JP2015533841A5 - - Google Patents
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- JP2015533841A5 JP2015533841A5 JP2015538330A JP2015538330A JP2015533841A5 JP 2015533841 A5 JP2015533841 A5 JP 2015533841A5 JP 2015538330 A JP2015538330 A JP 2015538330A JP 2015538330 A JP2015538330 A JP 2015538330A JP 2015533841 A5 JP2015533841 A5 JP 2015533841A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- mva
- identity
- promoter comprises
- copy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002773 nucleotide Substances 0.000 claims description 54
- 125000003729 nucleotide group Chemical group 0.000 claims description 54
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 14
- 150000007523 nucleic acids Chemical group 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 8
- 208000007089 vaccinia Diseases 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 2
- 230000005867 T cell response Effects 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719429P | 2012-10-28 | 2012-10-28 | |
| US61/719,429 | 2012-10-28 | ||
| PCT/EP2013/003239 WO2014063832A1 (en) | 2012-10-28 | 2013-10-28 | Pr13.5 promoter for robust t-cell and antibody responses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019054129A Division JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533841A JP2015533841A (ja) | 2015-11-26 |
| JP2015533841A5 true JP2015533841A5 (enExample) | 2016-10-20 |
| JP6505016B2 JP6505016B2 (ja) | 2019-04-24 |
Family
ID=49513897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015538330A Active JP6505016B2 (ja) | 2012-10-28 | 2013-10-28 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
| JP2019054129A Active JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019054129A Active JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9828414B2 (enExample) |
| EP (2) | EP3778904A1 (enExample) |
| JP (2) | JP6505016B2 (enExample) |
| KR (2) | KR102135818B1 (enExample) |
| CN (1) | CN104755622B (enExample) |
| AU (1) | AU2013337018B2 (enExample) |
| BR (1) | BR112015009320A2 (enExample) |
| CA (1) | CA2887623C (enExample) |
| CY (1) | CY1123181T1 (enExample) |
| DK (1) | DK2912183T3 (enExample) |
| EA (2) | EA201990114A1 (enExample) |
| ES (1) | ES2800623T3 (enExample) |
| HK (1) | HK1212383A1 (enExample) |
| HU (1) | HUE049706T2 (enExample) |
| IL (1) | IL238130B (enExample) |
| IN (1) | IN2015DN03326A (enExample) |
| LT (1) | LT2912183T (enExample) |
| MX (2) | MX380483B (enExample) |
| MY (2) | MY171687A (enExample) |
| NZ (1) | NZ706637A (enExample) |
| PT (1) | PT2912183T (enExample) |
| SG (2) | SG10201704657WA (enExample) |
| SI (1) | SI2912183T1 (enExample) |
| UA (1) | UA118340C2 (enExample) |
| WO (1) | WO2014063832A1 (enExample) |
| ZA (1) | ZA201502892B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015009320A2 (pt) * | 2012-10-28 | 2017-10-17 | Bavarian Nordic As | promotor pr13.5 para respostas de células t e anticorpo robustas |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| HUE059343T2 (hu) | 2016-01-29 | 2022-11-28 | Bavarian Nordic As | Rekombináns, módosított Ankara Vaccinia vírus (MVA) és ló encephalitis vírus oltóanyag |
| US10517944B2 (en) | 2016-05-02 | 2019-12-31 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV vaccine combinations |
| WO2018060368A2 (en) | 2016-09-28 | 2018-04-05 | Bavarian Nordic A/S | Compositions and methods for enhancing the stability of transgenes in poxviruses |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| US20190330655A1 (en) | 2016-12-28 | 2019-10-31 | Transgene Sa | Oncolytic viruses and therapeutic molecules |
| WO2018229711A1 (en) * | 2017-06-15 | 2018-12-20 | Janssen Vaccines & Prevention B.V. | Poxvirus vectors encoding hiv antigens, and methods of use thereof |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| US11273211B2 (en) | 2017-08-24 | 2022-03-15 | Bavarian Nordic A/S | Combination therapy for treating cancer with an intravenous administration of a recombinant MVA and an antibody |
| MX2020006471A (es) | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
| GB201807932D0 (en) * | 2018-05-16 | 2018-06-27 | Redchenko Irina | Compositions and methods for inducing an immune response |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| CN110904127B (zh) | 2018-09-18 | 2024-09-20 | 瓦赫宁恩研究基金会 | 非洲猪瘟病毒疫苗 |
| AU2019354101B2 (en) | 2018-10-05 | 2026-02-19 | Bavarian Nordic A/S | Combination therapy for treating cancer with an intravenous administration of a recombinant MVA and an immune checkpoint antagonist or agonist |
| BR112021009856A8 (pt) | 2018-11-20 | 2021-09-08 | Bavarian Nordic As | Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l |
| AU2020387646A1 (en) | 2019-11-20 | 2022-05-19 | Bavarian Nordic A/S | Recombinant MVA viruses for intratumoral and/or intravenous administration for treating cancer |
| JP2023528984A (ja) | 2020-06-10 | 2023-07-06 | バヴァリアン・ノルディック・アクティーゼルスカブ | コロナウイルス病に対する組換え修飾ワクシニアウイルスアンカラ（ｍｖａ）ワクチン |
| WO2022084333A1 (en) | 2020-10-20 | 2022-04-28 | Janssen Vaccines & Prevention B.V. | Hiv vaccine regimens |
| US20240392257A1 (en) | 2021-09-03 | 2024-11-28 | Bavarian Nordic A/S | Utilization of Micro-RNA for Downregulation of Cytotoxic Transgene Expression by Modified Vaccinia Virus Ankara (MVA) |
| WO2023118563A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Therapy for modulating immune response with recombinant mva encoding il-12 |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| CA3260357A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | RECOMBINANT MODIFIED ANKARA VIRUS (MVA) AND SMALL ACTIVATOR RNA (SPR) PRIMARY IMMUNIZATION REGIMEN |
| CN120380015A (zh) | 2022-08-18 | 2025-07-25 | 特兰斯吉恩公司 | 嵌合痘病毒 |
| EP4648781A1 (en) | 2023-01-12 | 2025-11-19 | Bavarian Nordic A/S | Recombinant modified sarna (vrp) for cancer vaccine |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
| WO2025238220A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Nucleic acids for vaccination encoding antigen-displaying protein nanoparticles |
| WO2025238218A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding antigen-displaying protein nanoparticles |
| WO2025238221A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding multi-antigen-displaying protein nanoparticles |
| WO2025238219A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Modified vaccinia virus ankara (mva) encoding antigen-displaying protein nanoparticles |
| WO2026041811A1 (en) | 2024-08-23 | 2026-02-26 | Transgene | Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| GB9922361D0 (en) * | 1999-09-21 | 1999-11-24 | Isis Innovation | Generating an immune response to an antigen |
| WO2002042480A2 (en) | 2000-11-23 | 2002-05-30 | Bavarian Nordic A/S | Modified vaccinia ankara virus variant |
| ES2424847T3 (es) * | 2004-06-25 | 2013-10-09 | Merial Ltd. | Genes del virus de la fiebre aftosa que expresan avipox recombinantes |
| JP2008301792A (ja) * | 2007-06-11 | 2008-12-18 | National Univ Corp Shizuoka Univ | 改変ポリヘドリンプロモーター、バクミド変異体及び目的タンパク質の製造方法 |
| JP2012509678A (ja) | 2008-11-27 | 2012-04-26 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組換えウイルス発現のためのプロモーター |
| US8394385B2 (en) * | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
| BR112015009320A2 (pt) * | 2012-10-28 | 2017-10-17 | Bavarian Nordic As | promotor pr13.5 para respostas de células t e anticorpo robustas |
-
2013
- 2013-10-28 BR BR112015009320A patent/BR112015009320A2/pt not_active Application Discontinuation
- 2013-10-28 EA EA201990114A patent/EA201990114A1/ru unknown
- 2013-10-28 MY MYPI2015701223A patent/MY171687A/en unknown
- 2013-10-28 PT PT137838520T patent/PT2912183T/pt unknown
- 2013-10-28 HK HK16100267.8A patent/HK1212383A1/xx unknown
- 2013-10-28 UA UAA201505223A patent/UA118340C2/uk unknown
- 2013-10-28 JP JP2015538330A patent/JP6505016B2/ja active Active
- 2013-10-28 CN CN201380054013.0A patent/CN104755622B/zh active Active
- 2013-10-28 KR KR1020157009206A patent/KR102135818B1/ko active Active
- 2013-10-28 SG SG10201704657WA patent/SG10201704657WA/en unknown
- 2013-10-28 KR KR1020207020263A patent/KR20200087880A/ko not_active Ceased
- 2013-10-28 US US14/437,939 patent/US9828414B2/en active Active
- 2013-10-28 SI SI201331731T patent/SI2912183T1/sl unknown
- 2013-10-28 EP EP20172647.8A patent/EP3778904A1/en active Pending
- 2013-10-28 AU AU2013337018A patent/AU2013337018B2/en active Active
- 2013-10-28 NZ NZ706637A patent/NZ706637A/en unknown
- 2013-10-28 SG SG11201503200PA patent/SG11201503200PA/en unknown
- 2013-10-28 LT LTEP13783852.0T patent/LT2912183T/lt unknown
- 2013-10-28 WO PCT/EP2013/003239 patent/WO2014063832A1/en not_active Ceased
- 2013-10-28 MY MYPI2018001787A patent/MY194609A/en unknown
- 2013-10-28 HU HUE13783852A patent/HUE049706T2/hu unknown
- 2013-10-28 IN IN3326DEN2015 patent/IN2015DN03326A/en unknown
- 2013-10-28 MX MX2015005264A patent/MX380483B/es unknown
- 2013-10-28 ES ES13783852T patent/ES2800623T3/es active Active
- 2013-10-28 EA EA201590831A patent/EA032498B1/ru not_active IP Right Cessation
- 2013-10-28 EP EP13783852.0A patent/EP2912183B1/en active Active
- 2013-10-28 DK DK13783852.0T patent/DK2912183T3/da active
- 2013-10-28 CA CA2887623A patent/CA2887623C/en active Active
-
2015
- 2015-04-02 IL IL238130A patent/IL238130B/en active IP Right Grant
- 2015-04-24 MX MX2021001638A patent/MX2021001638A/es unknown
- 2015-04-28 ZA ZA2015/02892A patent/ZA201502892B/en unknown
-
2017
- 2017-11-22 US US15/821,035 patent/US11028130B2/en active Active
-
2019
- 2019-03-22 JP JP2019054129A patent/JP6818797B2/ja active Active
-
2020
- 2020-07-08 CY CY20201100630T patent/CY1123181T1/el unknown
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