CY1119149T1 - Αντικαρκινικη πρωτεϊνη συντηξης - Google Patents

Αντικαρκινικη πρωτεϊνη συντηξης

Info

Publication number
CY1119149T1
CY1119149T1 CY20171100632T CY171100632T CY1119149T1 CY 1119149 T1 CY1119149 T1 CY 1119149T1 CY 20171100632 T CY20171100632 T CY 20171100632T CY 171100632 T CY171100632 T CY 171100632T CY 1119149 T1 CY1119149 T1 CY 1119149T1
Authority
CY
Cyprus
Prior art keywords
fusion protein
domain
sequence
terminus
cancer fusion
Prior art date
Application number
CY20171100632T
Other languages
English (en)
Inventor
Jerzy Szczepan Pieczykolan
Sebastian Dominik Pawlak
Bartlomiej Maciej Zerek
Piotr Kamil Rózga
Original Assignee
Adamed Sp. Z O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Sp. Z O.O. filed Critical Adamed Sp. Z O.O.
Publication of CY1119149T1 publication Critical patent/CY1119149T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Μια πρωτεΐνη σύντηξης που περιλαμβάνει την επικράτεια (α) η οποία είναι ένα λειτουργικό θραύσμα της αλληλουχίας πρωτεΐνης hTRAIL, το οποίο θραύσμα αρχίζει με ένα αμινοξύ σε μια θέση όχι χαμηλότερα από την hTRAIL95 ή ένα ομόλογο του εν λόγω λειτουργικού θραύσματος που έχει τουλάχιστον 70% ταυτότητα αλληλουχίας· και την επικράτεια (β) η οποία είναι μια αλληλουχία αντιαγγειογενετικού πεπτιδίου τελεστή, όπου η αλληλουχία της επικράτειας (β) συνδέεται στο C-τελικό ή στο Ν-τελικό άκρο της επικράτειας (α). Η πρωτεΐνη σύντηξης μπορεί να χρησιμοποιηθεί για τη θεραπεία καρκινικών ασθενειών.
CY20171100632T 2011-01-05 2017-06-15 Αντικαρκινικη πρωτεϊνη συντηξης CY1119149T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL393578A PL219845B1 (pl) 2011-01-05 2011-01-05 Przeciwnowotworowe białko fuzyjne
PCT/EP2012/050145 WO2012093158A1 (en) 2011-01-05 2012-01-05 Anticancer fusion protein

Publications (1)

Publication Number Publication Date
CY1119149T1 true CY1119149T1 (el) 2018-02-14

Family

ID=45476512

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100632T CY1119149T1 (el) 2011-01-05 2017-06-15 Αντικαρκινικη πρωτεϊνη συντηξης

Country Status (25)

Country Link
US (1) US9175059B2 (el)
EP (1) EP2661496B1 (el)
JP (1) JP5797773B2 (el)
KR (1) KR101950043B1 (el)
CN (1) CN103228788B (el)
AU (1) AU2012204900B2 (el)
BR (1) BR112013016980B1 (el)
CA (1) CA2814597C (el)
CY (1) CY1119149T1 (el)
DK (1) DK2661496T3 (el)
EA (1) EA025830B1 (el)
ES (1) ES2628377T3 (el)
HR (1) HRP20170905T1 (el)
HU (1) HUE032576T2 (el)
IL (1) IL226205B (el)
LT (1) LT2661496T (el)
ME (1) ME02756B (el)
MX (1) MX339203B (el)
PL (2) PL219845B1 (el)
PT (1) PT2661496T (el)
RS (1) RS56095B1 (el)
SG (1) SG190049A1 (el)
SI (1) SI2661496T1 (el)
UA (1) UA108778C2 (el)
WO (1) WO2012093158A1 (el)

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JP6548630B2 (ja) 2013-03-12 2019-07-24 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 特定の細胞型の選択的死滅のための細胞標的化結合領域と志賀毒素ａサブユニット領域とを含む細胞毒性タンパク質
WO2014141094A1 (en) 2013-03-14 2014-09-18 Adamed Sp. Z O.O. Anticancer conjugate
ES2686968T3 (es) * 2013-05-06 2018-10-23 China Pharmaceutical University Proteínas de fusión bifuncionales para inhibir la angiogénesis en el microambiente tumoral y para activar las respuestas inmunitarias adaptativas y los genes y usos de las mismas
EP3868776A1 (en) 2014-01-27 2021-08-25 Molecular Templates, Inc. Mhc class i epitope delivering polypeptides
JP6814634B2 (ja) 2014-02-05 2021-01-20 モレキュラー テンプレーツ，インク．Ｍｏｌｅｃｕｌａｒ Ｔｅｍｐｌａｔｅｓ， Ｉｎｃ． リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
ES2717751T3 (es) 2014-06-11 2019-06-25 Molecular Templates Inc Polipéptidos efectores de la subunidad A de la toxina de Shiga resistentes a la escisión por proteasa y moléculas dirigidas a células que los comprenden
US10392425B2 (en) 2015-02-05 2019-08-27 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof
US10428132B2 (en) 2015-02-11 2019-10-01 West China Hospital, Sichuan University Tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof
RS60441B1 (sr) 2015-05-30 2020-07-31 Molecular Templates Inc De-imunizovane, strukture shiga toksin a podjedinice i ciljani ćelijski molekuli koji sadrže isti
IL302130A (en) 2016-12-07 2023-06-01 Molecular Templates Inc Shiga toxin A subunit activator polypeptides, Shiga toxin activator scaffolds and cell-targeting molecules for site-specific conjugation
KR102590672B1 (ko) 2017-01-25 2023-10-18 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
WO2019204272A1 (en) 2018-04-17 2019-10-24 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds

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Also Published As

Publication number Publication date
CA2814597A1 (en) 2012-07-12
LT2661496T (lt) 2017-07-10
HRP20170905T1 (hr) 2017-09-08
DK2661496T3 (en) 2017-07-03
JP5797773B2 (ja) 2015-10-21
SG190049A1 (en) 2013-06-28
PL393578A1 (pl) 2012-07-16
BR112013016980A2 (pt) 2020-08-04
US20130288963A1 (en) 2013-10-31
CN103228788A (zh) 2013-07-31
PL2661496T3 (pl) 2017-08-31
ME02756B (me) 2018-01-20
EA025830B1 (ru) 2017-02-28
MX2013007872A (es) 2013-07-30
MX339203B (es) 2016-05-13
AU2012204900B2 (en) 2014-12-18
SI2661496T1 (sl) 2017-09-29
US9175059B2 (en) 2015-11-03
KR20140036143A (ko) 2014-03-25
AU2012204900A1 (en) 2013-05-02
UA108778C2 (xx) 2015-06-10
HUE032576T2 (en) 2017-09-28
KR101950043B1 (ko) 2019-02-19
CN103228788B (zh) 2016-09-07
ES2628377T3 (es) 2017-08-02
PL219845B1 (pl) 2015-07-31
EP2661496B1 (en) 2017-03-15
PT2661496T (pt) 2017-06-26
RS56095B1 (sr) 2017-10-31
WO2012093158A1 (en) 2012-07-12
IL226205B (en) 2018-10-31
JP2014504868A (ja) 2014-02-27
CA2814597C (en) 2019-01-08
NZ609219A (en) 2014-06-27
EA201391005A1 (ru) 2013-11-29
EP2661496A1 (en) 2013-11-13
IL226205A0 (en) 2013-07-31
BR112013016980B1 (pt) 2022-10-11

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