JP2019518788A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019518788A5 JP2019518788A5 JP2019511816A JP2019511816A JP2019518788A5 JP 2019518788 A5 JP2019518788 A5 JP 2019518788A5 JP 2019511816 A JP2019511816 A JP 2019511816A JP 2019511816 A JP2019511816 A JP 2019511816A JP 2019518788 A5 JP2019518788 A5 JP 2019518788A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- protein according
- seq
- sequence
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims description 32
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 230000035772 mutation Effects 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 3
- 108091033319 polynucleotide Proteins 0.000 claims description 3
- 239000002157 polynucleotide Substances 0.000 claims description 3
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims description 2
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102200118204 rs35890380 Human genes 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000013642 negative control Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1608197.8A GB201608197D0 (en) | 2016-05-10 | 2016-05-10 | Novel proteins |
| GB1608197.8 | 2016-05-10 | ||
| PCT/GB2017/051303 WO2017194941A1 (en) | 2016-05-10 | 2017-05-10 | Cd200 mutant and its uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518788A JP2019518788A (ja) | 2019-07-04 |
| JP2019518788A5 true JP2019518788A5 (enExample) | 2020-06-25 |
| JP6997767B2 JP6997767B2 (ja) | 2022-03-04 |
Family
ID=56297468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511816A Active JP6997767B2 (ja) | 2016-05-10 | 2017-05-10 | Ｃｄ２００変異体及びその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11203628B2 (enExample) |
| EP (1) | EP3455247A1 (enExample) |
| JP (1) | JP6997767B2 (enExample) |
| KR (2) | KR102498901B1 (enExample) |
| CN (1) | CN109219614B (enExample) |
| AU (1) | AU2017264825B2 (enExample) |
| BR (1) | BR112018073280A2 (enExample) |
| CA (1) | CA3023601A1 (enExample) |
| EA (1) | EA201892554A1 (enExample) |
| GB (1) | GB201608197D0 (enExample) |
| IL (1) | IL262846B2 (enExample) |
| MX (1) | MX386295B (enExample) |
| NZ (1) | NZ747665A (enExample) |
| SG (1) | SG11201809677XA (enExample) |
| WO (1) | WO2017194941A1 (enExample) |
| ZA (1) | ZA201807079B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201608197D0 (en) | 2016-05-10 | 2016-06-22 | Ducentis Biotherapeutics Ltd | Novel proteins |
| KR102186780B1 (ko) | 2019-02-18 | 2020-12-04 | 박주현 | 비행부와 탑승부를 분리하여 축으로 결합한 유인드론 |
| CN110859951A (zh) * | 2019-09-23 | 2020-03-06 | 中国药科大学 | Cd200蛋白和cd200融合蛋白在制备治疗银屑病药物中的应用 |
| GB202115803D0 (en) * | 2021-11-03 | 2021-12-15 | Ducentis Biotherapeutics Ltd | Novel proteins |
| KR20250025619A (ko) * | 2022-05-06 | 2025-02-24 | 두센티스 바이오테라퓨틱스 리미티드 | 신규한 cd200 융합 단백질 |
| WO2023214387A1 (en) * | 2022-05-06 | 2023-11-09 | Ducentis Biotherapeutics Limited | Novel cd200 fusion proteins |
| GB2626300A (en) * | 2022-12-08 | 2024-07-24 | Ducentis Biotherapeutics Ltd | Mutated CD200 proteins and methods of use therof |
| GB202303291D0 (en) | 2023-03-07 | 2023-04-19 | Secr Defence | Medicament and medicament combination for use in the treatment of infectious disease |
| GB202306711D0 (en) * | 2023-05-05 | 2023-06-21 | Ducentis Biotherapeutics Ltd | Novel proteins |
| WO2025106841A1 (en) * | 2023-11-15 | 2025-05-22 | The University Of Chicago | Methods and compositions for inducing antigen specific tolerance |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223729B2 (en) | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
| DK1032662T3 (da) * | 1997-11-07 | 2006-07-03 | Trillium Therapeutics Inc | Fremgangsmåder og sammensætninger til immunmodulation |
| MXPA01010480A (es) * | 1999-04-13 | 2002-03-27 | Schering Corp | Usos novedosos de la proteina 0x2 de mamifero y reactivos relacionados. |
| EP1261743A2 (en) * | 2000-03-07 | 2002-12-04 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| AU2333802A (en) * | 2000-11-22 | 2002-06-03 | Transplantation Technologies I | Truncated cd200 |
| TWI323734B (en) * | 2005-08-19 | 2010-04-21 | Abbott Lab | Dual variable domain immunoglobulin and uses thereof |
| CA2674578A1 (en) * | 2007-01-11 | 2008-07-24 | Boehringer Ingelheim International Gmbh | Cd200 and its receptor, cd200r, modulate bone mass via the differentiation of osteoclasts |
| EP2414385B1 (en) * | 2009-03-31 | 2015-04-22 | University of Washington | Compositions and methods for modulating the activity of complement regulatory proteins on target cells |
| EP2523976B1 (en) * | 2010-01-11 | 2018-04-25 | Alexion Pharmaceuticals, Inc. | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
| GB201608197D0 (en) | 2016-05-10 | 2016-06-22 | Ducentis Biotherapeutics Ltd | Novel proteins |
-
2016
- 2016-05-10 GB GBGB1608197.8A patent/GB201608197D0/en not_active Ceased
-
2017
- 2017-05-10 JP JP2019511816A patent/JP6997767B2/ja active Active
- 2017-05-10 US US16/300,382 patent/US11203628B2/en active Active
- 2017-05-10 KR KR1020187035514A patent/KR102498901B1/ko active Active
- 2017-05-10 KR KR1020237004504A patent/KR102689460B1/ko active Active
- 2017-05-10 CA CA3023601A patent/CA3023601A1/en active Pending
- 2017-05-10 NZ NZ747665A patent/NZ747665A/en unknown
- 2017-05-10 BR BR112018073280-0A patent/BR112018073280A2/pt active Search and Examination
- 2017-05-10 SG SG11201809677XA patent/SG11201809677XA/en unknown
- 2017-05-10 EA EA201892554A patent/EA201892554A1/ru unknown
- 2017-05-10 MX MX2018013778A patent/MX386295B/es unknown
- 2017-05-10 EP EP17724607.1A patent/EP3455247A1/en active Pending
- 2017-05-10 CN CN201780028505.0A patent/CN109219614B/zh active Active
- 2017-05-10 WO PCT/GB2017/051303 patent/WO2017194941A1/en not_active Ceased
- 2017-05-10 AU AU2017264825A patent/AU2017264825B2/en active Active
-
2018
- 2018-10-24 ZA ZA2018/07079A patent/ZA201807079B/en unknown
- 2018-11-07 IL IL262846A patent/IL262846B2/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019518788A5 (enExample) | ||
| Liang et al. | Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination | |
| Shaik et al. | Structural basis of coreceptor recognition by HIV-1 envelope spike | |
| Carfı́ et al. | Herpes simplex virus glycoprotein D bound to the human receptor HveA | |
| Huber et al. | A specific domain in α-catenin mediates binding to β-catenin or plakoglobin | |
| JP2019522466A5 (enExample) | ||
| JP5761831B2 (ja) | 癌及び慢性感染の治療のための作動薬活性を有するｉｌ−２由来のポリペプチド | |
| JP2019516665A5 (enExample) | ||
| JP2021500855A5 (enExample) | ||
| JP2019522465A5 (enExample) | ||
| JP2019521643A5 (enExample) | ||
| PE20190743A1 (es) | Metodos para el tratamiento de la atrofia muscular y enfermedad osea con el uso de proteinas trap hibridas novedosas del ligando actriib | |
| RU2015142999A (ru) | Слитые белки, содержащие связывающие части pdgf и vegf, и способы их применения | |
| JP2013519721A5 (enExample) | ||
| JP2017537926A5 (enExample) | ||
| JP2015212284A5 (enExample) | ||
| Wang et al. | Structural interaction and functional regulation of polycystin-2 by filamin | |
| JP2014510519A5 (enExample) | ||
| Feng et al. | Human β‐defensin‐3 structure motifs that are important in CXCR 4 antagonism | |
| Palacín et al. | Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms | |
| JP2019525764A5 (enExample) | ||
| Sette et al. | A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules | |
| CN116375880A (zh) | 融合蛋白及其制备方法和应用 | |
| US20210057047A1 (en) | In-silico method for designing a (d)-polypeptide ligand | |
| CN116836260A (zh) | 一种识别mage-a4的t细胞受体及其编码序列和应用 |