KR102568272B1 - Ｇｌｐ-1ｒ 항체 융합 단백질의 안정한 약제학적 용액 제형 - Google Patents

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Publication number

KR102568272B1

KR102568272B1 KR1020177023260A KR20177023260A KR102568272B1 KR 102568272 B1 KR102568272 B1 KR 102568272B1 KR 1020177023260 A KR1020177023260 A KR 1020177023260A KR 20177023260 A KR20177023260 A KR 20177023260A KR 102568272 B1 KR102568272 B1 KR 102568272B1

Authority

KR

South Korea

Prior art keywords

ser

glp

fusion protein

gly

solution formulation

Prior art date

2015-02-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 239000000203 mixture Substances 0.000 title claims abstract description 116
• 108020001507 fusion proteins Proteins 0.000 title claims abstract description 111
• 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 title claims abstract description 109
• 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 title claims abstract description 109
• 102000037865 fusion proteins Human genes 0.000 title claims abstract description 108
• 239000003186 pharmaceutical solution Substances 0.000 title claims abstract description 18
• 239000000243 solution Substances 0.000 claims abstract description 45
• 150000001413 amino acids Chemical class 0.000 claims abstract description 29
• 239000004094 surface-active agent Substances 0.000 claims abstract description 17
• 239000007853 buffer solution Substances 0.000 claims abstract description 9
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
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