JP2017528158A5 - - Google Patents

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JP2017528158A5
JP2017528158A5 JP2017524110A JP2017524110A JP2017528158A5 JP 2017528158 A5 JP2017528158 A5 JP 2017528158A5 JP 2017524110 A JP2017524110 A JP 2017524110A JP 2017524110 A JP2017524110 A JP 2017524110A JP 2017528158 A5 JP2017528158 A5 JP 2017528158A5
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JP
Japan
Prior art keywords
seq
lentiviral vector
vector
antigen receptor
chimeric antigen
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JP2017524110A
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English (en)
Japanese (ja)
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JP6940406B2 (ja
JP2017528158A (ja
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Priority claimed from PCT/EP2015/067090 external-priority patent/WO2016012623A1/en
Publication of JP2017528158A publication Critical patent/JP2017528158A/ja
Publication of JP2017528158A5 publication Critical patent/JP2017528158A5/ja
Priority to JP2020156063A priority Critical patent/JP7341110B2/ja
Application granted granted Critical
Publication of JP6940406B2 publication Critical patent/JP6940406B2/ja
Expired - Fee Related legal-status Critical Current
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JP2017524110A 2014-07-25 2015-07-24 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター Expired - Fee Related JP6940406B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020156063A JP7341110B2 (ja) 2014-07-25 2020-09-17 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462028889P 2014-07-25 2014-07-25
US62/028,889 2014-07-25
US201562155811P 2015-05-01 2015-05-01
US62/155,811 2015-05-01
EP15306036 2015-06-29
EP15306036.3 2015-06-29
PCT/EP2015/067090 WO2016012623A1 (en) 2014-07-25 2015-07-24 Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule

Related Child Applications (1)

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JP2020156063A Division JP7341110B2 (ja) 2014-07-25 2020-09-17 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター

Publications (3)

Publication Number Publication Date
JP2017528158A JP2017528158A (ja) 2017-09-28
JP2017528158A5 true JP2017528158A5 (enExample) 2018-08-30
JP6940406B2 JP6940406B2 (ja) 2021-09-29

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ID=53514131

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Application Number Title Priority Date Filing Date
JP2017524110A Expired - Fee Related JP6940406B2 (ja) 2014-07-25 2015-07-24 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター
JP2020156063A Active JP7341110B2 (ja) 2014-07-25 2020-09-17 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター
JP2023078059A Withdrawn JP2023113656A (ja) 2014-07-25 2023-05-10 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター

Family Applications After (2)

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JP2020156063A Active JP7341110B2 (ja) 2014-07-25 2020-09-17 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター
JP2023078059A Withdrawn JP2023113656A (ja) 2014-07-25 2023-05-10 キメラ抗原レセプター分子の制御的発現のためのレンチウイルスベクター

Country Status (6)

Country Link
US (2) US10752668B2 (enExample)
EP (2) EP3172228B1 (enExample)
JP (3) JP6940406B2 (enExample)
CN (2) CN113846062B (enExample)
CA (1) CA2956385A1 (enExample)
WO (1) WO2016012623A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013124474A2 (en) 2012-02-23 2013-08-29 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
EP3365453A2 (en) * 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
WO2017180587A2 (en) * 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
CN108276493B (zh) * 2016-12-30 2023-11-14 南京传奇生物科技有限公司 一种嵌合抗原受体及其应用
EP4647493A3 (en) 2017-04-27 2026-01-14 Juno Therapeutics, Inc. Oligomeric particle reagents and methods of use thereof
WO2018204352A1 (en) 2017-05-01 2018-11-08 The Trustees Of The University Of Pennsylvania Monoclonal antibodies against alpha-synuclein fibrils
US20200283485A1 (en) 2017-10-20 2020-09-10 Institut Curie Hook fusion protein for regulating the cellular trafficking of a target protein
US20200331975A1 (en) 2017-10-20 2020-10-22 Institut Curie Dap10/12 based cars adapted for rush
EP3704156A1 (en) 2017-11-03 2020-09-09 Sorrento Therapeutics, Inc. Cd38-directed chimeric antigen receptor constructs
WO2019145796A2 (en) 2018-01-17 2019-08-01 Aratinga Bio Tnp Polymer-encapsulated viral vectors for genetic therapy
EP3549597A1 (en) * 2018-04-06 2019-10-09 Heinrich-Heine-Universität Düsseldorf Synthetic signalling constructs and its use
AU2019253562B2 (en) * 2018-04-09 2025-11-27 The Trustees Of The University Of Pennsylvania Methods and compositions comprising a viral vector for expression of a transgene and an effector
WO2019200056A2 (en) * 2018-04-12 2019-10-17 Vivo-Til Therapeutics Inc. Viral vectors and packaging cell lines
CA3108657A1 (en) 2018-08-09 2020-02-13 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
US12522660B2 (en) 2018-10-31 2026-01-13 C3S2 Gmbh Methods for selection and stimulation of cells and apparatus for same
WO2021009263A1 (en) 2019-07-16 2021-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity for cd38 and uses thereof
EP4028413A1 (en) 2019-09-10 2022-07-20 Obsidian Therapeutics, Inc. Ca2-il15 fusion proteins for tunable regulation
GB201914611D0 (en) * 2019-10-09 2019-11-20 Autolus Ltd Engineered immune cell
US20230085724A1 (en) 2020-03-05 2023-03-23 Neotx Therapeutics Ltd. Methods and compositions for treating cancer with immune cells
WO2022051240A1 (en) * 2020-09-01 2022-03-10 The Trustees Of The University Of Pennsylvania Improved generation of lentiviral vectors for t cell transduction using cocal envelope
WO2022101482A1 (en) 2020-11-13 2022-05-19 Honing Biosciences Means and methods for regulating intracellular trafficking of secretory or cell membrane-anchored proteins of interest
AU2022267891A1 (en) * 2021-04-27 2023-11-09 Novartis Ag Viral vector production system
IT202100011576A1 (it) * 2021-05-06 2022-11-06 Univ Degli Studi Padova Nuova sequenza promotore per terapia genica
EP4433081A1 (en) 2021-11-15 2024-09-25 Theravectys Lentiviral vectors for expression of human papillomavirus (hpv) antigens and its implementation in the treatment of hpv induced cancers
WO2023230471A2 (en) * 2022-05-23 2023-11-30 The General Hospital Corporation Methods and compositions for immune cell crispr screens
AU2023316754A1 (en) 2022-07-27 2025-02-13 Institut Pasteur Lentiviral vectors for expression of human papillomavirus (hpv) antigens and its implementation in the treatment of hpv induced cancers
US20250025165A1 (en) 2023-07-21 2025-01-23 Cilag Gmbh International Systems and subsystems for articulating a surgical instrument
EP4624494A1 (en) 2024-03-29 2025-10-01 Institut Curie Her2 single domain antibody and uses thereof
WO2026020171A2 (en) 2024-07-19 2026-01-22 Aera Therapeutics, Inc. Chimeric antigen receptor constructs

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4411993A (en) 1981-04-29 1983-10-25 Steven Gillis Hybridoma antibody which inhibits interleukin 2 activity
USRE32011E (en) 1981-12-14 1985-10-22 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4543439A (en) 1982-12-13 1985-09-24 Massachusetts Institute Of Technology Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4902614A (en) 1984-12-03 1990-02-20 Teijin Limited Monoclonal antibody to human protein C
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
JPS63501765A (ja) 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング　インコ−ポレ−テッド 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP1541682A3 (en) 1988-09-02 2005-07-06 Dyax Corp. Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ　アンティボディー　テクノロジー　リミティド 特異的な結合ペアーの構成員の製造方法
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
DE69233769D1 (de) 1991-03-01 2009-09-24 Dyax Corp Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
DE4135543A1 (de) 1991-10-28 1993-04-29 Boehringer Mannheim Gmbh Rekombinantes core-streptavidin
KR20010083890A (ko) * 1998-10-05 2001-09-03 에드워드 에이. 맥더모트, 주니어 암 관련 항원 및 그의 용도
DE69941703D1 (de) 1999-10-11 2010-01-07 Pasteur Institut Lentivirale Vektoren für die Herstellung von immunotherapeutischen Zusammensetzungen
US6841359B2 (en) * 2000-10-31 2005-01-11 The General Hospital Corporation Streptavidin-binding peptides and uses thereof
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
JP2005507236A (ja) * 2001-04-03 2005-03-17 キュラジェン コーポレイション 抗原性ポリペプチドに結合する新規抗体、抗原をコードする核酸、および使用方法
WO2003076669A1 (es) * 2002-03-08 2003-09-18 Cueros Industrializados Del Bajio Proceso para la incorporación de particulas termoestables a cuero o piel
US20050032173A1 (en) 2003-08-05 2005-02-10 Mauricio Rojas Fusion proteins with a membrane translocating sequence and methods of using same to inhibit an immune response
US20130266551A1 (en) * 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
WO2006084388A1 (en) * 2005-02-11 2006-08-17 Uti Limited Partnership Monomeric streptavidin muteins
JP2009529917A (ja) * 2006-03-22 2009-08-27 ヴァイラル ロジック システムズ テクノロジー コーポレーション 標的ポリペプチドの同定方法および免疫学的疾患の治療のためのその使用
US7994317B2 (en) 2006-11-03 2011-08-09 GlaxoSmithKline, LLC sEH inhibitors and their use
EP2147683A1 (en) 2008-07-25 2010-01-27 DKFZ Deutsches Krebsforschungszentrum Construct and method for the internalization of cargo molecules into a cell
WO2010142785A1 (en) * 2009-06-11 2010-12-16 Institut Curie Methods and kits for regulating intracellular trafficking of a target protein
WO2012082841A2 (en) * 2010-12-14 2012-06-21 University Of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
KR20140029446A (ko) * 2011-04-15 2014-03-10 컴퓨젠 엘티디. 면역 관련 장애 및 암의 치료를 위한 폴리펩티드 및 폴리뉴클레오티드, 및 이들의 용도
US20130071414A1 (en) * 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
AU2013222288A1 (en) * 2012-02-22 2014-08-14 The Trustees Of The University Of Pennsylvania Use of ICOS-based CARs to enhance antitumor activity and CAR persistence
KR102264290B1 (ko) * 2012-08-20 2021-06-10 프레드 헛친슨 켄서 리서치 센터 세포 면역요법을 위한 방법 및 조성물
AU2013329186B2 (en) * 2012-10-10 2019-02-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
SG11201605046YA (en) * 2013-12-20 2016-07-28 Hutchinson Fred Cancer Res Tagged chimeric effector molecules and receptors thereof
IL295616A (en) * 2015-07-31 2022-10-01 Us Health Adapted cells and treatment methods

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