JP2018508571A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018508571A5 JP2018508571A5 JP2017560858A JP2017560858A JP2018508571A5 JP 2018508571 A5 JP2018508571 A5 JP 2018508571A5 JP 2017560858 A JP2017560858 A JP 2017560858A JP 2017560858 A JP2017560858 A JP 2017560858A JP 2018508571 A5 JP2018508571 A5 JP 2018508571A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- glp
- light chain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510071304 | 2015-02-11 | ||
| CN201510071304.1 | 2015-02-11 | ||
| PCT/CN2016/073279 WO2016127887A1 (zh) | 2015-02-11 | 2016-02-03 | 一种药用glp-1r抗体融合蛋白的稳定溶液制剂 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508571A JP2018508571A (ja) | 2018-03-29 |
| JP2018508571A5 true JP2018508571A5 (enExample) | 2020-06-18 |
| JP6731953B2 JP6731953B2 (ja) | 2020-07-29 |
Family
ID=56615305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560858A Active JP6731953B2 (ja) | 2015-02-11 | 2016-02-03 | Ｇｌｐ−１ｒ抗体融合タンパク質の安定な医薬溶液製剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10485870B2 (enExample) |
| EP (1) | EP3257524B1 (enExample) |
| JP (1) | JP6731953B2 (enExample) |
| KR (1) | KR102568272B1 (enExample) |
| CN (2) | CN121927035A (enExample) |
| AU (1) | AU2016218759B2 (enExample) |
| DK (1) | DK3257524T3 (enExample) |
| ES (1) | ES2833099T3 (enExample) |
| PL (1) | PL3257524T3 (enExample) |
| PT (1) | PT3257524T (enExample) |
| WO (1) | WO2016127887A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3684793A1 (en) | 2017-09-22 | 2020-07-29 | Regeneron Pharmaceuticals, Inc. | Glucagon-like peptide 1 receptor agonists and uses thereof |
| JP2025532651A (ja) | 2022-09-21 | 2025-10-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 肥満、糖尿病および肝機能障害を処置する方法 |
| WO2024086601A2 (en) * | 2022-10-19 | 2024-04-25 | Eli Lilly And Company | Preserved gip/glp agonist compositions |
| WO2026021575A1 (zh) * | 2024-07-26 | 2026-01-29 | 鸿运华宁（杭州）生物医药有限公司 | 一种gipr抗体融合蛋白质的药用稳定溶液制剂及其应用 |
| US20260199503A1 (en) | 2025-01-10 | 2026-07-16 | Regeneron Pharmaceuticals, Inc. | Glp1r agonist-tethered gdf8 antibody conjugates and uses thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9409496D0 (en) | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| US5899883A (en) | 1998-07-08 | 1999-05-04 | Jinq Shing Chern | Safety syringe |
| AU5027299A (en) | 1998-07-31 | 2000-02-28 | Novo Nordisk A/S | Use of glp-1 and analogues for preventing type ii diabetes |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| CN1204921C (zh) * | 2000-09-01 | 2005-06-08 | 中外制药株式会社 | 长期稳定溶液制剂 |
| SI1724284T1 (sl) | 2000-12-07 | 2009-12-31 | Lilly Co Eli | Glp-1 fuzijski proteini |
| JP5185624B2 (ja) * | 2004-12-02 | 2013-04-17 | ドマンティス リミテッド | 血清アルブミンおよびｇｌｐ−１またはｐｙｙを標的とする二重特異性抗体 |
| JP2008525452A (ja) * | 2004-12-22 | 2008-07-17 | イーライ リリー アンド カンパニー | Ｇｌｐ−１類似体融合蛋白質製剤 |
| US20060275288A1 (en) | 2005-01-20 | 2006-12-07 | Grihalde Nelson D | GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof |
| RS51319B (sr) | 2005-09-22 | 2010-12-31 | Biocompatibles Uk Limited | GLP-l (GLUKAGON-LIKE PEPTID-l) FUZIONI POLIPEPTIDI SA POVEĆANOM OTPORNOSTI NA PEPTIDAZE |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| KR20100020516A (ko) * | 2007-07-10 | 2010-02-22 | 일라이 릴리 앤드 캄파니 | Ｇｌｐ-1-ｆｃ 융합 단백질 제제 |
| US20090021453A1 (en) | 2007-07-19 | 2009-01-22 | Zachary Smith | Fashion accessory including alternating light emitting and non-light emitting elements of consistent lengths |
| CN101918027A (zh) * | 2007-11-02 | 2010-12-15 | 森托科尔奥索生物科技公司 | 半合成GLP-1肽-Fc融合构造、方法及其用途 |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| EP2259802A1 (en) | 2008-03-31 | 2010-12-15 | Glaxo Group Limited | Drug fusions and conjugates |
| JP5774595B2 (ja) | 2009-10-28 | 2015-09-09 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｇｌｐ−１ｒ抗体及びそれらの使用 |
| RU2558821C2 (ru) | 2009-11-17 | 2015-08-10 | Ипсен Фарма С.А.С. | ЛЕКАРСТВЕННАЯ ФОРМА ДЛЯ КОМБИНАЦИИ hGH И rhIGF-1 |
| CN102961745B (zh) * | 2012-09-27 | 2015-02-18 | 苏州康聚生物科技有限公司 | 抗体组合物制剂及其应用 |
| CN104371019B (zh) * | 2013-08-13 | 2019-09-10 | 鸿运华宁（杭州）生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
-
2016
- 2016-02-03 EP EP16748688.5A patent/EP3257524B1/en active Active
- 2016-02-03 WO PCT/CN2016/073279 patent/WO2016127887A1/zh not_active Ceased
- 2016-02-03 PL PL16748688T patent/PL3257524T3/pl unknown
- 2016-02-03 CN CN202610244442.3A patent/CN121927035A/zh active Pending
- 2016-02-03 JP JP2017560858A patent/JP6731953B2/ja active Active
- 2016-02-03 DK DK16748688.5T patent/DK3257524T3/da active
- 2016-02-03 KR KR1020177023260A patent/KR102568272B1/ko active Active
- 2016-02-03 ES ES16748688T patent/ES2833099T3/es active Active
- 2016-02-03 US US15/547,727 patent/US10485870B2/en active Active
- 2016-02-03 PT PT167486885T patent/PT3257524T/pt unknown
- 2016-02-03 AU AU2016218759A patent/AU2016218759B2/en active Active
- 2016-02-03 CN CN201610077253.8A patent/CN105854000A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2021134101A (ru) | Модифицированная j-цепь | |
| ES2676499T3 (es) | Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones | |
| ES2676023T3 (es) | Polipéptidos de IL-22 y proteínas de fusión de IL-22 Fc y métodos de uso | |
| PE20240015A1 (es) | Proteinas de fusion gdf15 y usos de estas | |
| UA124343C2 (uk) | Капсиди аденоасоційованого вірусу і спосіб його використання | |
| JP2018033454A5 (enExample) | ||
| IL313003A (en) | Tigit- and light-based chimeric proteins | |
| MX2020011391A (es) | Anticuerpo bcma humanizado y linfocitos t car-bcma. | |
| MX2018003410A (es) | Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso. | |
| PE20220708A1 (es) | Anticuerpos anti-cd73 | |
| EA201991577A1 (ru) | Новые антитела против рецептора трансферрина человека, способные преодолевать гематоэнцефалический барьер | |
| NZ724904A (en) | Hybrid immunoglobulin containing non-peptidyl linkage | |
| JP2015212284A5 (enExample) | ||
| JP2014224126A5 (enExample) | ||
| TW201613958A (en) | MIC-1 fusion proteins and uses thereof | |
| CY1123997T1 (el) | Νεα μεταλλακτικη παραλλαγη αλβουμινης ανθρωπινου ορου | |
| JP2018504907A5 (enExample) | ||
| EA201791238A1 (ru) | Способы и композиции, в которых используются варианты полипептидов klotho | |
| PE20091004A1 (es) | Proteinas de union a antigenos c-fms humanos | |
| AR095432A1 (es) | Proteínas de unión a antígeno | |
| EA201892554A1 (ru) | Мутант cd200 и его применения | |
| MX377692B (es) | Peptidos anti-inflamatorios y usos de los mismos. | |
| PE20220217A1 (es) | Anticuerpos humanizados contra la region de la cadena beta de la 9na familia trbv9 del tcr humano, y sus metodos de uso | |
| MX2018013342A (es) | Polipeptido de fusion multicircular "contorsbody" - ligante de diana de cadena sencilla. | |
| CY1119149T1 (el) | Αντικαρκινικη πρωτεϊνη συντηξης |