BR112018010933A2 - anticorpos multiespecíficos - Google Patents

anticorpos multiespecíficos

Info

Publication number
BR112018010933A2
BR112018010933A2 BR112018010933A BR112018010933A BR112018010933A2 BR 112018010933 A2 BR112018010933 A2 BR 112018010933A2 BR 112018010933 A BR112018010933 A BR 112018010933A BR 112018010933 A BR112018010933 A BR 112018010933A BR 112018010933 A2 BR112018010933 A2 BR 112018010933A2
Authority
BR
Brazil
Prior art keywords
therapy
research
multispecific antibodies
cell
populations
Prior art date
Application number
BR112018010933A
Other languages
English (en)
Inventor
John Wright Michael
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of BR112018010933A2 publication Critical patent/BR112018010933A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

a presente invenção se refere a complexos biespecíficos proteicos ligados de forma heterodimérica de acordo com a fórmula geral a(a1)n -x: yb(b1)m e bibliotecas / multiplexos dos mesmos para utilização em investigação e terapia e em particular um método in vitro / ex vivo de detecção da função biológica sinérgica de pares de alvos desconhecidos, que podem ser usados para capturar moléculas solúveis segregadas de uma célula particular, em terapia, em pesquisas e para fins experimentais, como em ensaios para caracterizar populações de pacientes, populações celulares relevantes para uma patologia ou prognóstico.
BR112018010933A 2015-12-03 2016-12-01 anticorpos multiespecíficos BR112018010933A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1521393.7A GB201521393D0 (en) 2015-12-03 2015-12-03 Antibodies
PCT/EP2016/079435 WO2017093406A1 (en) 2015-12-03 2016-12-01 Multispecific antibodies

Publications (1)

Publication Number Publication Date
BR112018010933A2 true BR112018010933A2 (pt) 2018-12-04

Family

ID=55234389

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018010933A BR112018010933A2 (pt) 2015-12-03 2016-12-01 anticorpos multiespecíficos

Country Status (9)

Country Link
US (1) US10774157B2 (pt)
EP (1) EP3383899A1 (pt)
JP (1) JP2019501887A (pt)
CN (1) CN108473556A (pt)
BR (1) BR112018010933A2 (pt)
CA (1) CA3005496A1 (pt)
EA (1) EA201891293A1 (pt)
GB (1) GB201521393D0 (pt)
WO (1) WO2017093406A1 (pt)

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