EA032498B1 - ПРОМОТОР Pr13.5 ДЛЯ УСТОЙЧИВЫХ Т-КЛЕТОЧНЫХ И ГУМОРАЛЬНЫХ ИММУННЫХ РЕАКЦИЙ - Google Patents
ПРОМОТОР Pr13.5 ДЛЯ УСТОЙЧИВЫХ Т-КЛЕТОЧНЫХ И ГУМОРАЛЬНЫХ ИММУННЫХ РЕАКЦИЙ Download PDFInfo
- Publication number
- EA032498B1 EA032498B1 EA201590831A EA201590831A EA032498B1 EA 032498 B1 EA032498 B1 EA 032498B1 EA 201590831 A EA201590831 A EA 201590831A EA 201590831 A EA201590831 A EA 201590831A EA 032498 B1 EA032498 B1 EA 032498B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- promoter
- mua
- recombinant
- nucleotide sequence
- cell
- Prior art date
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719429P | 2012-10-28 | 2012-10-28 | |
| PCT/EP2013/003239 WO2014063832A1 (en) | 2012-10-28 | 2013-10-28 | Pr13.5 promoter for robust t-cell and antibody responses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590831A1 EA201590831A1 (ru) | 2015-08-31 |
| EA032498B1 true EA032498B1 (ru) | 2019-06-28 |
Family
ID=49513897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590831A EA032498B1 (ru) | 2012-10-28 | 2013-10-28 | ПРОМОТОР Pr13.5 ДЛЯ УСТОЙЧИВЫХ Т-КЛЕТОЧНЫХ И ГУМОРАЛЬНЫХ ИММУННЫХ РЕАКЦИЙ |
| EA201990114A EA201990114A1 (ru) | 2012-10-28 | 2013-10-28 | Промотор pr13.5 для устойчивых т-клеточных и гуморальных иммунных реакций |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201990114A EA201990114A1 (ru) | 2012-10-28 | 2013-10-28 | Промотор pr13.5 для устойчивых т-клеточных и гуморальных иммунных реакций |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9828414B2 (enExample) |
| EP (2) | EP2912183B1 (enExample) |
| JP (2) | JP6505016B2 (enExample) |
| KR (2) | KR20200087880A (enExample) |
| CN (1) | CN104755622B (enExample) |
| AU (1) | AU2013337018B2 (enExample) |
| BR (1) | BR112015009320A2 (enExample) |
| CA (1) | CA2887623C (enExample) |
| CY (1) | CY1123181T1 (enExample) |
| DK (1) | DK2912183T3 (enExample) |
| EA (2) | EA032498B1 (enExample) |
| ES (1) | ES2800623T3 (enExample) |
| HK (1) | HK1212383A1 (enExample) |
| HU (1) | HUE049706T2 (enExample) |
| IL (1) | IL238130B (enExample) |
| IN (1) | IN2015DN03326A (enExample) |
| LT (1) | LT2912183T (enExample) |
| MX (2) | MX380483B (enExample) |
| MY (2) | MY194609A (enExample) |
| NZ (1) | NZ706637A (enExample) |
| PT (1) | PT2912183T (enExample) |
| SG (2) | SG11201503200PA (enExample) |
| SI (1) | SI2912183T1 (enExample) |
| UA (1) | UA118340C2 (enExample) |
| WO (1) | WO2014063832A1 (enExample) |
| ZA (1) | ZA201502892B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2887623C (en) * | 2012-10-28 | 2021-02-16 | Bavarian Nordic A/S | Pr13.5 promoter for robust t-cell and antibody responses |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| PL3407910T3 (pl) | 2016-01-29 | 2022-08-16 | Bavarian Nordic A/S | Rekombinowana zmodyfikowana szczepionka przeciwko wirusowi krowianki ankara (mva) przeciwko wirusowi zapalenia mózgu koni |
| CA3021341A1 (en) * | 2016-05-02 | 2017-11-09 | Janssen Vaccine & Prevention B.V. | Therapeutic hpv vaccine combinations |
| NZ752275A (en) | 2016-09-28 | 2025-07-25 | Bavarian Nordic As | Compositions and methods for enhancing the stability of transgenes in poxviruses |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| DK3562946T3 (da) | 2016-12-28 | 2022-01-31 | Transgene Sa | Oncolytiske virusser og terapeutiske molekyler |
| KR20200015759A (ko) | 2017-06-15 | 2020-02-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Hiv 항원을 인코딩하는 폭스바이러스 벡터, 및 그 사용 방법 |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| IL272546B2 (en) | 2017-08-24 | 2024-01-01 | Bavarian Nordic As | Combined therapy for the treatment of cancer with intravenous administration of recombinant MVA and antibody |
| SG11202005710YA (en) | 2017-12-19 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Methods and compositions for inducing an immune response against hepatitis b virus (hbv) |
| GB201807932D0 (en) | 2018-05-16 | 2018-06-27 | Redchenko Irina | Compositions and methods for inducing an immune response |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| CN110904127B (zh) | 2018-09-18 | 2024-09-20 | 瓦赫宁恩研究基金会 | 非洲猪瘟病毒疫苗 |
| CA3113818A1 (en) | 2018-10-05 | 2020-04-09 | Bavarian Nordic A/S | Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist |
| SG11202104918PA (en) | 2018-11-20 | 2021-06-29 | Bavarian Nordic As | Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l |
| IL293009B1 (en) | 2019-11-20 | 2025-09-01 | Bavarian Nordic As | Recombinant mva viruses for intratumoral and/or intravenous administration for cancer treatment |
| KR20230022206A (ko) | 2020-06-10 | 2023-02-14 | 버베리안 노딕 에이/에스 | 코로나바이러스 질환에 대응하는 재조합적 변형된 우두증 바이러스 앙카라 (mva) 백신 |
| US20220118081A1 (en) | 2020-10-20 | 2022-04-21 | Janssen Vaccines & Prevention B.V. | HIV vaccine regimens |
| WO2023031428A1 (en) | 2021-09-03 | 2023-03-09 | Bavarian Nordic A/S | Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva) |
| WO2023118563A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Therapy for modulating immune response with recombinant mva encoding il-12 |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| AU2023298083A1 (en) | 2022-06-29 | 2025-01-09 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
| JP2025528219A (ja) | 2022-08-18 | 2025-08-26 | トランジェーヌ | キメラポックスウイルス |
| IL321887A (en) | 2023-01-12 | 2025-09-01 | Bavarian Nordic As | Recombinantly modified Sarna (vrp) for cancer vaccine |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
| WO2025238218A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding antigen-displaying protein nanoparticles |
| WO2025238219A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Modified vaccinia virus ankara (mva) encoding antigen-displaying protein nanoparticles |
| WO2025238220A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Nucleic acids for vaccination encoding antigen-displaying protein nanoparticles |
| WO2025238221A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding multi-antigen-displaying protein nanoparticles |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006073431A2 (en) * | 2004-06-25 | 2006-07-13 | Merial Limited | Avipox recombinants expressing foot and mouth disease virus genes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| GB9922361D0 (en) * | 1999-09-21 | 1999-11-24 | Isis Innovation | Generating an immune response to an antigen |
| HU230198B1 (hu) | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
| JP2008301792A (ja) | 2007-06-11 | 2008-12-18 | National Univ Corp Shizuoka Univ | 改変ポリヘドリンプロモーター、バクミド変異体及び目的タンパク質の製造方法 |
| DK2367944T3 (en) | 2008-11-27 | 2019-04-15 | Bavarian Nordic As | PROMOTERS FOR RECOMBINANT VIRAL EXPRESSION |
| US8394385B2 (en) * | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
| CA2887623C (en) * | 2012-10-28 | 2021-02-16 | Bavarian Nordic A/S | Pr13.5 promoter for robust t-cell and antibody responses |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006073431A2 (en) * | 2004-06-25 | 2006-07-13 | Merial Limited | Avipox recombinants expressing foot and mouth disease virus genes |
Non-Patent Citations (10)
| Title |
|---|
| Anonymous: "Vaccinia virus WR, complete genome - Nucleotide - NCBI", GenBank Accession Number AY243312, 14 June 2006 [2006-06-14], XP055095213, Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/nuccore/29 692106 [retrieved on 2014-01-08] cited in the application *VACWR018 nucleotide and amino acid sequence* * |
| DAVISON, A.J. ; MOSS, B.: "Structure of vaccinia virus early promoters", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 210, no. 4, 20 December 1989 (1989-12-20), United Kingdom, pages 749 - 769, XP024010295, ISSN: 0022-2836, DOI: 10.1016/0022-2836(89)90107-1 * |
| J A TINE, D E LANAR, D M SMITH, B T WELLDE, P SCHULTHEISS, L A WARE, E B KAUFFMAN, R A WIRTZ, C DE TAISNE, G S HUI, S P CHANG, P C: "NYVAC-Pf7: a poxvirus-vectored, mutliantigen, multistage vaccine candidate for Plasmodium falciparum malaaia.", INFECTION AND IMMUNITY, vol. 64, no. 9, 1 September 1996 (1996-09-01), pages 3833 - 3844, XP055095101 * |
| KAREN BAUR, BRINKMANN, SCHWENEKER, P�TZHOLD, MEISING-HENSCHEL, HERMANN, STEIGERWALD, CHAPLIN, SUTER, HAUSMANN: "Immediate-early expression of a recombinant antigen by modified vaccinia virus Ankara breaks the immunodominance of strong vector-specific B8R antigen in acute and memory CD8 T-cell responses", JOURNAL OF VIROLOGY, vol. 84, no. 17, 1 September 2010 (2010-09-01), pages 8743 - 8752, XP055057695, DOI: 10.1128/JVI.00604-10 * |
| KOTWAL, G.J. ; MOSS, B.: "Analysis of a large cluster of nonessential genes deleted from a vaccinia virus terminal transposition mutant", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 167, no. 2, 1 December 1988 (1988-12-01), AMSTERDAM, NL, pages 524 - 537, XP023051144, ISSN: 0042-6822 * |
| M WACHSMAN, J H LUO, L AURELIAN, M E PERKUS, E PAOLETTI: "Antigen-presenting capacity of epidermal cells infected with vaccinia virus recombinants containing the herpes simplex virus glycoprotein D, and protective immunity", THE JOURNAL OF GENERAL VIROLOGY, SOC GENERAL MICROBIOL, ENGLAND, 1 September 1989 (1989-09-01), ENGLAND, pages 2513 - 2520, XP055095225, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/2550579> DOI: 10.1099/0022-1317-70-9-2513 * |
| MAGDALINI MOUTAFTSI, DAVID C TSCHARKE, KERRIE VAUGHAN, DAVID M KOELLE, LAWRENCE STERN, MAURICIO CALVO-CALLE, FRANCIS ENNIS, MASANO: "Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens", FUTURE MICROBIOLOGY, vol. 5, no. 2, 1 February 2010 (2010-02-01), pages 221 - 239, XP055095338, ISSN: 17460913, DOI: 10.2217/fmb.09.110 * |
| MAGDALINI, MOUTAFTSI, BUI HUYNH-HOA, PETERS BJOERN, SIDNEY JOHN, SALEK-ARDAKANI SHAHRAM, OSEROFF CARLA, PASQUETTO VALERIE, CROTTY: "Vaccinia Virus-Specific CD4+ T Cell Responses Target a Set of Antigens Largely Distinct from Those Targeted by CD8 T Cell Responses", THE JOURNAL OF IMMUNOLOGY, vol. 178, no. 11, 1 June 2007 (2007-06-01), pages 6814 - 6820, XP055095361 * |
| PERKUS M.E., LIMBACH K., PAOLETTI E.: "CLONING AND EXPRESSION OF FOREIGN GENES IN VACCINIA VIRUS, USING A HOST RANGE SELECTION SYSTEM.", JOURNAL OF VIROLOGY., THE AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 63., no. 09., 1 September 1989 (1989-09-01), US, pages 3829 - 3836., XP000351647, ISSN: 0022-538X * |
| SONIA T. WENNIER, BRINKMANN KAY, STEINH�U�ER CHARLOTTE, MAYL�NDER NICOLE, MNICH CLAUDIA, WIELERT URSULA, DIRMEIER ULRIKE, HAUSMANN: "A Novel Naturally Occurring Tandem Promoter in Modified Vaccinia Virus Ankara Drives Very Early Gene Expression and Potent Immune Responses", PLOS ONE, vol. 8, no. 8, pages e73511, XP055075403, DOI: 10.1371/journal.pone.0073511 * |
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