BR112015023394B8 - Sistema e complexo bioluminescente - Google Patents
Sistema e complexo bioluminescenteInfo
- Publication number
- BR112015023394B8 BR112015023394B8 BR112015023394A BR112015023394A BR112015023394B8 BR 112015023394 B8 BR112015023394 B8 BR 112015023394B8 BR 112015023394 A BR112015023394 A BR 112015023394A BR 112015023394 A BR112015023394 A BR 112015023394A BR 112015023394 B8 BR112015023394 B8 BR 112015023394B8
- Authority
- BR
- Brazil
- Prior art keywords
- luminescent
- bioluminescent
- complex
- peptide
- covalent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q30/00—Commerce
- G06Q30/02—Marketing; Price estimation or determination; Fundraising
- G06Q30/0283—Price estimation or determination
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q30/00—Commerce
- G06Q30/06—Buying, selling or leasing transactions
- G06Q30/0601—Electronic shopping [e-shopping]
- G06Q30/0631—Recommending goods or services
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
- H04W4/02—Services making use of location information
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
- H04W4/30—Services specially adapted for particular environments, situations or purposes
- H04W4/35—Services specially adapted for particular environments, situations or purposes for the management of goods or merchandise
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
- H04W4/30—Services specially adapted for particular environments, situations or purposes
- H04W4/38—Services specially adapted for particular environments, situations or purposes for collecting sensor information
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Business, Economics & Management (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Development Economics (AREA)
- Accounting & Taxation (AREA)
- Finance (AREA)
- General Engineering & Computer Science (AREA)
- Computer Networks & Wireless Communication (AREA)
- Signal Processing (AREA)
- Strategic Management (AREA)
- General Business, Economics & Management (AREA)
- Economics (AREA)
- Marketing (AREA)
- Theoretical Computer Science (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791549P | 2013-03-15 | 2013-03-15 | |
| US61/791,549 | 2013-03-15 | ||
| PCT/US2014/026354 WO2014151736A1 (en) | 2013-03-15 | 2014-03-13 | Activation of bioluminescence by structural complementation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112015023394A2 BR112015023394A2 (pt) | 2017-11-28 |
| BR112015023394B1 BR112015023394B1 (pt) | 2023-08-29 |
| BR112015023394B8 true BR112015023394B8 (pt) | 2023-09-26 |
Family
ID=51581027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015023394A BR112015023394B8 (pt) | 2013-03-15 | 2014-03-13 | Sistema e complexo bioluminescente |
Country Status (15)
| Country | Link |
|---|---|
| US (11) | US9797890B2 (enExample) |
| EP (4) | EP4169935A1 (enExample) |
| JP (4) | JP6654557B2 (enExample) |
| KR (3) | KR20150129721A (enExample) |
| CN (2) | CN105143249A (enExample) |
| AU (3) | AU2014236949C1 (enExample) |
| BR (1) | BR112015023394B8 (enExample) |
| CA (1) | CA2906063C (enExample) |
| DK (2) | DK3783011T5 (enExample) |
| ES (2) | ES2926463T3 (enExample) |
| IL (3) | IL286816B (enExample) |
| PL (2) | PL2970412T3 (enExample) |
| PT (2) | PT3783011T (enExample) |
| SG (2) | SG11201507306VA (enExample) |
| WO (1) | WO2014151736A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3783011T5 (da) | 2013-03-15 | 2024-08-19 | Promega Corp | Aktivering af bioluminescens via strukturel komplementering |
| US11365402B2 (en) | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
| JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションPromega Corporation | 内部タンパク質タグ |
| EP3254113B1 (en) * | 2015-02-05 | 2024-10-09 | Promega Corporation | Luciferase-based thermal shift assays |
| WO2017189751A1 (en) * | 2016-04-26 | 2017-11-02 | The University Of Utah Research Foundation | Target-binding activated split reporter systems for analyte detection and related components and methods |
| JP7227901B2 (ja) | 2016-10-20 | 2023-02-22 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ボツリヌス神経毒素の活性を測定するためのインビトロアッセイ法及び細胞ベースのアッセイ法 |
| US11579149B2 (en) * | 2017-11-01 | 2023-02-14 | Queen's University At Kingston | Hippo pathway bioluminescent biosensor |
| JP7248693B2 (ja) * | 2018-02-26 | 2023-03-29 | テクニーシェ・ユニバーシタイト・アイントホーベン | 溶液中の生物分子またはリガンドを検出し、定量化する生物発光バイオセンサー |
| EP4140991B1 (en) | 2018-06-01 | 2024-05-15 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| US20200270586A1 (en) * | 2018-06-12 | 2020-08-27 | Promega Corporation | Multipartite luciferase |
| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| JP7447101B2 (ja) | 2018-10-03 | 2024-03-11 | プロメガ コーポレイション | セレンテラジンならびにその類似体及び誘導体を安定化させるための組成物及び方法 |
| EP3887830A2 (en) | 2018-11-28 | 2021-10-06 | Promega Corporation | Reactive peptide labeling |
| US20200200765A1 (en) | 2018-12-04 | 2020-06-25 | Promega Corporation | Broad spectrum gpcr binding agents |
| EP3941195A4 (en) | 2019-03-20 | 2023-03-22 | Promega Corporation | PHOTOAFFINITY PROBES |
| WO2020210658A1 (en) * | 2019-04-10 | 2020-10-15 | Promega Corporation | Compositions and methods for analyte detection using bioluminescence |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| EP3986956A1 (en) | 2019-06-24 | 2022-04-27 | Promega Corporation | Modified polyamine polymers for delivery of biomolecules into cells |
| DE102019127894B4 (de) * | 2019-10-16 | 2022-05-12 | Sensor-Instruments Entwicklungs- Und Vertriebs-Gmbh | Produktkennzeichnungssystem und verfahren zur kennzeichnung eines produkts |
| EP4061853A4 (en) * | 2019-11-22 | 2023-12-27 | The Regents of the University of California | SPLIT ENZYME SYSTEM TO DETECT SPECIFIC DNA IN LIVING CELLS |
| US12241839B2 (en) | 2019-11-27 | 2025-03-04 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
| JP7745550B2 (ja) | 2019-12-10 | 2025-09-29 | プロメガ コーポレイション | 多官能性プローブを使用する生物発光検出用組成物及び生物発光検出方法 |
| JP2023520359A (ja) | 2020-03-25 | 2023-05-17 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | 放射性核種イメージングのためのレポーター系 |
| US20230176057A1 (en) * | 2020-05-11 | 2023-06-08 | Chan Zuckerberg Biohub, Inc. | Detection assay for sars-cov-2 virus |
| US20210363565A1 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
| JP2023540934A (ja) | 2020-08-28 | 2023-09-27 | プロメガ コーポレイション | Rasタンパク質のターゲットエンゲージメントアッセイ |
| WO2022245922A1 (en) * | 2021-05-18 | 2022-11-24 | The Board Of Regents Of The University Of Texas System | Poly-adp ribose (par) tracker optimized split-protein reassembly par detection reagents |
| JP2025515181A (ja) | 2022-05-04 | 2025-05-13 | プロメガ コーポレイション | 伸長表面ループ領域を有する修飾デハロゲナーゼ |
| EP4519426A2 (en) | 2022-05-04 | 2025-03-12 | Promega Corporation | Split modified dehalogenase variants |
| US20240060059A1 (en) | 2022-05-04 | 2024-02-22 | Promega Corporation | Circularly permuted dehalogenase variants |
| WO2023215497A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Photoactivatable compounds and uses thereof |
| WO2024151471A1 (en) * | 2023-01-09 | 2024-07-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High-throughput assay based on ligand-biased structural dynamics response |
| WO2024217577A1 (zh) * | 2023-04-21 | 2024-10-24 | 深圳琅技生命科技有限公司 | 一种肽以及含有该肽的发光复合物 |
| US20240368565A1 (en) * | 2023-05-04 | 2024-11-07 | Promega Corporation | Complementation-based tags and reporters for dual-modality labeling |
| WO2025064581A1 (en) * | 2023-09-18 | 2025-03-27 | The Brigham And Women’S Hospital, Inc. | Biosensor platform for the rapid detection of analytes |
| WO2025158412A1 (en) | 2024-01-26 | 2025-07-31 | Biohaven Therapeutics Ltd. | BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS |
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| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
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| GB9503969D0 (en) | 1995-02-28 | 1995-04-19 | Sams Bernard | Incrementing mechanism |
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| US5879739A (en) | 1997-02-20 | 1999-03-09 | Tower Semiconductor Ltd. | Batch process for forming metal plugs in a dielectric layer of a semiconductor wafer |
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| DE60142761D1 (de) * | 2000-04-26 | 2010-09-23 | Chisso Corp | Oplophorus Luciferase |
| US20040181830A1 (en) | 2001-05-07 | 2004-09-16 | Kovalic David K. | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
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| US7237811B1 (en) * | 2005-04-20 | 2007-07-03 | Lawrence Barry G | Casement window latch assembly |
| US20090149338A1 (en) | 2005-09-30 | 2009-06-11 | Hughes Thomas E | System for detecting protein-protein interactions |
| US7601517B2 (en) | 2006-01-10 | 2009-10-13 | Stanford University | Split protein self complementing fragments, systems, and methods of use thereof |
| WO2007132461A2 (en) | 2006-05-11 | 2007-11-22 | Ramot At Tel Aviv University Ltd. | Classification of protein sequences and uses of classified proteins |
| US20090075313A1 (en) | 2007-05-04 | 2009-03-19 | Stanford University | Split protein fragments, split protein systems, methods of making split protein systems, and methods of using split protein systems |
| CA2704226A1 (en) * | 2007-11-01 | 2009-05-07 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Cell-free methods for detecting protein-ligand interctions |
| CA2705808A1 (en) * | 2007-11-15 | 2009-05-22 | Endocyte, Inc. | Method of administering conjugates |
| WO2010090319A1 (ja) | 2009-02-09 | 2010-08-12 | チッソ株式会社 | セレンテラジン類縁体及びその製造方法 |
| JPWO2010119721A1 (ja) | 2009-04-17 | 2012-10-22 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
| WO2010127368A1 (en) * | 2009-05-01 | 2010-11-04 | Promega Corporation | Synthetic oplophorus luciferases with enhanced light output |
| EP2550529B1 (en) * | 2010-03-23 | 2021-11-17 | Iogenetics, LLC. | Bioinformatic processes for determination of peptide binding |
| ES2567410T3 (es) | 2010-11-02 | 2016-04-22 | Promega Corporation | Nuevos sustratos de coelenterazina y métodos de uso |
| US20150125438A1 (en) * | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
| CA2894435A1 (en) * | 2012-12-12 | 2014-06-19 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| DK3783011T5 (da) | 2013-03-15 | 2024-08-19 | Promega Corp | Aktivering af bioluminescens via strukturel komplementering |
| JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションPromega Corporation | 内部タンパク質タグ |
-
2014
- 2014-03-13 DK DK20197758.4T patent/DK3783011T5/da active
- 2014-03-13 EP EP22196592.4A patent/EP4169935A1/en active Pending
- 2014-03-13 WO PCT/US2014/026354 patent/WO2014151736A1/en not_active Ceased
- 2014-03-13 ES ES14769752T patent/ES2926463T3/es active Active
- 2014-03-13 AU AU2014236949A patent/AU2014236949C1/en active Active
- 2014-03-13 EP EP14769752.8A patent/EP2970412B1/en active Active
- 2014-03-13 PL PL14769752.8T patent/PL2970412T3/pl unknown
- 2014-03-13 US US14/209,610 patent/US9797890B2/en active Active
- 2014-03-13 SG SG11201507306VA patent/SG11201507306VA/en unknown
- 2014-03-13 PT PT201977584T patent/PT3783011T/pt unknown
- 2014-03-13 DK DK14769752.8T patent/DK2970412T5/da active
- 2014-03-13 CN CN201480015213.XA patent/CN105143249A/zh active Pending
- 2014-03-13 CA CA2906063A patent/CA2906063C/en active Active
- 2014-03-13 KR KR1020157024687A patent/KR20150129721A/ko not_active Ceased
- 2014-03-13 PT PT147697528T patent/PT2970412T/pt unknown
- 2014-03-13 CN CN202310649630.0A patent/CN117024548A/zh active Pending
- 2014-03-13 JP JP2016502113A patent/JP6654557B2/ja active Active
- 2014-03-13 EP EP20197758.4A patent/EP3783011B1/en active Active
- 2014-03-13 SG SG10201601929YA patent/SG10201601929YA/en unknown
- 2014-03-13 IL IL286816A patent/IL286816B/en unknown
- 2014-03-13 PL PL20197758.4T patent/PL3783011T3/pl unknown
- 2014-03-13 BR BR112015023394A patent/BR112015023394B8/pt active IP Right Grant
- 2014-03-13 ES ES20197758T patent/ES2929362T3/es active Active
- 2014-03-13 KR KR1020237017712A patent/KR20230079494A/ko active Pending
- 2014-03-13 KR KR1020217008951A patent/KR102675860B1/ko active Active
- 2014-03-13 EP EP22182344.6A patent/EP4177261A1/en active Pending
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