JP2016519065A5 - - Google Patents
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- JP2016519065A5 JP2016519065A5 JP2016502113A JP2016502113A JP2016519065A5 JP 2016519065 A5 JP2016519065 A5 JP 2016519065A5 JP 2016502113 A JP2016502113 A JP 2016502113A JP 2016502113 A JP2016502113 A JP 2016502113A JP 2016519065 A5 JP2016519065 A5 JP 2016519065A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- acid sequence
- amino acid
- seq
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 132
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 90
- 229920001184 polypeptide Polymers 0.000 claims description 88
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 81
- 230000003993 interaction Effects 0.000 claims description 24
- 230000004927 fusion Effects 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 17
- 150000007523 nucleic acids Chemical group 0.000 claims description 15
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 12
- 230000003834 intracellular effect Effects 0.000 claims description 9
- 238000005415 bioluminescence Methods 0.000 claims description 8
- 230000029918 bioluminescence Effects 0.000 claims description 8
- 238000004020 luminiscence type Methods 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims 1
- 239000012634 fragment Substances 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 102000037865 fusion proteins Human genes 0.000 description 7
- 108020001507 fusion proteins Proteins 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108091035707 Consensus sequence Proteins 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791549P | 2013-03-15 | 2013-03-15 | |
| US61/791,549 | 2013-03-15 | ||
| PCT/US2014/026354 WO2014151736A1 (en) | 2013-03-15 | 2014-03-13 | Activation of bioluminescence by structural complementation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013133A Division JP7280842B2 (ja) | 2013-03-15 | 2020-01-30 | 構造的相補性による生物発光の活性化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519065A JP2016519065A (ja) | 2016-06-30 |
| JP2016519065A5 true JP2016519065A5 (enExample) | 2017-04-13 |
| JP6654557B2 JP6654557B2 (ja) | 2020-02-26 |
Family
ID=51581027
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502113A Active JP6654557B2 (ja) | 2013-03-15 | 2014-03-13 | 構造的相補性による生物発光の活性化 |
| JP2020013133A Active JP7280842B2 (ja) | 2013-03-15 | 2020-01-30 | 構造的相補性による生物発光の活性化 |
| JP2023004036A Active JP7532562B2 (ja) | 2013-03-15 | 2023-01-13 | 構造的相補性による生物発光の活性化 |
| JP2024124929A Pending JP2024167207A (ja) | 2013-03-15 | 2024-07-31 | 構造的相補性による生物発光の活性化 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013133A Active JP7280842B2 (ja) | 2013-03-15 | 2020-01-30 | 構造的相補性による生物発光の活性化 |
| JP2023004036A Active JP7532562B2 (ja) | 2013-03-15 | 2023-01-13 | 構造的相補性による生物発光の活性化 |
| JP2024124929A Pending JP2024167207A (ja) | 2013-03-15 | 2024-07-31 | 構造的相補性による生物発光の活性化 |
Country Status (15)
| Country | Link |
|---|---|
| US (11) | US9797889B2 (enExample) |
| EP (4) | EP4169935A1 (enExample) |
| JP (4) | JP6654557B2 (enExample) |
| KR (3) | KR20150129721A (enExample) |
| CN (2) | CN105143249A (enExample) |
| AU (3) | AU2014236949C1 (enExample) |
| BR (1) | BR112015023394B8 (enExample) |
| CA (1) | CA2906063C (enExample) |
| DK (2) | DK2970412T5 (enExample) |
| ES (2) | ES2929362T3 (enExample) |
| IL (3) | IL286816B (enExample) |
| PL (2) | PL2970412T3 (enExample) |
| PT (2) | PT3783011T (enExample) |
| SG (2) | SG10201601929YA (enExample) |
| WO (1) | WO2014151736A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4169935A1 (en) * | 2013-03-15 | 2023-04-26 | Promega Corporation | Activation of bioluminescence by structural complementation |
| EP4219736A1 (en) * | 2014-09-12 | 2023-08-02 | Promega Corporation | Internal protein tags |
| US11365402B2 (en) | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
| EP4455668A3 (en) | 2015-02-05 | 2025-02-19 | Promega Corporation | Luciferase-based thermal shift assays |
| US10634680B2 (en) | 2016-04-26 | 2020-04-28 | University Of Utah Research Foundation | Target-binding activated split reporter systems for analyte detection and related components and methods |
| JP7227901B2 (ja) | 2016-10-20 | 2023-02-22 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ボツリヌス神経毒素の活性を測定するためのインビトロアッセイ法及び細胞ベースのアッセイ法 |
| CA3022981C (en) * | 2017-11-01 | 2025-05-06 | Univ Kingston | Hippo pathway bioluminescent biosensor |
| CN112352055A (zh) * | 2018-02-26 | 2021-02-09 | 艾恩德霍芬技术大学 | 用于检测和定量溶液中的生物分子或配体的生物发光生物传感器 |
| EP4140991B1 (en) | 2018-06-01 | 2024-05-15 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| JP2021526832A (ja) * | 2018-06-12 | 2021-10-11 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 多分子ルシフェラーゼ |
| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| JP7447101B2 (ja) | 2018-10-03 | 2024-03-11 | プロメガ コーポレイション | セレンテラジンならびにその類似体及び誘導体を安定化させるための組成物及び方法 |
| US11175228B2 (en) * | 2018-11-28 | 2021-11-16 | Promega Corporation | Reactive peptide labeling |
| US20200200765A1 (en) | 2018-12-04 | 2020-06-25 | Promega Corporation | Broad spectrum gpcr binding agents |
| US11913944B2 (en) | 2019-03-20 | 2024-02-27 | Promega Corporation | Photoaffinity probes |
| BR112021020354A2 (pt) * | 2019-04-10 | 2021-12-14 | Promega Corp | Composições e métodos para detecção de analito com o uso de bioluminescência |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| JP7650829B2 (ja) | 2019-06-24 | 2025-03-25 | プロメガ コーポレイション | 細胞中に生体分子を送達するための修飾ポリアミンポリマー |
| DE102019127894B4 (de) * | 2019-10-16 | 2022-05-12 | Sensor-Instruments Entwicklungs- Und Vertriebs-Gmbh | Produktkennzeichnungssystem und verfahren zur kennzeichnung eines produkts |
| WO2021102434A1 (en) * | 2019-11-22 | 2021-05-27 | The Regents Of The University Of California | Split-enzyme system to detect specific dna in living cells |
| JP7713448B2 (ja) | 2019-11-27 | 2025-07-25 | プロメガ コーポレイション | 多分子ルシフェラーゼペプチド及びポリペプチド |
| WO2021119149A1 (en) | 2019-12-10 | 2021-06-17 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
| US20230211023A1 (en) | 2020-03-25 | 2023-07-06 | Erasmus University Medical Center Rotterdam | Reporter system for radionuclide imaging |
| WO2021231498A2 (en) * | 2020-05-11 | 2021-11-18 | Chan Zuckerberg Biohub, Inc. | Detection assay for anti-sars-cov-2 antibodies |
| US20210363565A1 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
| CN116391129A (zh) | 2020-08-28 | 2023-07-04 | 普罗美加公司 | 针对ras蛋白的靶标接合测定法 |
| WO2022245922A1 (en) * | 2021-05-18 | 2022-11-24 | The Board Of Regents Of The University Of Texas System | Poly-adp ribose (par) tracker optimized split-protein reassembly par detection reagents |
| US20240174992A1 (en) | 2022-05-04 | 2024-05-30 | Promega Corporation | Split modified dehalogenase variants |
| EP4519290A1 (en) | 2022-05-04 | 2025-03-12 | Promega Corporation | Circularly permuted dehalogenase variants |
| US20230357266A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Photoactivatable compounds and uses thereof |
| US20240132859A1 (en) | 2022-05-04 | 2024-04-25 | Promega Corporation | Modified dehalogenase with extended surface loop regions |
| WO2024151471A1 (en) | 2023-01-09 | 2024-07-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High-throughput assay based on ligand-biased structural dynamics response |
| WO2024217577A1 (zh) * | 2023-04-21 | 2024-10-24 | 深圳琅技生命科技有限公司 | 一种肽以及含有该肽的发光复合物 |
| WO2024229422A2 (en) * | 2023-05-04 | 2024-11-07 | Promega Corporation | Complementation-based tags and reporters for dual-modality labeling |
| WO2025064581A1 (en) * | 2023-09-18 | 2025-03-27 | The Brigham And Women’S Hospital, Inc. | Biosensor platform for the rapid detection of analytes |
| WO2025158412A1 (en) | 2024-01-26 | 2025-07-31 | Biohaven Therapeutics Ltd. | BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5756688A (en) | 1992-10-14 | 1998-05-26 | Sterling Winthrop Inc. | MR imaging compositions and methods |
| EP0664819B1 (en) | 1992-10-14 | 1997-08-06 | Nycomed Imaging As | Chelating polymers |
| GB9503969D0 (en) | 1995-02-28 | 1995-04-19 | Sams Bernard | Incrementing mechanism |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US5879739A (en) | 1997-02-20 | 1999-03-09 | Tower Semiconductor Ltd. | Batch process for forming metal plugs in a dielectric layer of a semiconductor wafer |
| EP1156103B1 (en) * | 2000-04-26 | 2010-08-11 | Chisso Corporation | Oplophorus luciferase |
| JP4613441B2 (ja) * | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
| US20040181830A1 (en) | 2001-05-07 | 2004-09-16 | Kovalic David K. | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US7008642B1 (en) | 2001-02-12 | 2006-03-07 | Advanced Cardiovascular Systems, Inc. | Compositions for achieving a therapeutic effect in an anatomical structure and methods of using the same |
| US7195884B2 (en) | 2002-07-19 | 2007-03-27 | Promega Corp. | Methods and kits for transferases |
| AU2003283995A1 (en) * | 2002-09-30 | 2004-04-19 | Protein Design Labs, Inc. | Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes |
| US7237811B1 (en) * | 2005-04-20 | 2007-07-03 | Lawrence Barry G | Casement window latch assembly |
| EP1931787A4 (en) | 2005-09-30 | 2010-10-20 | Univ Montana State | SYSTEM FOR DETECTING PROTEIN-PROTEIN INTERACTIONS |
| US7601517B2 (en) | 2006-01-10 | 2009-10-13 | Stanford University | Split protein self complementing fragments, systems, and methods of use thereof |
| US20130332133A1 (en) | 2006-05-11 | 2013-12-12 | Ramot At Tel Aviv University Ltd. | Classification of Protein Sequences and Uses of Classified Proteins |
| US20090075313A1 (en) | 2007-05-04 | 2009-03-19 | Stanford University | Split protein fragments, split protein systems, methods of making split protein systems, and methods of using split protein systems |
| EP2210104A4 (en) | 2007-11-01 | 2011-02-23 | Univ Arizona State | CELL-FREE PROCEDURE FOR DETECTING PROTEIN-LIGAND INTERACTIONS |
| EP2222328A4 (en) * | 2007-11-15 | 2013-06-05 | Endocyte Inc | PROCESS FOR THE ADMINISTRATION OF CONJUGATES |
| WO2010090319A1 (ja) | 2009-02-09 | 2010-08-12 | チッソ株式会社 | セレンテラジン類縁体及びその製造方法 |
| EP2420573A1 (en) | 2009-04-17 | 2012-02-22 | National Institute of Advanced Industrial Science And Technology | Stable artificial bioluminescent enzyme having super-high brightness |
| BRPI1010019B1 (pt) | 2009-05-01 | 2019-02-05 | Promega Corp | polipeptídeo de luciferase modificada, vetor e kit compreendendo os mesmos |
| EP4012714A1 (en) * | 2010-03-23 | 2022-06-15 | Iogenetics, LLC. | Bioinformatic processes for determination of peptide binding |
| JP5889910B2 (ja) * | 2010-11-02 | 2016-03-22 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 新規セレンテラジン基質及び使用法 |
| US20150125438A1 (en) * | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
| US10024862B2 (en) * | 2012-12-12 | 2018-07-17 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| EP4169935A1 (en) | 2013-03-15 | 2023-04-26 | Promega Corporation | Activation of bioluminescence by structural complementation |
| EP4219736A1 (en) * | 2014-09-12 | 2023-08-02 | Promega Corporation | Internal protein tags |
-
2014
- 2014-03-13 EP EP22196592.4A patent/EP4169935A1/en active Pending
- 2014-03-13 BR BR112015023394A patent/BR112015023394B8/pt active IP Right Grant
- 2014-03-13 AU AU2014236949A patent/AU2014236949C1/en active Active
- 2014-03-13 JP JP2016502113A patent/JP6654557B2/ja active Active
- 2014-03-13 ES ES20197758T patent/ES2929362T3/es active Active
- 2014-03-13 KR KR1020157024687A patent/KR20150129721A/ko not_active Ceased
- 2014-03-13 KR KR1020217008951A patent/KR102675860B1/ko active Active
- 2014-03-13 SG SG10201601929YA patent/SG10201601929YA/en unknown
- 2014-03-13 EP EP14769752.8A patent/EP2970412B1/en active Active
- 2014-03-13 EP EP20197758.4A patent/EP3783011B1/en active Active
- 2014-03-13 PL PL14769752.8T patent/PL2970412T3/pl unknown
- 2014-03-13 CN CN201480015213.XA patent/CN105143249A/zh active Pending
- 2014-03-13 US US14/209,546 patent/US9797889B2/en active Active
- 2014-03-13 CA CA2906063A patent/CA2906063C/en active Active
- 2014-03-13 US US14/209,610 patent/US9797890B2/en active Active
- 2014-03-13 CN CN202310649630.0A patent/CN117024548A/zh active Pending
- 2014-03-13 ES ES14769752T patent/ES2926463T3/es active Active
- 2014-03-13 EP EP22182344.6A patent/EP4177261A1/en active Pending
- 2014-03-13 IL IL286816A patent/IL286816B/en unknown
- 2014-03-13 KR KR1020237017712A patent/KR20230079494A/ko active Pending
- 2014-03-13 WO PCT/US2014/026354 patent/WO2014151736A1/en not_active Ceased
- 2014-03-13 PL PL20197758.4T patent/PL3783011T3/pl unknown
- 2014-03-13 PT PT201977584T patent/PT3783011T/pt unknown
- 2014-03-13 DK DK14769752.8T patent/DK2970412T5/da active
- 2014-03-13 DK DK20197758.4T patent/DK3783011T5/da active
- 2014-03-13 SG SG11201507306VA patent/SG11201507306VA/en unknown
- 2014-03-13 PT PT147697528T patent/PT2970412T/pt unknown
-
2015
- 2015-09-01 IL IL240985A patent/IL240985B/en active IP Right Grant
-
2016
- 2016-03-17 US US15/073,249 patent/US9869670B2/en active Active
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2017
- 2017-09-27 US US15/717,534 patent/US10107800B2/en active Active
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2018
- 2018-02-19 US US15/899,219 patent/US10184936B2/en active Active
- 2018-06-29 US US16/023,972 patent/US10288605B2/en active Active
- 2018-07-13 US US16/035,117 patent/US10648971B2/en active Active
- 2018-10-31 AU AU2018256548A patent/AU2018256548B2/en active Active
-
2020
- 2020-01-30 JP JP2020013133A patent/JP7280842B2/ja active Active
- 2020-04-16 IL IL273989A patent/IL273989B/en unknown
- 2020-04-17 US US16/851,841 patent/US11493504B2/en active Active
- 2020-08-04 AU AU2020213288A patent/AU2020213288B2/en active Active
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2022
- 2022-11-07 US US18/053,273 patent/US12367513B2/en active Active
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2023
- 2023-01-13 JP JP2023004036A patent/JP7532562B2/ja active Active
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2024
- 2024-07-31 JP JP2024124929A patent/JP2024167207A/ja active Pending
- 2024-09-19 US US18/890,453 patent/US12366572B2/en active Active
- 2024-09-23 US US18/893,549 patent/US20250045806A1/en active Pending
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