JP2013520426A5 - - Google Patents
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- JP2013520426A5 JP2013520426A5 JP2012553974A JP2012553974A JP2013520426A5 JP 2013520426 A5 JP2013520426 A5 JP 2013520426A5 JP 2012553974 A JP2012553974 A JP 2012553974A JP 2012553974 A JP2012553974 A JP 2012553974A JP 2013520426 A5 JP2013520426 A5 JP 2013520426A5
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- Prior art keywords
- polypeptide
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- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 150000001413 amino acids Chemical group 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 102000002090 Fibronectin type III Human genes 0.000 claims 2
- 108050009401 Fibronectin type III Proteins 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 102000007562 Serum Albumin Human genes 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 210000000068 Th17 cell Anatomy 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 102000028557 immunoglobulin binding proteins Human genes 0.000 claims 1
- 108091009323 immunoglobulin binding proteins Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 230000007918 pathogenicity Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30556610P | 2010-02-18 | 2010-02-18 | |
| US61/305,566 | 2010-02-18 | ||
| US33070610P | 2010-05-03 | 2010-05-03 | |
| US61/330,706 | 2010-05-03 | ||
| PCT/US2011/024959 WO2011103105A1 (en) | 2010-02-18 | 2011-02-16 | Fibronectin based scaffold domain proteins that bind il-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520426A JP2013520426A (ja) | 2013-06-06 |
| JP2013520426A5 true JP2013520426A5 (enExample) | 2014-01-23 |
Family
ID=43901183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553974A Pending JP2013520426A (ja) | 2010-02-18 | 2011-02-16 | Ｉｌ−２３に結合する、フィブロネクチンをベースとする足場ドメインタンパク質 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8927693B2 (enExample) |
| EP (1) | EP2536757B1 (enExample) |
| JP (1) | JP2013520426A (enExample) |
| KR (1) | KR20130010461A (enExample) |
| CN (1) | CN102762591A (enExample) |
| AR (1) | AR080229A1 (enExample) |
| AU (1) | AU2011218243A1 (enExample) |
| BR (1) | BR112012019881A2 (enExample) |
| CA (1) | CA2790329A1 (enExample) |
| CL (1) | CL2012002296A1 (enExample) |
| EA (1) | EA201270713A1 (enExample) |
| MX (1) | MX2012009050A (enExample) |
| PE (1) | PE20130041A1 (enExample) |
| SG (1) | SG183215A1 (enExample) |
| TN (1) | TN2012000372A1 (enExample) |
| TW (1) | TWI508736B (enExample) |
| WO (1) | WO2011103105A1 (enExample) |
| ZA (1) | ZA201206969B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| EP2247615B1 (en) | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| TW201138808A (en) * | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (en) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| KR102049223B1 (ko) | 2010-11-04 | 2019-11-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 항－ｉｌ－２３ 항체 |
| EP2655411A1 (en) * | 2010-12-22 | 2013-10-30 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind il-23 |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| US9347058B2 (en) | 2011-05-17 | 2016-05-24 | Bristol-Myers Squibb Company | Methods for the selection of binding proteins |
| US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| EP2773964A4 (en) * | 2011-11-03 | 2015-06-24 | Stc Biolog Inc | METHOD FOR DETERMINING THE PHARMACOLOGICAL PROPERTIES OF RECOMBINANT PROTEINS |
| CN109206516A (zh) | 2012-05-03 | 2019-01-15 | 勃林格殷格翰国际有限公司 | 抗IL-23p19抗体 |
| RS58801B1 (sr) | 2012-09-13 | 2019-07-31 | Bristol Myers Squibb Co | Skafold domenski proteini na bazi fibronektina koji se vezuju za miostatin |
| CZ2012829A3 (cs) | 2012-11-23 | 2014-06-11 | Biotechnologický Ústav Av Čr, V.V.I. | Polypeptidy pro léčbu autoimunitních chorob založenou na blokaci receptoru pro lidský cytokin IL-23 |
| US20150361159A1 (en) | 2013-02-01 | 2015-12-17 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
| WO2014124017A1 (en) * | 2013-02-06 | 2014-08-14 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
| US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
| KR20150062352A (ko) * | 2013-11-29 | 2015-06-08 | 일진엘이디(주) | 유전체층을 가진 발광 다이오드 |
| AU2015231170B2 (en) | 2014-03-20 | 2019-10-03 | Bristol-Myers Squibb Company | Serum albumin-binding fibronectin type III domains |
| EP3172339A1 (en) | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| CA2959629C (en) | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| KR20170120616A (ko) | 2015-02-04 | 2017-10-31 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 질환의 치료 방법 |
| EP3353198B1 (en) | 2015-09-23 | 2020-06-17 | Bristol-Myers Squibb Company | Glypican-3binding fibronectin based scafflold molecules |
| US10766946B2 (en) | 2015-09-23 | 2020-09-08 | Bristol-Myers Squibb Company | Fast-off rate serum albumin binding fibronectin type III domains |
| WO2017115828A1 (ja) * | 2015-12-29 | 2017-07-06 | 国立大学法人東京工業大学 | 標的結合ペプチドの安定化方法 |
| TWI897843B (zh) * | 2017-05-03 | 2025-09-21 | 美商必治妥美雅史谷比公司 | 結合至肌肉生長抑制素以纖維連接蛋白為主之支架結構域蛋白質的穩定調配物 |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| EP3789049A1 (en) * | 2019-09-06 | 2021-03-10 | QGel SA | Method for obtaining healthy intestinal organoids |
| TW202535466A (zh) | 2019-09-09 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| ATE139900T1 (de) | 1992-11-13 | 1996-07-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| IL131016A (en) | 1997-01-21 | 2004-12-15 | Gen Hospital Corp | Selection of proteins using RNA-protein blends |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| JP2003528632A (ja) | 2000-03-31 | 2003-09-30 | インスティティ・パスツール | 血管内皮成長因子（ｖｅｇｆ）−媒介性脈管形成を阻害するペプチド、該ペプチドをエンコードするポリヌクレオチド及びその使用方法 |
| CA2416219C (en) | 2000-07-11 | 2016-10-11 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| CA2418835A1 (en) * | 2000-10-16 | 2002-04-25 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| NZ540194A (en) | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| CN102816241B (zh) | 2004-02-09 | 2015-07-22 | 人类基因科学公司 | 清蛋白融合蛋白 |
| CN1317389C (zh) * | 2004-09-02 | 2007-05-23 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 抑制纤连蛋白表达的反义寡核苷酸的结构和用途 |
| US20070269422A1 (en) | 2006-05-17 | 2007-11-22 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| DE102006032337A1 (de) | 2006-07-12 | 2008-01-17 | BSH Bosch und Siemens Hausgeräte GmbH | Verfahren zur Steuerung eines Schleuderablaufes einer Waschmaschine und zur Durchführung des Verfahrens geeignete Waschmaschine |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| HUE042172T2 (hu) * | 2007-02-23 | 2019-06-28 | Merck Sharp & Dohme | Genetikailag elõállított anti-il-23P19 antitestek |
| MX2009009167A (es) * | 2007-02-28 | 2009-09-04 | Schering Corp | Terapia de combinacion para el tratamiento de trastornos inmunes. |
| TW200944231A (en) | 2007-11-30 | 2009-11-01 | Glaxo Group Ltd | Antigen-binding constructs |
| AU2008345424A1 (en) * | 2007-12-27 | 2009-07-09 | Novartis Ag | Improved fibronectin-based binding molecules and their use |
| EP2247615B1 (en) * | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| CN102076713B (zh) * | 2008-05-02 | 2015-03-25 | 诺华股份有限公司 | 改进的基于纤连蛋白的结合分子及其用途 |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| CA2759942A1 (en) * | 2009-04-27 | 2010-10-07 | Novartis Ag | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betai subunit |
-
2011
- 2011-02-16 PE PE2012001260A patent/PE20130041A1/es not_active Application Discontinuation
- 2011-02-16 JP JP2012553974A patent/JP2013520426A/ja active Pending
- 2011-02-16 KR KR1020127024171A patent/KR20130010461A/ko not_active Withdrawn
- 2011-02-16 EP EP11708608.2A patent/EP2536757B1/en not_active Not-in-force
- 2011-02-16 CN CN2011800100540A patent/CN102762591A/zh active Pending
- 2011-02-16 WO PCT/US2011/024959 patent/WO2011103105A1/en not_active Ceased
- 2011-02-16 US US13/579,204 patent/US8927693B2/en active Active
- 2011-02-16 EA EA201270713A patent/EA201270713A1/ru unknown
- 2011-02-16 AU AU2011218243A patent/AU2011218243A1/en not_active Abandoned
- 2011-02-16 MX MX2012009050A patent/MX2012009050A/es active IP Right Grant
- 2011-02-16 SG SG2012058517A patent/SG183215A1/en unknown
- 2011-02-16 BR BR112012019881A patent/BR112012019881A2/pt not_active IP Right Cessation
- 2011-02-16 CA CA2790329A patent/CA2790329A1/en not_active Abandoned
- 2011-02-18 TW TW100105496A patent/TWI508736B/zh not_active IP Right Cessation
- 2011-02-18 AR ARP110100518A patent/AR080229A1/es unknown
-
2012
- 2012-07-23 TN TNP2012000372A patent/TN2012000372A1/en unknown
- 2012-08-17 CL CL2012002296A patent/CL2012002296A1/es unknown
- 2012-09-17 ZA ZA2012/06969A patent/ZA201206969B/en unknown
-
2014
- 2014-11-25 US US14/553,379 patent/US9714281B2/en active Active