KR102135818B1 - 강력한 ｔ-세포 및 항체 반응을 위한 ｐｒ13.5 프로모터 - Google Patents

강력한 ｔ-세포 및 항체 반응을 위한 ｐｒ13.5 프로모터 Download PDF

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KR102135818B1
KR102135818B1 KR1020157009206A KR20157009206A KR102135818B1 KR 102135818 B1 KR102135818 B1 KR 102135818B1 KR 1020157009206 A KR1020157009206 A KR 1020157009206A KR 20157009206 A KR20157009206 A KR 20157009206A KR 102135818 B1 KR102135818 B1 KR 102135818B1
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KR20150079596A (ko
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로빈 슈타이거발트
케이 브린크만
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버베리안 노딕 에이/에스
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020157009206A 2012-10-28 2013-10-28 강력한 ｔ-세포 및 항체 반응을 위한 ｐｒ13.5 프로모터 Active KR102135818B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261719429P 2012-10-28 2012-10-28
US61/719,429 2012-10-28
PCT/EP2013/003239 WO2014063832A1 (en) 2012-10-28 2013-10-28 Pr13.5 promoter for robust t-cell and antibody responses

Related Child Applications (1)

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KR1020207020263A Division KR20200087880A (ko) 2012-10-28 2013-10-28 강력한 ｔ-세포 및 항체 반응을 위한 ｐｒ13.5 프로모터

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KR20150079596A KR20150079596A (ko) 2015-07-08
KR102135818B1 true KR102135818B1 (ko) 2020-07-22

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KR1020207020263A Ceased KR20200087880A (ko) 2012-10-28 2013-10-28 강력한 ｔ-세포 및 항체 반응을 위한 ｐｒ13.5 프로모터

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US (2) US9828414B2 (enExample)
EP (2) EP3778904A1 (enExample)
JP (2) JP6505016B2 (enExample)
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CN (1) CN104755622B (enExample)
AU (1) AU2013337018B2 (enExample)
BR (1) BR112015009320A2 (enExample)
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HU (1) HUE049706T2 (enExample)
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MY (2) MY171687A (enExample)
NZ (1) NZ706637A (enExample)
PT (1) PT2912183T (enExample)
SG (2) SG11201503200PA (enExample)
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UA (1) UA118340C2 (enExample)
WO (1) WO2014063832A1 (enExample)
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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX380483B (es) * 2012-10-28 2025-03-12 Bavarian Nordic As Promotor pr13.5 para respuestas de anticuerpos y linfocitos t fuertes.
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
WO2017129765A1 (en) 2016-01-29 2017-08-03 Bavarian Nordic A/S Recombinant modified vaccinia virus ankara (mva) equine encephalitis virus vaccine
EP3452087A1 (en) * 2016-05-02 2019-03-13 Janssen Vaccines & Prevention B.V. Therapeutic hpv vaccine combinations
AU2017336269B2 (en) 2016-09-28 2022-06-16 Bavarian Nordic A/S Compositions and methods for enhancing the stability of transgenes in poxviruses
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
CA3045228C (en) 2016-12-28 2024-01-02 Transgene Sa Oncolytic viruses and therapeutic molecules
BR112019026126A2 (pt) 2017-06-15 2020-06-30 Janssen Vaccines & Prevention B.V. vetores de poxvírus que codificam antígenos do hiv e métodos de uso dos mesmos
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
IL272546B2 (en) 2017-08-24 2024-01-01 Bavarian Nordic As Combined therapy for the treatment of cancer with intravenous administration of recombinant MVA and antibody
JP2021506300A (ja) 2017-12-19 2021-02-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｂ型肝炎ウイルス（ｈｂｖ）に対する免疫応答を誘導するための方法および組成物
GB201807932D0 (en) * 2018-05-16 2018-06-27 Redchenko Irina Compositions and methods for inducing an immune response
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
CN110904127B (zh) 2018-09-18 2024-09-20 瓦赫宁恩研究基金会 非洲猪瘟病毒疫苗
IL281988B2 (en) 2018-10-05 2025-03-01 Bavarian Nordic As Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist
JP7625518B2 (ja) 2018-11-20 2025-02-03 バヴァリアン・ノルディック・アクティーゼルスカブ ４－１ｂｂｌ（ｃｄ１３７ｌ）及び／またはｃｄ４０ｌをコードする組み換えｍｖａの腫瘍内及び／または静脈内投与によって、がんを治療する療法
BR112022009798A2 (pt) 2019-11-20 2022-10-18 Bavarian Nordic As Vírus mva recombinante para administração intratumoral e/ou intravenosa para tratamento de câncer
US20230233670A1 (en) 2020-06-10 2023-07-27 Bavarian Nordic A/S A Recombinant Modified Vaccinia Virus (MVA) Vaccine Against Coronavirus Disease
WO2022084333A1 (en) 2020-10-20 2022-04-28 Janssen Vaccines & Prevention B.V. Hiv vaccine regimens
JP2024535145A (ja) 2021-09-03 2024-09-27 バヴァリアン・ノルディック・アクティーゼルスカブ 改変ワクシニアウイルスアンカラ（ｍｖａ）による細胞傷害性導入遺伝子発現を下方調節するためのマイクロｒｎａの利用
WO2023118508A1 (en) 2021-12-23 2023-06-29 Bavarian Nordic A/S Recombinant mva viruses for intraperitoneal administration for treating cancer
WO2023118563A1 (en) 2021-12-23 2023-06-29 Bavarian Nordic A/S Therapy for modulating immune response with recombinant mva encoding il-12
IL317745A (en) 2022-06-29 2025-02-01 Bavarian Nordic As Modified recombinant SARNA (VRP) and Vaccinia Ankara virus (MVA) prime regimen
KR20250052416A (ko) 2022-08-18 2025-04-18 트랜스진 키메라 폭스바이러스
AU2024208643A1 (en) 2023-01-12 2025-06-26 Bavarian Nordic A/S RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE
FR3160186A1 (fr) 2024-03-13 2025-09-19 Odimma Therapeutics Vecteur non-viral pour transcription augmentee
WO2025238221A1 (en) 2024-05-17 2025-11-20 Bavarian Nordic A/S Viral vectors encoding multi-antigen-displaying protein nanoparticles
WO2025238219A1 (en) 2024-05-17 2025-11-20 Bavarian Nordic A/S Modified vaccinia virus ankara (mva) encoding antigen-displaying protein nanoparticles
WO2025238220A1 (en) 2024-05-17 2025-11-20 Bavarian Nordic A/S Nucleic acids for vaccination encoding antigen-displaying protein nanoparticles
WO2025238218A1 (en) 2024-05-17 2025-11-20 Bavarian Nordic A/S Viral vectors encoding antigen-displaying protein nanoparticles
WO2026041811A1 (en) 2024-08-23 2026-02-26 Transgene Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell
FR3171450A1 (fr) 2025-01-17 2026-07-24 Odimma Therapeutics Virus enveloppé pour la transfection d’acides nucléiques exogènes.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006073431A2 (en) * 2004-06-25 2006-07-13 Merial Limited Avipox recombinants expressing foot and mouth disease virus genes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711957D0 (en) * 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
GB9922361D0 (en) * 1999-09-21 1999-11-24 Isis Innovation Generating an immune response to an antigen
HU230198B1 (hu) 2000-11-23 2015-10-28 Bavarian Nordic A/S Módosított Vacciniavírus Ankara-variáns
JP2008301792A (ja) * 2007-06-11 2008-12-18 National Univ Corp Shizuoka Univ 改変ポリヘドリンプロモーター、バクミド変異体及び目的タンパク質の製造方法
CA2741724C (en) 2008-11-27 2016-10-04 Bavarian Nordic A/S Promoters for recombinant viral expression
US8394385B2 (en) * 2009-03-13 2013-03-12 Bavarian Nordic A/S Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines
MX380483B (es) * 2012-10-28 2025-03-12 Bavarian Nordic As Promotor pr13.5 para respuestas de anticuerpos y linfocitos t fuertes.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006073431A2 (en) * 2004-06-25 2006-07-13 Merial Limited Avipox recombinants expressing foot and mouth disease virus genes

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CN104755622B (zh) 2021-04-20
JP6818797B2 (ja) 2021-01-20
US20180111966A1 (en) 2018-04-26
LT2912183T (lt) 2020-07-27
SG10201704657WA (en) 2017-07-28
MY171687A (en) 2019-10-23
EP2912183B1 (en) 2020-05-06
UA118340C2 (uk) 2019-01-10
JP6505016B2 (ja) 2019-04-24
MX2021001638A (es) 2021-05-12
HUE049706T2 (hu) 2020-10-28
SG11201503200PA (en) 2015-05-28
US20150299267A1 (en) 2015-10-22
EP3778904A1 (en) 2021-02-17
NZ706637A (en) 2019-02-22
IL238130A0 (en) 2015-05-31
EA201990114A1 (ru) 2019-09-30
ZA201502892B (en) 2020-08-26
IL238130B (en) 2019-09-26
ES2800623T3 (es) 2021-01-04
EP2912183A1 (en) 2015-09-02
US11028130B2 (en) 2021-06-08
EA201590831A1 (ru) 2015-08-31
WO2014063832A1 (en) 2014-05-01
DK2912183T3 (da) 2020-07-27
PT2912183T (pt) 2020-06-05
MX380483B (es) 2025-03-12
CA2887623A1 (en) 2014-05-01
KR20200087880A (ko) 2020-07-21
BR112015009320A2 (pt) 2017-10-17
CN104755622A (zh) 2015-07-01
US9828414B2 (en) 2017-11-28
AU2013337018B2 (en) 2019-09-05
AU2013337018A1 (en) 2015-04-30
MX2015005264A (es) 2015-07-17
HK1212383A1 (en) 2016-06-10
IN2015DN03326A (enExample) 2015-10-09
KR20150079596A (ko) 2015-07-08
JP2015533841A (ja) 2015-11-26
CY1123181T1 (el) 2021-10-29
MY194609A (en) 2022-12-06
EA032498B1 (ru) 2019-06-28
CA2887623C (en) 2021-02-16
AU2013337018A9 (en) 2018-08-30
JP2019131572A (ja) 2019-08-08
SI2912183T1 (sl) 2020-07-31

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