JP2017505605A5 - - Google Patents

Info

Publication number

JP2017505605A5

JP2017505605A5 JP2016545896A JP2016545896A JP2017505605A5 JP 2017505605 A5 JP2017505605 A5 JP 2017505605A5 JP 2016545896 A JP2016545896 A JP 2016545896A JP 2016545896 A JP2016545896 A JP 2016545896A JP 2017505605 A5 JP2017505605 A5 JP 2017505605A5

Authority

JP

Japan

Prior art keywords

mycobacterial

fusion

nucleic acid

hetero

immunogenic combination

Prior art date

2015-01-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000427 antigen Substances 0.000 claims 35
• 102000036639 antigens Human genes 0.000 claims 35
• 108091007433 antigens Proteins 0.000 claims 35
• 230000004927 fusion Effects 0.000 claims 22
• 230000002163 immunogen Effects 0.000 claims 22
• 108020004707 nucleic acids Proteins 0.000 claims 15
• 102000039446 nucleic acids Human genes 0.000 claims 15
• 150000007523 nucleic acids Chemical class 0.000 claims 14
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 239000013598 vector Substances 0.000 claims 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 6
• 101150079015 esxB gene Proteins 0.000 claims 6
• 241000186359 Mycobacterium Species 0.000 claims 5
• 101710166488 6 kDa early secretory antigenic target Proteins 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 208000027531 mycobacterial infectious disease Diseases 0.000 claims 3
• 206010062207 Mycobacterial infection Diseases 0.000 claims 2
• 241000186366 Mycobacterium bovis Species 0.000 claims 2
• 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
• 238000004113 cell culture Methods 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
• 201000008827 tuberculosis Diseases 0.000 claims 2
• 241000701161 unidentified adenovirus Species 0.000 claims 2
• 208000007089 vaccinia Diseases 0.000 claims 2
• 239000013603 viral vector Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000710929 Alphavirus Species 0.000 claims 1
• 241000178270 Canarypox virus Species 0.000 claims 1
• 208000000666 Fowlpox Diseases 0.000 claims 1
• 241000700662 Fowlpox virus Species 0.000 claims 1
• 241000714192 Human spumaretrovirus Species 0.000 claims 1
• 241000712079 Measles morbillivirus Species 0.000 claims 1
• 101000612837 Mus musculus Tetraspanin-7 Proteins 0.000 claims 1
• 208000031998 Mycobacterium Infections Diseases 0.000 claims 1
• 241001467553 Mycobacterium africanum Species 0.000 claims 1
• 241001467552 Mycobacterium bovis BCG Species 0.000 claims 1
• 241001312372 Mycobacterium canettii Species 0.000 claims 1
• 241000211133 Mycobacterium caprae Species 0.000 claims 1
• 241000187919 Mycobacterium microti Species 0.000 claims 1
• 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 230000005867 T cell response Effects 0.000 claims 1
• 241000700618 Vaccinia virus Species 0.000 claims 1
• 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 239000013066 combination product Substances 0.000 claims 1
• 229940127555 combination product Drugs 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• -1 hetero Nucleic acid Chemical class 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 239000013600 plasmid vector Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000007420 reactivation Effects 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1
• 241001529453 unidentified herpesvirus Species 0.000 claims 1
• 241001430294 unidentified retrovirus Species 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1