JP2015527074A5 - - Google Patents
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- Publication number
- JP2015527074A5 JP2015527074A5 JP2015530507A JP2015530507A JP2015527074A5 JP 2015527074 A5 JP2015527074 A5 JP 2015527074A5 JP 2015530507 A JP2015530507 A JP 2015530507A JP 2015530507 A JP2015530507 A JP 2015530507A JP 2015527074 A5 JP2015527074 A5 JP 2015527074A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- vector
- encoding
- nucleotide sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013598 vector Substances 0.000 claims description 22
- 108010006519 Molecular Chaperones Proteins 0.000 claims description 14
- 102000005431 Molecular Chaperones Human genes 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 239000002773 nucleotide Substances 0.000 claims description 12
- 125000003729 nucleotide group Chemical group 0.000 claims description 12
- 102000005962 receptors Human genes 0.000 claims description 5
- 108020003175 receptors Proteins 0.000 claims description 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 108010078791 Carrier Proteins Proteins 0.000 claims description 3
- 102000014914 Carrier Proteins Human genes 0.000 claims description 3
- 102000012547 Olfactory receptors Human genes 0.000 claims description 3
- 108050002069 Olfactory receptors Proteins 0.000 claims description 3
- 108091006027 G proteins Proteins 0.000 claims description 2
- 102000030782 GTP binding Human genes 0.000 claims description 2
- 108091000058 GTP-Binding Proteins 0.000 claims description 2
- 101710092268 Heat shock protein 70 homolog Proteins 0.000 claims description 2
- 101000635752 Homo sapiens Receptor-transporting protein 2 Proteins 0.000 claims description 2
- 101710163458 Movement protein Hsp70h Proteins 0.000 claims description 2
- 102100030850 Receptor-transporting protein 2 Human genes 0.000 claims description 2
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims description 2
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 230000019491 signal transduction Effects 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 101150042744 ric8b gene Proteins 0.000 claims 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- 101150012445 ric8a gene Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698930P | 2012-09-10 | 2012-09-10 | |
| PCT/IB2013/002242 WO2014037800A2 (en) | 2012-09-10 | 2013-09-26 | Compositions and methods for increasing the expression and signalling of proteins on cell surfaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527074A JP2015527074A (ja) | 2015-09-17 |
| JP2015527074A5 true JP2015527074A5 (enExample) | 2016-11-04 |
Family
ID=50237708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530507A Pending JP2015527074A (ja) | 2012-09-10 | 2013-09-26 | 細胞表面におけるタンパク質の発現及びシグナル伝達を増大するための組成物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9783585B2 (enExample) |
| EP (1) | EP2893020B1 (enExample) |
| JP (1) | JP2015527074A (enExample) |
| AU (1) | AU2013311316A1 (enExample) |
| WO (1) | WO2014037800A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015116771A1 (en) * | 2014-01-29 | 2015-08-06 | The Johns Hopkins University | Compositions and methods for increasing the expression and signalling of proteins on cell surfaces |
| GB202108867D0 (en) | 2021-06-21 | 2021-08-04 | Givaudan Sa | Screening system |
| US20260210939A1 (en) | 2022-12-15 | 2026-07-23 | Givaudan Sa | Modified olfactory receptors |
| WO2025257381A1 (en) | 2024-06-14 | 2025-12-18 | Givaudan Sa | Modified olfactory receptors |
| EP4664463A1 (en) | 2024-06-14 | 2025-12-17 | Givaudan SA | Computer-implemented method for olfactory property prediction |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5993778A (en) | 1997-05-07 | 1999-11-30 | Firestein; Stuart J. | Functional expression of, and assay for, functional cellular receptors in vivo |
| JP2005506039A (ja) * | 2000-12-29 | 2005-03-03 | ネオジェネシス ファーマシューティカルズ インコーポレイテッド | アフィニティ選択に基づいた疎水性タンパク質のスクリーニング |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| CA2571080C (en) * | 2004-06-18 | 2013-05-28 | Duke University | Modulators of odorant receptors |
| US20090155267A1 (en) * | 2005-02-09 | 2009-06-18 | Apollo Life Sciences Limited | Molecule and chimeric molecules thereof |
| WO2011069156A2 (en) * | 2009-12-04 | 2011-06-09 | Duke University | Compositions and methods for enhancing odorant receptor activity |
| JP5697383B2 (ja) * | 2010-09-03 | 2015-04-08 | 花王株式会社 | 悪臭抑制剤の探索方法 |
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2013
- 2013-09-26 AU AU2013311316A patent/AU2013311316A1/en not_active Abandoned
- 2013-09-26 EP EP13836094.6A patent/EP2893020B1/en active Active
- 2013-09-26 JP JP2015530507A patent/JP2015527074A/ja active Pending
- 2013-09-26 US US14/427,090 patent/US9783585B2/en active Active
- 2013-09-26 WO PCT/IB2013/002242 patent/WO2014037800A2/en not_active Ceased