JP2015533841A5 - - Google Patents
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- Publication number
- JP2015533841A5 JP2015533841A5 JP2015538330A JP2015538330A JP2015533841A5 JP 2015533841 A5 JP2015533841 A5 JP 2015533841A5 JP 2015538330 A JP2015538330 A JP 2015538330A JP 2015538330 A JP2015538330 A JP 2015538330A JP 2015533841 A5 JP2015533841 A5 JP 2015533841A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- mva
- identity
- promoter comprises
- copy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims description 54
- 125000003729 nucleotide group Chemical group 0.000 claims description 54
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 14
- 150000007523 nucleic acids Chemical group 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 8
- 208000007089 vaccinia Diseases 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 2
- 230000005867 T cell response Effects 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719429P | 2012-10-28 | 2012-10-28 | |
| US61/719,429 | 2012-10-28 | ||
| PCT/EP2013/003239 WO2014063832A1 (en) | 2012-10-28 | 2013-10-28 | Pr13.5 promoter for robust t-cell and antibody responses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019054129A Division JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533841A JP2015533841A (ja) | 2015-11-26 |
| JP2015533841A5 true JP2015533841A5 (enExample) | 2016-10-20 |
| JP6505016B2 JP6505016B2 (ja) | 2019-04-24 |
Family
ID=49513897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015538330A Active JP6505016B2 (ja) | 2012-10-28 | 2013-10-28 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
| JP2019054129A Active JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019054129A Active JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9828414B2 (enExample) |
| EP (2) | EP3778904A1 (enExample) |
| JP (2) | JP6505016B2 (enExample) |
| KR (2) | KR102135818B1 (enExample) |
| CN (1) | CN104755622B (enExample) |
| AU (1) | AU2013337018B2 (enExample) |
| BR (1) | BR112015009320A2 (enExample) |
| CA (1) | CA2887623C (enExample) |
| CY (1) | CY1123181T1 (enExample) |
| DK (1) | DK2912183T3 (enExample) |
| EA (2) | EA201990114A1 (enExample) |
| ES (1) | ES2800623T3 (enExample) |
| HK (1) | HK1212383A1 (enExample) |
| HU (1) | HUE049706T2 (enExample) |
| IL (1) | IL238130B (enExample) |
| IN (1) | IN2015DN03326A (enExample) |
| LT (1) | LT2912183T (enExample) |
| MX (2) | MX380483B (enExample) |
| MY (2) | MY171687A (enExample) |
| NZ (1) | NZ706637A (enExample) |
| PT (1) | PT2912183T (enExample) |
| SG (2) | SG11201503200PA (enExample) |
| SI (1) | SI2912183T1 (enExample) |
| UA (1) | UA118340C2 (enExample) |
| WO (1) | WO2014063832A1 (enExample) |
| ZA (1) | ZA201502892B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2912183T (pt) * | 2012-10-28 | 2020-06-05 | Bavarian Nordic As | Promotor pr13.5 para respostas robustas de células t e anticorpos |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| EP3407910B1 (en) | 2016-01-29 | 2022-04-13 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) equine encephalitis virus vaccine |
| US10517944B2 (en) | 2016-05-02 | 2019-12-31 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV vaccine combinations |
| US11052139B2 (en) | 2016-09-28 | 2021-07-06 | Bavarian Nordic A/S | Compositions and methods for enhancing the stability of transgenes in poxviruses |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| ES2905478T3 (es) | 2016-12-28 | 2022-04-08 | Transgene Sa | Virus oncolíticos y moléculas terapéuticas |
| EP3638302B1 (en) | 2017-06-15 | 2024-03-13 | Janssen Vaccines & Prevention B.V. | Poxvirus vectors encoding hiv antigens, and methods of use thereof |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| JP7202362B2 (ja) | 2017-08-24 | 2023-01-11 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えｍｖａ及び抗体の静脈内投与を用いた、がん治療のための併用療法 |
| MX2020006471A (es) | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
| GB201807932D0 (en) * | 2018-05-16 | 2018-06-27 | Redchenko Irina | Compositions and methods for inducing an immune response |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| CN110904127B (zh) | 2018-09-18 | 2024-09-20 | 瓦赫宁恩研究基金会 | 非洲猪瘟病毒疫苗 |
| EP3860641A1 (en) | 2018-10-05 | 2021-08-11 | Bavarian Nordic A/S | Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist |
| BR112021009856A8 (pt) | 2018-11-20 | 2021-09-08 | Bavarian Nordic As | Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l |
| BR112022009798A2 (pt) | 2019-11-20 | 2022-10-18 | Bavarian Nordic As | Vírus mva recombinante para administração intratumoral e/ou intravenosa para tratamento de câncer |
| MX2022015489A (es) | 2020-06-10 | 2023-03-22 | Bavarian Nordic As | Vacuna de virus vaccinia modificado de ankara (mva) recombinante contra la enfermedad del coronavirus. |
| US20220118081A1 (en) | 2020-10-20 | 2022-04-21 | Janssen Vaccines & Prevention B.V. | HIV vaccine regimens |
| CN118234850A (zh) | 2021-09-03 | 2024-06-21 | 巴法里安诺迪克有限公司 | 利用微rna来下调经修饰的安卡拉痘苗病毒(mva)的细胞毒性转基因的表达 |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| CA3240596A1 (en) | 2021-12-23 | 2023-06-29 | Cigdem ATAY LANGBEIN | Therapy for modulating immune response with recombinant mva encoding il-12 |
| CA3260357A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic As | RECOMBINANT MODIFIED ANKARA VIRUS (MVA) AND SMALL ACTIVATOR RNA (SPR) PRIMARY IMMUNIZATION REGIMEN |
| CN120380015A (zh) | 2022-08-18 | 2025-07-25 | 特兰斯吉恩公司 | 嵌合痘病毒 |
| AU2024208643A1 (en) | 2023-01-12 | 2025-06-26 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
| WO2025238218A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding antigen-displaying protein nanoparticles |
| WO2025238220A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Nucleic acids for vaccination encoding antigen-displaying protein nanoparticles |
| WO2025238219A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Modified vaccinia virus ankara (mva) encoding antigen-displaying protein nanoparticles |
| WO2025238221A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding multi-antigen-displaying protein nanoparticles |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| GB9922361D0 (en) * | 1999-09-21 | 1999-11-24 | Isis Innovation | Generating an immune response to an antigen |
| DE20122302U1 (de) | 2000-11-23 | 2005-02-24 | Bavarian Nordic A/S | Variante des Modifizierten Vaccinia-Ankara-Virus |
| DK1773387T3 (da) * | 2004-06-25 | 2013-07-15 | Merial Ltd | Avipox-rekombinanter der udtrykker mund- og klovesyge-virusgener |
| JP2008301792A (ja) | 2007-06-11 | 2008-12-18 | National Univ Corp Shizuoka Univ | 改変ポリヘドリンプロモーター、バクミド変異体及び目的タンパク質の製造方法 |
| CA2741724C (en) | 2008-11-27 | 2016-10-04 | Bavarian Nordic A/S | Promoters for recombinant viral expression |
| US8394385B2 (en) * | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
| PT2912183T (pt) * | 2012-10-28 | 2020-06-05 | Bavarian Nordic As | Promotor pr13.5 para respostas robustas de células t e anticorpos |
-
2013
- 2013-10-28 PT PT137838520T patent/PT2912183T/pt unknown
- 2013-10-28 DK DK13783852.0T patent/DK2912183T3/da active
- 2013-10-28 HU HUE13783852A patent/HUE049706T2/hu unknown
- 2013-10-28 WO PCT/EP2013/003239 patent/WO2014063832A1/en not_active Ceased
- 2013-10-28 EP EP20172647.8A patent/EP3778904A1/en active Pending
- 2013-10-28 MY MYPI2015701223A patent/MY171687A/en unknown
- 2013-10-28 UA UAA201505223A patent/UA118340C2/uk unknown
- 2013-10-28 SG SG11201503200PA patent/SG11201503200PA/en unknown
- 2013-10-28 EA EA201990114A patent/EA201990114A1/ru unknown
- 2013-10-28 SG SG10201704657WA patent/SG10201704657WA/en unknown
- 2013-10-28 US US14/437,939 patent/US9828414B2/en active Active
- 2013-10-28 SI SI201331731T patent/SI2912183T1/sl unknown
- 2013-10-28 LT LTEP13783852.0T patent/LT2912183T/lt unknown
- 2013-10-28 AU AU2013337018A patent/AU2013337018B2/en active Active
- 2013-10-28 MY MYPI2018001787A patent/MY194609A/en unknown
- 2013-10-28 KR KR1020157009206A patent/KR102135818B1/ko active Active
- 2013-10-28 JP JP2015538330A patent/JP6505016B2/ja active Active
- 2013-10-28 CA CA2887623A patent/CA2887623C/en active Active
- 2013-10-28 NZ NZ706637A patent/NZ706637A/en unknown
- 2013-10-28 BR BR112015009320A patent/BR112015009320A2/pt not_active Application Discontinuation
- 2013-10-28 IN IN3326DEN2015 patent/IN2015DN03326A/en unknown
- 2013-10-28 KR KR1020207020263A patent/KR20200087880A/ko not_active Ceased
- 2013-10-28 EP EP13783852.0A patent/EP2912183B1/en active Active
- 2013-10-28 HK HK16100267.8A patent/HK1212383A1/xx unknown
- 2013-10-28 MX MX2015005264A patent/MX380483B/es unknown
- 2013-10-28 CN CN201380054013.0A patent/CN104755622B/zh active Active
- 2013-10-28 ES ES13783852T patent/ES2800623T3/es active Active
- 2013-10-28 EA EA201590831A patent/EA032498B1/ru not_active IP Right Cessation
-
2015
- 2015-04-02 IL IL238130A patent/IL238130B/en active IP Right Grant
- 2015-04-24 MX MX2021001638A patent/MX2021001638A/es unknown
- 2015-04-28 ZA ZA2015/02892A patent/ZA201502892B/en unknown
-
2017
- 2017-11-22 US US15/821,035 patent/US11028130B2/en active Active
-
2019
- 2019-03-22 JP JP2019054129A patent/JP6818797B2/ja active Active
-
2020
- 2020-07-08 CY CY20201100630T patent/CY1123181T1/el unknown
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