡cido nucleico recombinante que codifica um anticorpo. tambã©m ã© divulgado neste documento um mã©todo para gerar um anticorpo sintã©tico em um sujeito ao se administrar a composiã§ã£o ao sujeito. a divulgaã§ã£o tambã©m prov㪠um mã©todo para prevenir e/ou tratar a doenã§a em um sujeito usando dita composiã§ã£o e mã©todo de geraã§ã£o.
BR112015013700A 2012-12-13 2013-12-13 composição, sequência nucleotídica, anticorpo sintético, e, uso da composição BR112015013700A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261737094P 2012-12-13 2012-12-13
US201361881376P 2013-09-23 2013-09-23
US201361896646P 2013-10-28 2013-10-28
PCT/US2013/075137 WO2014093894A2 (en) 2012-12-13 2013-12-13 Dna antibody constructs and method of using same

Publications (2)

Publication Number Publication Date
BR112015013700A2 true BR112015013700A2 (pt) 2017-11-14
BR112015013700A8 BR112015013700A8 (pt) 2020-02-18

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015013700A BR112015013700A8 (pt) 2012-12-13 2013-12-13 composição, sequência nucleotídica, anticorpo sintético, e, uso da composição
BR112016013493-1A BR112016013493B1 (pt) 2012-12-13 2014-12-13 Molécula de ácido nucleico, composição, e, uso da molécula de ácido nucleico

Family Applications After (1)

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BR112016013493-1A BR112016013493B1 (pt) 2012-12-13 2014-12-13 Molécula de ácido nucleico, composição, e, uso da molécula de ácido nucleico

Country Status (15)

Country Link
US (4) US9994629B2 (pt)
EP (1) EP2931318A4 (pt)
JP (6) JP6898060B2 (pt)
KR (4) KR20230156146A (pt)
CN (1) CN104853782A (pt)
AU (7) AU2013358944B2 (pt)
BR (2) BR112015013700A8 (pt)
CA (1) CA2889723A1 (pt)
EA (1) EA201591131A1 (pt)
HK (1) HK1213481A1 (pt)
MX (4) MX2015007575A (pt)
MY (1) MY175708A (pt)
SG (1) SG10202002718RA (pt)
WO (1) WO2014093894A2 (pt)
ZA (1) ZA201503583B (pt)

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CN104853782A (zh) * 2012-12-13 2015-08-19 宾夕法尼亚大学理事会 Dna抗体构建体及其使用方法
JP7078350B2 (ja) 2013-10-28 2022-05-31 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｄｎａ抗体構築物及びその使用方法
CN105829341A (zh) 2013-12-13 2016-08-03 宾夕法尼亚大学理事会 Dna抗体构建体及其使用方法
CA2962799A1 (en) * 2014-10-01 2016-04-07 The Trustees Of The University Of Pennsylvania Vaccines having an antigen and interleukin-21 as an adjuvant
KR20170085131A (ko) * 2014-12-01 2017-07-21 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Dna 항체 작제물 및 그 이용 방법
CN116675776A (zh) 2015-10-25 2023-09-01 赛诺菲 用于预防或治疗hiv感染的三特异性和/或三价结合蛋白
WO2017106326A1 (en) * 2015-12-14 2017-06-22 The Trustees Of The University Of Pennsylvania Aav-anti pcsk9 antibody constructs and uses thereof
MX2018011425A (es) * 2016-03-21 2019-09-04 B Weiner David Construcciones de anticuerpos de adn y método para utilizarlas.
HUE063824T2 (hu) 2016-04-13 2024-02-28 Sanofi Sa Trispecifikus és/vagy trivalens kötõfehérjék
KR20230058733A (ko) * 2016-05-05 2023-05-03 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Il-6 및 cd126을 표적으로하는 dna 단일 클론 항체
US11896654B2 (en) * 2016-05-05 2024-02-13 The Trustees Of The University Of Pennsylvania DNA monoclonal antibodies targeting checkpoint molecules
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